Dr. Francisco Xavier del Espíritu Santo Soberon Mainero
Investigador
Estructura, Función y Manipulación de Péptidos y Proteínas
Genómica y transcriptomica de patógenos y parásitos
Número de registros: 6
- Activos
- Vencidos
- Exploración del espacio de variantes del dominio de unión al receptor (ace2) del virus sars-cov-2 mediante redes neurales, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2022 - 2024
- Evolución dirigida del dominio de prefenato deshidrogenasa de la proteína t de e. coli, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2016 - 2019
- Evolución dirigida de proteínas, PRESUPUESTO UNAM, 2014 - 2020
- Estudios evoulutivos y mecanísticos de la enzima bifuncional fosforibosil isomerasa (pria) presente en bacterias del grupo de los actinomicetos., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2005 - 2006
- Diseño y desarrollo de un andamiaje estable para evolución dirigida de actividades catalíticas., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2004 - 2007
- Evolución dirigida de proteínas: desarrollo de conceptos y metodologías para la generación de reconocimiento y catálisis de novo, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 1997 - 2002
Nivel D del PRIDE
Nivel III del SNII
Nivel III del SNII
Doctorado, en Investigacion Biomedica Basica, Instituto de Investigaciones Biomedicas-CEINGEBI-UNAM (1984)
Maestría, en Investigacion Biomedica Basica, Instituto de Investigaciones Biomedicas-UNAM (1981)
Licenciatura, Química, Universidad Iberoamericana (1978)
Premio Nacional de Química "Andrés Manuel del Río", Sociedad Química de México, 1999
- Activos
- Graduados
-
Doctorado
-
M.C. Brenda Georgina Uribe Vazquez
Caracterización bioquímica, biofísica y estructural de variantes de KatG que confieren resistencia a isoniazida en Mycobacterium tuberculosis
1 - Guerrero Corona, Diego (2019). Microbioma de tracto respiratorio en pacientes con infecciones respiratorias agudas .
INMEGEN,
Maestria en Ciencias Bioquimicas,
UNAM.
*
2 - Cruz Correa, Omar Fernando (2019). Caracterizacion de la diversidad en genes importantes de farmacogenomica mediante secuenciacion de nueva generacion .
Instituto de Biotecnologia,
Doctorado en Bioquimicas,
UNAM.
3 - Uribe Vazquez, Brenda Georgina (2017). Caracterizacion funcional de mutaciones nuevas en KatG de mycobacterium tuberculosis resistente a isoniazida encontradas en aislados clinicos de pacientes mexicanos .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
4 - Lopez de los Santos, Yossef (2014). Ingenieria de las proteinas del sistema pts en escherichia coli.
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
5 - Cruz Correa, Omar Fernando (2013). Desarrollo de pruebas genomicas prioritarias para la salud publica de Mexico .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
6 - Cantu Alessio Robles, Vito Adrian (2013). Analisis de una libreria binaria de mutantes de NPR .
Instituto de Biotecnologia,
Maestria en Ciencias,
UNAM.
7 - Ochoa Leyva, Adrian (2011). Explorando la relacion estructurafuncion de las asas SS/a de un barril (SS/a)8 : implicaciones para el diseno de nuevas funciones enzimaticas .
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
8 - Verdel Aranda, Karina (2009). Cinetica enzimatica de fosforribosil antranilato isomerasas (PRAI) obtenidas por evolucion dirigida .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
9 - Flores Escobar, Biviana (2008). Diseno y construccion de variantes de la enzima fosforribosil antranilato isomerasa (PRAI) con asas de aldolasas clase I .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
10 - Gaytan Colin, Ruben Paul (2003). Nuevas estrategias de sintesis de DNA para la evolucion dirigida de proteinas : generacion y enriquecimiento de bibliotecas con mutantes de baja multiplicidad.
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
11 - Riano Umbarila, Lidia (2000). Desarrollo de un sistema de seleccion para la actividad de aldolasa .
Instituto de Biotecnologia,
Maestria en Ciencias (Bioquimica),
UNAM.
12 - Ledezma Candanoza, Luis Moises (2000). Estudio de la catalisis y del reconocimiento especifico al ADN por la endonucleasa EcoRI .
Instituto de Biotecnologia,
Maestria en Ciencias Biomedicas,
UNAM.
13 - Gonzalez Zuniga, Victor Manuel (1998). El mecanismo de activacion trascripcional a distancia en bacteria y la region de control positivo de NifA .
Instituto de Biotecnologia,
Doctorado en Biotecnologia,
UNAM.
14 - Chihu Amparan, Lilia (1998). Mutagenesis combinatoria de la region del sitio activo de la beta lactamasa tem1 de Escherichia coli .
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
Asesor: Soberon Mainero, Francisco Xavier, Fuchs Gomez, Lidia Yolanda
15 - Rio Guerra, Gabriel del (1997). Estudio del sitio catalitico de una alfaamilasa por medio de ingenieria de proteinas .
Instituto de Biotecnologia,
Doctorado en Biotecnologia,
UNAM.
16 - Flores Soto, Humberto (1995). Analisis del reconocimiento molecular por medio de ingenieria de proteinas.
Instituto de Biotecnologia,
Doctorado en Biotecnologia,
UNAM.
17 - Cota Segura, Ernesto (1995). Estudio de regiones conservadas de la betalactamasa clase A de E. coli.
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
18 - Viadiu Ilarraza, Hector (1994). Modificacion de la especificidad de la Blactamasa por mutagenesis combinatoria.
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
19 - Rio Guerra, Gabriel del (1994). Mutagenesis de residuos involucrados en la estabilidad al PH alcalino de la penicilino acilasa de E. coli .
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
20 - Ramirez Alvarado, Marina (1994). Ingenieria de proteinas para reacciones de alcoholisis mutagenesis combinatoria de alfaamilasa .
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
21 - Flores Soto, Humberto (1994). Analisis de la intervencion DNA proteina de la endonucleasa Ecori, por medio de mutagenesis dirigida .
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
22 - Osuna Quintero, Joel (1992). Analisis del sitio activo de enzimas mediante mutagenesis combinatoria .
Instituto de Biotecnologia,
Doctor en Investigacion Biomedica Basica,
UNAM.
23 - Munguia Zamudio, Maria Elena (1992). Clonacion y expresion del fragmento C de la toxina tetanica en Escherichia coli .
Instituto de Biotecnologia,
Maestroia en Biotecnologia,
UNAM.
24 - Flores Soto, Humberto (1991). Caracterizacion de mutantes en el sitio de reconocimiento de la endonucleasa Eco RI .
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
*
25 - Osuna Quintero, Joel (1989). Aislamineto de un fragmento inmunogenico de toxina tetanica.
CEINGEBI,
Maestria en Investigacion Biomedica Basica,
UNAM.
26 - Cruz Reyes, Jorge Armando (1989). Un sistema experimental para el aislamiento del sustrato minimo de replicacion en plasmidos tipo Col E1 .
CEINGEBI,
Licenciatura en Investigacion Biomedica Basica,
UNAM.
27 - Munguia Zamudio, Maria Elena (1987). Estudios sobre estabilidad y replicacion inducible en plasmidos tipo col el .
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
*
28 - Lomeli Buyoli, Hilda Maria (1987). Determinacion de una region hacia arriba del promotor requerida para la transcripcion optima del primero de replicacion del plasmido pBR327 .
CEINGEBI,
Maestria en Investigacion Biomedica Basica,
UNAM.
29 - Lomeli Buyoli, Hilda Maria (1984). Introduccion de un sitio de restriccion adyacente al origen de replicacion del plasmido pBR327.
Escuela Nacional de Estudios Superiores Zaragoza,
Quimico Farmaceutico Biologo,
UNAM.
*
30 - Cuevas Guerrero, Mario Alberto (1983). Sintesis de polinucleotidos mediante tecnica estandarizada .
FES Zaragoza,
Quimico Farmaceutico Biologo,
UNAM.
*
Total de publicaciones: 134
- Tipo
- Fecha
Artículo
31 - Galeana-Cadena,D., Ramirez-Martinez,G., Choreno-Parra,J.A., Silva-Herzog,E., Hernandez-Cardenas,C.M., Soberon,X., Zuniga,J. (2024). Microbiome in the Nasopharynx: Insights into the Impact of COVID-19 Severity.
Heliyon,
10 (10),
e31562.
Artículo
32 - Uribe-Vazquez,B., Diaz-Vilchis,A, Avila-Linares,A., Saab-Rincon,G, Marin-Tovar,Y., Flores,H, Pastor,N, Huerta-Miranda,G, Rudino-Pinera,E., Soberon,X (2024). Characterization of a catalase-peroxidase variant (L333V-KatG) identified in an INH-resistant Mycobacterium tuberculosis clinical isolate.
Biochemistry and Biophysics Reports,
37,
101649.
Revisión
33 - Alvarado-Pena,N., Galeana-Cadena,D., Gomez-Garcia,I.A, Soberon-Mainero,X, Silva-Herzog,E (2023). The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment.
Frontiers in Microbiology,
14,
1237998.
Artículo
34 - Barbosa-Amezcua,M., Cuevas-Cordoba,B., Fresno,C., Haase-Hernandez,J.I., Carrillo-Sanchez,K., Mata-Rocha,M., Munoz-Torrico,M., Backer,C., Gonzalez-Covarrubias,V., Alaez-Verson,C., Soberon,X. (2022). Rapid Identification of Drug Resistance and Phylogeny in M. tuberculosis, Directly from Sputum Samples.
Microbiology Spectrum,
10 (5),
e0125222.
Artículo
35 - Martinez-Magana,J.J., Genis-Mendoza,A.D., Gonzalez-Covarrubias,V., Juarez-Rojop,I.E., Tovilla-Zarate,C.A., Soberon,X., Lanzagorta,N., Nicolini,H. (2022). Association of FAAH p.Pro129Thr and COMT p.Ala72Ser with schizophrenia and comorbid substance use through next-generation sequencing: an exploratory analysis.
Brazilian Journal of Psychiatry,
44 (2),
164-170.
*
Artículo
36 - Aguilar-Ordonez,I., Perez-Villatoro,F., Garcia-Ortiz,H., Barajas-Olmos,F., Ballesteros-Villascan,J., Gonzalez-Buenfil,R., Fresno,C., Garciarrubio,A., Fernandez-Lopez,J.C., Tovar,H., Hernandez-Lemus,E., Orozco,L., Soberon,X., Morett,E. (2021). Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights.
PLoS ONE,
16 (4),
e0249773,
[correction May 25 2022].
artículo
37 - Cuevas-Cordoba,B., Fresno,C., Haase-Hernandez,J.I., Barbosa-Amezcua,M., Mata-Rocha,M., Munoz-Torrico,M., Salazar-Lezama,M.A., Martinez-Orozco,J.A., Narvaez-Diaz,L.A., Salas-Hernandez,J., Gonzalez-Covarrubias,V., Soberon,X. (2021). A bioinformatics pipeline for Mycobacterium tuberculosis sequencing that cleans contaminant reads from sputum samples.
PLoS ONE,
16 (10),
e0258774.
*
Artículo
38 - Gonzalez-Covarrubias,V,, Sanchez-Ibarra,H., Lozano-Gonzalez, K., Villicana, S., Texis,T., Rodriguez-Dorantes,M., Cortes-Ramirez,S., Lavalle-Gonzalez,F,, Soberon,X., Barrera-Saldana,H. (2021). Transporters, TBC1D4, and ARID5B Variants to Explain Glycated Hemoglobin Variability in Patients with Type 2 Diabetes.
Pharmacology,
106 (11-12),
588-596.
Artículo
39 - Jaimes-Hoy,L., Perez-Maldonado,A., Narvaez-Bahena,E., de la Cruz Guarneros,N., Rodriguez-Rodriguez,A., Charli,J.L., Soberon,X., Joseph-Bravo,P. (2021). Sex dimorphic changes in Trh gene methylation and thyroid-axis response to energy demands in maternally-separated rats.
Endocrinology,
May 27 Online ahead of print [comentario vol 162 (9) pp 1-2].
Artículo
40 - Valdez-Palomares,F., Munoz-Torrico,M., Palacios-Gonzalez,B., Soberon,X., Silva-Herzog,E. (2021). Altered Microbial Composition of Drug-Sensitive and Drug-Resistant TB Patients Compared with Healthy Volunteers.
Microorganisms,
9 (8),
1762.
Revisión
41 - Gonzalez-Covarrubias,V., Lozano,K., Texis,T., Guzman-Cruz,C.K., Rodriguez-Dorantes,M., Rubio-Carrasco,K., Mendez-Lorenzo,L.H., Soberon,X. (2020). Pharmacogenomics: Current Actionable Variants.
Revista de Investigacion Clinica,
73 (3).
*
Artículo
42 - Cabrera-Contreras,R., Santamaria,R.I., Bustos,P., Martinez-Flores,I., Melendez-Herrada,E., Morelos-Ramirez,R., Barbosa-Amezcua,M., Gonzalez-Covarrubias,V., Silva-Herzog,E., Soberon,X., Gonzalez,V. (2019). Genomic diversity of prevalent Staphylococcus epidermidis multidrug-resistant strains isolated from a Children's Hospital in Mexico City in an eight-years survey.
PeerJ,
7,
e8068.
*
Artículo
43 - Flannick,J., Mercader,J.M., Fuchsberger,C., Udler,M.S., Mahajan,A., Wessel,J., Teslovich,T.M., Caulkins,L., Koesterer,R., Barajas-Olmos,F., Blackwell,T.W., Boerwinkle,E., Brody,J.A., Centeno-Cruz,F., Chen,L., Chen,S., Contreras-Cubas,C., Cordova,E., Correa,A., Cortes,M., Defronzo,R.A., Dolan,L., Drews,K.L., Elliott,A., Floyd,J.S., Gabriel,S., Garay-Sevilla,M.E., Garcia-Ortiz,H., Gross,M., Han,S., Heard-Costa,N.L., Jackson,A.U., Jorgensen,M.E., Kang,H.M., Kelsey,M., Kim,B.J., Koistinen,H.A., Kuusisto,J., Leader,J.B., Linneberg,A., Liu,C.T., Liu,J., Lyssenko,V., Manning,A.K., Marcketta,A., Malacara-Hernandez,J.M., Martinez-Hernandez,A., Matsuo,K., Mayer-Davis,E., Mendoza-Caamal,E., Mohlke,K.L., Morrison,A.C., Ndungu,A., Ng,M.C.Y., O'Dushlaine,C., Payne,A.J., Pihoker,C., Post,W.S., Preuss,M., Psaty,B.M., Vasan,R.S., Rayner,N.W., Reiner,A.P., Revilla-Monsalve,C., Robertson,N.R., Santoro,N., Schurmann,C., So,W.Y., Soberon,X., Stringham,H.M., Strom,T.M., Tam,C.H.T., Thameem,F., Tomlinson,B., Torres,J.M., Tracy,R.P., van Dam,R.M., Vujkovic,M., Wang,S., Welch,R.P., Witte,D.R., Wong,T.Y., Atzmon,G., Barzilai,N., Blangero,J., Bonnycastle,L.L., Bowden,D.W., Chambers,J.C., Chan,E., Cheng,C.Y., Cho,Y.S., Collins,F.S., de Vries,P.S., Duggirala,R., Glaser,B., Gonzalez,C., Gonzalez,M.E., Groop,L., Kooner,J.S., Kwak,S.H., Laakso,M., Lehman,D.M., Nilsson,P., Spector,T.D., Tai,E.S., Tuomi,T., Tuomilehto,J., Wilson,J.G., guilar-Salinas,C.A., Bottinger,E., Burke,B., Carey,D.J., Chan,J.C.N., Dupuis,J., Frossard,P., Heckbert,S.R., Hwang,M.Y., Kim,Y.J., Kirchner,H.L., Lee,J.Y., Lee,J., Loos,R.J.F., Ma,R.C.W., Morris,A.D., O'Donnell,C.J., Palmer,C.N.A., Pankow,J., Park,K.S., Rasheed,A., Saleheen,D., Sim,X., Small,K.S., Teo,Y.Y., Haiman,C., Hanis,C.L., Henderson,B.E., Orozco,L., Tusie-Luna,T., Dewey,F.E., Baras,A., Gieger,C., Meitinger,T., Strauch,K., Lange,L., Grarup,N., Hansen,T., Pedersen,O., Zeitler,P., Dabelea,D., Abecasis,G., Bell,G.I., Cox,N.J., Seielstad,M., Sladek,R., Meigs,J.B., Rich,S.S., Rotter,J.I., Altshuler,D., Burtt,N.P., Scott,L.J., Morris,A.P., Florez,J.C., McCarthy,M.I., Boehnke,M. (2019). Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Nature,
570 (7759),
71-76.
*
Artículo
44 - Gonzalez-Covarrubias,V., Morales-Franco,M., Cruz-Correa,O.F., Martinez-Hernandez,A., Garcia-Ortiz,H., Barajas-Olmos,F., Genis-Mendoza,A.D., Martinez-Magana,J.J., Nicolini,H., Orozco,L., Soberon,X. (2019). Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico.
Frontiers in Pharmacology,
10,
1169.
*
Artículo
45 - Madrazo-Moya,C.F., Cancino-Munoz,I., Cuevas-Cordoba,B., Gonzalez-Covarrubias,V., Barbosa-Amezcua,M., Soberon,X., Muniz-Salazar,R., Martinez-Guarneros,A., Backer,C., Zarrabal-Meza,J., Sampieri-Ramirez,C., Enciso-Moreno,A., Lauzardo,M., Comas,I., Zenteno-Cuevas,R. (2019). Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico.
PLoS ONE,
14 (6),
e0213046.
*
Artículo
46 - Martinez-Magana,J.J., Genis-Mendoza,A.D., Gonzalez-Covarrubias,V., Jimenez-Guenchi,J., Galindo-Chavez,A.G., Roche-Bergua,A., Castaneda-Gonzalez,C., Lanzagorta,N., Soberon,X., Nicolini,H. (2019). Exploratory analysis of rare and novel variants in Mexican patients diagnosed with schizophrenia and dementia.
Revista de Investigacion Clinica,
71 (4),
246-254.
*
Artículo
47 - Ayon-Nunez, D.A., Fragoso, G., Espitia, C., Garcia-Varela, M., Soberon, X., Rosas, G., Laclette, J.P., Bobes, R.J. (2018). Identification and characterization of Taenia solium enolase as a plasminogen-binding protein.
Acta Tropica,
182,
69-79.
*
Artículo
48 - Flores-Bautista, J., Navarrete-Perea, J., Fragoso, G., Flisser, A., Soberon, X., Laclette, J.P. (2018). Fate of uptaken host proteins in Taenia solium and Taenia crassiceps cysticerci.
Bioscience Reports,
38 (4),
BSR20180636.
*
Artículo
49 - Bikel, S., Jacobo-Albavera, L., Sanchez-Munoz, F., Cornejo-Granados, F., Canizales-Quinteros, S., Soberon, X., Sotelo-Mundo, R.R., Del Rio-Navarro, B.E., Mendoza-Vargas, A., Sanchez, F., Ochoa-Leyva, A. (2017). A novel approach for human whole transcriptome analysis based on absolute gene expression of microarray data.
PeerJ,
5,
e4133.
Artículo
50 - Bobes, R.J., Navarrete-Perea, J., Ochoa-Leyva, A., Anaya, V.H., Hernandez, M., Cervantes-Torres, J., Estrada, K., Sanchez-Lopez, F., Soberon, X., Rosas, G., Maroni-Nunes C., Garcia-Varela, M., Sotelo-Mundo, R.R., Lopez-Zavala, A.A., Gevorkian, G., Acero, G., Laclette, J.P., Fragoso, G., Sciutto, E. (2017). Experimental and theoretical approaches to investigate the immunogenicity of Taenia solium-derived KE7 antigen.
Infection and Immunity,
85,
e00395-17.
Artículo
51 - Cruz-Correa, O.F., Leon-Cachon, R.B., Barrera-Saldana, H.A., Soberon, X. (2017). Prediction of atorvastatin plasmatic concentrations in healthy volunteers using integrated pharmacogenetics sequencing.
Pharmacogenomics,
18 (2),
121-131.
Artículo
52 - Gonzalez-Covarrubias, V., Urena-Carrion, J., Villegas-Torres, B., Cossio-Aranda, J.E., Trevethan-Cravioto, S., Izaguirre-Avila, R., Fiscal-Lopez, O.J., Soberon, X. (2017). Pharmacogenetic Variation in Over 100 Genes in Patients Receiving Acenocumarol.
Frontiers in Pharmacology,
8,
863.
*
Artículo in consortium
53 - Marquez-Luna,C., Loh,P.R., Price,A.L., South Asian Type 2 Diabet SAT2D, SIGMA Type 2 Diabet Consortium, Soberon,X. (2017). Multiethnic polygenic risk scores improve risk prediction in diverse populations.
Genetic Epidemiology,
41 (8),
811-823.
*
Artículo
54 - Mercader, J.M., Liao, R.G., Davis, A., Dymek, Z., Estrada, K., Tukiainen, T., Huerta-Chagoya, A., Moreno-Macias, H., Jablonski, K.A., Hanson, R.L., Walford, G.A., Moran, I., Chen, L., Agarwala, V., Ordonez-Sanchez, M.L., Rodriguez-Guillen, R., Rodriguez-Torres, M., Segura-Kato, Y., Garcia-Ortiz, H., Centeno-Cruz, F., Barajas-Olmos, F., Caulkins, L., Puppala, S., Fontanillas, P., Williams, A., Bonas-Guarch, S., Hartl, C., Ripke, S., Tooley, K., Lane, J., Zerrweck, C., Martinez-Hernandez, A., Cordova, E.J., Mendoza-Caamal, E., Contreras-Cubas, C., Gonzalez-Villalpando, M.E., Cruz-Bautista, I., Munoz-Hernandez, L., Gomez-Velasco, D., Alvirde, U., Henderson, B.E., Wilkens, L.R., Le, Marchand L., Arellano-Campos, O., Riba, L., Harden, M., Platform, B.G., Gabriel, S., Abboud, H.E., Cortes, M.L., Revilla-Monsalve, C., Islas-Andrade, S., Soberon, X., Curran, J.E., Jenkinson, C.P., Defronzo, R.A., Lehman, D.M., Hanis, C.L., Bell, G.I., Boehnke, M., Blangero, J., Duggirala, R., Saxena, R., MacArthur, D., Ferrer, J., McCarroll, S.A., Torrents, D., Knowler, W.C., Baier, L.J., Burtt, N., Gonzalez-Villalpando, C., Haiman, C.A., Aguilar-Salinas, C.A., Tusie-Luna, T., Flannick, J., Jacobs, S.B.R., Orozco, L., Altshuler, D., Florez, J.C. (2017). A Loss-Of-Function Splice Acceptor Variant in IGF2 is Protective for Type 2 Diabetes.
Diabetes,
66 (11),
2903-2914.
*
Artículo
55 - Navarrete-Perea, J., Moguel, B.A., Bobes, R.J., Villalobos, N., Carrero, J.C., Sciutto, E., Soberon, X., Laclette, J.P. (2017). Protein profiles of Taenia solium cysts obtained from skeletal muscles and the central nervous system of pigs: Search for tissue-specific proteins.
Experimental Parasitology,
172,
23-29.
Artículo
56 - Navarrete-Perea, J., Isasa, M., Paulo, J.A., Corral-Corral, R., Flores-Bautista, J., Hernandez-Tellez, B., Bobes, R.J., Fragoso, G., Sciutto, E., Soberon, X., Gygi, S.P., Laclette, J.P. (2017). Quantitative multiplexed proteomics of Taenia solium cysts obtained from the skeletal muscle and central nervous system of pigs.
PLoS Neglected Tropical Diseases,
11 (9),
e0005962.
Artículo
57 - Romero-Hidalgo, S., Ochoa-Leyva, A., Garciarrubio, A., Acuna-Alonzo, V., Antunez-Arguelles, E., Balcazar-Quintero, M., Barquera-Lozano, R., Carnevale, A., Cornejo-Granados, F., Fernandez-Lopez, J.C., Garcia-Herrera, R., Garcia-Ortiz, H., Granados-Silvestre, A., Granados, J., Guerrero-Romero, F., Hernandez-Lemus, E., Leon-Mimila, P., Macin-Perez, G., Martinez-Hernandez, A., Menjivar, M., Morett, E., Orozco, L., Ortiz-Lopez, G., Perez-Villatoro, F., Rivera-Morales, J., Riveros-McKay, F., Villalobos-Comparan, M., Villamil-Ramirez, H., Villarreal-Molina, T., Canizales-Quinteros, S., Soberon, X. (2017). Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing.
Nature Communications,
8 (1),
1005.
Artículo in consortium
58 - Rusu,V., Hoch,E., Mercader,J.M., Tenen,D.E., Gymrek,M., Hartigan,C.R., Deran,M., von Grotthuss,M., Fontanillas,P., Spooner,A., Guzman,G., Deik,A.A., Pierce,K.A., Dennis,C., Clish,C.B., Carr,S.A., Wagner,B.K., Schenone,M., Ng,M.C.Y., Chen,B.H., Centeno-Cruz,F., Zerrweck,C., Orozco,L., Altshuler,D.M., Schreiber,S.L., Florez,J.C., Jacobs,S.B.R., Lander,E.S., MEDIA Consortium, SIGMA T2D Consortium, Soberon,X. (2017). Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.
Cell,
170 (1),
199-+.
*
Carta
59 - Cruz-Correa,O.F., Ramirez-Hobak,L., Arenas,R., Soberon,X. (2016). Metagenomics in onychomycosis. Analysis of a case with a possible role of malassezia globosa in the pathogenesis [Metagen¢mica en onicomicosis. El an lisis de un caso que revela el posible papel de Malassezia globosa en la pathogennesis].
Dermatología Cosmética, Médica y Quirúrgica,
14 (3),
245-248.
*
Artículo
60 - Gonzalez-Covarrubias,V., Martinez-Magana,J.J., Coronado-Sosa,R., Villegas-Torres,B., Genis-Mendoza,A.D., Canales-Herrerias,P., Nicolini,H., Soberon,X. (2016). Exploring Variation in Known Pharmacogenetic Variants and its Association with Drug Response in Different Mexican Populations.
Pharmaceutical Research,
33 (11),
2644-2652.
*
Artículo in consortium
61 - Lek,M., Karczewski,K.J., Minikel,E.V., Samocha,K.E., Banks,E., Fennell,T., O'Donnell-Luria,A.H., Ware,J.S., Hill,A.J., Cummings,B.B., Tukiainen,T., Birnbaum,D.P., Kosmicki,J.A., Duncan,L.E., Estrada,K., Zhao,F.M., Zou,J., Pierce-Hollman,E., Berghout,J., Cooper,D.N., Deflaux,N., DePristo,M., Do,R., Flannick,J., Fromer,M., Gauthier,L., Goldstein,J., Gupta,N., Howrigan,D., Kiezun,A., Kurki,M.I., Moonshine,A.L., Natarajan,P., Orozeo,L., Peloso,G.M., Poplin,R., Rivas,M.A., Ruano-Rubio,V., Rose,S.A., Ruderfer,D.M., Shakir,K., Stenson,P.D., Stevens,C., Thomas,B.P., Tiao,G., Tusie-Luna,M.T., Weisburd,B., Won,H.H., Yu,D.M., Altshuler,D.M., Ardissino,D., Boehnke,M., Danesh,J., Donnelly,S., Elosua,R., Florez,J.C., Gabriel,S.B., Getz,G., Glatt,S.J., Hultman,C.M., Kathiresan,S., Laakso,M., NcCarroll,S., McCarthy,M.I., McGovern,D., McPherson,R., Neale,B.M., Palotie,A., Purcell,S.M., Saleheen,D., Scharf,J.M., Sklar,P., Sullivan,P.F., Tuomilehto,J., Tsuang,M.T., Watkins,H.C., Wilson,J.G., Daly,M.J., Macarthur,D.G., Exome Aggregation Consortium, Soberon,X. (2016). Analysis of protein-coding genetic variation in 60,706 humans.
Nature,
536 (7616),
285-+.
*
Artículo
62 - Navarrete-Perea,J., Toledano-Magana,Y., Torre,P., Sciutto,E., Bobes,R.J., Soberon,X., Laclette,J.P. (2016). Role of porcine serum haptoglobin in the host-parasite relationship of Taenia solium cysticercosis.
Molecular and Biochemical Parasitology,
207 (2),
61-67.
Revisión
63 - Bikel,S., Valdez-Lara,A., Cornejo-Granados,F., Rico,K., Canizales-Quinteros,S., Soberon,X., Del Pozo-Yauner,L., Ochoa-Leyva,A. (2015). Combining metagenomics, metatranscriptomics and viromics to explore novel microbial interactions: towards a systems-level understanding of human microbiome.
Computational and Structural Biotechnology Journal,
13,
390-401.
Artículo
64 - Gomez,S., Adalid-Peralta,L., Palafox-Fonseca,H., Cantu-Robles,V.A., Soberon,X., Sciutto,E., Fragoso,G., Bobes,R.J., Laclette,J.P., Yauner,L.D., Ochoa-Leyva,A. (2015). Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR).
Scientific Reports,
5,
9683 [erratum en vol 5 (12385) ].
Artículo
65 - Villegas-Torres,B., Sanchez-Giron,F., Jaramillo-Villafuerte,K., Soberon,X., Gonzalez-Covarrubias,V. (2015). Genotype frequencies of VKORC1 and CYP2C9 in Native and Mestizo populations from Mexico, potential impact for coumarin dosing.
Gene,
558 (2),
235-240.
*
Artículo
66 - Estrada,K., Aukrust,I., Bjorkhaug,L., Burtt,N.P., Mercader,J.M., Garcia-Ortiz,H., Huerta-Chagoya,A., Moreno-Macias,H., Walford,G., Flannick,J., Williams,A.L., Gomez-Vazquez,M.J., Fernandez-Lopez,J.C., Martinez-Hernandez,A., Centeno-Cruz,F., Mendoza-Caamal,E., Revilla-Monsalve,C., Islas-Andrade,S., Cordova,E.J., Soberon,X., Gonzalez-Villalpando,M.E., Henderson,E., Wilkens,L.R., Le Marchand,L., Arellano-Campos,O., Ordonez-Sanchez,M.L., Rodriguez-Torres,M., Rodriguez-Guillen,R., Riba,L., Najmi,L.A., Jacobs,S.B., Fennell,T., Gabriel,S., Fontanillas,P., Hanis,C.L., Lehman,D.M., Jenkinson,C.P., Abboud,H.E., Bell,G.I., Cortes,M.L., Boehnke,M., Gonzalez-Villalpando,C., Orozco,L., Haiman,C.A., Tusie-Luna,T., Aguilar-Salinas,C.A., Altshuler,D., Njolstad,P.R., Florez,J.C., Macarthur,D.G. (2014). Association of a Low-Frequency Variant in HNF1A With Type 2 Diabetes in a Latino Population.
JAMA,
311 (22),
2305-2314.
*
Artículo
67 - Majithia,A.R., Flannick,J., Shahinian,P., Guo,M., Bray,M.A., Fontanillas,P., Gabriel,S.B., Rosen,E.D., Altshuler,D., SIGMA T2D Consortium, Soberon,X. (2014). Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.
Proceedings of the National Academy of Sciences of the United States of America,
111 (36),
13127-13132.
*
Artículo
68 - Moreno-Estrada,A., Gignoux,C.R., Fernandez-Lopez,J.C., Zakharia,F., Sikora,M., Contreras,A.V., Acuna-Alonzo,V., Sandoval,K., Eng,C., Romero-Hidalgo,S., Ortiz-Tello,P., Robles,V., Kenny,E.E., Nuno-Arana,I., Barquera-Lozano,R., Macin-Perez,G., Granados-Arriola,J., Huntsman,S., Galanter,J.M., Via,M., Ford,J.G., Chapela,R., Rodriguez-Cintron,W., Rodriguez-Santana,J.R., Romieu,I., Sienra-Monge,J.J., del Rio-Navarro,B., London,S.J., Ruiz-Linares,A., Garcia-Herrera,R., Estrada,K., Hidalgo-Miranda,A., Jimenez-Sanchez,G., Carnevale,A., Soberon,X., Canizales-Quinteros,S., Rangel-Villalobos,H., Silva-Zolezzi,I., Burchard,E.G., Bustamante,C.D. (2014). The genetics of Mexico recapitulates Native American substructure and affects biomedical traits.
Science,
344 (6189),
1280-1285.
*
Artículo
69 - Williams,A.L., Jacobs,S.B., Moreno-Macias,H., Huerta-Chagoya,A., Churchhouse,C., Marquez-Luna,C., Garcia-Ortiz,H., Gomez-Vazquez,M.J., Burtt,N.P., Aguilar-Salinas,C.A., Gonzalez-Villalpando,C., Florez,J.C., Orozco,L., Haiman,C.A., Tusie-Luna,T., Altshuler,D., Williams,A.L., Marquez-Luna,C., Huerta-Chagoya,A., Ripke,S., Gomez-Vazquez,M.J., Manning,A.K., Moreno-Macias,H., Garcia-Ortiz,H., Neale,B., Burtt,N.P., Aguilar-Salinas,C.A., Reich,D., Stram,D.O., Fernandez-Lopez,J.C., Romero-Hidalgo,S., Altshuler,D., Florez,J.C., Tusie-Luna,T., Patterson,N., Haiman,C.A., Aguilar-Delfin,I., Martinez-Hernandez,A., Centeno-Cruz,F., Mendoza-Caamal,E., Revilla-Monsalve,C., Islas-Andrade,S., Cordova,E., Rodriguez-Arellano,E., Soberon,X., Orozco,L., Florez,J.C., Gonzalez-Villalpando,C., Gonzalez-Villalpando,M.E., Haiman,C.A., Henderson,B.E., Monroe,K., Wilkens,L., Kolonel,L.N., Le Marchand,L., Riba,L., Ordonez-Sanchez,M.L., Rodriguez-Guillen,R., Cruz-Bautista,I., Rodriguez-Torres,M., Munoz-Hernandez,L.L., Saenz,T., Gomez,D., Alvirde,U., Burtt,N.P., Onofrio,R.C., Brodeur,W.M., Gage,D., Murphy,J., Franklin,J., Mahan,S., Ardlie,K., Crenshaw,A.T., Winckler,W., Prufer,K., Shunkov,M.V., Sawyer,S., Stenzel,U., Kelso,J., Lek,M., Sankararaman,S., Williams,A.L., Patterson,N., Macarthur,D.G., Reich,D., Derevianko,A.P., Paabo,S., Jacobs,S.B., Churchhouse,C., Gopal,S., Grammatikos,J.A., Smith,I.C., Bullock,K.H., Deik,A.A., Souza,A.L., Pierce,K.A., Clish,C.B., Altshuler,D., Fennell,T., Farjoun,Y., Genomics,Platform B., Gabriel,S., Stram,D.O., Gross,M.D., Pereira,M.A., Seielstad,M., Koh,W.P., Tai,E.S., Flannick,J., Fontanillas,P., Morris,A., Teslovich,T.M., Burtt,N.P., Atzmon,G., Blangero,J., Bowden,D.W., Chambers,J., Shin,Cho Y., Duggirala,R., Glaser,B., Hanis,C., Kooner,J., Laakso,M., Lee,J.Y., Tai,E.S., Ying,Teo Y., Wilson,J.G., Haiman,C.A., Henderson,B.E., Monroe,K., Wilkens,L., Kolonel,L.N., Le Marchand,L., Puppala,S., Farook,V.S., Thameem,F., Abboud,H.E., Defronzo,R.A., Jenkinson,C.P., Lehman,D.M., Curran,J.E., Blangero,J., Duggirala,R., Burtt,N.P., Cortes,M.L., Altshuler,D., Florez,J.C., Haiman,C.A., Henderson,B.E., Aguilar-Salinas,C.A., Gonzalez-Villalpando,C., Orozco,L., Tusie-Luna,T. (2014). Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
Nature,
506 (7486),
97-101.
*
Artículo
70 - Ochoa-Leyva,A., Montero-Moran,G., Saab-Rincon,G., Brieba,L.G., Soberon,X. (2013). Alternative Splice Variants in TIM Barrel Proteins from Human Genome Correlate with the Structural and Evolutionary Modularity of this Versatile Protein Fold.
PLoS ONE,
8 (8),
e70582.
Artículo
71 - Tsai,I.J., Zarowiecki,M., Holroyd,N., Garciarrubio,A., Sanchez-Flores,A., Brooks,K.L., Tracey,A., Bobes,R.J., Fragoso,G., Sciutto,E., Aslett,M., Beasley,H., Bennett,H.M., Cai,Jianping, Camicia,F., Clark,R., Cucher,M., De Silva,N., Day,T.A., Deplazes,P., Estrada,K., Fernandez,C., Holland,P.W.H., Hou,Junling, Hu,Songnian, Huckvale,Thomas, Hung,S.S., Kamenetzky,L., Keane,J.A., Kiss,F., Koziol,U., Lambert,O., Liu,K., Luo,Xuenong, Luo,Yingfeng, Macchiaroli,N., Nichol,S., Paps,Jordi, Parkinson,J., Pouchkina-Stantcheva,N., Riddiford,N., Rosenzvit,M., Salinas,G., Wasmuth,James D., Zamanian,M., Zheng,Yadong, Cai,Xuepeng, Soberon,X., Olson,P.D., Laclette,J.P., Brehm,Klaus, Berriman,M., Ochoa-Leyva,A. (2013). The genomes of four tapeworm species reveal adaptations to parasitism.
Nature,
496 (7443),
57-63.
Artículo
72 - Lopez-de Los Santos Y., Chan,H., Cantu,V.A., Rettner,R., Sanchez,F., Zhang,Z., Saier,M.H., Soberon,X. (2012). Genetic engineering of the phosphocarrier protein NPr of the Escherichia coli phosphotransferase system selectively improves sugar uptake activity.
Journal of Biological Chemistry,
287 (35),
29931-29939.
Artículo
73 - Saab-Rincon,G., Olvera,L., Olvera,M., Rudino-Pinera,E., Benites,E., Soberon,X., Morett,E. (2012). Evolutionary Walk between (beta/alpha)(8) Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase.
Journal of Molecular Biology,
416 (2),
255-270.
Artículo
74 - Ochoa-Leyva,A., Barona-Gomez,F., Saab-Rincon,G., Verdel-Aranda,K., Sanchez,F., Soberon,X. (2011). Exploring the Structure-Function Loop Adaptability of a (beta/alpha)(8)-Barrel Enzyme through Loop Swapping and Hinge Variability.
Journal of Molecular Biology,
411 (1),
143-157.
Artículo
75 - Noda-Garcia,L., Camacho-Zarco,A.R., Verdel-Aranda,K., Wright,H., Soberon,X., Fulop,V., Barona-Gomez,F. (2010). Identification and analysis of residues contained on beta --> alpha loops of the dual-substrate (betaalpha)(8) phosphoribosyl isomerase a (PriA) specific for its phosphoribosyl anthranilate isomerase activity.
Protein Science,
19 (3),
535-543.
Artículo
76 - Ochoa-Leyva,A., Soberon,X., Sanchez,F., Arguello,M., Montero-Moran,G., Saab-Rincon,G. (2009). Protein design through systematic catalytic loop exchange (SCLE) in the (beta/alpha)(8)-fold.
Journal of Molecular Biology,
387 (4),
949-964.
Artículo; Actas Paper
Artículo
78 - Damian-Almazo,J.Y., Moreno,A., Lopez-Munguia,A., Soberon,X., Gonzalez-Munoz,F., Saab-Rincon,G. (2008). Enhancement of the alcoholytic activity of {alpha}-amylase AmyA from Thermotoga maritima MSB8 (DSM 3109) by site directed mutagenesis.
Applied and Environmental Microbiology,
74 (16),
5168-5177.
Artículo
79 - Flores-Ramirez,G., Rivera,M., Morales-Pablos,A., Osuna,J., Soberon,X., Gaytan,P. (2007). The effect of amino acid deletions and substitutions in the longest loop of GFP.
BMC Chemical Biology,
7 (1),
1.
Artículo
80 - Vazquez-Limon,C., Vega-Badillo,J., Martinez,A., Espinosa-Molina,G., Gosset,G., Soberon,X., Lopez-Munguia,A., Osuna,J. (2007). Growth rate of a non-fermentative Escherichia coli strain is influenced by NAD(+) regeneration.
Biotechnology Letters,
29 (12),
1857-1863.
Artículo; Actas Paper
81 - Aguilar-Diaz,H., Bobes,R.J., Carrero,J.C., Camacho-Carranza,R., Cervantes,C., Cevallos,M.A., Davila,G., Rodriguez-Dorantes,M., Escobedo,G., Fernandez,J.L., Fragoso,G., Gaytan,P., Garciarrubio,A., Gonzalez,V.M., Gonzalez,L., Jose,M.V., Jimenez,L., Laclette,J.P., Landa,A., Larralde,C., Morales-Montor,J., Morett,E., Ostoa-Saloma,P., Sciutto,E., Santamaria,R.I., Soberon,X., de la Torre P., Valdes,V., Yanez,J. (2006). The genome project of Taenia solium.
Parasitology International,
55 (Suppl),
S127-S130.
Artículo
82 - Monroy-Lagos,O., Soberon,X., Gaytan,P., Osuna,J. (2006). Improvement of an unusual twin-arginine transporter leader Peptide by a codon-based randomization approach.
Applied and Environmental Microbiology,
72 (5),
3797-3801.
Revisión
83 - Soberon,X., Saier,M.H.,Jr. (2006). Engineering Transport Protein Function: Theoretical and Technical Considerations Using the Sugar-Transporting Phosphotransferase System of Escherichia coli as a Model System.
Journal of Molecular Microbiology and Biotechnology,
11 (6),
302-307.
Artículo
84 - Souza,V., Espinosa-Asuar,L., Escalante,A.E., Eguiarte,L.E., Farmer,J., Forney,L., Lloret,L., Rodriguez-Martinez,J.M., Soberon,X., Dirzo,R., Elser,J.J. (2006). An endangered oasis of aquatic microbial biodiversity in the Chihuahuan desert.
Proceedings of the National Academy of Sciences of the United States of America,
103 (17),
6565-6570.
Artículo
85 - Gaytan,P., Yanez,J., Grande,R., Morett,E., Soberon,X. (2005). Improving random mutagenesis by purification of the oligonucleotide variants.
Combinatorial Chemistry & High Throughput Screening,
8 (6),
537-544.
Artículo
86 - Saab-Rincon,G., Mancera,E., Montero-Moran,G., Sanchez,F., Soberon,X. (2005). Generation of variability by in vivo recombination of halves of a (beta/alpha)(8) barrel protein.
Biomolecular Engineering,
22 (4),
113-120.
Artículo
87 - Baez-Viveros,J.L., Osuna,J., Hernandez-Chavez,G., Soberon,X., Bolivar,F., Gosset,G. (2004). Metabolic engineering and protein directed evolution increase the yield of L-phenylalanine synthesized from glucose in Escherichia coli.
Biotechnology and Bioengineering,
87 (4),
516-524.
Artículo
88 - Flores,G., Soberon,X., Osuna,J. (2004). Production of a fully functional, permuted single-chain penicillin G acylase.
Protein Science,
13 (6),
1677-1683.
Artículo
Artículo
90 - Osuna,J., Yanez,J., Soberon,X., Gaytan,P. (2004). Protein evolution by codon-based random deletions.
Nucleic Acids Research,
32 (17),
e136.
Artículo
91 - Soberon,X., Fuentes-Gallego,P., Saab-Rincon,G. (2004). In vivo fragment complementation of a (beta/alpha)(8) barrel protein: generation of variability by recombination.
FEBS Letters,
560 (1-3),
167-172.
Artículo
92 - Yanez,J., Arguello,M., Osuna,J., Soberon,X., Gaytan,P. (2004). Combinatorial codon-based amino acid substitutions.
Nucleic Acids Research,
32 (20),
e158.
Artículo
93 - Rivera,M.H., Lopez-Munguia,A., Soberon,X., Saab-Rincon,G. (2003). alpha-Amylase from Bacillus licheniformis mutants near to the catalytic site: effects on hydrolytic and transglycosylation activity.
Protein Engineering,
16 (7),
505-514.
Artículo
94 - Gaytan,P., Osuna,J., Soberon,X. (2002). Novel ceftazidime-resistance beta-lactamases generated by a codon-based mutagenesis method and selection.
Nucleic Acids Research,
30 (16),
e84-e84.
Artículo
95 - Osuna,J., Perez-Blancas,A., Soberon,X. (2002). Improving a circularly permuted TEM-1 beta-lactamase by directed evolution.
Protein Engineering,
15 (6),
463-470.
Artículo
96 - Gaytan,P., Yanez,J., Sanchez,F., Soberon,X. (2001). Orthogonal combinatorial mutagenesis: a codon-level combinatorial mutagenesis method useful for low multiplicity and amino acid-scanning protocols.
Nucleic Acids Research,
29 (3),
E9.
Artículo
97 - Saab-Rincon,G., Juarez,V.R., Osuna,J., Sanchez,F., Soberon,X. (2001). Different strategies to recover the activity of monomeric triosephosphate isomerase by directed evolution.
Protein Engineering,
14 (3),
149-155.
Artículo
98 - Moreno-Hagelsieb,G., Gomez-Puyou,A., Soberon,X. (1999). Escherichia coli TEM1 beta-lactamase in CTAB reverse micelles: exchange/diffusion-limited catalysis.
FEBS Letters,
459 (1),
111-114.
Artículo
99 - Saab-Rincon,G., Del Rio,G., Santamaria,R.I., Lopez-Munguia,A., Soberon,X. (1999). Introducing transglycosylation activity in a liquefying alpha-amylase.
FEBS Letters,
453 (1-2),
100-106.
Artículo
100 - Santamaria,R.I., Del Rio,G., Saab,G., Rodriguez,M.E., Soberon,X., Lopez-Manguia,A. (1999). Alcoholysis reactions from starch with alpha-amylases.
FEBS Letters,
452 (3),
346-350.
Artículo
101 - Galindo,E., Lagunas,F., Osuna,J., Soberon,X., Garcia,J.L. (1998). A microbial biosensor for 6-aminopenicillanic acid.
Enzyme and Microbial Technology,
23 (5),
331-334.
Artículo
102 - Garcia,J.L., Nunez,C.J., Gonzalez,E.G., Osuna,J., Soberon,X., Galindo,E. (1998). Microbial sensor for new-generation cephalosporins based in a protein-engineered beta-lactamase.
Applied Biochemistry and Biotechnology,
73 (2-3),
243-256.
Artículo
103 - Gaytan,P., Yanez,J., Sanchez,F., Mackie,H., Soberon,X. (1998). Combination of DMT-mononucleotide and Fmoc-trinucleotide phosphoramidites in oligonucleotide synthesis affords an automatable codon-level mutagenesis method.
Chemistry and Biology,
5 (9),
519-527.
Artículo
104 - Gonzalez,V., Olvera,L., Soberon,X., Morett,E. (1998). In vivo studies on the positive control function of NifA: a conserved hydrophobic amino acid patch at the central domain involved in transcriptional activation.
Molecular Microbiology,
28 (1),
55-67.
Artículo
105 - Del Rio,G., Morett,E., Soberon,X. (1997). Did cyclodextrin glycosyltransferases evolve from alpha-amylases?.
FEBS Letters,
416 (2),
221-224.
Artículo
106 - Flores,H., Soberon,X., Sanchez,J., Bravo,A. (1997). Isolated domain II and III from the Bacillus thuringiensis Cry1Ab delta-endotoxin binds to lepidopteran midgut membranes.
FEBS Letters,
414 (2),
313-318.
Artículo
107 - Gaytan,P., Yanez,J., Soberon,X., Martinez,R. (1997). A new method for oligonucleotide derivatization of the 3' or 5'-termini with a CPG-support carrying the natural product isoargentatin-D.
Tetrahedron Letters,
38 (35),
6123-6126.
Artículo
108 - Muir,R.S., Flores,H., Zinder,N.D., Model,P., Soberon,X., Heitman,J. (1997). Temperature-sensitive mutants of the EcoRI endonuclease.
Journal of Molecular Biology,
274 (5),
722-737.
Artículo
109 - Osuna,J., Soberon,X., Morett,E. (1997). A proposed architecture for the central domain of the bacterial enhancer-binding proteins based on secondary structure prediction and fold recognition.
Protein Science,
6 (3),
543-555.
Artículo
110 - Del Rio,G., Lopez-Munguia,A., Soberon,X. (1996). An engineered penicillin acylase with altered surface charge is more stable in alkaline pH.
Annals of the New York Academy of Sciences,
799,
61-64.
Artículo
111 - Moreno-Hagelsieb,G., Soberon,X. (1996). Protein engineering as a powerful tool for the chemical modification of enzymes.
Biological Research,
29 (1),
127-140.
Artículo
112 - Del Rio,G., Rodriguez,M.E., Munguia,M.E., Lopez-Munguia,A., Soberon,X. (1995). Mutant Escherichia coli penicillin acylase with enhanced stability at alkaline pH.
Biotechnology and Bioengineering,
48 (2),
141-148.
Artículo
113 - Flores,H., Osuna,J., Heitman,J., Soberon,X. (1995). Saturation mutagenesis of His114 of EcoRI reveals relaxed-specificity mutants.
Gene,
157 (1-2),
295-301.
Artículo
114 - Osuna,J., Viadiu,H., Fink,A.L., Soberon,X. (1995). Substitution of Asp for Asn at position 132 in the active site of TEM beta-lactamase. Activity toward different substrates and effects of neighboring residues.
Journal of Biological Chemistry,
270 (2),
775-780.
Artículo
115 - Viadiu,H., Osuna,J., Fink,A.L., Soberon,X. (1995). A new TEM beta-lactamase double mutant with broadened specificity reveals substrate-dependent functional interactions.
Journal of Biological Chemistry,
270 (2),
781-787.
Artículo
116 - Del Rio,G., Osuna,J., Soberon,X. (1994). Combinatorial libraries of proteins: analysis of efficiency of mutagenesis techniques.
Biotechniques,
17 (6),
1132-1139.
Artículo
117 - Gurrola,G.B., Moreno-Hagelsieb,G., Zamudio,F.Z., Garcia,M., Soberon,X., Possani,L.D. (1994). The disulfide bridges of toxin 2 from the scorpion Centruroides noxius Hoffmann and its three-dimensional structure calculated using the coordinates of variant 3 from Centruroides sculpturatus.
FEBS Letters,
347 (1),
59-62.
Revisión
118 - Osuna,J., Flores,H., Soberon,X. (1994). Microbial systems and directed evolution of protein activities.
Critical Reviews in Microbiology,
20 (2),
107-116.
Artículo
119 - Merino,E., Osuna,J., Bolivar,F., Soberon,X. (1992). A general, PCR-based method for single or combinatorial oligonucleotide-directed mutagenesis on pUC/M13 vectors.
Biotechniques,
12 (4),
508-510.
Artículo
120 - Pereyra-Alferez,B., Bravo,A., Quintero,R., Soberon,X. (1992). The delta-endotoxin protein family displays a hydrophobic motif that might be implicated in toxicity.
Molecular Microbiology,
6 (15),
2095-2098.
Artículo
121 - Lopez,S., Lopez,I., Romero,P., Mendez,E., Soberon,X., Arias,C.F. (1991). Rotavirus YM gene 4: analysis of its deduced amino acid sequence and prediction of the secondary structure of the VP4 protein.
Journal of Virology,
65 (7),
3738-3745.
Artículo
Note
123 - Fuchs,L.Y., Ovando,C., Joseph,P., Soberon,X., Charli,J.L. (1990). Repetitive DNA sequence from the crayfish Procambarus clarkii.
Nucleic Acids Research,
18 (6),
1650.
Artículo
124 - Pastor,N., Pinero,D., Valdes,A.M., Soberon,X. (1990). Molecular evolution of class A beta-lactamases: phylogeny and patterns of sequence conservation.
Molecular Microbiology,
4 (11),
1957-1965.
Artículo
125 - Balbas,P., Soberon,X., Merino,E., Zurita,M., Lomeli,H., Valle,F., FLORES,N., Bolivar,F. (1986). Plasmid vector pBR322 and its special-purpose derivatives--a review.
Gene,
50 (1-3),
3-40.
Note
Artículo
127 - Rossi,J.J., Soberon,X., Marumoto,Y., McMahon,J., Itakura,K. (1983). Biological expression of an Escherichia coli consensus sequence promoter and some mutant derivatives.
Proceedings of the National Academy of Sciences of the United States of America,
80 (11),
3203-3207.
*
Artículo
128 - Inouye,S., Soberon,X., Franceschini,T., Nakamura,K., Itakura,K., Inouye,M. (1982). Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane.
Proceedings of the National Academy of Sciences of the United States of America,
79 (11),
3438-3441 .
*
Artículo
129 - Miyada,C.G., Soberon,X., Itakura,K., Wilcox,G. (1982). The use of synthetic oligodeoxyribonucleotides to produce specific deletions in the araBAD promoter of Escherichia coli B/r.
Gene,
17 (2),
167-177.
*
Artículo
130 - Zarucki-Schulz,T., Tsai,S.Y., Itakura,K., Soberon,X., Wallace,R.B., Tsai,M.J., Woo,S.L., O'Malley,B.W. (1982). Point mutagenesis of the ovalbumin gene promoter sequence and its effect on in vitro transcription.
Journal of Biological Chemistry,
257 (18),
11070-11077.
*
Artículo
131 - Covarrubias,L., Cervantes,L., Covarrubias,A., Soberon,X., Vichido,I., Blanco,A., Kupersztoch-Portnoy,Y.M., Bolivar,F. (1981). Construction and characterization of new cloning vehicles. V. Mobilization and coding properties of pBR322 and several deletion derivatives including pBR327 and pBR328.
Gene,
13 (1),
25-35.
*
Artículo
132 - Soberon,X., Covarrubias,L., Bolivar,F. (1980). Construction and characterization of new cloning vehicles. IV. Deletion derivatives of pBR322 and pBR325.
Gene,
9 (3-4),
287-305.
*
Nacional
133 - Soberon,X. (2012). La medicina genómica en México, consideraciones para su desarrollo. Fortalezas y desafíos de los servicios de salud de México en el siglo XXI.
202-205.
Internacional
134 - Frausto-Solis,J., Soberon-Mainero,X., Linan-Garcia,E. (2009). MultiQuenching annealing algorithm for protein folding problem. Mexican International Conference on Artificial Intelligence. MICAI 2009: Advances in Artificial Intelligence .
Lecture Notes in Computer Science ,
578-589.
Nacional
135 - Segovia,L., Soberon,X. (2008). Evolución experimental de proteínas. Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 26.
291-302,
Mexico, D.F..
Internacional
136 - Barona-Gomez,F., Ochoa-Leyva,A., Soberon,X. (2007). Advances and perspectives in protein engineering: from natural history to directed evolution of enzymes. Advances in Protein Physical Chemistry.
407-438,
Kerala: Research Signpost.
Memoria in extenso
137 - Frausto-Solis,J., Roman,E.F., Romero,D., Soberon,X., Linan-Garcia,E. (2007). Analytically tuned simulated annealing applied to the protein folding problem. Lecture Notes in Computer Science vol 4488.
370-377.
Nacional
138 - Soberon,X., Montero,G.M. (2004). Ingeniería de proteínas y evolución dirigida. Fundamentos y casos exitosos de la biotecnologia moderna cap 7.
195-217,
Mexico.
Nacional
139 - Soberon,X. (2003). Biocatálisis y evolución dirigida de proteínas. Fronteras de la Biología en los Inicios del Siglo XXI, Módulo VII.
35-45,
Mexico,D.F..
Nacional
Memoria in extenso
141 - Saab-Rincon,G., Del Rio,G, Santamaria,R, Diaz,M.L, Soberon,X., Lopez-Munguia,A. (2002). Novel and potential applications of alpha-amylases in the food industry. Engineering and Food for the 21st Century. Proceedings of the Eighth International Congress on Engineering and Food.
913-924,
Boca Raton, Fla.
Nacional
142 - Soberon,X., Bolivar,F. (2001). Evolución de los conceptos de gen y genoma. Ciencias de la vida.
61-83.
Internacional
143 - Balbas,P., Soberon,X., Bolivar,F., Rodriguez,R.L. (1988). The plasmid, pBR322. Biotechnology (Reading, Mass.).
5-41,
10.
Divulgación
144 - Soberon, X., Bergna, M., Valez, M. A. (2018). Iguales o difererentes? Genómica.
64 pp,
Ciudad de Mexico: Ediciones Tecolote.
Nacional
145 - Bolivar-Zapata, F.G., Arias-Ortiz, C. F., Artega-Vazquez, M. A., Barrera-Saldana, H. A., Galindo-Fentanes, E., Gracia-Gasca, A., Herrera-Estrella, L. R., Higuera-Ciapara, I., Larque-Saavedra, F. A., Lopez-Munguia Canales, A., Ramirez-Reivich, O. T., Revah-Moiseev, S., Soberon-Mainero, X., Torres-Pacheco, I., Uribe de la Mora, J. M., Vazquez-Ramos, J. M., Viniegra-Gonzalez, G. (2017). Transgénicos: Grandes beneficios, ausencia de daños y mitos.
Mexico.
Nacional
146 - Bolivar-Zapata,F.G., Arias-Ortiz,C.F., Arriaga-Arellano,E., Barrera-Saldaña,H., de la Torres-Martinez,M., Espinosa-Fernandez,J., Galindo-Fentanes,E., Galvez-Mariscal,A, Gracia-Gasca,A., Herrera-Estrella,L., Larque-Saavedra,A., Lopez-Munguia Canales,A., Noyola-Robles,A., Paredes-Lopez,O., Ramirez-Reivich,O.T., Revah-Moiseev,S., Soberon-Mainero,J., Soberon-Mainero,X., Torres-Pacheco,I., Uribe de la Mora,J., Viniegra-Gonzalez,G. (2011). Por un uso responsable de los organismos genéticamente modificados.
Mexico.
Preprint
147 - Oropeza-Valdez,J.J., Padron-Manrique,C., Vazquez-Jimenez,A., Soberon,X., Resendis-Antonio,O. (2024). Exploring Metabolic Anomalies in COVID-19 and Post-COVID-19: A Machine Learning Approach with Explainable Artificial Intelligence.
bioRxiv,
Preprint posted April 17,
2024.
Nacional divulgacion
148 - Soberon-Mainero,X. (2023). La Ingeniería Genética: una muy poderosa técnica, definidora de una carrera científica.
Biotecnología en Movimiento. Revista de divulgación del Instituto de Biotecnología de la UNAM,
35.
Editorial Material, Meeting Report
149 - Cornejo-Granados,F., Calderon de la Barca,A.M., Torres,N., Martinez-Romero,E., Torres,J., Lopez-Vidal,Y., Soberon,X., Partida-Martinez,L.P., Pinto-Cardoso,S., Alcaraz,L.D., Pardo-Lopez,L., Canizales-Quinteros,S., Puente,J.L., Ochoa-Leyva,A. (2019). Microbiome-MX 2018: Microbiota and Microbiome opportunities in Mexico, a megadiverse country.
Research in Microbiology,
170 (4-5),
235-241.
Divulgación
150 - Soberon-Mainero,X., Gonzalez-Covarrubias,V. (2014). Enfermedades infecciosas, hacia una medicina personalizada.
Revista Digital Universitaria,
15 (6),
art 43.
*
Editorial Material
151 - Soberon-Mainero,X., Melendez-Zajgla,J. (2010). [The Instituto Nacional de Medicina Genomica. Vocation and challenges].
Revista de Investigacion Clinica,
62 (5),
391-392.
*
Nacional
152 - Baez-Viveros,J.L., Osuna,J., Hernandez-Chavez,G., Soberon,X., Bolivar,F., Gosset,G. (2006). Metabolic via engineering for the production of aromatic substances in Escherichia coli.
Revista Latinoamericana de Microbiologia,
48 (2),
92.
Nacional
153 - Yanez,J., Soberon,X., Gaytan,P. (2004). Rutas alternas de síntesis para la preparación de Fmoc-Trinucleósido-Difosfato Fosforamiditos.
Revista de la Sociedad Química de México,
48 (1),
26-37.
Divulgación
154 - Soberon Mainero,X (2003). Veinte años del Instituto de Biotecnología.
Revista Universidad de Mexico,
629.
Divulgación
155 - Soberon-Mainero,X. (2003). Veinte años del Instituto de Biotecnología.
Revista de la Universidad de México,
629.
Divulgación
156 - Soberon Mainero, X. (2002). La revolución de las ciencias genómicas.
Revista Universidad Nacional,
617.
Divulgación
157 - Soberon-Mainero,X. (2002). La ingenieria genética y un campo de aplicación: la biocatálisis y la industria química limpia.
Mensaje Bioquimico,
26,
1-18.
Divulgación
158 - Soberon,X. (2001). La biotecnologia: un ejercito microscopico al servicio del hombre.
Hypatia,
2,
6-7.
Divulgación
159 - Soberon,X. (2001). Nuevos paradigmas relacionados con la ciencia biologica experimental: implicaciones cientificas, tecnologicas y sociales.
Revista Universidad de Mexico,
605-606,
59-63.
Divulgación
160 - Soberon,X. (2000). El convenio UNAM-INE-Diversa y el aprovechamiento de recursos geneticos.
BioTecnologia. Sociedad Mexicana de Biotecnologia y Bioingenieria,
5,
14-15.
Divulgación
News Item
162 - Soberon,X. (1999). Enzymes directly evolving toward commercial applications.
Nature Biotechnology,
17 (6),
539-540.
Nacional
163 - Oliver,G., Balbas,P., Valle,F., Soberon,X., Bolivar,F. (1985). [Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli].
Revista Latinoamericana de Microbiologia,
27 (2),
141-150.
164 - Soberon Mainero, Francisco Xavier (1982). Uso de vehiculos moleculares de clonacion y de sintesis quimica de polinucleotidos para el estadio de la expresion genica.
Instituto de Investigaciones Biomedicas,
Maestria en Investigacion Biomedica Basica,
UNAM.
*
Asesor: Itakura, Keiichi, Bolivar Zapata, Francisco
Artículo
165 - Galeana-Cadena,D., Ramirez-Martinez,G., Choreno-Parra,J.A., Silva-Herzog,E., Hernandez-Cardenas,C.M., Soberon,X., Zuniga,J.. Microbiome in the Nasopharynx: Insights into the Impact of COVID-19 Severity.
Heliyon,
10 (10),
e31562.
Artículo
166 - Uribe-Vazquez,B., Diaz-Vilchis,A, Avila-Linares,A., Saab-Rincon,G, Marin-Tovar,Y., Flores,H, Pastor,N, Huerta-Miranda,G, Rudino-Pinera,E., Soberon,X. Characterization of a catalase-peroxidase variant (L333V-KatG) identified in an INH-resistant Mycobacterium tuberculosis clinical isolate.
Biochemistry and Biophysics Reports,
37,
101649.
Preprint
167 - Oropeza-Valdez,J.J., Padron-Manrique,C., Vazquez-Jimenez,A., Soberon,X., Resendis-Antonio,O.. Exploring Metabolic Anomalies in COVID-19 and Post-COVID-19: A Machine Learning Approach with Explainable Artificial Intelligence.
bioRxiv,
Preprint posted April 17,
2024.
Revisión
168 - Alvarado-Pena,N., Galeana-Cadena,D., Gomez-Garcia,I.A, Soberon-Mainero,X, Silva-Herzog,E. The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment.
Frontiers in Microbiology,
14,
1237998.
Nacional divulgacion
169 - Soberon-Mainero,X.. La Ingeniería Genética: una muy poderosa técnica, definidora de una carrera científica.
Biotecnología en Movimiento. Revista de divulgación del Instituto de Biotecnología de la UNAM,
35.
Artículo
170 - Barbosa-Amezcua,M., Cuevas-Cordoba,B., Fresno,C., Haase-Hernandez,J.I., Carrillo-Sanchez,K., Mata-Rocha,M., Munoz-Torrico,M., Backer,C., Gonzalez-Covarrubias,V., Alaez-Verson,C., Soberon,X.. Rapid Identification of Drug Resistance and Phylogeny in M. tuberculosis, Directly from Sputum Samples.
Microbiology Spectrum,
10 (5),
e0125222.
Artículo
171 - Martinez-Magana,J.J., Genis-Mendoza,A.D., Gonzalez-Covarrubias,V., Juarez-Rojop,I.E., Tovilla-Zarate,C.A., Soberon,X., Lanzagorta,N., Nicolini,H.. Association of FAAH p.Pro129Thr and COMT p.Ala72Ser with schizophrenia and comorbid substance use through next-generation sequencing: an exploratory analysis.
Brazilian Journal of Psychiatry,
44 (2),
164-170.
*
Artículo
172 - Aguilar-Ordonez,I., Perez-Villatoro,F., Garcia-Ortiz,H., Barajas-Olmos,F., Ballesteros-Villascan,J., Gonzalez-Buenfil,R., Fresno,C., Garciarrubio,A., Fernandez-Lopez,J.C., Tovar,H., Hernandez-Lemus,E., Orozco,L., Soberon,X., Morett,E.. Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights.
PLoS ONE,
16 (4),
e0249773,
[correction May 25 2022].
artículo
173 - Cuevas-Cordoba,B., Fresno,C., Haase-Hernandez,J.I., Barbosa-Amezcua,M., Mata-Rocha,M., Munoz-Torrico,M., Salazar-Lezama,M.A., Martinez-Orozco,J.A., Narvaez-Diaz,L.A., Salas-Hernandez,J., Gonzalez-Covarrubias,V., Soberon,X.. A bioinformatics pipeline for Mycobacterium tuberculosis sequencing that cleans contaminant reads from sputum samples.
PLoS ONE,
16 (10),
e0258774.
*
Artículo
174 - Gonzalez-Covarrubias,V,, Sanchez-Ibarra,H., Lozano-Gonzalez, K., Villicana, S., Texis,T., Rodriguez-Dorantes,M., Cortes-Ramirez,S., Lavalle-Gonzalez,F,, Soberon,X., Barrera-Saldana,H.. Transporters, TBC1D4, and ARID5B Variants to Explain Glycated Hemoglobin Variability in Patients with Type 2 Diabetes.
Pharmacology,
106 (11-12),
588-596.
Artículo
175 - Jaimes-Hoy,L., Perez-Maldonado,A., Narvaez-Bahena,E., de la Cruz Guarneros,N., Rodriguez-Rodriguez,A., Charli,J.L., Soberon,X., Joseph-Bravo,P.. Sex dimorphic changes in Trh gene methylation and thyroid-axis response to energy demands in maternally-separated rats.
Endocrinology,
May 27 Online ahead of print [comentario vol 162 (9) pp 1-2].
Artículo
176 - Valdez-Palomares,F., Munoz-Torrico,M., Palacios-Gonzalez,B., Soberon,X., Silva-Herzog,E.. Altered Microbial Composition of Drug-Sensitive and Drug-Resistant TB Patients Compared with Healthy Volunteers.
Microorganisms,
9 (8),
1762.
Revisión
177 - Gonzalez-Covarrubias,V., Lozano,K., Texis,T., Guzman-Cruz,C.K., Rodriguez-Dorantes,M., Rubio-Carrasco,K., Mendez-Lorenzo,L.H., Soberon,X.. Pharmacogenomics: Current Actionable Variants.
Revista de Investigacion Clinica,
73 (3).
*
Artículo
178 - Cabrera-Contreras,R., Santamaria,R.I., Bustos,P., Martinez-Flores,I., Melendez-Herrada,E., Morelos-Ramirez,R., Barbosa-Amezcua,M., Gonzalez-Covarrubias,V., Silva-Herzog,E., Soberon,X., Gonzalez,V.. Genomic diversity of prevalent Staphylococcus epidermidis multidrug-resistant strains isolated from a Children's Hospital in Mexico City in an eight-years survey.
PeerJ,
7,
e8068.
*
Artículo
179 - Flannick,J., Mercader,J.M., Fuchsberger,C., Udler,M.S., Mahajan,A., Wessel,J., Teslovich,T.M., Caulkins,L., Koesterer,R., Barajas-Olmos,F., Blackwell,T.W., Boerwinkle,E., Brody,J.A., Centeno-Cruz,F., Chen,L., Chen,S., Contreras-Cubas,C., Cordova,E., Correa,A., Cortes,M., Defronzo,R.A., Dolan,L., Drews,K.L., Elliott,A., Floyd,J.S., Gabriel,S., Garay-Sevilla,M.E., Garcia-Ortiz,H., Gross,M., Han,S., Heard-Costa,N.L., Jackson,A.U., Jorgensen,M.E., Kang,H.M., Kelsey,M., Kim,B.J., Koistinen,H.A., Kuusisto,J., Leader,J.B., Linneberg,A., Liu,C.T., Liu,J., Lyssenko,V., Manning,A.K., Marcketta,A., Malacara-Hernandez,J.M., Martinez-Hernandez,A., Matsuo,K., Mayer-Davis,E., Mendoza-Caamal,E., Mohlke,K.L., Morrison,A.C., Ndungu,A., Ng,M.C.Y., O'Dushlaine,C., Payne,A.J., Pihoker,C., Post,W.S., Preuss,M., Psaty,B.M., Vasan,R.S., Rayner,N.W., Reiner,A.P., Revilla-Monsalve,C., Robertson,N.R., Santoro,N., Schurmann,C., So,W.Y., Soberon,X., Stringham,H.M., Strom,T.M., Tam,C.H.T., Thameem,F., Tomlinson,B., Torres,J.M., Tracy,R.P., van Dam,R.M., Vujkovic,M., Wang,S., Welch,R.P., Witte,D.R., Wong,T.Y., Atzmon,G., Barzilai,N., Blangero,J., Bonnycastle,L.L., Bowden,D.W., Chambers,J.C., Chan,E., Cheng,C.Y., Cho,Y.S., Collins,F.S., de Vries,P.S., Duggirala,R., Glaser,B., Gonzalez,C., Gonzalez,M.E., Groop,L., Kooner,J.S., Kwak,S.H., Laakso,M., Lehman,D.M., Nilsson,P., Spector,T.D., Tai,E.S., Tuomi,T., Tuomilehto,J., Wilson,J.G., guilar-Salinas,C.A., Bottinger,E., Burke,B., Carey,D.J., Chan,J.C.N., Dupuis,J., Frossard,P., Heckbert,S.R., Hwang,M.Y., Kim,Y.J., Kirchner,H.L., Lee,J.Y., Lee,J., Loos,R.J.F., Ma,R.C.W., Morris,A.D., O'Donnell,C.J., Palmer,C.N.A., Pankow,J., Park,K.S., Rasheed,A., Saleheen,D., Sim,X., Small,K.S., Teo,Y.Y., Haiman,C., Hanis,C.L., Henderson,B.E., Orozco,L., Tusie-Luna,T., Dewey,F.E., Baras,A., Gieger,C., Meitinger,T., Strauch,K., Lange,L., Grarup,N., Hansen,T., Pedersen,O., Zeitler,P., Dabelea,D., Abecasis,G., Bell,G.I., Cox,N.J., Seielstad,M., Sladek,R., Meigs,J.B., Rich,S.S., Rotter,J.I., Altshuler,D., Burtt,N.P., Scott,L.J., Morris,A.P., Florez,J.C., McCarthy,M.I., Boehnke,M.. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Nature,
570 (7759),
71-76.
*
Artículo
180 - Gonzalez-Covarrubias,V., Morales-Franco,M., Cruz-Correa,O.F., Martinez-Hernandez,A., Garcia-Ortiz,H., Barajas-Olmos,F., Genis-Mendoza,A.D., Martinez-Magana,J.J., Nicolini,H., Orozco,L., Soberon,X.. Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico.
Frontiers in Pharmacology,
10,
1169.
*
Artículo
181 - Madrazo-Moya,C.F., Cancino-Munoz,I., Cuevas-Cordoba,B., Gonzalez-Covarrubias,V., Barbosa-Amezcua,M., Soberon,X., Muniz-Salazar,R., Martinez-Guarneros,A., Backer,C., Zarrabal-Meza,J., Sampieri-Ramirez,C., Enciso-Moreno,A., Lauzardo,M., Comas,I., Zenteno-Cuevas,R.. Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico.
PLoS ONE,
14 (6),
e0213046.
*
Artículo
182 - Martinez-Magana,J.J., Genis-Mendoza,A.D., Gonzalez-Covarrubias,V., Jimenez-Guenchi,J., Galindo-Chavez,A.G., Roche-Bergua,A., Castaneda-Gonzalez,C., Lanzagorta,N., Soberon,X., Nicolini,H.. Exploratory analysis of rare and novel variants in Mexican patients diagnosed with schizophrenia and dementia.
Revista de Investigacion Clinica,
71 (4),
246-254.
*
Editorial Material, Meeting Report
183 - Cornejo-Granados,F., Calderon de la Barca,A.M., Torres,N., Martinez-Romero,E., Torres,J., Lopez-Vidal,Y., Soberon,X., Partida-Martinez,L.P., Pinto-Cardoso,S., Alcaraz,L.D., Pardo-Lopez,L., Canizales-Quinteros,S., Puente,J.L., Ochoa-Leyva,A.. Microbiome-MX 2018: Microbiota and Microbiome opportunities in Mexico, a megadiverse country.
Research in Microbiology,
170 (4-5),
235-241.
Artículo
184 - Ayon-Nunez, D.A., Fragoso, G., Espitia, C., Garcia-Varela, M., Soberon, X., Rosas, G., Laclette, J.P., Bobes, R.J.. Identification and characterization of Taenia solium enolase as a plasminogen-binding protein.
Acta Tropica,
182,
69-79.
*
Artículo
185 - Flores-Bautista, J., Navarrete-Perea, J., Fragoso, G., Flisser, A., Soberon, X., Laclette, J.P.. Fate of uptaken host proteins in Taenia solium and Taenia crassiceps cysticerci.
Bioscience Reports,
38 (4),
BSR20180636.
*
Divulgación
186 - Soberon, X., Bergna, M., Valez, M. A.. Iguales o difererentes? Genómica.
64 pp,
Ciudad de Mexico: Ediciones Tecolote.
Artículo
187 - Bikel, S., Jacobo-Albavera, L., Sanchez-Munoz, F., Cornejo-Granados, F., Canizales-Quinteros, S., Soberon, X., Sotelo-Mundo, R.R., Del Rio-Navarro, B.E., Mendoza-Vargas, A., Sanchez, F., Ochoa-Leyva, A.. A novel approach for human whole transcriptome analysis based on absolute gene expression of microarray data.
PeerJ,
5,
e4133.
Artículo
188 - Bobes, R.J., Navarrete-Perea, J., Ochoa-Leyva, A., Anaya, V.H., Hernandez, M., Cervantes-Torres, J., Estrada, K., Sanchez-Lopez, F., Soberon, X., Rosas, G., Maroni-Nunes C., Garcia-Varela, M., Sotelo-Mundo, R.R., Lopez-Zavala, A.A., Gevorkian, G., Acero, G., Laclette, J.P., Fragoso, G., Sciutto, E.. Experimental and theoretical approaches to investigate the immunogenicity of Taenia solium-derived KE7 antigen.
Infection and Immunity,
85,
e00395-17.
Artículo
189 - Cruz-Correa, O.F., Leon-Cachon, R.B., Barrera-Saldana, H.A., Soberon, X.. Prediction of atorvastatin plasmatic concentrations in healthy volunteers using integrated pharmacogenetics sequencing.
Pharmacogenomics,
18 (2),
121-131.
Artículo
190 - Gonzalez-Covarrubias, V., Urena-Carrion, J., Villegas-Torres, B., Cossio-Aranda, J.E., Trevethan-Cravioto, S., Izaguirre-Avila, R., Fiscal-Lopez, O.J., Soberon, X.. Pharmacogenetic Variation in Over 100 Genes in Patients Receiving Acenocumarol.
Frontiers in Pharmacology,
8,
863.
*
Artículo in consortium
191 - Marquez-Luna,C., Loh,P.R., Price,A.L., South Asian Type 2 Diabet SAT2D, SIGMA Type 2 Diabet Consortium, Soberon,X.. Multiethnic polygenic risk scores improve risk prediction in diverse populations.
Genetic Epidemiology,
41 (8),
811-823.
*
Artículo
192 - Mercader, J.M., Liao, R.G., Davis, A., Dymek, Z., Estrada, K., Tukiainen, T., Huerta-Chagoya, A., Moreno-Macias, H., Jablonski, K.A., Hanson, R.L., Walford, G.A., Moran, I., Chen, L., Agarwala, V., Ordonez-Sanchez, M.L., Rodriguez-Guillen, R., Rodriguez-Torres, M., Segura-Kato, Y., Garcia-Ortiz, H., Centeno-Cruz, F., Barajas-Olmos, F., Caulkins, L., Puppala, S., Fontanillas, P., Williams, A., Bonas-Guarch, S., Hartl, C., Ripke, S., Tooley, K., Lane, J., Zerrweck, C., Martinez-Hernandez, A., Cordova, E.J., Mendoza-Caamal, E., Contreras-Cubas, C., Gonzalez-Villalpando, M.E., Cruz-Bautista, I., Munoz-Hernandez, L., Gomez-Velasco, D., Alvirde, U., Henderson, B.E., Wilkens, L.R., Le, Marchand L., Arellano-Campos, O., Riba, L., Harden, M., Platform, B.G., Gabriel, S., Abboud, H.E., Cortes, M.L., Revilla-Monsalve, C., Islas-Andrade, S., Soberon, X., Curran, J.E., Jenkinson, C.P., Defronzo, R.A., Lehman, D.M., Hanis, C.L., Bell, G.I., Boehnke, M., Blangero, J., Duggirala, R., Saxena, R., MacArthur, D., Ferrer, J., McCarroll, S.A., Torrents, D., Knowler, W.C., Baier, L.J., Burtt, N., Gonzalez-Villalpando, C., Haiman, C.A., Aguilar-Salinas, C.A., Tusie-Luna, T., Flannick, J., Jacobs, S.B.R., Orozco, L., Altshuler, D., Florez, J.C.. A Loss-Of-Function Splice Acceptor Variant in IGF2 is Protective for Type 2 Diabetes.
Diabetes,
66 (11),
2903-2914.
*
Artículo
193 - Navarrete-Perea, J., Moguel, B.A., Bobes, R.J., Villalobos, N., Carrero, J.C., Sciutto, E., Soberon, X., Laclette, J.P.. Protein profiles of Taenia solium cysts obtained from skeletal muscles and the central nervous system of pigs: Search for tissue-specific proteins.
Experimental Parasitology,
172,
23-29.
Artículo
194 - Navarrete-Perea, J., Isasa, M., Paulo, J.A., Corral-Corral, R., Flores-Bautista, J., Hernandez-Tellez, B., Bobes, R.J., Fragoso, G., Sciutto, E., Soberon, X., Gygi, S.P., Laclette, J.P.. Quantitative multiplexed proteomics of Taenia solium cysts obtained from the skeletal muscle and central nervous system of pigs.
PLoS Neglected Tropical Diseases,
11 (9),
e0005962.
Artículo
195 - Romero-Hidalgo, S., Ochoa-Leyva, A., Garciarrubio, A., Acuna-Alonzo, V., Antunez-Arguelles, E., Balcazar-Quintero, M., Barquera-Lozano, R., Carnevale, A., Cornejo-Granados, F., Fernandez-Lopez, J.C., Garcia-Herrera, R., Garcia-Ortiz, H., Granados-Silvestre, A., Granados, J., Guerrero-Romero, F., Hernandez-Lemus, E., Leon-Mimila, P., Macin-Perez, G., Martinez-Hernandez, A., Menjivar, M., Morett, E., Orozco, L., Ortiz-Lopez, G., Perez-Villatoro, F., Rivera-Morales, J., Riveros-McKay, F., Villalobos-Comparan, M., Villamil-Ramirez, H., Villarreal-Molina, T., Canizales-Quinteros, S., Soberon, X.. Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing.
Nature Communications,
8 (1),
1005.
Artículo in consortium
196 - Rusu,V., Hoch,E., Mercader,J.M., Tenen,D.E., Gymrek,M., Hartigan,C.R., Deran,M., von Grotthuss,M., Fontanillas,P., Spooner,A., Guzman,G., Deik,A.A., Pierce,K.A., Dennis,C., Clish,C.B., Carr,S.A., Wagner,B.K., Schenone,M., Ng,M.C.Y., Chen,B.H., Centeno-Cruz,F., Zerrweck,C., Orozco,L., Altshuler,D.M., Schreiber,S.L., Florez,J.C., Jacobs,S.B.R., Lander,E.S., MEDIA Consortium, SIGMA T2D Consortium, Soberon,X.. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.
Cell,
170 (1),
199-+.
*
Nacional
197 - Bolivar-Zapata, F.G., Arias-Ortiz, C. F., Artega-Vazquez, M. A., Barrera-Saldana, H. A., Galindo-Fentanes, E., Gracia-Gasca, A., Herrera-Estrella, L. R., Higuera-Ciapara, I., Larque-Saavedra, F. A., Lopez-Munguia Canales, A., Ramirez-Reivich, O. T., Revah-Moiseev, S., Soberon-Mainero, X., Torres-Pacheco, I., Uribe de la Mora, J. M., Vazquez-Ramos, J. M., Viniegra-Gonzalez, G.. Transgénicos: Grandes beneficios, ausencia de daños y mitos.
Mexico.
Carta
198 - Cruz-Correa,O.F., Ramirez-Hobak,L., Arenas,R., Soberon,X.. Metagenomics in onychomycosis. Analysis of a case with a possible role of malassezia globosa in the pathogenesis [Metagen¢mica en onicomicosis. El an lisis de un caso que revela el posible papel de Malassezia globosa en la pathogennesis].
Dermatología Cosmética, Médica y Quirúrgica,
14 (3),
245-248.
*
Artículo
199 - Gonzalez-Covarrubias,V., Martinez-Magana,J.J., Coronado-Sosa,R., Villegas-Torres,B., Genis-Mendoza,A.D., Canales-Herrerias,P., Nicolini,H., Soberon,X.. Exploring Variation in Known Pharmacogenetic Variants and its Association with Drug Response in Different Mexican Populations.
Pharmaceutical Research,
33 (11),
2644-2652.
*
Artículo in consortium
200 - Lek,M., Karczewski,K.J., Minikel,E.V., Samocha,K.E., Banks,E., Fennell,T., O'Donnell-Luria,A.H., Ware,J.S., Hill,A.J., Cummings,B.B., Tukiainen,T., Birnbaum,D.P., Kosmicki,J.A., Duncan,L.E., Estrada,K., Zhao,F.M., Zou,J., Pierce-Hollman,E., Berghout,J., Cooper,D.N., Deflaux,N., DePristo,M., Do,R., Flannick,J., Fromer,M., Gauthier,L., Goldstein,J., Gupta,N., Howrigan,D., Kiezun,A., Kurki,M.I., Moonshine,A.L., Natarajan,P., Orozeo,L., Peloso,G.M., Poplin,R., Rivas,M.A., Ruano-Rubio,V., Rose,S.A., Ruderfer,D.M., Shakir,K., Stenson,P.D., Stevens,C., Thomas,B.P., Tiao,G., Tusie-Luna,M.T., Weisburd,B., Won,H.H., Yu,D.M., Altshuler,D.M., Ardissino,D., Boehnke,M., Danesh,J., Donnelly,S., Elosua,R., Florez,J.C., Gabriel,S.B., Getz,G., Glatt,S.J., Hultman,C.M., Kathiresan,S., Laakso,M., NcCarroll,S., McCarthy,M.I., McGovern,D., McPherson,R., Neale,B.M., Palotie,A., Purcell,S.M., Saleheen,D., Scharf,J.M., Sklar,P., Sullivan,P.F., Tuomilehto,J., Tsuang,M.T., Watkins,H.C., Wilson,J.G., Daly,M.J., Macarthur,D.G., Exome Aggregation Consortium, Soberon,X.. Analysis of protein-coding genetic variation in 60,706 humans.
Nature,
536 (7616),
285-+.
*
Artículo
201 - Navarrete-Perea,J., Toledano-Magana,Y., Torre,P., Sciutto,E., Bobes,R.J., Soberon,X., Laclette,J.P.. Role of porcine serum haptoglobin in the host-parasite relationship of Taenia solium cysticercosis.
Molecular and Biochemical Parasitology,
207 (2),
61-67.
Revisión
202 - Bikel,S., Valdez-Lara,A., Cornejo-Granados,F., Rico,K., Canizales-Quinteros,S., Soberon,X., Del Pozo-Yauner,L., Ochoa-Leyva,A.. Combining metagenomics, metatranscriptomics and viromics to explore novel microbial interactions: towards a systems-level understanding of human microbiome.
Computational and Structural Biotechnology Journal,
13,
390-401.
Artículo
203 - Gomez,S., Adalid-Peralta,L., Palafox-Fonseca,H., Cantu-Robles,V.A., Soberon,X., Sciutto,E., Fragoso,G., Bobes,R.J., Laclette,J.P., Yauner,L.D., Ochoa-Leyva,A.. Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR).
Scientific Reports,
5,
9683 [erratum en vol 5 (12385) ].
Artículo
204 - Villegas-Torres,B., Sanchez-Giron,F., Jaramillo-Villafuerte,K., Soberon,X., Gonzalez-Covarrubias,V.. Genotype frequencies of VKORC1 and CYP2C9 in Native and Mestizo populations from Mexico, potential impact for coumarin dosing.
Gene,
558 (2),
235-240.
*
Artículo
205 - Estrada,K., Aukrust,I., Bjorkhaug,L., Burtt,N.P., Mercader,J.M., Garcia-Ortiz,H., Huerta-Chagoya,A., Moreno-Macias,H., Walford,G., Flannick,J., Williams,A.L., Gomez-Vazquez,M.J., Fernandez-Lopez,J.C., Martinez-Hernandez,A., Centeno-Cruz,F., Mendoza-Caamal,E., Revilla-Monsalve,C., Islas-Andrade,S., Cordova,E.J., Soberon,X., Gonzalez-Villalpando,M.E., Henderson,E., Wilkens,L.R., Le Marchand,L., Arellano-Campos,O., Ordonez-Sanchez,M.L., Rodriguez-Torres,M., Rodriguez-Guillen,R., Riba,L., Najmi,L.A., Jacobs,S.B., Fennell,T., Gabriel,S., Fontanillas,P., Hanis,C.L., Lehman,D.M., Jenkinson,C.P., Abboud,H.E., Bell,G.I., Cortes,M.L., Boehnke,M., Gonzalez-Villalpando,C., Orozco,L., Haiman,C.A., Tusie-Luna,T., Aguilar-Salinas,C.A., Altshuler,D., Njolstad,P.R., Florez,J.C., Macarthur,D.G.. Association of a Low-Frequency Variant in HNF1A With Type 2 Diabetes in a Latino Population.
JAMA,
311 (22),
2305-2314.
*
Artículo
206 - Majithia,A.R., Flannick,J., Shahinian,P., Guo,M., Bray,M.A., Fontanillas,P., Gabriel,S.B., Rosen,E.D., Altshuler,D., SIGMA T2D Consortium, Soberon,X.. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.
Proceedings of the National Academy of Sciences of the United States of America,
111 (36),
13127-13132.
*
Artículo
207 - Moreno-Estrada,A., Gignoux,C.R., Fernandez-Lopez,J.C., Zakharia,F., Sikora,M., Contreras,A.V., Acuna-Alonzo,V., Sandoval,K., Eng,C., Romero-Hidalgo,S., Ortiz-Tello,P., Robles,V., Kenny,E.E., Nuno-Arana,I., Barquera-Lozano,R., Macin-Perez,G., Granados-Arriola,J., Huntsman,S., Galanter,J.M., Via,M., Ford,J.G., Chapela,R., Rodriguez-Cintron,W., Rodriguez-Santana,J.R., Romieu,I., Sienra-Monge,J.J., del Rio-Navarro,B., London,S.J., Ruiz-Linares,A., Garcia-Herrera,R., Estrada,K., Hidalgo-Miranda,A., Jimenez-Sanchez,G., Carnevale,A., Soberon,X., Canizales-Quinteros,S., Rangel-Villalobos,H., Silva-Zolezzi,I., Burchard,E.G., Bustamante,C.D.. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits.
Science,
344 (6189),
1280-1285.
*
Artículo
208 - Williams,A.L., Jacobs,S.B., Moreno-Macias,H., Huerta-Chagoya,A., Churchhouse,C., Marquez-Luna,C., Garcia-Ortiz,H., Gomez-Vazquez,M.J., Burtt,N.P., Aguilar-Salinas,C.A., Gonzalez-Villalpando,C., Florez,J.C., Orozco,L., Haiman,C.A., Tusie-Luna,T., Altshuler,D., Williams,A.L., Marquez-Luna,C., Huerta-Chagoya,A., Ripke,S., Gomez-Vazquez,M.J., Manning,A.K., Moreno-Macias,H., Garcia-Ortiz,H., Neale,B., Burtt,N.P., Aguilar-Salinas,C.A., Reich,D., Stram,D.O., Fernandez-Lopez,J.C., Romero-Hidalgo,S., Altshuler,D., Florez,J.C., Tusie-Luna,T., Patterson,N., Haiman,C.A., Aguilar-Delfin,I., Martinez-Hernandez,A., Centeno-Cruz,F., Mendoza-Caamal,E., Revilla-Monsalve,C., Islas-Andrade,S., Cordova,E., Rodriguez-Arellano,E., Soberon,X., Orozco,L., Florez,J.C., Gonzalez-Villalpando,C., Gonzalez-Villalpando,M.E., Haiman,C.A., Henderson,B.E., Monroe,K., Wilkens,L., Kolonel,L.N., Le Marchand,L., Riba,L., Ordonez-Sanchez,M.L., Rodriguez-Guillen,R., Cruz-Bautista,I., Rodriguez-Torres,M., Munoz-Hernandez,L.L., Saenz,T., Gomez,D., Alvirde,U., Burtt,N.P., Onofrio,R.C., Brodeur,W.M., Gage,D., Murphy,J., Franklin,J., Mahan,S., Ardlie,K., Crenshaw,A.T., Winckler,W., Prufer,K., Shunkov,M.V., Sawyer,S., Stenzel,U., Kelso,J., Lek,M., Sankararaman,S., Williams,A.L., Patterson,N., Macarthur,D.G., Reich,D., Derevianko,A.P., Paabo,S., Jacobs,S.B., Churchhouse,C., Gopal,S., Grammatikos,J.A., Smith,I.C., Bullock,K.H., Deik,A.A., Souza,A.L., Pierce,K.A., Clish,C.B., Altshuler,D., Fennell,T., Farjoun,Y., Genomics,Platform B., Gabriel,S., Stram,D.O., Gross,M.D., Pereira,M.A., Seielstad,M., Koh,W.P., Tai,E.S., Flannick,J., Fontanillas,P., Morris,A., Teslovich,T.M., Burtt,N.P., Atzmon,G., Blangero,J., Bowden,D.W., Chambers,J., Shin,Cho Y., Duggirala,R., Glaser,B., Hanis,C., Kooner,J., Laakso,M., Lee,J.Y., Tai,E.S., Ying,Teo Y., Wilson,J.G., Haiman,C.A., Henderson,B.E., Monroe,K., Wilkens,L., Kolonel,L.N., Le Marchand,L., Puppala,S., Farook,V.S., Thameem,F., Abboud,H.E., Defronzo,R.A., Jenkinson,C.P., Lehman,D.M., Curran,J.E., Blangero,J., Duggirala,R., Burtt,N.P., Cortes,M.L., Altshuler,D., Florez,J.C., Haiman,C.A., Henderson,B.E., Aguilar-Salinas,C.A., Gonzalez-Villalpando,C., Orozco,L., Tusie-Luna,T.. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
Nature,
506 (7486),
97-101.
*
Divulgación
209 - Soberon-Mainero,X., Gonzalez-Covarrubias,V.. Enfermedades infecciosas, hacia una medicina personalizada.
Revista Digital Universitaria,
15 (6),
art 43.
*
Artículo
210 - Ochoa-Leyva,A., Montero-Moran,G., Saab-Rincon,G., Brieba,L.G., Soberon,X.. Alternative Splice Variants in TIM Barrel Proteins from Human Genome Correlate with the Structural and Evolutionary Modularity of this Versatile Protein Fold.
PLoS ONE,
8 (8),
e70582.
Artículo
211 - Tsai,I.J., Zarowiecki,M., Holroyd,N., Garciarrubio,A., Sanchez-Flores,A., Brooks,K.L., Tracey,A., Bobes,R.J., Fragoso,G., Sciutto,E., Aslett,M., Beasley,H., Bennett,H.M., Cai,Jianping, Camicia,F., Clark,R., Cucher,M., De Silva,N., Day,T.A., Deplazes,P., Estrada,K., Fernandez,C., Holland,P.W.H., Hou,Junling, Hu,Songnian, Huckvale,Thomas, Hung,S.S., Kamenetzky,L., Keane,J.A., Kiss,F., Koziol,U., Lambert,O., Liu,K., Luo,Xuenong, Luo,Yingfeng, Macchiaroli,N., Nichol,S., Paps,Jordi, Parkinson,J., Pouchkina-Stantcheva,N., Riddiford,N., Rosenzvit,M., Salinas,G., Wasmuth,James D., Zamanian,M., Zheng,Yadong, Cai,Xuepeng, Soberon,X., Olson,P.D., Laclette,J.P., Brehm,Klaus, Berriman,M., Ochoa-Leyva,A.. The genomes of four tapeworm species reveal adaptations to parasitism.
Nature,
496 (7443),
57-63.
Artículo
212 - Lopez-de Los Santos Y., Chan,H., Cantu,V.A., Rettner,R., Sanchez,F., Zhang,Z., Saier,M.H., Soberon,X.. Genetic engineering of the phosphocarrier protein NPr of the Escherichia coli phosphotransferase system selectively improves sugar uptake activity.
Journal of Biological Chemistry,
287 (35),
29931-29939.
Artículo
213 - Saab-Rincon,G., Olvera,L., Olvera,M., Rudino-Pinera,E., Benites,E., Soberon,X., Morett,E.. Evolutionary Walk between (beta/alpha)(8) Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase.
Journal of Molecular Biology,
416 (2),
255-270.
Nacional
214 - Soberon,X.. La medicina genómica en México, consideraciones para su desarrollo. Fortalezas y desafíos de los servicios de salud de México en el siglo XXI.
202-205.
Artículo
215 - Ochoa-Leyva,A., Barona-Gomez,F., Saab-Rincon,G., Verdel-Aranda,K., Sanchez,F., Soberon,X.. Exploring the Structure-Function Loop Adaptability of a (beta/alpha)(8)-Barrel Enzyme through Loop Swapping and Hinge Variability.
Journal of Molecular Biology,
411 (1),
143-157.
Nacional
216 - Bolivar-Zapata,F.G., Arias-Ortiz,C.F., Arriaga-Arellano,E., Barrera-Saldaña,H., de la Torres-Martinez,M., Espinosa-Fernandez,J., Galindo-Fentanes,E., Galvez-Mariscal,A, Gracia-Gasca,A., Herrera-Estrella,L., Larque-Saavedra,A., Lopez-Munguia Canales,A., Noyola-Robles,A., Paredes-Lopez,O., Ramirez-Reivich,O.T., Revah-Moiseev,S., Soberon-Mainero,J., Soberon-Mainero,X., Torres-Pacheco,I., Uribe de la Mora,J., Viniegra-Gonzalez,G.. Por un uso responsable de los organismos genéticamente modificados.
Mexico.
Artículo
217 - Noda-Garcia,L., Camacho-Zarco,A.R., Verdel-Aranda,K., Wright,H., Soberon,X., Fulop,V., Barona-Gomez,F.. Identification and analysis of residues contained on beta --> alpha loops of the dual-substrate (betaalpha)(8) phosphoribosyl isomerase a (PriA) specific for its phosphoribosyl anthranilate isomerase activity.
Protein Science,
19 (3),
535-543.
Editorial Material
218 - Soberon-Mainero,X., Melendez-Zajgla,J.. [The Instituto Nacional de Medicina Genomica. Vocation and challenges].
Revista de Investigacion Clinica,
62 (5),
391-392.
*
Artículo
219 - Ochoa-Leyva,A., Soberon,X., Sanchez,F., Arguello,M., Montero-Moran,G., Saab-Rincon,G.. Protein design through systematic catalytic loop exchange (SCLE) in the (beta/alpha)(8)-fold.
Journal of Molecular Biology,
387 (4),
949-964.
Internacional
220 - Frausto-Solis,J., Soberon-Mainero,X., Linan-Garcia,E.. MultiQuenching annealing algorithm for protein folding problem. Mexican International Conference on Artificial Intelligence. MICAI 2009: Advances in Artificial Intelligence .
Lecture Notes in Computer Science ,
578-589.
Artículo; Actas Paper
221 - Damian-Almazo,J.Y., Lopez-Munguia A., Soberon-Mainero,X., Saab-Rincon,G.. Role of the phenylalanine 260 residue in defining product profile and alcoholytic activity of the a-amylase AmyA from Thermotoga maritima.
Biologia,
63 (6),
1035-1043.
Artículo
222 - Damian-Almazo,J.Y., Moreno,A., Lopez-Munguia,A., Soberon,X., Gonzalez-Munoz,F., Saab-Rincon,G.. Enhancement of the alcoholytic activity of {alpha}-amylase AmyA from Thermotoga maritima MSB8 (DSM 3109) by site directed mutagenesis.
Applied and Environmental Microbiology,
74 (16),
5168-5177.
Nacional
223 - Segovia,L., Soberon,X.. Evolución experimental de proteínas. Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 26.
291-302,
Mexico, D.F..
Artículo
224 - Flores-Ramirez,G., Rivera,M., Morales-Pablos,A., Osuna,J., Soberon,X., Gaytan,P.. The effect of amino acid deletions and substitutions in the longest loop of GFP.
BMC Chemical Biology,
7 (1),
1.
Artículo
225 - Vazquez-Limon,C., Vega-Badillo,J., Martinez,A., Espinosa-Molina,G., Gosset,G., Soberon,X., Lopez-Munguia,A., Osuna,J.. Growth rate of a non-fermentative Escherichia coli strain is influenced by NAD(+) regeneration.
Biotechnology Letters,
29 (12),
1857-1863.
Internacional
226 - Barona-Gomez,F., Ochoa-Leyva,A., Soberon,X.. Advances and perspectives in protein engineering: from natural history to directed evolution of enzymes. Advances in Protein Physical Chemistry.
407-438,
Kerala: Research Signpost.
Memoria in extenso
227 - Frausto-Solis,J., Roman,E.F., Romero,D., Soberon,X., Linan-Garcia,E.. Analytically tuned simulated annealing applied to the protein folding problem. Lecture Notes in Computer Science vol 4488.
370-377.
Artículo; Actas Paper
228 - Aguilar-Diaz,H., Bobes,R.J., Carrero,J.C., Camacho-Carranza,R., Cervantes,C., Cevallos,M.A., Davila,G., Rodriguez-Dorantes,M., Escobedo,G., Fernandez,J.L., Fragoso,G., Gaytan,P., Garciarrubio,A., Gonzalez,V.M., Gonzalez,L., Jose,M.V., Jimenez,L., Laclette,J.P., Landa,A., Larralde,C., Morales-Montor,J., Morett,E., Ostoa-Saloma,P., Sciutto,E., Santamaria,R.I., Soberon,X., de la Torre P., Valdes,V., Yanez,J.. The genome project of Taenia solium.
Parasitology International,
55 (Suppl),
S127-S130.
Artículo
229 - Monroy-Lagos,O., Soberon,X., Gaytan,P., Osuna,J.. Improvement of an unusual twin-arginine transporter leader Peptide by a codon-based randomization approach.
Applied and Environmental Microbiology,
72 (5),
3797-3801.
Revisión
230 - Soberon,X., Saier,M.H.,Jr.. Engineering Transport Protein Function: Theoretical and Technical Considerations Using the Sugar-Transporting Phosphotransferase System of Escherichia coli as a Model System.
Journal of Molecular Microbiology and Biotechnology,
11 (6),
302-307.
Artículo
231 - Souza,V., Espinosa-Asuar,L., Escalante,A.E., Eguiarte,L.E., Farmer,J., Forney,L., Lloret,L., Rodriguez-Martinez,J.M., Soberon,X., Dirzo,R., Elser,J.J.. An endangered oasis of aquatic microbial biodiversity in the Chihuahuan desert.
Proceedings of the National Academy of Sciences of the United States of America,
103 (17),
6565-6570.
Nacional
232 - Baez-Viveros,J.L., Osuna,J., Hernandez-Chavez,G., Soberon,X., Bolivar,F., Gosset,G.. Metabolic via engineering for the production of aromatic substances in Escherichia coli.
Revista Latinoamericana de Microbiologia,
48 (2),
92.
Artículo
233 - Gaytan,P., Yanez,J., Grande,R., Morett,E., Soberon,X.. Improving random mutagenesis by purification of the oligonucleotide variants.
Combinatorial Chemistry & High Throughput Screening,
8 (6),
537-544.
Artículo
234 - Saab-Rincon,G., Mancera,E., Montero-Moran,G., Sanchez,F., Soberon,X.. Generation of variability by in vivo recombination of halves of a (beta/alpha)(8) barrel protein.
Biomolecular Engineering,
22 (4),
113-120.
Artículo
235 - Baez-Viveros,J.L., Osuna,J., Hernandez-Chavez,G., Soberon,X., Bolivar,F., Gosset,G.. Metabolic engineering and protein directed evolution increase the yield of L-phenylalanine synthesized from glucose in Escherichia coli.
Biotechnology and Bioengineering,
87 (4),
516-524.
Artículo
236 - Flores,G., Soberon,X., Osuna,J.. Production of a fully functional, permuted single-chain penicillin G acylase.
Protein Science,
13 (6),
1677-1683.
Artículo
237 - Moreno,A., Saab-Rincon,G., Santamaria,R.I., Soberon,X., Lopez-Munguia,A.. A more efficient starch degradation by the combination of hydrolase and transferase activities of alpha-amylase and cyclomaltodextrin glucanotransferase.
Starch-Starke,
56 (2),
63-68.
Artículo
238 - Osuna,J., Yanez,J., Soberon,X., Gaytan,P.. Protein evolution by codon-based random deletions.
Nucleic Acids Research,
32 (17),
e136.
Artículo
239 - Soberon,X., Fuentes-Gallego,P., Saab-Rincon,G.. In vivo fragment complementation of a (beta/alpha)(8) barrel protein: generation of variability by recombination.
FEBS Letters,
560 (1-3),
167-172.
Artículo
240 - Yanez,J., Arguello,M., Osuna,J., Soberon,X., Gaytan,P.. Combinatorial codon-based amino acid substitutions.
Nucleic Acids Research,
32 (20),
e158.
Nacional
241 - Soberon,X., Montero,G.M.. Ingeniería de proteínas y evolución dirigida. Fundamentos y casos exitosos de la biotecnologia moderna cap 7.
195-217,
Mexico.
Nacional
242 - Yanez,J., Soberon,X., Gaytan,P.. Rutas alternas de síntesis para la preparación de Fmoc-Trinucleósido-Difosfato Fosforamiditos.
Revista de la Sociedad Química de México,
48 (1),
26-37.
Artículo
243 - Rivera,M.H., Lopez-Munguia,A., Soberon,X., Saab-Rincon,G.. alpha-Amylase from Bacillus licheniformis mutants near to the catalytic site: effects on hydrolytic and transglycosylation activity.
Protein Engineering,
16 (7),
505-514.
Nacional
244 - Soberon,X.. Biocatálisis y evolución dirigida de proteínas. Fronteras de la Biología en los Inicios del Siglo XXI, Módulo VII.
35-45,
Mexico,D.F..
Nacional
Divulgación
246 - Soberon Mainero,X. Veinte años del Instituto de Biotecnología.
Revista Universidad de Mexico,
629.
Divulgación
247 - Soberon-Mainero,X.. Veinte años del Instituto de Biotecnología.
Revista de la Universidad de México,
629.
Artículo
248 - Gaytan,P., Osuna,J., Soberon,X.. Novel ceftazidime-resistance beta-lactamases generated by a codon-based mutagenesis method and selection.
Nucleic Acids Research,
30 (16),
e84-e84.
Artículo
249 - Osuna,J., Perez-Blancas,A., Soberon,X.. Improving a circularly permuted TEM-1 beta-lactamase by directed evolution.
Protein Engineering,
15 (6),
463-470.
Memoria in extenso
250 - Saab-Rincon,G., Del Rio,G, Santamaria,R, Diaz,M.L, Soberon,X., Lopez-Munguia,A.. Novel and potential applications of alpha-amylases in the food industry. Engineering and Food for the 21st Century. Proceedings of the Eighth International Congress on Engineering and Food.
913-924,
Boca Raton, Fla.
Divulgación
251 - Soberon Mainero, X.. La revolución de las ciencias genómicas.
Revista Universidad Nacional,
617.
Divulgación
252 - Soberon-Mainero,X.. La ingenieria genética y un campo de aplicación: la biocatálisis y la industria química limpia.
Mensaje Bioquimico,
26,
1-18.
Artículo
253 - Gaytan,P., Yanez,J., Sanchez,F., Soberon,X.. Orthogonal combinatorial mutagenesis: a codon-level combinatorial mutagenesis method useful for low multiplicity and amino acid-scanning protocols.
Nucleic Acids Research,
29 (3),
E9.
Artículo
254 - Saab-Rincon,G., Juarez,V.R., Osuna,J., Sanchez,F., Soberon,X.. Different strategies to recover the activity of monomeric triosephosphate isomerase by directed evolution.
Protein Engineering,
14 (3),
149-155.
Nacional
255 - Soberon,X., Bolivar,F.. Evolución de los conceptos de gen y genoma. Ciencias de la vida.
61-83.
Divulgación
256 - Soberon,X.. La biotecnologia: un ejercito microscopico al servicio del hombre.
Hypatia,
2,
6-7.
Divulgación
257 - Soberon,X.. Nuevos paradigmas relacionados con la ciencia biologica experimental: implicaciones cientificas, tecnologicas y sociales.
Revista Universidad de Mexico,
605-606,
59-63.
Divulgación
258 - Soberon,X.. El convenio UNAM-INE-Diversa y el aprovechamiento de recursos geneticos.
BioTecnologia. Sociedad Mexicana de Biotecnologia y Bioingenieria,
5,
14-15.
Divulgación
Artículo
260 - Moreno-Hagelsieb,G., Gomez-Puyou,A., Soberon,X.. Escherichia coli TEM1 beta-lactamase in CTAB reverse micelles: exchange/diffusion-limited catalysis.
FEBS Letters,
459 (1),
111-114.
Artículo
261 - Saab-Rincon,G., Del Rio,G., Santamaria,R.I., Lopez-Munguia,A., Soberon,X.. Introducing transglycosylation activity in a liquefying alpha-amylase.
FEBS Letters,
453 (1-2),
100-106.
Artículo
262 - Santamaria,R.I., Del Rio,G., Saab,G., Rodriguez,M.E., Soberon,X., Lopez-Manguia,A.. Alcoholysis reactions from starch with alpha-amylases.
FEBS Letters,
452 (3),
346-350.
News Item
263 - Soberon,X.. Enzymes directly evolving toward commercial applications.
Nature Biotechnology,
17 (6),
539-540.
Artículo
264 - Galindo,E., Lagunas,F., Osuna,J., Soberon,X., Garcia,J.L.. A microbial biosensor for 6-aminopenicillanic acid.
Enzyme and Microbial Technology,
23 (5),
331-334.
Artículo
265 - Garcia,J.L., Nunez,C.J., Gonzalez,E.G., Osuna,J., Soberon,X., Galindo,E.. Microbial sensor for new-generation cephalosporins based in a protein-engineered beta-lactamase.
Applied Biochemistry and Biotechnology,
73 (2-3),
243-256.
Artículo
266 - Gaytan,P., Yanez,J., Sanchez,F., Mackie,H., Soberon,X.. Combination of DMT-mononucleotide and Fmoc-trinucleotide phosphoramidites in oligonucleotide synthesis affords an automatable codon-level mutagenesis method.
Chemistry and Biology,
5 (9),
519-527.
Artículo
267 - Gonzalez,V., Olvera,L., Soberon,X., Morett,E.. In vivo studies on the positive control function of NifA: a conserved hydrophobic amino acid patch at the central domain involved in transcriptional activation.
Molecular Microbiology,
28 (1),
55-67.
Artículo
268 - Del Rio,G., Morett,E., Soberon,X.. Did cyclodextrin glycosyltransferases evolve from alpha-amylases?.
FEBS Letters,
416 (2),
221-224.
Artículo
269 - Flores,H., Soberon,X., Sanchez,J., Bravo,A.. Isolated domain II and III from the Bacillus thuringiensis Cry1Ab delta-endotoxin binds to lepidopteran midgut membranes.
FEBS Letters,
414 (2),
313-318.
Artículo
270 - Gaytan,P., Yanez,J., Soberon,X., Martinez,R.. A new method for oligonucleotide derivatization of the 3' or 5'-termini with a CPG-support carrying the natural product isoargentatin-D.
Tetrahedron Letters,
38 (35),
6123-6126.
Artículo
271 - Muir,R.S., Flores,H., Zinder,N.D., Model,P., Soberon,X., Heitman,J.. Temperature-sensitive mutants of the EcoRI endonuclease.
Journal of Molecular Biology,
274 (5),
722-737.
Artículo
272 - Osuna,J., Soberon,X., Morett,E.. A proposed architecture for the central domain of the bacterial enhancer-binding proteins based on secondary structure prediction and fold recognition.
Protein Science,
6 (3),
543-555.
Artículo
273 - Del Rio,G., Lopez-Munguia,A., Soberon,X.. An engineered penicillin acylase with altered surface charge is more stable in alkaline pH.
Annals of the New York Academy of Sciences,
799,
61-64.
Artículo
274 - Moreno-Hagelsieb,G., Soberon,X.. Protein engineering as a powerful tool for the chemical modification of enzymes.
Biological Research,
29 (1),
127-140.
Artículo
275 - Del Rio,G., Rodriguez,M.E., Munguia,M.E., Lopez-Munguia,A., Soberon,X.. Mutant Escherichia coli penicillin acylase with enhanced stability at alkaline pH.
Biotechnology and Bioengineering,
48 (2),
141-148.
Artículo
276 - Flores,H., Osuna,J., Heitman,J., Soberon,X.. Saturation mutagenesis of His114 of EcoRI reveals relaxed-specificity mutants.
Gene,
157 (1-2),
295-301.
Artículo
277 - Osuna,J., Viadiu,H., Fink,A.L., Soberon,X.. Substitution of Asp for Asn at position 132 in the active site of TEM beta-lactamase. Activity toward different substrates and effects of neighboring residues.
Journal of Biological Chemistry,
270 (2),
775-780.
Artículo
278 - Viadiu,H., Osuna,J., Fink,A.L., Soberon,X.. A new TEM beta-lactamase double mutant with broadened specificity reveals substrate-dependent functional interactions.
Journal of Biological Chemistry,
270 (2),
781-787.
Artículo
279 - Del Rio,G., Osuna,J., Soberon,X.. Combinatorial libraries of proteins: analysis of efficiency of mutagenesis techniques.
Biotechniques,
17 (6),
1132-1139.
Artículo
280 - Gurrola,G.B., Moreno-Hagelsieb,G., Zamudio,F.Z., Garcia,M., Soberon,X., Possani,L.D.. The disulfide bridges of toxin 2 from the scorpion Centruroides noxius Hoffmann and its three-dimensional structure calculated using the coordinates of variant 3 from Centruroides sculpturatus.
FEBS Letters,
347 (1),
59-62.
Revisión
281 - Osuna,J., Flores,H., Soberon,X.. Microbial systems and directed evolution of protein activities.
Critical Reviews in Microbiology,
20 (2),
107-116.
Artículo
282 - Merino,E., Osuna,J., Bolivar,F., Soberon,X.. A general, PCR-based method for single or combinatorial oligonucleotide-directed mutagenesis on pUC/M13 vectors.
Biotechniques,
12 (4),
508-510.
Artículo
283 - Pereyra-Alferez,B., Bravo,A., Quintero,R., Soberon,X.. The delta-endotoxin protein family displays a hydrophobic motif that might be implicated in toxicity.
Molecular Microbiology,
6 (15),
2095-2098.
Artículo
284 - Lopez,S., Lopez,I., Romero,P., Mendez,E., Soberon,X., Arias,C.F.. Rotavirus YM gene 4: analysis of its deduced amino acid sequence and prediction of the secondary structure of the VP4 protein.
Journal of Virology,
65 (7),
3738-3745.
Artículo
Note
286 - Fuchs,L.Y., Ovando,C., Joseph,P., Soberon,X., Charli,J.L.. Repetitive DNA sequence from the crayfish Procambarus clarkii.
Nucleic Acids Research,
18 (6),
1650.
Artículo
287 - Pastor,N., Pinero,D., Valdes,A.M., Soberon,X.. Molecular evolution of class A beta-lactamases: phylogeny and patterns of sequence conservation.
Molecular Microbiology,
4 (11),
1957-1965.
Internacional
288 - Balbas,P., Soberon,X., Bolivar,F., Rodriguez,R.L.. The plasmid, pBR322. Biotechnology (Reading, Mass.).
5-41,
10.
Artículo
289 - Balbas,P., Soberon,X., Merino,E., Zurita,M., Lomeli,H., Valle,F., FLORES,N., Bolivar,F.. Plasmid vector pBR322 and its special-purpose derivatives--a review.
Gene,
50 (1-3),
3-40.
Nacional
290 - Oliver,G., Balbas,P., Valle,F., Soberon,X., Bolivar,F.. [Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli].
Revista Latinoamericana de Microbiologia,
27 (2),
141-150.
Artículo
292 - Rossi,J.J., Soberon,X., Marumoto,Y., McMahon,J., Itakura,K.. Biological expression of an Escherichia coli consensus sequence promoter and some mutant derivatives.
Proceedings of the National Academy of Sciences of the United States of America,
80 (11),
3203-3207.
*
Artículo
293 - Inouye,S., Soberon,X., Franceschini,T., Nakamura,K., Itakura,K., Inouye,M.. Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane.
Proceedings of the National Academy of Sciences of the United States of America,
79 (11),
3438-3441 .
*
Artículo
294 - Miyada,C.G., Soberon,X., Itakura,K., Wilcox,G.. The use of synthetic oligodeoxyribonucleotides to produce specific deletions in the araBAD promoter of Escherichia coli B/r.
Gene,
17 (2),
167-177.
*
Artículo
295 - Zarucki-Schulz,T., Tsai,S.Y., Itakura,K., Soberon,X., Wallace,R.B., Tsai,M.J., Woo,S.L., O'Malley,B.W.. Point mutagenesis of the ovalbumin gene promoter sequence and its effect on in vitro transcription.
Journal of Biological Chemistry,
257 (18),
11070-11077.
*
296 - Soberon Mainero, Francisco Xavier. Uso de vehiculos moleculares de clonacion y de sintesis quimica de polinucleotidos para el estadio de la expresion genica.
Instituto de Investigaciones Biomedicas,
Maestria en Investigacion Biomedica Basica,
UNAM.
*
Asesor: Itakura, Keiichi, Bolivar Zapata, Francisco
Artículo
297 - Covarrubias,L., Cervantes,L., Covarrubias,A., Soberon,X., Vichido,I., Blanco,A., Kupersztoch-Portnoy,Y.M., Bolivar,F.. Construction and characterization of new cloning vehicles. V. Mobilization and coding properties of pBR322 and several deletion derivatives including pBR327 and pBR328.
Gene,
13 (1),
25-35.
*
Artículo
298 - Soberon,X., Covarrubias,L., Bolivar,F.. Construction and characterization of new cloning vehicles. IV. Deletion derivatives of pBR322 and pBR325.
Gene,
9 (3-4),
287-305.
*
- Teléfonos
-
Oficina +52 (777) 329-1641
desde la CDMX 562-27641
Red UNAM 27641