Dr. Francisco Xavier del Espíritu Santo Soberon Mainero
Investigador Titular C Tiempo Completo
Estructura, Función y Manipulación de Péptidos y Proteínas
Genómica y transcriptomica de patógenos y parásitos
Número de registros: 6
- Activos
- Vencidos
- Exploración del espacio de variantes del dominio de unión al receptor (ace2) del virus sars-cov-2 mediante redes neurales, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2022 - 2024
- Evolución dirigida del dominio de prefenato deshidrogenasa de la proteína t de e. coli, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2016 - 2019
- Evolución dirigida de proteínas, PRESUPUESTO UNAM, 2014 - 2020
- Estudios evoulutivos y mecanísticos de la enzima bifuncional fosforibosil isomerasa (pria) presente en bacterias del grupo de los actinomicetos., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2005 - 2006
- Diseño y desarrollo de un andamiaje estable para evolución dirigida de actividades catalíticas., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2004 - 2007
- Evolución dirigida de proteínas: desarrollo de conceptos y metodologías para la generación de reconocimiento y catálisis de novo, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 1997 - 2002
Nivel D del PRIDE
Nivel III del SNII
Nivel III del SNII
Doctorado, en Investigacion Biomedica Basica, Instituto de Investigaciones Biomedicas-CEINGEBI-UNAM (1984)
Maestría, en Investigacion Biomedica Basica, Instituto de Investigaciones Biomedicas-UNAM (1981)
Licenciatura, Química, Universidad Iberoamericana (1978)
Premio Nacional de Química "Andrés Manuel del Río", Sociedad Química de México, 1999
- Activos
- Graduados
-
Doctorado
-
M.C. Brenda Georgina Uribe Vazquez
Caracterización bioquímica, biofísica y estructural de variantes de KatG que confieren resistencia a isoniazida en Mycobacterium tuberculosis
1 - Guerrero Corona, Diego (2019). Microbioma de tracto respiratorio en pacientes con infecciones respiratorias agudas .
INMEGEN,
Maestria en Ciencias Bioquimicas,
UNAM.
*
2 - Cruz Correa, Omar Fernando (2019). Caracterizacion de la diversidad en genes importantes de farmacogenomica mediante secuenciacion de nueva generacion .
Instituto de Biotecnologia,
Doctorado en Bioquimicas,
UNAM.
3 - Uribe Vazquez, Brenda Georgina (2017). Caracterizacion funcional de mutaciones nuevas en KatG de mycobacterium tuberculosis resistente a isoniazida encontradas en aislados clinicos de pacientes mexicanos .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
4 - Lopez de los Santos, Yossef (2014). Ingenieria de las proteinas del sistema pts en escherichia coli.
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
5 - Cruz Correa, Omar Fernando (2013). Desarrollo de pruebas genomicas prioritarias para la salud publica de Mexico .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
6 - Cantu Alessio Robles, Vito Adrian (2013). Analisis de una libreria binaria de mutantes de NPR .
Instituto de Biotecnologia,
Maestria en Ciencias,
UNAM.
7 - Ochoa Leyva, Adrian (2011). Explorando la relacion estructurafuncion de las asas SS/a de un barril (SS/a)8 : implicaciones para el diseno de nuevas funciones enzimaticas .
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
8 - Verdel Aranda, Karina (2009). Cinetica enzimatica de fosforribosil antranilato isomerasas (PRAI) obtenidas por evolucion dirigida .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
9 - Flores Escobar, Biviana (2008). Diseno y construccion de variantes de la enzima fosforribosil antranilato isomerasa (PRAI) con asas de aldolasas clase I .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
10 - Gaytan Colin, Ruben Paul (2003). Nuevas estrategias de sintesis de DNA para la evolucion dirigida de proteinas : generacion y enriquecimiento de bibliotecas con mutantes de baja multiplicidad.
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
11 - Riano Umbarila, Lidia (2000). Desarrollo de un sistema de seleccion para la actividad de aldolasa .
Instituto de Biotecnologia,
Maestria en Ciencias (Bioquimica),
UNAM.
12 - Ledezma Candanoza, Luis Moises (2000). Estudio de la catalisis y del reconocimiento especifico al ADN por la endonucleasa EcoRI .
Instituto de Biotecnologia,
Maestria en Ciencias Biomedicas,
UNAM.
13 - Gonzalez Zuniga, Victor Manuel (1998). El mecanismo de activacion trascripcional a distancia en bacteria y la region de control positivo de NifA .
Instituto de Biotecnologia,
Doctorado en Biotecnologia,
UNAM.
14 - Chihu Amparan, Lilia (1998). Mutagenesis combinatoria de la region del sitio activo de la beta lactamasa tem1 de Escherichia coli .
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
Asesor: Soberon Mainero, Francisco Xavier, Fuchs Gomez, Lidia Yolanda
15 - Rio Guerra, Gabriel del (1997). Estudio del sitio catalitico de una alfaamilasa por medio de ingenieria de proteinas .
Instituto de Biotecnologia,
Doctorado en Biotecnologia,
UNAM.
16 - Flores Soto, Humberto (1995). Analisis del reconocimiento molecular por medio de ingenieria de proteinas.
Instituto de Biotecnologia,
Doctorado en Biotecnologia,
UNAM.
17 - Cota Segura, Ernesto (1995). Estudio de regiones conservadas de la betalactamasa clase A de E. coli.
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
18 - Viadiu Ilarraza, Hector (1994). Modificacion de la especificidad de la Blactamasa por mutagenesis combinatoria.
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
19 - Rio Guerra, Gabriel del (1994). Mutagenesis de residuos involucrados en la estabilidad al PH alcalino de la penicilino acilasa de E. coli .
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
20 - Ramirez Alvarado, Marina (1994). Ingenieria de proteinas para reacciones de alcoholisis mutagenesis combinatoria de alfaamilasa .
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
21 - Flores Soto, Humberto (1994). Analisis de la intervencion DNA proteina de la endonucleasa Ecori, por medio de mutagenesis dirigida .
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
22 - Osuna Quintero, Joel (1992). Analisis del sitio activo de enzimas mediante mutagenesis combinatoria .
Instituto de Biotecnologia,
Doctor en Investigacion Biomedica Basica,
UNAM.
23 - Munguia Zamudio, Maria Elena (1992). Clonacion y expresion del fragmento C de la toxina tetanica en Escherichia coli .
Instituto de Biotecnologia,
Maestroia en Biotecnologia,
UNAM.
24 - Flores Soto, Humberto (1991). Caracterizacion de mutantes en el sitio de reconocimiento de la endonucleasa Eco RI .
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
*
25 - Osuna Quintero, Joel (1989). Aislamineto de un fragmento inmunogenico de toxina tetanica.
CEINGEBI,
Maestria en Investigacion Biomedica Basica,
UNAM.
26 - Cruz Reyes, Jorge Armando (1989). Un sistema experimental para el aislamiento del sustrato minimo de replicacion en plasmidos tipo Col E1 .
CEINGEBI,
Licenciatura en Investigacion Biomedica Basica,
UNAM.
27 - Munguia Zamudio, Maria Elena (1987). Estudios sobre estabilidad y replicacion inducible en plasmidos tipo col el .
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
*
28 - Lomeli Buyoli, Hilda Maria (1987). Determinacion de una region hacia arriba del promotor requerida para la transcripcion optima del primero de replicacion del plasmido pBR327 .
CEINGEBI,
Maestria en Investigacion Biomedica Basica,
UNAM.
29 - Lomeli Buyoli, Hilda Maria (1984). Introduccion de un sitio de restriccion adyacente al origen de replicacion del plasmido pBR327.
Escuela Nacional de Estudios Superiores Zaragoza,
Quimico Farmaceutico Biologo,
UNAM.
*
30 - Cuevas Guerrero, Mario Alberto (1983). Sintesis de polinucleotidos mediante tecnica estandarizada .
FES Zaragoza,
Quimico Farmaceutico Biologo,
UNAM.
*
Total de publicaciones: 135
- Tipo
- Fecha
Artículo
31 - Galeana-Cadena,D., Ramirez-Martinez,G., Choreno-Parra,J.A., Silva-Herzog,E., Hernandez-Cardenas,C.M., Soberon,X., Zuniga,J. (2024). Microbiome in the Nasopharynx: Insights into the Impact of COVID-19 Severity.
Heliyon,
10 (10),
e31562.
Artículo
32 - Oropeza-Valdez,J.J., Padron-Manrique,C., Vazquez-Jimenez,A., Soberon,X., Resendis-Antonio,O. (2024). Exploring metabolic anomalies in COVID-19 and post-COVID-19: a machine learning approach with explainable artificial intelligence.
Frontiers in Molecular Biosciences,
11,
1429281.
Artículo
33 - Uribe-Vazquez,B., Diaz-Vilchis,A, Avila-Linares,A., Saab-Rincon,G, Marin-Tovar,Y., Flores,H, Pastor,N, Huerta-Miranda,G, Rudino-Pinera,E., Soberon,X (2024). Characterization of a catalase-peroxidase variant (L333V-KatG) identified in an INH-resistant Mycobacterium tuberculosis clinical isolate.
Biochemistry and Biophysics Reports,
37,
101649.
Revisión
34 - Alvarado-Pena,N., Galeana-Cadena,D., Gomez-Garcia,I.A, Soberon-Mainero,X, Silva-Herzog,E (2023). The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment.
Frontiers in Microbiology,
14,
1237998.
Artículo
35 - Barbosa-Amezcua,M., Cuevas-Cordoba,B., Fresno,C., Haase-Hernandez,J.I., Carrillo-Sanchez,K., Mata-Rocha,M., Munoz-Torrico,M., Backer,C., Gonzalez-Covarrubias,V., Alaez-Verson,C., Soberon,X. (2022). Rapid Identification of Drug Resistance and Phylogeny in M. tuberculosis, Directly from Sputum Samples.
Microbiology Spectrum,
10 (5),
e0125222.
Artículo
36 - Martinez-Magana,J.J., Genis-Mendoza,A.D., Gonzalez-Covarrubias,V., Juarez-Rojop,I.E., Tovilla-Zarate,C.A., Soberon,X., Lanzagorta,N., Nicolini,H. (2022). Association of FAAH p.Pro129Thr and COMT p.Ala72Ser with schizophrenia and comorbid substance use through next-generation sequencing: an exploratory analysis.
Brazilian Journal of Psychiatry,
44 (2),
164-170.
*
Artículo
37 - Aguilar-Ordonez,I., Perez-Villatoro,F., Garcia-Ortiz,H., Barajas-Olmos,F., Ballesteros-Villascan,J., Gonzalez-Buenfil,R., Fresno,C., Garciarrubio,A., Fernandez-Lopez,J.C., Tovar,H., Hernandez-Lemus,E., Orozco,L., Soberon,X., Morett,E. (2021). Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights.
PLoS ONE,
16 (4),
e0249773,
[correction May 25 2022].
artículo
38 - Cuevas-Cordoba,B., Fresno,C., Haase-Hernandez,J.I., Barbosa-Amezcua,M., Mata-Rocha,M., Munoz-Torrico,M., Salazar-Lezama,M.A., Martinez-Orozco,J.A., Narvaez-Diaz,L.A., Salas-Hernandez,J., Gonzalez-Covarrubias,V., Soberon,X. (2021). A bioinformatics pipeline for Mycobacterium tuberculosis sequencing that cleans contaminant reads from sputum samples.
PLoS ONE,
16 (10),
e0258774.
*
Artículo
39 - Gonzalez-Covarrubias,V,, Sanchez-Ibarra,H., Lozano-Gonzalez, K., Villicana, S., Texis,T., Rodriguez-Dorantes,M., Cortes-Ramirez,S., Lavalle-Gonzalez,F,, Soberon,X., Barrera-Saldana,H. (2021). Transporters, TBC1D4, and ARID5B Variants to Explain Glycated Hemoglobin Variability in Patients with Type 2 Diabetes.
Pharmacology,
106 (11-12),
588-596.
Artículo
40 - Jaimes-Hoy,L., Perez-Maldonado,A., Narvaez-Bahena,E., de la Cruz Guarneros,N., Rodriguez-Rodriguez,A., Charli,J.L., Soberon,X., Joseph-Bravo,P. (2021). Sex dimorphic changes in Trh gene methylation and thyroid-axis response to energy demands in maternally-separated rats.
Endocrinology,
May 27 Online ahead of print [comentario vol 162 (9) pp 1-2].
Artículo
41 - Valdez-Palomares,F., Munoz-Torrico,M., Palacios-Gonzalez,B., Soberon,X., Silva-Herzog,E. (2021). Altered Microbial Composition of Drug-Sensitive and Drug-Resistant TB Patients Compared with Healthy Volunteers.
Microorganisms,
9 (8),
1762.
Revisión
42 - Gonzalez-Covarrubias,V., Lozano,K., Texis,T., Guzman-Cruz,C.K., Rodriguez-Dorantes,M., Rubio-Carrasco,K., Mendez-Lorenzo,L.H., Soberon,X. (2020). Pharmacogenomics: Current Actionable Variants.
Revista de Investigacion Clinica,
73 (3).
*
Artículo
43 - Cabrera-Contreras,R., Santamaria,R.I., Bustos,P., Martinez-Flores,I., Melendez-Herrada,E., Morelos-Ramirez,R., Barbosa-Amezcua,M., Gonzalez-Covarrubias,V., Silva-Herzog,E., Soberon,X., Gonzalez,V. (2019). Genomic diversity of prevalent Staphylococcus epidermidis multidrug-resistant strains isolated from a Children's Hospital in Mexico City in an eight-years survey.
PeerJ,
7,
e8068.
*
Artículo
44 - Flannick,J., Mercader,J.M., Fuchsberger,C., Udler,M.S., Mahajan,A., Wessel,J., Teslovich,T.M., Caulkins,L., Koesterer,R., Barajas-Olmos,F., Blackwell,T.W., Boerwinkle,E., Brody,J.A., Centeno-Cruz,F., Chen,L., Chen,S., Contreras-Cubas,C., Cordova,E., Correa,A., Cortes,M., Defronzo,R.A., Dolan,L., Drews,K.L., Elliott,A., Floyd,J.S., Gabriel,S., Garay-Sevilla,M.E., Garcia-Ortiz,H., Gross,M., Han,S., Heard-Costa,N.L., Jackson,A.U., Jorgensen,M.E., Kang,H.M., Kelsey,M., Kim,B.J., Koistinen,H.A., Kuusisto,J., Leader,J.B., Linneberg,A., Liu,C.T., Liu,J., Lyssenko,V., Manning,A.K., Marcketta,A., Malacara-Hernandez,J.M., Martinez-Hernandez,A., Matsuo,K., Mayer-Davis,E., Mendoza-Caamal,E., Mohlke,K.L., Morrison,A.C., Ndungu,A., Ng,M.C.Y., O'Dushlaine,C., Payne,A.J., Pihoker,C., Post,W.S., Preuss,M., Psaty,B.M., Vasan,R.S., Rayner,N.W., Reiner,A.P., Revilla-Monsalve,C., Robertson,N.R., Santoro,N., Schurmann,C., So,W.Y., Soberon,X., Stringham,H.M., Strom,T.M., Tam,C.H.T., Thameem,F., Tomlinson,B., Torres,J.M., Tracy,R.P., van Dam,R.M., Vujkovic,M., Wang,S., Welch,R.P., Witte,D.R., Wong,T.Y., Atzmon,G., Barzilai,N., Blangero,J., Bonnycastle,L.L., Bowden,D.W., Chambers,J.C., Chan,E., Cheng,C.Y., Cho,Y.S., Collins,F.S., de Vries,P.S., Duggirala,R., Glaser,B., Gonzalez,C., Gonzalez,M.E., Groop,L., Kooner,J.S., Kwak,S.H., Laakso,M., Lehman,D.M., Nilsson,P., Spector,T.D., Tai,E.S., Tuomi,T., Tuomilehto,J., Wilson,J.G., guilar-Salinas,C.A., Bottinger,E., Burke,B., Carey,D.J., Chan,J.C.N., Dupuis,J., Frossard,P., Heckbert,S.R., Hwang,M.Y., Kim,Y.J., Kirchner,H.L., Lee,J.Y., Lee,J., Loos,R.J.F., Ma,R.C.W., Morris,A.D., O'Donnell,C.J., Palmer,C.N.A., Pankow,J., Park,K.S., Rasheed,A., Saleheen,D., Sim,X., Small,K.S., Teo,Y.Y., Haiman,C., Hanis,C.L., Henderson,B.E., Orozco,L., Tusie-Luna,T., Dewey,F.E., Baras,A., Gieger,C., Meitinger,T., Strauch,K., Lange,L., Grarup,N., Hansen,T., Pedersen,O., Zeitler,P., Dabelea,D., Abecasis,G., Bell,G.I., Cox,N.J., Seielstad,M., Sladek,R., Meigs,J.B., Rich,S.S., Rotter,J.I., Altshuler,D., Burtt,N.P., Scott,L.J., Morris,A.P., Florez,J.C., McCarthy,M.I., Boehnke,M. (2019). Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Nature,
570 (7759),
71-76.
*
Artículo
45 - Gonzalez-Covarrubias,V., Morales-Franco,M., Cruz-Correa,O.F., Martinez-Hernandez,A., Garcia-Ortiz,H., Barajas-Olmos,F., Genis-Mendoza,A.D., Martinez-Magana,J.J., Nicolini,H., Orozco,L., Soberon,X. (2019). Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico.
Frontiers in Pharmacology,
10,
1169.
*
Artículo
46 - Madrazo-Moya,C.F., Cancino-Munoz,I., Cuevas-Cordoba,B., Gonzalez-Covarrubias,V., Barbosa-Amezcua,M., Soberon,X., Muniz-Salazar,R., Martinez-Guarneros,A., Backer,C., Zarrabal-Meza,J., Sampieri-Ramirez,C., Enciso-Moreno,A., Lauzardo,M., Comas,I., Zenteno-Cuevas,R. (2019). Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico.
PLoS ONE,
14 (6),
e0213046.
*
Artículo
47 - Martinez-Magana,J.J., Genis-Mendoza,A.D., Gonzalez-Covarrubias,V., Jimenez-Guenchi,J., Galindo-Chavez,A.G., Roche-Bergua,A., Castaneda-Gonzalez,C., Lanzagorta,N., Soberon,X., Nicolini,H. (2019). Exploratory analysis of rare and novel variants in Mexican patients diagnosed with schizophrenia and dementia.
Revista de Investigacion Clinica,
71 (4),
246-254.
*
Artículo
48 - Ayon-Nunez, D.A., Fragoso, G., Espitia, C., Garcia-Varela, M., Soberon, X., Rosas, G., Laclette, J.P., Bobes, R.J. (2018). Identification and characterization of Taenia solium enolase as a plasminogen-binding protein.
Acta Tropica,
182,
69-79.
*
Artículo
49 - Flores-Bautista, J., Navarrete-Perea, J., Fragoso, G., Flisser, A., Soberon, X., Laclette, J.P. (2018). Fate of uptaken host proteins in Taenia solium and Taenia crassiceps cysticerci.
Bioscience Reports,
38 (4),
BSR20180636.
*
Artículo
50 - Bikel, S., Jacobo-Albavera, L., Sanchez-Munoz, F., Cornejo-Granados, F., Canizales-Quinteros, S., Soberon, X., Sotelo-Mundo, R.R., Del Rio-Navarro, B.E., Mendoza-Vargas, A., Sanchez, F., Ochoa-Leyva, A. (2017). A novel approach for human whole transcriptome analysis based on absolute gene expression of microarray data.
PeerJ,
5,
e4133.
Artículo
51 - Bobes, R.J., Navarrete-Perea, J., Ochoa-Leyva, A., Anaya, V.H., Hernandez, M., Cervantes-Torres, J., Estrada, K., Sanchez-Lopez, F., Soberon, X., Rosas, G., Maroni-Nunes C., Garcia-Varela, M., Sotelo-Mundo, R.R., Lopez-Zavala, A.A., Gevorkian, G., Acero, G., Laclette, J.P., Fragoso, G., Sciutto, E. (2017). Experimental and theoretical approaches to investigate the immunogenicity of Taenia solium-derived KE7 antigen.
Infection and Immunity,
85,
e00395-17.
Artículo
52 - Cruz-Correa, O.F., Leon-Cachon, R.B., Barrera-Saldana, H.A., Soberon, X. (2017). Prediction of atorvastatin plasmatic concentrations in healthy volunteers using integrated pharmacogenetics sequencing.
Pharmacogenomics,
18 (2),
121-131.
Artículo
53 - Gonzalez-Covarrubias, V., Urena-Carrion, J., Villegas-Torres, B., Cossio-Aranda, J.E., Trevethan-Cravioto, S., Izaguirre-Avila, R., Fiscal-Lopez, O.J., Soberon, X. (2017). Pharmacogenetic Variation in Over 100 Genes in Patients Receiving Acenocumarol.
Frontiers in Pharmacology,
8,
863.
*
Artículo in consortium
54 - Marquez-Luna,C., Loh,P.R., Price,A.L., South Asian Type 2 Diabet SAT2D, SIGMA Type 2 Diabet Consortium, Soberon,X. (2017). Multiethnic polygenic risk scores improve risk prediction in diverse populations.
Genetic Epidemiology,
41 (8),
811-823.
*
Artículo
55 - Mercader, J.M., Liao, R.G., Davis, A., Dymek, Z., Estrada, K., Tukiainen, T., Huerta-Chagoya, A., Moreno-Macias, H., Jablonski, K.A., Hanson, R.L., Walford, G.A., Moran, I., Chen, L., Agarwala, V., Ordonez-Sanchez, M.L., Rodriguez-Guillen, R., Rodriguez-Torres, M., Segura-Kato, Y., Garcia-Ortiz, H., Centeno-Cruz, F., Barajas-Olmos, F., Caulkins, L., Puppala, S., Fontanillas, P., Williams, A., Bonas-Guarch, S., Hartl, C., Ripke, S., Tooley, K., Lane, J., Zerrweck, C., Martinez-Hernandez, A., Cordova, E.J., Mendoza-Caamal, E., Contreras-Cubas, C., Gonzalez-Villalpando, M.E., Cruz-Bautista, I., Munoz-Hernandez, L., Gomez-Velasco, D., Alvirde, U., Henderson, B.E., Wilkens, L.R., Le, Marchand L., Arellano-Campos, O., Riba, L., Harden, M., Platform, B.G., Gabriel, S., Abboud, H.E., Cortes, M.L., Revilla-Monsalve, C., Islas-Andrade, S., Soberon, X., Curran, J.E., Jenkinson, C.P., Defronzo, R.A., Lehman, D.M., Hanis, C.L., Bell, G.I., Boehnke, M., Blangero, J., Duggirala, R., Saxena, R., MacArthur, D., Ferrer, J., McCarroll, S.A., Torrents, D., Knowler, W.C., Baier, L.J., Burtt, N., Gonzalez-Villalpando, C., Haiman, C.A., Aguilar-Salinas, C.A., Tusie-Luna, T., Flannick, J., Jacobs, S.B.R., Orozco, L., Altshuler, D., Florez, J.C. (2017). A Loss-Of-Function Splice Acceptor Variant in IGF2 is Protective for Type 2 Diabetes.
Diabetes,
66 (11),
2903-2914.
*
Artículo
56 - Navarrete-Perea, J., Moguel, B.A., Bobes, R.J., Villalobos, N., Carrero, J.C., Sciutto, E., Soberon, X., Laclette, J.P. (2017). Protein profiles of Taenia solium cysts obtained from skeletal muscles and the central nervous system of pigs: Search for tissue-specific proteins.
Experimental Parasitology,
172,
23-29.
Artículo
57 - Navarrete-Perea, J., Isasa, M., Paulo, J.A., Corral-Corral, R., Flores-Bautista, J., Hernandez-Tellez, B., Bobes, R.J., Fragoso, G., Sciutto, E., Soberon, X., Gygi, S.P., Laclette, J.P. (2017). Quantitative multiplexed proteomics of Taenia solium cysts obtained from the skeletal muscle and central nervous system of pigs.
PLoS Neglected Tropical Diseases,
11 (9),
e0005962.
Artículo
58 - Romero-Hidalgo, S., Ochoa-Leyva, A., Garciarrubio, A., Acuna-Alonzo, V., Antunez-Arguelles, E., Balcazar-Quintero, M., Barquera-Lozano, R., Carnevale, A., Cornejo-Granados, F., Fernandez-Lopez, J.C., Garcia-Herrera, R., Garcia-Ortiz, H., Granados-Silvestre, A., Granados, J., Guerrero-Romero, F., Hernandez-Lemus, E., Leon-Mimila, P., Macin-Perez, G., Martinez-Hernandez, A., Menjivar, M., Morett, E., Orozco, L., Ortiz-Lopez, G., Perez-Villatoro, F., Rivera-Morales, J., Riveros-McKay, F., Villalobos-Comparan, M., Villamil-Ramirez, H., Villarreal-Molina, T., Canizales-Quinteros, S., Soberon, X. (2017). Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing.
Nature Communications,
8 (1),
1005.
Artículo in consortium
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Nature,
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63 - Navarrete-Perea,J., Toledano-Magana,Y., Torre,P., Sciutto,E., Bobes,R.J., Soberon,X., Laclette,J.P. (2016). Role of porcine serum haptoglobin in the host-parasite relationship of Taenia solium cysticercosis.
Molecular and Biochemical Parasitology,
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64 - Bikel,S., Valdez-Lara,A., Cornejo-Granados,F., Rico,K., Canizales-Quinteros,S., Soberon,X., Del Pozo-Yauner,L., Ochoa-Leyva,A. (2015). Combining metagenomics, metatranscriptomics and viromics to explore novel microbial interactions: towards a systems-level understanding of human microbiome.
Computational and Structural Biotechnology Journal,
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65 - Gomez,S., Adalid-Peralta,L., Palafox-Fonseca,H., Cantu-Robles,V.A., Soberon,X., Sciutto,E., Fragoso,G., Bobes,R.J., Laclette,J.P., Yauner,L.D., Ochoa-Leyva,A. (2015). Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR).
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66 - Villegas-Torres,B., Sanchez-Giron,F., Jaramillo-Villafuerte,K., Soberon,X., Gonzalez-Covarrubias,V. (2015). Genotype frequencies of VKORC1 and CYP2C9 in Native and Mestizo populations from Mexico, potential impact for coumarin dosing.
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68 - Majithia,A.R., Flannick,J., Shahinian,P., Guo,M., Bray,M.A., Fontanillas,P., Gabriel,S.B., Rosen,E.D., Altshuler,D., SIGMA T2D Consortium, Soberon,X. (2014). Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.
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70 - Williams,A.L., Jacobs,S.B., Moreno-Macias,H., Huerta-Chagoya,A., Churchhouse,C., Marquez-Luna,C., Garcia-Ortiz,H., Gomez-Vazquez,M.J., Burtt,N.P., Aguilar-Salinas,C.A., Gonzalez-Villalpando,C., Florez,J.C., Orozco,L., Haiman,C.A., Tusie-Luna,T., Altshuler,D., Williams,A.L., Marquez-Luna,C., Huerta-Chagoya,A., Ripke,S., Gomez-Vazquez,M.J., Manning,A.K., Moreno-Macias,H., Garcia-Ortiz,H., Neale,B., Burtt,N.P., Aguilar-Salinas,C.A., Reich,D., Stram,D.O., Fernandez-Lopez,J.C., Romero-Hidalgo,S., Altshuler,D., Florez,J.C., Tusie-Luna,T., Patterson,N., Haiman,C.A., Aguilar-Delfin,I., Martinez-Hernandez,A., Centeno-Cruz,F., Mendoza-Caamal,E., Revilla-Monsalve,C., Islas-Andrade,S., Cordova,E., Rodriguez-Arellano,E., Soberon,X., Orozco,L., Florez,J.C., Gonzalez-Villalpando,C., Gonzalez-Villalpando,M.E., Haiman,C.A., Henderson,B.E., Monroe,K., Wilkens,L., Kolonel,L.N., Le Marchand,L., Riba,L., Ordonez-Sanchez,M.L., Rodriguez-Guillen,R., Cruz-Bautista,I., Rodriguez-Torres,M., Munoz-Hernandez,L.L., Saenz,T., Gomez,D., Alvirde,U., Burtt,N.P., Onofrio,R.C., Brodeur,W.M., Gage,D., Murphy,J., Franklin,J., Mahan,S., Ardlie,K., Crenshaw,A.T., Winckler,W., Prufer,K., Shunkov,M.V., Sawyer,S., Stenzel,U., Kelso,J., Lek,M., Sankararaman,S., Williams,A.L., Patterson,N., Macarthur,D.G., Reich,D., Derevianko,A.P., Paabo,S., Jacobs,S.B., Churchhouse,C., Gopal,S., Grammatikos,J.A., Smith,I.C., Bullock,K.H., Deik,A.A., Souza,A.L., Pierce,K.A., Clish,C.B., Altshuler,D., Fennell,T., Farjoun,Y., Genomics,Platform B., Gabriel,S., Stram,D.O., Gross,M.D., Pereira,M.A., Seielstad,M., Koh,W.P., Tai,E.S., Flannick,J., Fontanillas,P., Morris,A., Teslovich,T.M., Burtt,N.P., Atzmon,G., Blangero,J., Bowden,D.W., Chambers,J., Shin,Cho Y., Duggirala,R., Glaser,B., Hanis,C., Kooner,J., Laakso,M., Lee,J.Y., Tai,E.S., Ying,Teo Y., Wilson,J.G., Haiman,C.A., Henderson,B.E., Monroe,K., Wilkens,L., Kolonel,L.N., Le Marchand,L., Puppala,S., Farook,V.S., Thameem,F., Abboud,H.E., Defronzo,R.A., Jenkinson,C.P., Lehman,D.M., Curran,J.E., Blangero,J., Duggirala,R., Burtt,N.P., Cortes,M.L., Altshuler,D., Florez,J.C., Haiman,C.A., Henderson,B.E., Aguilar-Salinas,C.A., Gonzalez-Villalpando,C., Orozco,L., Tusie-Luna,T. (2014). Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
Nature,
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71 - Ochoa-Leyva,A., Montero-Moran,G., Saab-Rincon,G., Brieba,L.G., Soberon,X. (2013). Alternative Splice Variants in TIM Barrel Proteins from Human Genome Correlate with the Structural and Evolutionary Modularity of this Versatile Protein Fold.
PLoS ONE,
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72 - Tsai,I.J., Zarowiecki,M., Holroyd,N., Garciarrubio,A., Sanchez-Flores,A., Brooks,K.L., Tracey,A., Bobes,R.J., Fragoso,G., Sciutto,E., Aslett,M., Beasley,H., Bennett,H.M., Cai,Jianping, Camicia,F., Clark,R., Cucher,M., De Silva,N., Day,T.A., Deplazes,P., Estrada,K., Fernandez,C., Holland,P.W.H., Hou,Junling, Hu,Songnian, Huckvale,Thomas, Hung,S.S., Kamenetzky,L., Keane,J.A., Kiss,F., Koziol,U., Lambert,O., Liu,K., Luo,Xuenong, Luo,Yingfeng, Macchiaroli,N., Nichol,S., Paps,Jordi, Parkinson,J., Pouchkina-Stantcheva,N., Riddiford,N., Rosenzvit,M., Salinas,G., Wasmuth,James D., Zamanian,M., Zheng,Yadong, Cai,Xuepeng, Soberon,X., Olson,P.D., Laclette,J.P., Brehm,Klaus, Berriman,M., Ochoa-Leyva,A. (2013). The genomes of four tapeworm species reveal adaptations to parasitism.
Nature,
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73 - Lopez-de Los Santos Y., Chan,H., Cantu,V.A., Rettner,R., Sanchez,F., Zhang,Z., Saier,M.H., Soberon,X. (2012). Genetic engineering of the phosphocarrier protein NPr of the Escherichia coli phosphotransferase system selectively improves sugar uptake activity.
Journal of Biological Chemistry,
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74 - Saab-Rincon,G., Olvera,L., Olvera,M., Rudino-Pinera,E., Benites,E., Soberon,X., Morett,E. (2012). Evolutionary Walk between (beta/alpha)(8) Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase.
Journal of Molecular Biology,
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75 - Ochoa-Leyva,A., Barona-Gomez,F., Saab-Rincon,G., Verdel-Aranda,K., Sanchez,F., Soberon,X. (2011). Exploring the Structure-Function Loop Adaptability of a (beta/alpha)(8)-Barrel Enzyme through Loop Swapping and Hinge Variability.
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Protein Science,
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79 - Damian-Almazo,J.Y., Moreno,A., Lopez-Munguia,A., Soberon,X., Gonzalez-Munoz,F., Saab-Rincon,G. (2008). Enhancement of the alcoholytic activity of {alpha}-amylase AmyA from Thermotoga maritima MSB8 (DSM 3109) by site directed mutagenesis.
Applied and Environmental Microbiology,
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80 - Flores-Ramirez,G., Rivera,M., Morales-Pablos,A., Osuna,J., Soberon,X., Gaytan,P. (2007). The effect of amino acid deletions and substitutions in the longest loop of GFP.
BMC Chemical Biology,
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81 - Vazquez-Limon,C., Vega-Badillo,J., Martinez,A., Espinosa-Molina,G., Gosset,G., Soberon,X., Lopez-Munguia,A., Osuna,J. (2007). Growth rate of a non-fermentative Escherichia coli strain is influenced by NAD(+) regeneration.
Biotechnology Letters,
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Parasitology International,
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83 - Monroy-Lagos,O., Soberon,X., Gaytan,P., Osuna,J. (2006). Improvement of an unusual twin-arginine transporter leader Peptide by a codon-based randomization approach.
Applied and Environmental Microbiology,
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84 - Soberon,X., Saier,M.H.,Jr. (2006). Engineering Transport Protein Function: Theoretical and Technical Considerations Using the Sugar-Transporting Phosphotransferase System of Escherichia coli as a Model System.
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85 - Souza,V., Espinosa-Asuar,L., Escalante,A.E., Eguiarte,L.E., Farmer,J., Forney,L., Lloret,L., Rodriguez-Martinez,J.M., Soberon,X., Dirzo,R., Elser,J.J. (2006). An endangered oasis of aquatic microbial biodiversity in the Chihuahuan desert.
Proceedings of the National Academy of Sciences of the United States of America,
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86 - Gaytan,P., Yanez,J., Grande,R., Morett,E., Soberon,X. (2005). Improving random mutagenesis by purification of the oligonucleotide variants.
Combinatorial Chemistry & High Throughput Screening,
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87 - Saab-Rincon,G., Mancera,E., Montero-Moran,G., Sanchez,F., Soberon,X. (2005). Generation of variability by in vivo recombination of halves of a (beta/alpha)(8) barrel protein.
Biomolecular Engineering,
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88 - Baez-Viveros,J.L., Osuna,J., Hernandez-Chavez,G., Soberon,X., Bolivar,F., Gosset,G. (2004). Metabolic engineering and protein directed evolution increase the yield of L-phenylalanine synthesized from glucose in Escherichia coli.
Biotechnology and Bioengineering,
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89 - Flores,G., Soberon,X., Osuna,J. (2004). Production of a fully functional, permuted single-chain penicillin G acylase.
Protein Science,
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91 - Osuna,J., Yanez,J., Soberon,X., Gaytan,P. (2004). Protein evolution by codon-based random deletions.
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FEBS Letters,
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Nucleic Acids Research,
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Protein Engineering,
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95 - Gaytan,P., Osuna,J., Soberon,X. (2002). Novel ceftazidime-resistance beta-lactamases generated by a codon-based mutagenesis method and selection.
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96 - Osuna,J., Perez-Blancas,A., Soberon,X. (2002). Improving a circularly permuted TEM-1 beta-lactamase by directed evolution.
Protein Engineering,
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Protein Engineering,
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FEBS Letters,
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FEBS Letters,
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FEBS Letters,
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Enzyme and Microbial Technology,
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Chemistry and Biology,
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Molecular Microbiology,
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FEBS Letters,
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FEBS Letters,
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Tetrahedron Letters,
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Artículo
122 - Lopez,S., Lopez,I., Romero,P., Mendez,E., Soberon,X., Arias,C.F. (1991). Rotavirus YM gene 4: analysis of its deduced amino acid sequence and prediction of the secondary structure of the VP4 protein.
Journal of Virology,
65 (7),
3738-3745.
Artículo
Note
124 - Fuchs,L.Y., Ovando,C., Joseph,P., Soberon,X., Charli,J.L. (1990). Repetitive DNA sequence from the crayfish Procambarus clarkii.
Nucleic Acids Research,
18 (6),
1650.
Artículo
125 - Pastor,N., Pinero,D., Valdes,A.M., Soberon,X. (1990). Molecular evolution of class A beta-lactamases: phylogeny and patterns of sequence conservation.
Molecular Microbiology,
4 (11),
1957-1965.
Artículo
126 - Balbas,P., Soberon,X., Merino,E., Zurita,M., Lomeli,H., Valle,F., FLORES,N., Bolivar,F. (1986). Plasmid vector pBR322 and its special-purpose derivatives--a review.
Gene,
50 (1-3),
3-40.
Note
Artículo
128 - Rossi,J.J., Soberon,X., Marumoto,Y., McMahon,J., Itakura,K. (1983). Biological expression of an Escherichia coli consensus sequence promoter and some mutant derivatives.
Proceedings of the National Academy of Sciences of the United States of America,
80 (11),
3203-3207.
*
Artículo
129 - Inouye,S., Soberon,X., Franceschini,T., Nakamura,K., Itakura,K., Inouye,M. (1982). Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane.
Proceedings of the National Academy of Sciences of the United States of America,
79 (11),
3438-3441 .
*
Artículo
130 - Miyada,C.G., Soberon,X., Itakura,K., Wilcox,G. (1982). The use of synthetic oligodeoxyribonucleotides to produce specific deletions in the araBAD promoter of Escherichia coli B/r.
Gene,
17 (2),
167-177.
*
Artículo
131 - Zarucki-Schulz,T., Tsai,S.Y., Itakura,K., Soberon,X., Wallace,R.B., Tsai,M.J., Woo,S.L., O'Malley,B.W. (1982). Point mutagenesis of the ovalbumin gene promoter sequence and its effect on in vitro transcription.
Journal of Biological Chemistry,
257 (18),
11070-11077.
*
Artículo
132 - Covarrubias,L., Cervantes,L., Covarrubias,A., Soberon,X., Vichido,I., Blanco,A., Kupersztoch-Portnoy,Y.M., Bolivar,F. (1981). Construction and characterization of new cloning vehicles. V. Mobilization and coding properties of pBR322 and several deletion derivatives including pBR327 and pBR328.
Gene,
13 (1),
25-35.
*
Artículo
133 - Soberon,X., Covarrubias,L., Bolivar,F. (1980). Construction and characterization of new cloning vehicles. IV. Deletion derivatives of pBR322 and pBR325.
Gene,
9 (3-4),
287-305.
*
Nacional
134 - Soberon,X. (2012). La medicina genómica en México, consideraciones para su desarrollo. Fortalezas y desafíos de los servicios de salud de México en el siglo XXI.
202-205.
Internacional
135 - Frausto-Solis,J., Soberon-Mainero,X., Linan-Garcia,E. (2009). MultiQuenching annealing algorithm for protein folding problem. Mexican International Conference on Artificial Intelligence. MICAI 2009: Advances in Artificial Intelligence .
Lecture Notes in Computer Science ,
578-589.
Nacional
136 - Segovia,L., Soberon,X. (2008). Evolución experimental de proteínas. Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 26.
291-302,
Mexico, D.F..
Internacional
137 - Barona-Gomez,F., Ochoa-Leyva,A., Soberon,X. (2007). Advances and perspectives in protein engineering: from natural history to directed evolution of enzymes. Advances in Protein Physical Chemistry.
407-438,
Kerala: Research Signpost.
Memoria in extenso
138 - Frausto-Solis,J., Roman,E.F., Romero,D., Soberon,X., Linan-Garcia,E. (2007). Analytically tuned simulated annealing applied to the protein folding problem. Lecture Notes in Computer Science vol 4488.
370-377.
Nacional
139 - Soberon,X., Montero,G.M. (2004). Ingeniería de proteínas y evolución dirigida. Fundamentos y casos exitosos de la biotecnologia moderna cap 7.
195-217,
Mexico.
Nacional
140 - Soberon,X. (2003). Biocatálisis y evolución dirigida de proteínas. Fronteras de la Biología en los Inicios del Siglo XXI, Módulo VII.
35-45,
Mexico,D.F..
Nacional
Memoria in extenso
142 - Saab-Rincon,G., Del Rio,G, Santamaria,R, Diaz,M.L, Soberon,X., Lopez-Munguia,A. (2002). Novel and potential applications of alpha-amylases in the food industry. Engineering and Food for the 21st Century. Proceedings of the Eighth International Congress on Engineering and Food.
913-924,
Boca Raton, Fla.
Nacional
143 - Soberon,X., Bolivar,F. (2001). Evolución de los conceptos de gen y genoma. Ciencias de la vida.
61-83.
Internacional
144 - Balbas,P., Soberon,X., Bolivar,F., Rodriguez,R.L. (1988). The plasmid, pBR322. Biotechnology (Reading, Mass.).
5-41,
10.
Divulgación
145 - Soberon, X., Bergna, M., Valez, M. A. (2018). Iguales o difererentes? Genómica.
64 pp,
Ciudad de Mexico: Ediciones Tecolote.
Nacional
146 - Bolivar-Zapata, F.G., Arias-Ortiz, C. F., Artega-Vazquez, M. A., Barrera-Saldana, H. A., Galindo-Fentanes, E., Gracia-Gasca, A., Herrera-Estrella, L. R., Higuera-Ciapara, I., Larque-Saavedra, F. A., Lopez-Munguia Canales, A., Ramirez-Reivich, O. T., Revah-Moiseev, S., Soberon-Mainero, X., Torres-Pacheco, I., Uribe de la Mora, J. M., Vazquez-Ramos, J. M., Viniegra-Gonzalez, G. (2017). Transgénicos: Grandes beneficios, ausencia de daños y mitos.
Mexico.
Nacional
147 - Bolivar-Zapata,F.G., Arias-Ortiz,C.F., Arriaga-Arellano,E., Barrera-Saldaña,H., de la Torres-Martinez,M., Espinosa-Fernandez,J., Galindo-Fentanes,E., Galvez-Mariscal,A, Gracia-Gasca,A., Herrera-Estrella,L., Larque-Saavedra,A., Lopez-Munguia Canales,A., Noyola-Robles,A., Paredes-Lopez,O., Ramirez-Reivich,O.T., Revah-Moiseev,S., Soberon-Mainero,J., Soberon-Mainero,X., Torres-Pacheco,I., Uribe de la Mora,J., Viniegra-Gonzalez,G. (2011). Por un uso responsable de los organismos genéticamente modificados.
Mexico.
Preprint
148 - Oropeza-Valdez,J.J., Padron-Manrique,C., Vazquez-Jimenez,A., Soberon,X., Resendis-Antonio,O. (2024). Exploring Metabolic Anomalies in COVID-19 and Post-COVID-19: A Machine Learning Approach with Explainable Artificial Intelligence.
bioRxiv,
Preprint posted April 17,
2024.
Nacional divulgacion
149 - Soberon-Mainero,X. (2023). La Ingeniería Genética: una muy poderosa técnica, definidora de una carrera científica.
Biotecnología en Movimiento. Revista de divulgación del Instituto de Biotecnología de la UNAM,
35.
Editorial Material, Meeting Report
150 - Cornejo-Granados,F., Calderon de la Barca,A.M., Torres,N., Martinez-Romero,E., Torres,J., Lopez-Vidal,Y., Soberon,X., Partida-Martinez,L.P., Pinto-Cardoso,S., Alcaraz,L.D., Pardo-Lopez,L., Canizales-Quinteros,S., Puente,J.L., Ochoa-Leyva,A. (2019). Microbiome-MX 2018: Microbiota and Microbiome opportunities in Mexico, a megadiverse country.
Research in Microbiology,
170 (4-5),
235-241.
Divulgación
151 - Soberon-Mainero,X., Gonzalez-Covarrubias,V. (2014). Enfermedades infecciosas, hacia una medicina personalizada.
Revista Digital Universitaria,
15 (6),
art 43.
*
Editorial Material
152 - Soberon-Mainero,X., Melendez-Zajgla,J. (2010). [The Instituto Nacional de Medicina Genomica. Vocation and challenges].
Revista de Investigacion Clinica,
62 (5),
391-392.
*
Nacional
153 - Baez-Viveros,J.L., Osuna,J., Hernandez-Chavez,G., Soberon,X., Bolivar,F., Gosset,G. (2006). Metabolic via engineering for the production of aromatic substances in Escherichia coli.
Revista Latinoamericana de Microbiologia,
48 (2),
92.
Nacional
154 - Yanez,J., Soberon,X., Gaytan,P. (2004). Rutas alternas de síntesis para la preparación de Fmoc-Trinucleósido-Difosfato Fosforamiditos.
Revista de la Sociedad Química de México,
48 (1),
26-37.
Divulgación
155 - Soberon Mainero,X (2003). Veinte años del Instituto de Biotecnología.
Revista Universidad de Mexico,
629.
Divulgación
156 - Soberon-Mainero,X. (2003). Veinte años del Instituto de Biotecnología.
Revista de la Universidad de México,
629.
Divulgación
157 - Soberon Mainero, X. (2002). La revolución de las ciencias genómicas.
Revista Universidad Nacional,
617.
Divulgación
158 - Soberon-Mainero,X. (2002). La ingenieria genética y un campo de aplicación: la biocatálisis y la industria química limpia.
Mensaje Bioquimico,
26,
1-18.
Divulgación
159 - Soberon,X. (2001). La biotecnologia: un ejercito microscopico al servicio del hombre.
Hypatia,
2,
6-7.
Divulgación
160 - Soberon,X. (2001). Nuevos paradigmas relacionados con la ciencia biologica experimental: implicaciones cientificas, tecnologicas y sociales.
Revista Universidad de Mexico,
605-606,
59-63.
Divulgación
161 - Soberon,X. (2000). El convenio UNAM-INE-Diversa y el aprovechamiento de recursos geneticos.
BioTecnologia. Sociedad Mexicana de Biotecnologia y Bioingenieria,
5,
14-15.
Divulgación
News Item
163 - Soberon,X. (1999). Enzymes directly evolving toward commercial applications.
Nature Biotechnology,
17 (6),
539-540.
Nacional
164 - Oliver,G., Balbas,P., Valle,F., Soberon,X., Bolivar,F. (1985). [Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli].
Revista Latinoamericana de Microbiologia,
27 (2),
141-150.
165 - Soberon Mainero, Francisco Xavier (1982). Uso de vehiculos moleculares de clonacion y de sintesis quimica de polinucleotidos para el estadio de la expresion genica.
Instituto de Investigaciones Biomedicas,
Maestria en Investigacion Biomedica Basica,
UNAM.
*
Asesor: Itakura, Keiichi, Bolivar Zapata, Francisco
Artículo
166 - Galeana-Cadena,D., Ramirez-Martinez,G., Choreno-Parra,J.A., Silva-Herzog,E., Hernandez-Cardenas,C.M., Soberon,X., Zuniga,J.. Microbiome in the Nasopharynx: Insights into the Impact of COVID-19 Severity.
Heliyon,
10 (10),
e31562.
Artículo
167 - Oropeza-Valdez,J.J., Padron-Manrique,C., Vazquez-Jimenez,A., Soberon,X., Resendis-Antonio,O.. Exploring metabolic anomalies in COVID-19 and post-COVID-19: a machine learning approach with explainable artificial intelligence.
Frontiers in Molecular Biosciences,
11,
1429281.
Artículo
168 - Uribe-Vazquez,B., Diaz-Vilchis,A, Avila-Linares,A., Saab-Rincon,G, Marin-Tovar,Y., Flores,H, Pastor,N, Huerta-Miranda,G, Rudino-Pinera,E., Soberon,X. Characterization of a catalase-peroxidase variant (L333V-KatG) identified in an INH-resistant Mycobacterium tuberculosis clinical isolate.
Biochemistry and Biophysics Reports,
37,
101649.
Preprint
169 - Oropeza-Valdez,J.J., Padron-Manrique,C., Vazquez-Jimenez,A., Soberon,X., Resendis-Antonio,O.. Exploring Metabolic Anomalies in COVID-19 and Post-COVID-19: A Machine Learning Approach with Explainable Artificial Intelligence.
bioRxiv,
Preprint posted April 17,
2024.
Revisión
170 - Alvarado-Pena,N., Galeana-Cadena,D., Gomez-Garcia,I.A, Soberon-Mainero,X, Silva-Herzog,E. The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment.
Frontiers in Microbiology,
14,
1237998.
Nacional divulgacion
171 - Soberon-Mainero,X.. La Ingeniería Genética: una muy poderosa técnica, definidora de una carrera científica.
Biotecnología en Movimiento. Revista de divulgación del Instituto de Biotecnología de la UNAM,
35.
Artículo
172 - Barbosa-Amezcua,M., Cuevas-Cordoba,B., Fresno,C., Haase-Hernandez,J.I., Carrillo-Sanchez,K., Mata-Rocha,M., Munoz-Torrico,M., Backer,C., Gonzalez-Covarrubias,V., Alaez-Verson,C., Soberon,X.. Rapid Identification of Drug Resistance and Phylogeny in M. tuberculosis, Directly from Sputum Samples.
Microbiology Spectrum,
10 (5),
e0125222.
Artículo
173 - Martinez-Magana,J.J., Genis-Mendoza,A.D., Gonzalez-Covarrubias,V., Juarez-Rojop,I.E., Tovilla-Zarate,C.A., Soberon,X., Lanzagorta,N., Nicolini,H.. Association of FAAH p.Pro129Thr and COMT p.Ala72Ser with schizophrenia and comorbid substance use through next-generation sequencing: an exploratory analysis.
Brazilian Journal of Psychiatry,
44 (2),
164-170.
*
Artículo
174 - Aguilar-Ordonez,I., Perez-Villatoro,F., Garcia-Ortiz,H., Barajas-Olmos,F., Ballesteros-Villascan,J., Gonzalez-Buenfil,R., Fresno,C., Garciarrubio,A., Fernandez-Lopez,J.C., Tovar,H., Hernandez-Lemus,E., Orozco,L., Soberon,X., Morett,E.. Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights.
PLoS ONE,
16 (4),
e0249773,
[correction May 25 2022].
artículo
175 - Cuevas-Cordoba,B., Fresno,C., Haase-Hernandez,J.I., Barbosa-Amezcua,M., Mata-Rocha,M., Munoz-Torrico,M., Salazar-Lezama,M.A., Martinez-Orozco,J.A., Narvaez-Diaz,L.A., Salas-Hernandez,J., Gonzalez-Covarrubias,V., Soberon,X.. A bioinformatics pipeline for Mycobacterium tuberculosis sequencing that cleans contaminant reads from sputum samples.
PLoS ONE,
16 (10),
e0258774.
*
Artículo
176 - Gonzalez-Covarrubias,V,, Sanchez-Ibarra,H., Lozano-Gonzalez, K., Villicana, S., Texis,T., Rodriguez-Dorantes,M., Cortes-Ramirez,S., Lavalle-Gonzalez,F,, Soberon,X., Barrera-Saldana,H.. Transporters, TBC1D4, and ARID5B Variants to Explain Glycated Hemoglobin Variability in Patients with Type 2 Diabetes.
Pharmacology,
106 (11-12),
588-596.
Artículo
177 - Jaimes-Hoy,L., Perez-Maldonado,A., Narvaez-Bahena,E., de la Cruz Guarneros,N., Rodriguez-Rodriguez,A., Charli,J.L., Soberon,X., Joseph-Bravo,P.. Sex dimorphic changes in Trh gene methylation and thyroid-axis response to energy demands in maternally-separated rats.
Endocrinology,
May 27 Online ahead of print [comentario vol 162 (9) pp 1-2].
Artículo
178 - Valdez-Palomares,F., Munoz-Torrico,M., Palacios-Gonzalez,B., Soberon,X., Silva-Herzog,E.. Altered Microbial Composition of Drug-Sensitive and Drug-Resistant TB Patients Compared with Healthy Volunteers.
Microorganisms,
9 (8),
1762.
Revisión
179 - Gonzalez-Covarrubias,V., Lozano,K., Texis,T., Guzman-Cruz,C.K., Rodriguez-Dorantes,M., Rubio-Carrasco,K., Mendez-Lorenzo,L.H., Soberon,X.. Pharmacogenomics: Current Actionable Variants.
Revista de Investigacion Clinica,
73 (3).
*
Artículo
180 - Cabrera-Contreras,R., Santamaria,R.I., Bustos,P., Martinez-Flores,I., Melendez-Herrada,E., Morelos-Ramirez,R., Barbosa-Amezcua,M., Gonzalez-Covarrubias,V., Silva-Herzog,E., Soberon,X., Gonzalez,V.. Genomic diversity of prevalent Staphylococcus epidermidis multidrug-resistant strains isolated from a Children's Hospital in Mexico City in an eight-years survey.
PeerJ,
7,
e8068.
*
Artículo
181 - Flannick,J., Mercader,J.M., Fuchsberger,C., Udler,M.S., Mahajan,A., Wessel,J., Teslovich,T.M., Caulkins,L., Koesterer,R., Barajas-Olmos,F., Blackwell,T.W., Boerwinkle,E., Brody,J.A., Centeno-Cruz,F., Chen,L., Chen,S., Contreras-Cubas,C., Cordova,E., Correa,A., Cortes,M., Defronzo,R.A., Dolan,L., Drews,K.L., Elliott,A., Floyd,J.S., Gabriel,S., Garay-Sevilla,M.E., Garcia-Ortiz,H., Gross,M., Han,S., Heard-Costa,N.L., Jackson,A.U., Jorgensen,M.E., Kang,H.M., Kelsey,M., Kim,B.J., Koistinen,H.A., Kuusisto,J., Leader,J.B., Linneberg,A., Liu,C.T., Liu,J., Lyssenko,V., Manning,A.K., Marcketta,A., Malacara-Hernandez,J.M., Martinez-Hernandez,A., Matsuo,K., Mayer-Davis,E., Mendoza-Caamal,E., Mohlke,K.L., Morrison,A.C., Ndungu,A., Ng,M.C.Y., O'Dushlaine,C., Payne,A.J., Pihoker,C., Post,W.S., Preuss,M., Psaty,B.M., Vasan,R.S., Rayner,N.W., Reiner,A.P., Revilla-Monsalve,C., Robertson,N.R., Santoro,N., Schurmann,C., So,W.Y., Soberon,X., Stringham,H.M., Strom,T.M., Tam,C.H.T., Thameem,F., Tomlinson,B., Torres,J.M., Tracy,R.P., van Dam,R.M., Vujkovic,M., Wang,S., Welch,R.P., Witte,D.R., Wong,T.Y., Atzmon,G., Barzilai,N., Blangero,J., Bonnycastle,L.L., Bowden,D.W., Chambers,J.C., Chan,E., Cheng,C.Y., Cho,Y.S., Collins,F.S., de Vries,P.S., Duggirala,R., Glaser,B., Gonzalez,C., Gonzalez,M.E., Groop,L., Kooner,J.S., Kwak,S.H., Laakso,M., Lehman,D.M., Nilsson,P., Spector,T.D., Tai,E.S., Tuomi,T., Tuomilehto,J., Wilson,J.G., guilar-Salinas,C.A., Bottinger,E., Burke,B., Carey,D.J., Chan,J.C.N., Dupuis,J., Frossard,P., Heckbert,S.R., Hwang,M.Y., Kim,Y.J., Kirchner,H.L., Lee,J.Y., Lee,J., Loos,R.J.F., Ma,R.C.W., Morris,A.D., O'Donnell,C.J., Palmer,C.N.A., Pankow,J., Park,K.S., Rasheed,A., Saleheen,D., Sim,X., Small,K.S., Teo,Y.Y., Haiman,C., Hanis,C.L., Henderson,B.E., Orozco,L., Tusie-Luna,T., Dewey,F.E., Baras,A., Gieger,C., Meitinger,T., Strauch,K., Lange,L., Grarup,N., Hansen,T., Pedersen,O., Zeitler,P., Dabelea,D., Abecasis,G., Bell,G.I., Cox,N.J., Seielstad,M., Sladek,R., Meigs,J.B., Rich,S.S., Rotter,J.I., Altshuler,D., Burtt,N.P., Scott,L.J., Morris,A.P., Florez,J.C., McCarthy,M.I., Boehnke,M.. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Nature,
570 (7759),
71-76.
*
Artículo
182 - Gonzalez-Covarrubias,V., Morales-Franco,M., Cruz-Correa,O.F., Martinez-Hernandez,A., Garcia-Ortiz,H., Barajas-Olmos,F., Genis-Mendoza,A.D., Martinez-Magana,J.J., Nicolini,H., Orozco,L., Soberon,X.. Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico.
Frontiers in Pharmacology,
10,
1169.
*
Artículo
183 - Madrazo-Moya,C.F., Cancino-Munoz,I., Cuevas-Cordoba,B., Gonzalez-Covarrubias,V., Barbosa-Amezcua,M., Soberon,X., Muniz-Salazar,R., Martinez-Guarneros,A., Backer,C., Zarrabal-Meza,J., Sampieri-Ramirez,C., Enciso-Moreno,A., Lauzardo,M., Comas,I., Zenteno-Cuevas,R.. Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico.
PLoS ONE,
14 (6),
e0213046.
*
Artículo
184 - Martinez-Magana,J.J., Genis-Mendoza,A.D., Gonzalez-Covarrubias,V., Jimenez-Guenchi,J., Galindo-Chavez,A.G., Roche-Bergua,A., Castaneda-Gonzalez,C., Lanzagorta,N., Soberon,X., Nicolini,H.. Exploratory analysis of rare and novel variants in Mexican patients diagnosed with schizophrenia and dementia.
Revista de Investigacion Clinica,
71 (4),
246-254.
*
Editorial Material, Meeting Report
185 - Cornejo-Granados,F., Calderon de la Barca,A.M., Torres,N., Martinez-Romero,E., Torres,J., Lopez-Vidal,Y., Soberon,X., Partida-Martinez,L.P., Pinto-Cardoso,S., Alcaraz,L.D., Pardo-Lopez,L., Canizales-Quinteros,S., Puente,J.L., Ochoa-Leyva,A.. Microbiome-MX 2018: Microbiota and Microbiome opportunities in Mexico, a megadiverse country.
Research in Microbiology,
170 (4-5),
235-241.
Artículo
186 - Ayon-Nunez, D.A., Fragoso, G., Espitia, C., Garcia-Varela, M., Soberon, X., Rosas, G., Laclette, J.P., Bobes, R.J.. Identification and characterization of Taenia solium enolase as a plasminogen-binding protein.
Acta Tropica,
182,
69-79.
*
Artículo
187 - Flores-Bautista, J., Navarrete-Perea, J., Fragoso, G., Flisser, A., Soberon, X., Laclette, J.P.. Fate of uptaken host proteins in Taenia solium and Taenia crassiceps cysticerci.
Bioscience Reports,
38 (4),
BSR20180636.
*
Divulgación
188 - Soberon, X., Bergna, M., Valez, M. A.. Iguales o difererentes? Genómica.
64 pp,
Ciudad de Mexico: Ediciones Tecolote.
Artículo
189 - Bikel, S., Jacobo-Albavera, L., Sanchez-Munoz, F., Cornejo-Granados, F., Canizales-Quinteros, S., Soberon, X., Sotelo-Mundo, R.R., Del Rio-Navarro, B.E., Mendoza-Vargas, A., Sanchez, F., Ochoa-Leyva, A.. A novel approach for human whole transcriptome analysis based on absolute gene expression of microarray data.
PeerJ,
5,
e4133.
Artículo
190 - Bobes, R.J., Navarrete-Perea, J., Ochoa-Leyva, A., Anaya, V.H., Hernandez, M., Cervantes-Torres, J., Estrada, K., Sanchez-Lopez, F., Soberon, X., Rosas, G., Maroni-Nunes C., Garcia-Varela, M., Sotelo-Mundo, R.R., Lopez-Zavala, A.A., Gevorkian, G., Acero, G., Laclette, J.P., Fragoso, G., Sciutto, E.. Experimental and theoretical approaches to investigate the immunogenicity of Taenia solium-derived KE7 antigen.
Infection and Immunity,
85,
e00395-17.
Artículo
191 - Cruz-Correa, O.F., Leon-Cachon, R.B., Barrera-Saldana, H.A., Soberon, X.. Prediction of atorvastatin plasmatic concentrations in healthy volunteers using integrated pharmacogenetics sequencing.
Pharmacogenomics,
18 (2),
121-131.
Artículo
192 - Gonzalez-Covarrubias, V., Urena-Carrion, J., Villegas-Torres, B., Cossio-Aranda, J.E., Trevethan-Cravioto, S., Izaguirre-Avila, R., Fiscal-Lopez, O.J., Soberon, X.. Pharmacogenetic Variation in Over 100 Genes in Patients Receiving Acenocumarol.
Frontiers in Pharmacology,
8,
863.
*
Artículo in consortium
193 - Marquez-Luna,C., Loh,P.R., Price,A.L., South Asian Type 2 Diabet SAT2D, SIGMA Type 2 Diabet Consortium, Soberon,X.. Multiethnic polygenic risk scores improve risk prediction in diverse populations.
Genetic Epidemiology,
41 (8),
811-823.
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Artículo
194 - Mercader, J.M., Liao, R.G., Davis, A., Dymek, Z., Estrada, K., Tukiainen, T., Huerta-Chagoya, A., Moreno-Macias, H., Jablonski, K.A., Hanson, R.L., Walford, G.A., Moran, I., Chen, L., Agarwala, V., Ordonez-Sanchez, M.L., Rodriguez-Guillen, R., Rodriguez-Torres, M., Segura-Kato, Y., Garcia-Ortiz, H., Centeno-Cruz, F., Barajas-Olmos, F., Caulkins, L., Puppala, S., Fontanillas, P., Williams, A., Bonas-Guarch, S., Hartl, C., Ripke, S., Tooley, K., Lane, J., Zerrweck, C., Martinez-Hernandez, A., Cordova, E.J., Mendoza-Caamal, E., Contreras-Cubas, C., Gonzalez-Villalpando, M.E., Cruz-Bautista, I., Munoz-Hernandez, L., Gomez-Velasco, D., Alvirde, U., Henderson, B.E., Wilkens, L.R., Le, Marchand L., Arellano-Campos, O., Riba, L., Harden, M., Platform, B.G., Gabriel, S., Abboud, H.E., Cortes, M.L., Revilla-Monsalve, C., Islas-Andrade, S., Soberon, X., Curran, J.E., Jenkinson, C.P., Defronzo, R.A., Lehman, D.M., Hanis, C.L., Bell, G.I., Boehnke, M., Blangero, J., Duggirala, R., Saxena, R., MacArthur, D., Ferrer, J., McCarroll, S.A., Torrents, D., Knowler, W.C., Baier, L.J., Burtt, N., Gonzalez-Villalpando, C., Haiman, C.A., Aguilar-Salinas, C.A., Tusie-Luna, T., Flannick, J., Jacobs, S.B.R., Orozco, L., Altshuler, D., Florez, J.C.. A Loss-Of-Function Splice Acceptor Variant in IGF2 is Protective for Type 2 Diabetes.
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195 - Navarrete-Perea, J., Moguel, B.A., Bobes, R.J., Villalobos, N., Carrero, J.C., Sciutto, E., Soberon, X., Laclette, J.P.. Protein profiles of Taenia solium cysts obtained from skeletal muscles and the central nervous system of pigs: Search for tissue-specific proteins.
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196 - Navarrete-Perea, J., Isasa, M., Paulo, J.A., Corral-Corral, R., Flores-Bautista, J., Hernandez-Tellez, B., Bobes, R.J., Fragoso, G., Sciutto, E., Soberon, X., Gygi, S.P., Laclette, J.P.. Quantitative multiplexed proteomics of Taenia solium cysts obtained from the skeletal muscle and central nervous system of pigs.
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197 - Romero-Hidalgo, S., Ochoa-Leyva, A., Garciarrubio, A., Acuna-Alonzo, V., Antunez-Arguelles, E., Balcazar-Quintero, M., Barquera-Lozano, R., Carnevale, A., Cornejo-Granados, F., Fernandez-Lopez, J.C., Garcia-Herrera, R., Garcia-Ortiz, H., Granados-Silvestre, A., Granados, J., Guerrero-Romero, F., Hernandez-Lemus, E., Leon-Mimila, P., Macin-Perez, G., Martinez-Hernandez, A., Menjivar, M., Morett, E., Orozco, L., Ortiz-Lopez, G., Perez-Villatoro, F., Rivera-Morales, J., Riveros-McKay, F., Villalobos-Comparan, M., Villamil-Ramirez, H., Villarreal-Molina, T., Canizales-Quinteros, S., Soberon, X.. Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing.
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198 - Rusu,V., Hoch,E., Mercader,J.M., Tenen,D.E., Gymrek,M., Hartigan,C.R., Deran,M., von Grotthuss,M., Fontanillas,P., Spooner,A., Guzman,G., Deik,A.A., Pierce,K.A., Dennis,C., Clish,C.B., Carr,S.A., Wagner,B.K., Schenone,M., Ng,M.C.Y., Chen,B.H., Centeno-Cruz,F., Zerrweck,C., Orozco,L., Altshuler,D.M., Schreiber,S.L., Florez,J.C., Jacobs,S.B.R., Lander,E.S., MEDIA Consortium, SIGMA T2D Consortium, Soberon,X.. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.
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199 - Bolivar-Zapata, F.G., Arias-Ortiz, C. F., Artega-Vazquez, M. A., Barrera-Saldana, H. A., Galindo-Fentanes, E., Gracia-Gasca, A., Herrera-Estrella, L. R., Higuera-Ciapara, I., Larque-Saavedra, F. A., Lopez-Munguia Canales, A., Ramirez-Reivich, O. T., Revah-Moiseev, S., Soberon-Mainero, X., Torres-Pacheco, I., Uribe de la Mora, J. M., Vazquez-Ramos, J. M., Viniegra-Gonzalez, G.. Transgénicos: Grandes beneficios, ausencia de daños y mitos.
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200 - Cruz-Correa,O.F., Ramirez-Hobak,L., Arenas,R., Soberon,X.. Metagenomics in onychomycosis. Analysis of a case with a possible role of malassezia globosa in the pathogenesis [Metagen¢mica en onicomicosis. El an lisis de un caso que revela el posible papel de Malassezia globosa en la pathogennesis].
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201 - Gonzalez-Covarrubias,V., Martinez-Magana,J.J., Coronado-Sosa,R., Villegas-Torres,B., Genis-Mendoza,A.D., Canales-Herrerias,P., Nicolini,H., Soberon,X.. Exploring Variation in Known Pharmacogenetic Variants and its Association with Drug Response in Different Mexican Populations.
Pharmaceutical Research,
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202 - Lek,M., Karczewski,K.J., Minikel,E.V., Samocha,K.E., Banks,E., Fennell,T., O'Donnell-Luria,A.H., Ware,J.S., Hill,A.J., Cummings,B.B., Tukiainen,T., Birnbaum,D.P., Kosmicki,J.A., Duncan,L.E., Estrada,K., Zhao,F.M., Zou,J., Pierce-Hollman,E., Berghout,J., Cooper,D.N., Deflaux,N., DePristo,M., Do,R., Flannick,J., Fromer,M., Gauthier,L., Goldstein,J., Gupta,N., Howrigan,D., Kiezun,A., Kurki,M.I., Moonshine,A.L., Natarajan,P., Orozeo,L., Peloso,G.M., Poplin,R., Rivas,M.A., Ruano-Rubio,V., Rose,S.A., Ruderfer,D.M., Shakir,K., Stenson,P.D., Stevens,C., Thomas,B.P., Tiao,G., Tusie-Luna,M.T., Weisburd,B., Won,H.H., Yu,D.M., Altshuler,D.M., Ardissino,D., Boehnke,M., Danesh,J., Donnelly,S., Elosua,R., Florez,J.C., Gabriel,S.B., Getz,G., Glatt,S.J., Hultman,C.M., Kathiresan,S., Laakso,M., NcCarroll,S., McCarthy,M.I., McGovern,D., McPherson,R., Neale,B.M., Palotie,A., Purcell,S.M., Saleheen,D., Scharf,J.M., Sklar,P., Sullivan,P.F., Tuomilehto,J., Tsuang,M.T., Watkins,H.C., Wilson,J.G., Daly,M.J., Macarthur,D.G., Exome Aggregation Consortium, Soberon,X.. Analysis of protein-coding genetic variation in 60,706 humans.
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203 - Navarrete-Perea,J., Toledano-Magana,Y., Torre,P., Sciutto,E., Bobes,R.J., Soberon,X., Laclette,J.P.. Role of porcine serum haptoglobin in the host-parasite relationship of Taenia solium cysticercosis.
Molecular and Biochemical Parasitology,
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204 - Bikel,S., Valdez-Lara,A., Cornejo-Granados,F., Rico,K., Canizales-Quinteros,S., Soberon,X., Del Pozo-Yauner,L., Ochoa-Leyva,A.. Combining metagenomics, metatranscriptomics and viromics to explore novel microbial interactions: towards a systems-level understanding of human microbiome.
Computational and Structural Biotechnology Journal,
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205 - Gomez,S., Adalid-Peralta,L., Palafox-Fonseca,H., Cantu-Robles,V.A., Soberon,X., Sciutto,E., Fragoso,G., Bobes,R.J., Laclette,J.P., Yauner,L.D., Ochoa-Leyva,A.. Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR).
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206 - Villegas-Torres,B., Sanchez-Giron,F., Jaramillo-Villafuerte,K., Soberon,X., Gonzalez-Covarrubias,V.. Genotype frequencies of VKORC1 and CYP2C9 in Native and Mestizo populations from Mexico, potential impact for coumarin dosing.
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207 - Estrada,K., Aukrust,I., Bjorkhaug,L., Burtt,N.P., Mercader,J.M., Garcia-Ortiz,H., Huerta-Chagoya,A., Moreno-Macias,H., Walford,G., Flannick,J., Williams,A.L., Gomez-Vazquez,M.J., Fernandez-Lopez,J.C., Martinez-Hernandez,A., Centeno-Cruz,F., Mendoza-Caamal,E., Revilla-Monsalve,C., Islas-Andrade,S., Cordova,E.J., Soberon,X., Gonzalez-Villalpando,M.E., Henderson,E., Wilkens,L.R., Le Marchand,L., Arellano-Campos,O., Ordonez-Sanchez,M.L., Rodriguez-Torres,M., Rodriguez-Guillen,R., Riba,L., Najmi,L.A., Jacobs,S.B., Fennell,T., Gabriel,S., Fontanillas,P., Hanis,C.L., Lehman,D.M., Jenkinson,C.P., Abboud,H.E., Bell,G.I., Cortes,M.L., Boehnke,M., Gonzalez-Villalpando,C., Orozco,L., Haiman,C.A., Tusie-Luna,T., Aguilar-Salinas,C.A., Altshuler,D., Njolstad,P.R., Florez,J.C., Macarthur,D.G.. Association of a Low-Frequency Variant in HNF1A With Type 2 Diabetes in a Latino Population.
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208 - Majithia,A.R., Flannick,J., Shahinian,P., Guo,M., Bray,M.A., Fontanillas,P., Gabriel,S.B., Rosen,E.D., Altshuler,D., SIGMA T2D Consortium, Soberon,X.. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.
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209 - Moreno-Estrada,A., Gignoux,C.R., Fernandez-Lopez,J.C., Zakharia,F., Sikora,M., Contreras,A.V., Acuna-Alonzo,V., Sandoval,K., Eng,C., Romero-Hidalgo,S., Ortiz-Tello,P., Robles,V., Kenny,E.E., Nuno-Arana,I., Barquera-Lozano,R., Macin-Perez,G., Granados-Arriola,J., Huntsman,S., Galanter,J.M., Via,M., Ford,J.G., Chapela,R., Rodriguez-Cintron,W., Rodriguez-Santana,J.R., Romieu,I., Sienra-Monge,J.J., del Rio-Navarro,B., London,S.J., Ruiz-Linares,A., Garcia-Herrera,R., Estrada,K., Hidalgo-Miranda,A., Jimenez-Sanchez,G., Carnevale,A., Soberon,X., Canizales-Quinteros,S., Rangel-Villalobos,H., Silva-Zolezzi,I., Burchard,E.G., Bustamante,C.D.. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits.
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210 - Williams,A.L., Jacobs,S.B., Moreno-Macias,H., Huerta-Chagoya,A., Churchhouse,C., Marquez-Luna,C., Garcia-Ortiz,H., Gomez-Vazquez,M.J., Burtt,N.P., Aguilar-Salinas,C.A., Gonzalez-Villalpando,C., Florez,J.C., Orozco,L., Haiman,C.A., Tusie-Luna,T., Altshuler,D., Williams,A.L., Marquez-Luna,C., Huerta-Chagoya,A., Ripke,S., Gomez-Vazquez,M.J., Manning,A.K., Moreno-Macias,H., Garcia-Ortiz,H., Neale,B., Burtt,N.P., Aguilar-Salinas,C.A., Reich,D., Stram,D.O., Fernandez-Lopez,J.C., Romero-Hidalgo,S., Altshuler,D., Florez,J.C., Tusie-Luna,T., Patterson,N., Haiman,C.A., Aguilar-Delfin,I., Martinez-Hernandez,A., Centeno-Cruz,F., Mendoza-Caamal,E., Revilla-Monsalve,C., Islas-Andrade,S., Cordova,E., Rodriguez-Arellano,E., Soberon,X., Orozco,L., Florez,J.C., Gonzalez-Villalpando,C., Gonzalez-Villalpando,M.E., Haiman,C.A., Henderson,B.E., Monroe,K., Wilkens,L., Kolonel,L.N., Le Marchand,L., Riba,L., Ordonez-Sanchez,M.L., Rodriguez-Guillen,R., Cruz-Bautista,I., Rodriguez-Torres,M., Munoz-Hernandez,L.L., Saenz,T., Gomez,D., Alvirde,U., Burtt,N.P., Onofrio,R.C., Brodeur,W.M., Gage,D., Murphy,J., Franklin,J., Mahan,S., Ardlie,K., Crenshaw,A.T., Winckler,W., Prufer,K., Shunkov,M.V., Sawyer,S., Stenzel,U., Kelso,J., Lek,M., Sankararaman,S., Williams,A.L., Patterson,N., Macarthur,D.G., Reich,D., Derevianko,A.P., Paabo,S., Jacobs,S.B., Churchhouse,C., Gopal,S., Grammatikos,J.A., Smith,I.C., Bullock,K.H., Deik,A.A., Souza,A.L., Pierce,K.A., Clish,C.B., Altshuler,D., Fennell,T., Farjoun,Y., Genomics,Platform B., Gabriel,S., Stram,D.O., Gross,M.D., Pereira,M.A., Seielstad,M., Koh,W.P., Tai,E.S., Flannick,J., Fontanillas,P., Morris,A., Teslovich,T.M., Burtt,N.P., Atzmon,G., Blangero,J., Bowden,D.W., Chambers,J., Shin,Cho Y., Duggirala,R., Glaser,B., Hanis,C., Kooner,J., Laakso,M., Lee,J.Y., Tai,E.S., Ying,Teo Y., Wilson,J.G., Haiman,C.A., Henderson,B.E., Monroe,K., Wilkens,L., Kolonel,L.N., Le Marchand,L., Puppala,S., Farook,V.S., Thameem,F., Abboud,H.E., Defronzo,R.A., Jenkinson,C.P., Lehman,D.M., Curran,J.E., Blangero,J., Duggirala,R., Burtt,N.P., Cortes,M.L., Altshuler,D., Florez,J.C., Haiman,C.A., Henderson,B.E., Aguilar-Salinas,C.A., Gonzalez-Villalpando,C., Orozco,L., Tusie-Luna,T.. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
Nature,
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211 - Soberon-Mainero,X., Gonzalez-Covarrubias,V.. Enfermedades infecciosas, hacia una medicina personalizada.
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212 - Ochoa-Leyva,A., Montero-Moran,G., Saab-Rincon,G., Brieba,L.G., Soberon,X.. Alternative Splice Variants in TIM Barrel Proteins from Human Genome Correlate with the Structural and Evolutionary Modularity of this Versatile Protein Fold.
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213 - Tsai,I.J., Zarowiecki,M., Holroyd,N., Garciarrubio,A., Sanchez-Flores,A., Brooks,K.L., Tracey,A., Bobes,R.J., Fragoso,G., Sciutto,E., Aslett,M., Beasley,H., Bennett,H.M., Cai,Jianping, Camicia,F., Clark,R., Cucher,M., De Silva,N., Day,T.A., Deplazes,P., Estrada,K., Fernandez,C., Holland,P.W.H., Hou,Junling, Hu,Songnian, Huckvale,Thomas, Hung,S.S., Kamenetzky,L., Keane,J.A., Kiss,F., Koziol,U., Lambert,O., Liu,K., Luo,Xuenong, Luo,Yingfeng, Macchiaroli,N., Nichol,S., Paps,Jordi, Parkinson,J., Pouchkina-Stantcheva,N., Riddiford,N., Rosenzvit,M., Salinas,G., Wasmuth,James D., Zamanian,M., Zheng,Yadong, Cai,Xuepeng, Soberon,X., Olson,P.D., Laclette,J.P., Brehm,Klaus, Berriman,M., Ochoa-Leyva,A.. The genomes of four tapeworm species reveal adaptations to parasitism.
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214 - Lopez-de Los Santos Y., Chan,H., Cantu,V.A., Rettner,R., Sanchez,F., Zhang,Z., Saier,M.H., Soberon,X.. Genetic engineering of the phosphocarrier protein NPr of the Escherichia coli phosphotransferase system selectively improves sugar uptake activity.
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215 - Saab-Rincon,G., Olvera,L., Olvera,M., Rudino-Pinera,E., Benites,E., Soberon,X., Morett,E.. Evolutionary Walk between (beta/alpha)(8) Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase.
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216 - Soberon,X.. La medicina genómica en México, consideraciones para su desarrollo. Fortalezas y desafíos de los servicios de salud de México en el siglo XXI.
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217 - Ochoa-Leyva,A., Barona-Gomez,F., Saab-Rincon,G., Verdel-Aranda,K., Sanchez,F., Soberon,X.. Exploring the Structure-Function Loop Adaptability of a (beta/alpha)(8)-Barrel Enzyme through Loop Swapping and Hinge Variability.
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218 - Bolivar-Zapata,F.G., Arias-Ortiz,C.F., Arriaga-Arellano,E., Barrera-Saldaña,H., de la Torres-Martinez,M., Espinosa-Fernandez,J., Galindo-Fentanes,E., Galvez-Mariscal,A, Gracia-Gasca,A., Herrera-Estrella,L., Larque-Saavedra,A., Lopez-Munguia Canales,A., Noyola-Robles,A., Paredes-Lopez,O., Ramirez-Reivich,O.T., Revah-Moiseev,S., Soberon-Mainero,J., Soberon-Mainero,X., Torres-Pacheco,I., Uribe de la Mora,J., Viniegra-Gonzalez,G.. Por un uso responsable de los organismos genéticamente modificados.
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219 - Noda-Garcia,L., Camacho-Zarco,A.R., Verdel-Aranda,K., Wright,H., Soberon,X., Fulop,V., Barona-Gomez,F.. Identification and analysis of residues contained on beta --> alpha loops of the dual-substrate (betaalpha)(8) phosphoribosyl isomerase a (PriA) specific for its phosphoribosyl anthranilate isomerase activity.
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220 - Soberon-Mainero,X., Melendez-Zajgla,J.. [The Instituto Nacional de Medicina Genomica. Vocation and challenges].
Revista de Investigacion Clinica,
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221 - Ochoa-Leyva,A., Soberon,X., Sanchez,F., Arguello,M., Montero-Moran,G., Saab-Rincon,G.. Protein design through systematic catalytic loop exchange (SCLE) in the (beta/alpha)(8)-fold.
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222 - Frausto-Solis,J., Soberon-Mainero,X., Linan-Garcia,E.. MultiQuenching annealing algorithm for protein folding problem. Mexican International Conference on Artificial Intelligence. MICAI 2009: Advances in Artificial Intelligence .
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223 - Damian-Almazo,J.Y., Lopez-Munguia A., Soberon-Mainero,X., Saab-Rincon,G.. Role of the phenylalanine 260 residue in defining product profile and alcoholytic activity of the a-amylase AmyA from Thermotoga maritima.
Biologia,
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224 - Damian-Almazo,J.Y., Moreno,A., Lopez-Munguia,A., Soberon,X., Gonzalez-Munoz,F., Saab-Rincon,G.. Enhancement of the alcoholytic activity of {alpha}-amylase AmyA from Thermotoga maritima MSB8 (DSM 3109) by site directed mutagenesis.
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225 - Segovia,L., Soberon,X.. Evolución experimental de proteínas. Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 26.
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226 - Flores-Ramirez,G., Rivera,M., Morales-Pablos,A., Osuna,J., Soberon,X., Gaytan,P.. The effect of amino acid deletions and substitutions in the longest loop of GFP.
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227 - Vazquez-Limon,C., Vega-Badillo,J., Martinez,A., Espinosa-Molina,G., Gosset,G., Soberon,X., Lopez-Munguia,A., Osuna,J.. Growth rate of a non-fermentative Escherichia coli strain is influenced by NAD(+) regeneration.
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228 - Barona-Gomez,F., Ochoa-Leyva,A., Soberon,X.. Advances and perspectives in protein engineering: from natural history to directed evolution of enzymes. Advances in Protein Physical Chemistry.
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229 - Frausto-Solis,J., Roman,E.F., Romero,D., Soberon,X., Linan-Garcia,E.. Analytically tuned simulated annealing applied to the protein folding problem. Lecture Notes in Computer Science vol 4488.
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230 - Aguilar-Diaz,H., Bobes,R.J., Carrero,J.C., Camacho-Carranza,R., Cervantes,C., Cevallos,M.A., Davila,G., Rodriguez-Dorantes,M., Escobedo,G., Fernandez,J.L., Fragoso,G., Gaytan,P., Garciarrubio,A., Gonzalez,V.M., Gonzalez,L., Jose,M.V., Jimenez,L., Laclette,J.P., Landa,A., Larralde,C., Morales-Montor,J., Morett,E., Ostoa-Saloma,P., Sciutto,E., Santamaria,R.I., Soberon,X., de la Torre P., Valdes,V., Yanez,J.. The genome project of Taenia solium.
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231 - Monroy-Lagos,O., Soberon,X., Gaytan,P., Osuna,J.. Improvement of an unusual twin-arginine transporter leader Peptide by a codon-based randomization approach.
Applied and Environmental Microbiology,
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232 - Soberon,X., Saier,M.H.,Jr.. Engineering Transport Protein Function: Theoretical and Technical Considerations Using the Sugar-Transporting Phosphotransferase System of Escherichia coli as a Model System.
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233 - Souza,V., Espinosa-Asuar,L., Escalante,A.E., Eguiarte,L.E., Farmer,J., Forney,L., Lloret,L., Rodriguez-Martinez,J.M., Soberon,X., Dirzo,R., Elser,J.J.. An endangered oasis of aquatic microbial biodiversity in the Chihuahuan desert.
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234 - Baez-Viveros,J.L., Osuna,J., Hernandez-Chavez,G., Soberon,X., Bolivar,F., Gosset,G.. Metabolic via engineering for the production of aromatic substances in Escherichia coli.
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235 - Gaytan,P., Yanez,J., Grande,R., Morett,E., Soberon,X.. Improving random mutagenesis by purification of the oligonucleotide variants.
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236 - Saab-Rincon,G., Mancera,E., Montero-Moran,G., Sanchez,F., Soberon,X.. Generation of variability by in vivo recombination of halves of a (beta/alpha)(8) barrel protein.
Biomolecular Engineering,
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237 - Baez-Viveros,J.L., Osuna,J., Hernandez-Chavez,G., Soberon,X., Bolivar,F., Gosset,G.. Metabolic engineering and protein directed evolution increase the yield of L-phenylalanine synthesized from glucose in Escherichia coli.
Biotechnology and Bioengineering,
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238 - Flores,G., Soberon,X., Osuna,J.. Production of a fully functional, permuted single-chain penicillin G acylase.
Protein Science,
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239 - Moreno,A., Saab-Rincon,G., Santamaria,R.I., Soberon,X., Lopez-Munguia,A.. A more efficient starch degradation by the combination of hydrolase and transferase activities of alpha-amylase and cyclomaltodextrin glucanotransferase.
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240 - Osuna,J., Yanez,J., Soberon,X., Gaytan,P.. Protein evolution by codon-based random deletions.
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241 - Soberon,X., Fuentes-Gallego,P., Saab-Rincon,G.. In vivo fragment complementation of a (beta/alpha)(8) barrel protein: generation of variability by recombination.
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167-172.
Artículo
242 - Yanez,J., Arguello,M., Osuna,J., Soberon,X., Gaytan,P.. Combinatorial codon-based amino acid substitutions.
Nucleic Acids Research,
32 (20),
e158.
Nacional
243 - Soberon,X., Montero,G.M.. Ingeniería de proteínas y evolución dirigida. Fundamentos y casos exitosos de la biotecnologia moderna cap 7.
195-217,
Mexico.
Nacional
244 - Yanez,J., Soberon,X., Gaytan,P.. Rutas alternas de síntesis para la preparación de Fmoc-Trinucleósido-Difosfato Fosforamiditos.
Revista de la Sociedad Química de México,
48 (1),
26-37.
Artículo
245 - Rivera,M.H., Lopez-Munguia,A., Soberon,X., Saab-Rincon,G.. alpha-Amylase from Bacillus licheniformis mutants near to the catalytic site: effects on hydrolytic and transglycosylation activity.
Protein Engineering,
16 (7),
505-514.
Nacional
246 - Soberon,X.. Biocatálisis y evolución dirigida de proteínas. Fronteras de la Biología en los Inicios del Siglo XXI, Módulo VII.
35-45,
Mexico,D.F..
Nacional
Divulgación
248 - Soberon Mainero,X. Veinte años del Instituto de Biotecnología.
Revista Universidad de Mexico,
629.
Divulgación
249 - Soberon-Mainero,X.. Veinte años del Instituto de Biotecnología.
Revista de la Universidad de México,
629.
Artículo
250 - Gaytan,P., Osuna,J., Soberon,X.. Novel ceftazidime-resistance beta-lactamases generated by a codon-based mutagenesis method and selection.
Nucleic Acids Research,
30 (16),
e84-e84.
Artículo
251 - Osuna,J., Perez-Blancas,A., Soberon,X.. Improving a circularly permuted TEM-1 beta-lactamase by directed evolution.
Protein Engineering,
15 (6),
463-470.
Memoria in extenso
252 - Saab-Rincon,G., Del Rio,G, Santamaria,R, Diaz,M.L, Soberon,X., Lopez-Munguia,A.. Novel and potential applications of alpha-amylases in the food industry. Engineering and Food for the 21st Century. Proceedings of the Eighth International Congress on Engineering and Food.
913-924,
Boca Raton, Fla.
Divulgación
253 - Soberon Mainero, X.. La revolución de las ciencias genómicas.
Revista Universidad Nacional,
617.
Divulgación
254 - Soberon-Mainero,X.. La ingenieria genética y un campo de aplicación: la biocatálisis y la industria química limpia.
Mensaje Bioquimico,
26,
1-18.
Artículo
255 - Gaytan,P., Yanez,J., Sanchez,F., Soberon,X.. Orthogonal combinatorial mutagenesis: a codon-level combinatorial mutagenesis method useful for low multiplicity and amino acid-scanning protocols.
Nucleic Acids Research,
29 (3),
E9.
Artículo
256 - Saab-Rincon,G., Juarez,V.R., Osuna,J., Sanchez,F., Soberon,X.. Different strategies to recover the activity of monomeric triosephosphate isomerase by directed evolution.
Protein Engineering,
14 (3),
149-155.
Nacional
257 - Soberon,X., Bolivar,F.. Evolución de los conceptos de gen y genoma. Ciencias de la vida.
61-83.
Divulgación
258 - Soberon,X.. La biotecnologia: un ejercito microscopico al servicio del hombre.
Hypatia,
2,
6-7.
Divulgación
259 - Soberon,X.. Nuevos paradigmas relacionados con la ciencia biologica experimental: implicaciones cientificas, tecnologicas y sociales.
Revista Universidad de Mexico,
605-606,
59-63.
Divulgación
260 - Soberon,X.. El convenio UNAM-INE-Diversa y el aprovechamiento de recursos geneticos.
BioTecnologia. Sociedad Mexicana de Biotecnologia y Bioingenieria,
5,
14-15.
Divulgación
Artículo
262 - Moreno-Hagelsieb,G., Gomez-Puyou,A., Soberon,X.. Escherichia coli TEM1 beta-lactamase in CTAB reverse micelles: exchange/diffusion-limited catalysis.
FEBS Letters,
459 (1),
111-114.
Artículo
263 - Saab-Rincon,G., Del Rio,G., Santamaria,R.I., Lopez-Munguia,A., Soberon,X.. Introducing transglycosylation activity in a liquefying alpha-amylase.
FEBS Letters,
453 (1-2),
100-106.
Artículo
264 - Santamaria,R.I., Del Rio,G., Saab,G., Rodriguez,M.E., Soberon,X., Lopez-Manguia,A.. Alcoholysis reactions from starch with alpha-amylases.
FEBS Letters,
452 (3),
346-350.
News Item
265 - Soberon,X.. Enzymes directly evolving toward commercial applications.
Nature Biotechnology,
17 (6),
539-540.
Artículo
266 - Galindo,E., Lagunas,F., Osuna,J., Soberon,X., Garcia,J.L.. A microbial biosensor for 6-aminopenicillanic acid.
Enzyme and Microbial Technology,
23 (5),
331-334.
Artículo
267 - Garcia,J.L., Nunez,C.J., Gonzalez,E.G., Osuna,J., Soberon,X., Galindo,E.. Microbial sensor for new-generation cephalosporins based in a protein-engineered beta-lactamase.
Applied Biochemistry and Biotechnology,
73 (2-3),
243-256.
Artículo
268 - Gaytan,P., Yanez,J., Sanchez,F., Mackie,H., Soberon,X.. Combination of DMT-mononucleotide and Fmoc-trinucleotide phosphoramidites in oligonucleotide synthesis affords an automatable codon-level mutagenesis method.
Chemistry and Biology,
5 (9),
519-527.
Artículo
269 - Gonzalez,V., Olvera,L., Soberon,X., Morett,E.. In vivo studies on the positive control function of NifA: a conserved hydrophobic amino acid patch at the central domain involved in transcriptional activation.
Molecular Microbiology,
28 (1),
55-67.
Artículo
270 - Del Rio,G., Morett,E., Soberon,X.. Did cyclodextrin glycosyltransferases evolve from alpha-amylases?.
FEBS Letters,
416 (2),
221-224.
Artículo
271 - Flores,H., Soberon,X., Sanchez,J., Bravo,A.. Isolated domain II and III from the Bacillus thuringiensis Cry1Ab delta-endotoxin binds to lepidopteran midgut membranes.
FEBS Letters,
414 (2),
313-318.
Artículo
272 - Gaytan,P., Yanez,J., Soberon,X., Martinez,R.. A new method for oligonucleotide derivatization of the 3' or 5'-termini with a CPG-support carrying the natural product isoargentatin-D.
Tetrahedron Letters,
38 (35),
6123-6126.
Artículo
273 - Muir,R.S., Flores,H., Zinder,N.D., Model,P., Soberon,X., Heitman,J.. Temperature-sensitive mutants of the EcoRI endonuclease.
Journal of Molecular Biology,
274 (5),
722-737.
Artículo
274 - Osuna,J., Soberon,X., Morett,E.. A proposed architecture for the central domain of the bacterial enhancer-binding proteins based on secondary structure prediction and fold recognition.
Protein Science,
6 (3),
543-555.
Artículo
275 - Del Rio,G., Lopez-Munguia,A., Soberon,X.. An engineered penicillin acylase with altered surface charge is more stable in alkaline pH.
Annals of the New York Academy of Sciences,
799,
61-64.
Artículo
276 - Moreno-Hagelsieb,G., Soberon,X.. Protein engineering as a powerful tool for the chemical modification of enzymes.
Biological Research,
29 (1),
127-140.
Artículo
277 - Del Rio,G., Rodriguez,M.E., Munguia,M.E., Lopez-Munguia,A., Soberon,X.. Mutant Escherichia coli penicillin acylase with enhanced stability at alkaline pH.
Biotechnology and Bioengineering,
48 (2),
141-148.
Artículo
278 - Flores,H., Osuna,J., Heitman,J., Soberon,X.. Saturation mutagenesis of His114 of EcoRI reveals relaxed-specificity mutants.
Gene,
157 (1-2),
295-301.
Artículo
279 - Osuna,J., Viadiu,H., Fink,A.L., Soberon,X.. Substitution of Asp for Asn at position 132 in the active site of TEM beta-lactamase. Activity toward different substrates and effects of neighboring residues.
Journal of Biological Chemistry,
270 (2),
775-780.
Artículo
280 - Viadiu,H., Osuna,J., Fink,A.L., Soberon,X.. A new TEM beta-lactamase double mutant with broadened specificity reveals substrate-dependent functional interactions.
Journal of Biological Chemistry,
270 (2),
781-787.
Artículo
281 - Del Rio,G., Osuna,J., Soberon,X.. Combinatorial libraries of proteins: analysis of efficiency of mutagenesis techniques.
Biotechniques,
17 (6),
1132-1139.
Artículo
282 - Gurrola,G.B., Moreno-Hagelsieb,G., Zamudio,F.Z., Garcia,M., Soberon,X., Possani,L.D.. The disulfide bridges of toxin 2 from the scorpion Centruroides noxius Hoffmann and its three-dimensional structure calculated using the coordinates of variant 3 from Centruroides sculpturatus.
FEBS Letters,
347 (1),
59-62.
Revisión
283 - Osuna,J., Flores,H., Soberon,X.. Microbial systems and directed evolution of protein activities.
Critical Reviews in Microbiology,
20 (2),
107-116.
Artículo
284 - Merino,E., Osuna,J., Bolivar,F., Soberon,X.. A general, PCR-based method for single or combinatorial oligonucleotide-directed mutagenesis on pUC/M13 vectors.
Biotechniques,
12 (4),
508-510.
Artículo
285 - Pereyra-Alferez,B., Bravo,A., Quintero,R., Soberon,X.. The delta-endotoxin protein family displays a hydrophobic motif that might be implicated in toxicity.
Molecular Microbiology,
6 (15),
2095-2098.
Artículo
286 - Lopez,S., Lopez,I., Romero,P., Mendez,E., Soberon,X., Arias,C.F.. Rotavirus YM gene 4: analysis of its deduced amino acid sequence and prediction of the secondary structure of the VP4 protein.
Journal of Virology,
65 (7),
3738-3745.
Artículo
Note
288 - Fuchs,L.Y., Ovando,C., Joseph,P., Soberon,X., Charli,J.L.. Repetitive DNA sequence from the crayfish Procambarus clarkii.
Nucleic Acids Research,
18 (6),
1650.
Artículo
289 - Pastor,N., Pinero,D., Valdes,A.M., Soberon,X.. Molecular evolution of class A beta-lactamases: phylogeny and patterns of sequence conservation.
Molecular Microbiology,
4 (11),
1957-1965.
Internacional
290 - Balbas,P., Soberon,X., Bolivar,F., Rodriguez,R.L.. The plasmid, pBR322. Biotechnology (Reading, Mass.).
5-41,
10.
Artículo
291 - Balbas,P., Soberon,X., Merino,E., Zurita,M., Lomeli,H., Valle,F., FLORES,N., Bolivar,F.. Plasmid vector pBR322 and its special-purpose derivatives--a review.
Gene,
50 (1-3),
3-40.
Nacional
292 - Oliver,G., Balbas,P., Valle,F., Soberon,X., Bolivar,F.. [Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli].
Revista Latinoamericana de Microbiologia,
27 (2),
141-150.
Artículo
294 - Rossi,J.J., Soberon,X., Marumoto,Y., McMahon,J., Itakura,K.. Biological expression of an Escherichia coli consensus sequence promoter and some mutant derivatives.
Proceedings of the National Academy of Sciences of the United States of America,
80 (11),
3203-3207.
*
Artículo
295 - Inouye,S., Soberon,X., Franceschini,T., Nakamura,K., Itakura,K., Inouye,M.. Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane.
Proceedings of the National Academy of Sciences of the United States of America,
79 (11),
3438-3441 .
*
Artículo
296 - Miyada,C.G., Soberon,X., Itakura,K., Wilcox,G.. The use of synthetic oligodeoxyribonucleotides to produce specific deletions in the araBAD promoter of Escherichia coli B/r.
Gene,
17 (2),
167-177.
*
Artículo
297 - Zarucki-Schulz,T., Tsai,S.Y., Itakura,K., Soberon,X., Wallace,R.B., Tsai,M.J., Woo,S.L., O'Malley,B.W.. Point mutagenesis of the ovalbumin gene promoter sequence and its effect on in vitro transcription.
Journal of Biological Chemistry,
257 (18),
11070-11077.
*
298 - Soberon Mainero, Francisco Xavier. Uso de vehiculos moleculares de clonacion y de sintesis quimica de polinucleotidos para el estadio de la expresion genica.
Instituto de Investigaciones Biomedicas,
Maestria en Investigacion Biomedica Basica,
UNAM.
*
Asesor: Itakura, Keiichi, Bolivar Zapata, Francisco
Artículo
299 - Covarrubias,L., Cervantes,L., Covarrubias,A., Soberon,X., Vichido,I., Blanco,A., Kupersztoch-Portnoy,Y.M., Bolivar,F.. Construction and characterization of new cloning vehicles. V. Mobilization and coding properties of pBR322 and several deletion derivatives including pBR327 and pBR328.
Gene,
13 (1),
25-35.
*
Artículo
300 - Soberon,X., Covarrubias,L., Bolivar,F.. Construction and characterization of new cloning vehicles. IV. Deletion derivatives of pBR322 and pBR325.
Gene,
9 (3-4),
287-305.
*
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