Dra. Patricia Ileana Joseph Bravo
Investigador
Neurobiología Celular y Molecular
Número de registros: 18
- Activos
- Vencidos
- Caracterización del efecto del estrés crónico e intermitente, a largo plazo, sobre la respuesta del eje tiroideo y el metabolismo., DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2019 - 2021
- Efecto del estrés durante adolescencia sobre la respuesta del eje hipotálamo-pituitaria-tiroides a retos metabólicos y su repercusión en la homeostasis energética del roedor adulto de ambos sexos, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2018 - 2021
- Efecto del estrés crónico en la respuesta de las neuronas trhérgicas y el eje tiroideo ante retos de demanda energética, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2016 - 2019
- Aspectos moleculares y celulares de la comunicación peptidérgica en el sistema nervioso, PRESUPUESTO UNAM, 2014 - 2020
- Dinámica de los efectos de glucocorticoides en la respuesta de las neuronas trhérgicas hipofisiotrópicas y el eje tiroideo a estímulos de demanda energética, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2013 - 2016
- Efectos del estrés postnatal sobre la respuesta del eje hipotálamo-pituitaria-tiroides a retos metabólicos. búsqueda de cambios epigenéticos, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2012 - 2016
- Efecto de glucocorticoides y hormonas tiroideas en la regulación neuronal de la transcripción del gen de trh, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2010 - 2012
- Cambios en la conducta de ansiedad y en la transformacion thrergica del sistema limbico en ratas sometidas a un estrés agudo, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2009
- Efecto del estrés sobre la actividad de las neuronas trhérgicas del sistema límbico, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2008 - 2011
- Respuesta de las neuronas trhérgicas del sistema límbico al estrés, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2007 - 2009
- Estudios sobre la función del trh en el sistema límbico, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2004 - 2007
- Estudio sobre la biosíntesis del trh en el eje neuroendócrino., DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2004 - 2005
- El trh como neuromodulador en el sistema límbico., DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2004 - 2005
- Efectos de los glucocorticoides sobre la expresión del protrh., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2003
- Regulación de la biosíntesis de trh en el núcleo paraventricular del hipotálamo (iii)., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2000 - 2003
- Regulación del metabolismo de trh en el sistema nervioso central (iv)., DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2000 - 2003
- Regulación de la biosíntesis de trh en el núcleo paraventricular: vías y mecanismos de regulación (ii), CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 1998 - 2001
- Regulación del metabolismo del trh en el sistema nervioso ii, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 1997 - 2000
Nivel D del PRIDE
Nivel III del SNI
Nivel III del SNI
Doctorado, en Bioquímica, Universidad de Londres; Colegio Imperial de Ciencia y Tecnología; Depto. de Bioquímica; Londres - Inglaterra (1978)
Maestría, en Nutrición y Metabolismo, Mass. Inst. of Technology Cambridge, Mass E.U.A. Dept. de Ciencia en Nutrición y Metabolismo (1974)
Licenciatura, Química, Fac. de Química-UNAM (1970)
Miembro del Consejo Consultivo de Posgrado de la UNAM, 2003
Distinción Juana Ramírez de Abaje, UNAM, 2003
Premio Miguel Aleman, 1988
-
Doctorado
-
Efecto de las hormonas sexuales en las neuronas TRHérgicas de ratas hembra sometidas a estrés
-
M.C. Marco Antonio Parra Montes de oca
El estrés durante la adolescencia de ratas modifica su respuesta a retos metabólicos. -
Cambios epigenéticos en el promotor de TRH en respuesta al estrés perinatal
-
Licenciatura
1 - Gutierrez Mata, Angelica (2020). El estres durante la adolescencia modifica la respuesta del eje tiroideo al ejercicio.
Instituto de Biotecnologia,
Maestría en Ciencias Bioquímicas,
UNAM.
Asesor: Joseph-Bravo, Patricia
2 - Castillo Campos, Andrea (2019). Efecto del estres cronico variable sobre el eje hipotalamopituitariatiroides en respuesta al frio .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Joseph-Bravo, Patricia
3 - Velazquez Vazquez, Diana Elisa (2018). Estudio de la interaccion entre el receptor de glucocorticoides y la subunidad catalitica de PKA en la regulacion de la expresion del gen pro-TRH .
Facultad de Ciencias,
Licenciatura en Biologia,
UNAM.
Asesor: Joseph-Bravo, Patricia
4 - Sotelo Rivera, Israim (2017). Regulacion dinamica de la senalizacion de glucocorticoides en la expresion de TRH y el funcionamiento del eje tiroideo .
Instituto de Biotecnologia,
Doctorado en Bioquimicas,
UNAM.
Asesor: Joseph-Bravo, Patricia
5 - Sotelo Rivera, Israim (2012). Estudio del mecanismo molecular de la interferencia entre el receptor de glucocorticoides y la senal de AMPc en el gen proTRH.
Instituto de Biotecnologia,
Maestria en Ciencias (Bioquimicas),
UNAM.
Asesor: Joseph-Bravo, Patricia
6 - Perez Maldonado, Adrian (2012). Analisis molecular de los sitios cre y las secuencias adyacentes en el contexto del promotor del gen de trh en respuesta a la estimulacion con t3 y activadores de la pka.
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Joseph-Bravo, Patricia
7 - Perez Maldonado, Adrian (2010). Determinacion del papel transcripcional del sitio CRE-1 del promotor del gen de TRH.
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
Asesor: Joseph-Bravo, Patricia
8 - Gutierrez Mariscal, Mariana (2010). Participacion de las neuronas TRHergicas amigdalinas en la conducta de ansiedad .
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
Asesor: Joseph-Bravo, Patricia
9 - Horjales Araujo, Maria Emilia (2007). Efecto de una dieta a base de tortillas en el comportamiento alimenticio y el metabolismo en ratas .
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
Asesor: Joseph-Bravo, Patricia
10 - Rebolledo Solleiro, Daniela (2006). Estudio del efecto del estres agudo en el metabolismo del neuropeptido TRH (Hormona Liberadora de Tirotropina) en el sistema limbico.
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
Asesor: Joseph-Bravo, Patricia
11 - Garcia Vazquez, Arlene Iskra (2006). El estres psicologico modula la actividad de las neuronas TRHergicas en el sistema limbico.
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Joseph-Bravo, Patricia
12 - Aguilar Valles, Argel (2005). Activacion de la sneuronas TRHergicas en hipocampo de ratas entrenadas en el laberinto de Morris .
Instituto de Biotecnologia,
Maestria en Ciencias (Bioquimica),
UNAM.
Asesor: Joseph-Bravo, Patricia
13 - Gortari Gallardo, Patricia Bertna Judith (2003). Regulacion de ectopeptidasas en el sistema nerviosos central.
Instituto de Neurobiologia,
Doctorado en Ciencias Fisiologicas,
UNAM.
Asesor: Joseph-Bravo, Patricia
14 - Torres Guerrero, Haydee K. (2002). Estudio sobre la inactivacion del TRH en terminales nerviosas.
Instituto de Investigaciones Biomedicas,
UNAM.
15 - Sanchez Jaramillo, Edith (2002). Heterogeneidad molecular y fisiologica de las neuronas trhergicas del nucleo para ventricular del hipotalamo de la rata .
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
Asesor: Joseph-Bravo, Patricia
16 - Carreon Rodriguez, Alfonso (2000). Interaccion de activadores de proteinas cinasas A y C, glucocorticoides y hormonas tiroideas en la regulacion de la biosintesis rapida de la hormona liberadora de tirotropinaen cultivos primarios de celulas hipotalamicas fetales de rata.
Instituto de Biotecnologia,
Maestria en Ciencias (Bioquimica),
IBT,
UNAM.
Asesor: Joseph-Bravo, Patricia, Perez-Martinez,L.
17 - de Gortari Gallardo, Patricia Bertha Judith (1994). Cambios en la actividad de la enzima piroglutamato aminopeptidasa II provocados por el estimulo electrico en el sistema nervioso central .
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
Asesor: Joseph-Bravo, Patricia
18 - Ponce Romero, Georgina (1991). Algunos aspectos del control de la actividad hipofisaria .
Centro de Investigacion sobre Ingenieria Genetica y Biotecnologia,
Doctora en Investigacion Biomedica Basica,
UNAM.
Asesor: Joseph-Bravo, Patricia
19 - Cruz Fuentes, Carlos Sabas (1991). Estudio sobre el metabolismo de la neurona TRHergica .
Doctorado en Investigacion Biomedica Basica,
UNAM.
Asesor: Joseph-Bravo, Patricia
20 - Covarrubias Robles, Maria de Lourdes (1991). Regulacion de la biosintesis de TRH en cultivos de celulas dispersas de hipotalamo de rata.
Instituto de Biotecnologia,
Maestria en Investigacion Biomedica Basica,
UNAM.
Asesor: Joseph-Bravo, Patricia
21 - Covarrubias Robles, Luis Fernando (1989). Importancia del estudio a nivel molecular para la comprension del funcionamiento celular en eucariotes superiores regulacion de la actividad celular TRT-ERGICA .
Doctorado en Investigacion Biomedica Basica,
UNAM.
Asesor: Joseph-Bravo, Patricia
22 - Covarrubias Robles, Luis Fernando (1989). Importancia del estudio a nivel molecular para la comprension del funcionamiento celular en eucariotes superiores regulacion de la actividad celular TRTERGICA .
Instituto de Biotecnologia,
Doctorado en Investigacion Biomedica Basica,
UNAM.
Asesor: Joseph-Bravo, Patricia
23 - Baez Saldana, Armida (1989). Vias catabolicas extracelulares del neuropeptido TRH (Hormona libertadora de tirotropina) en el hipotalamo de la rata.
Facultad de Ciencias Quimicas,
Maestro en Ciencias Quimicas (Bioquimica),
UNAM.
24 - Guerra Nava, Cesar Eduardo (1987). Cultivo de celulas nerviosas de raton .
Licenciatura en Investigacion Biomedica Basica,
UNAM.
25 - Mendez Ubach, Milagros (1986). Propiedades que definen al TRH extrahipotalamico como posible neuromodulador en el sistema nervioso de rata.
Centro de Investigacion sobre Ingenieria Genetica y Biotecnologia,
Maestria en Ciencias Quimicas (Bioquimica),
UNAM.
Asesor: Joseph-Bravo, Patricia
26 - Saavedra Duran, Rafael Simitrio (1985). Obtencion y caracterizacion de aticuerpos monoclonales contra el factor liberador de la hormona lutienizante (LHRH).
Facultad de Quimica,
Quimico Farmaceutico Biologo,
UNAM.
27 - Garat, Beatriz (1984). Caracterizacion de una enzima membranal involucrada en la degradacion de la hormona liberadora de la tirotropia (TRH) en cerebro de rata .
Instituto de Investigaciones Biomedicas,
Maestro en Investigacion Biomedica Basica,
UNAM.
28 - Cohen Cory, Susana (1984). Caracterizacion del precursor biosintetico del factor liberador de la hormona luteinizante (LHRH).
Facultad de Quimica,
Quimico Farmaceutico Biologo,
UNAM.
29 - Redondo Meda, Jose Luis (1983). Cultivo de celulas dispersas de hipotalamo de raton .
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
Total de publicaciones: 129
- Tipo
- Fecha
Artículo
30 - Castillo-Campos,A., Gutierrez-Mata,A., Charli,J.L., Joseph-Bravo,P. (2021). Chronic stress inhibits hypothalamus-pituitary-thyroid axis and brown adipose tissue responses to acute cold exposure in male rats.
Journal of Endocrinological Investigation,
44,
713.
Artículo
31 - Jaimes-Hoy,L., Perez-Maldonado,A., Narvaez-Bahena,E., de la Cruz Guarneros,N., Rodriguez-Rodriguez,A., Charli,J.L., Soberon,X., Joseph-Bravo,P. (2021). Sex dimorphic changes in Trh gene methylation and thyroid-axis response to energy demands in maternally-separated rats.
Endocrinology,
May 27 Online ahead of print [comentario vol 162 (9) pp 1-2].
Revisión
32 - Lazcano,I., Rodriguez-Rodriguez,A., Uribe,R.M., Orozco,A., Joseph-Bravo,P., Charli,J.L. (2021). Evolution of thyrotropin-releasing factor extracellular communication units.
General and Comparative Endocrinology,
305,
113642.
Revisión
33 - Charli,J.L., Rodriguez-Rodriguez,A., Hernandez-Ortega,K., Cote-Velez,A., Uribe,R.M., Jaimes-Hoy,L., Joseph-Bravo,P. (2020). The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target?.
Frontiers in Pharmacology,
11,
640.
Artículo
34 - Farkas,E., Varga,E., Kovacs,B., Szilvasy-Szabo,A., Cote-Velez,A., Peterfi,Z., Matziari,M., Toth,M., Zelena,D., Mezriczky,Z., Kadar,A., Kovari,D., Watanabe,M., Kano,M., Mackie,K., Rozsa,B., Ruska,Y., Toth,B., Mate,Z., Erdelyi,F., Szabo,G., Gereben,B., Lechan,R.M., Charli,J.L., Joseph-Bravo,P., Fekete,C. (2020). A glial-neuronal circuit in the median eminence regulates thyrotropin-releasing hormone-release via the endocannabinoid system.
iScience,
23 (3),
100921.
Artículo
35 - Joseph-Bravo,P., Lazcano,I., Jaimes-Hoy,L., Gutierrez-Mariscal,M., Sanchez-Jaramillo,E., Uribe,R.M., Charli,J.L. (2020). Sexually dimorphic dynamics of thyroid axis activity during fasting in rats.
Frontiers in Bioscience, Landmark,
25 (7),
1305-1323.
Artículo
36 - Jaimes-Hoy,L., Romero,F., Charli,J.L., Joseph-Bravo,P. (2019). Sex Dimorphic Responses of the Hypothalamus-Pituitary-Thyroid Axis to Maternal Separation and Palatable Diet.
Frontiers in Endocrinology,
10,
445.
Artículo
37 - Parra-Montes de Oca, M. A., Gutierrez-Mariscal, M., Salmeron-Jimenez, M. F., Jaimes-Hoy, L., Charli, J. L., Joseph-Bravo, P. (2019). Voluntary Exercise-Induced Activation of Thyroid Axis and Reduction of White Fat Depots Is Attenuated by Chronic Stress in a Sex Dimorphic Pattern in Adult Rats.
Frontiers in Endocrinology,
10,
418.
Revisión
38 - Rodriguez-Rodriguez, A., Lazcano, I., Sanchez-Jaramillo, E., Uribe, R. M., Jaimes-Hoy, L., Joseph-Bravo, P., Charli, J. L. (2019). Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries.
Frontiers in Endocrinology,
10,
401.
Artículo
39 - Cote-Velez, A., Martinez-Baez A., Lezama, L., Uribe, R.M., Joseph-Bravo, P., Charli, J.L. (2017). A screen for modulators reveals that orexin-A rapidly stimulates thyrotropin releasing hormone expression and release in hypothalamic cell culture.
Neuropeptides,
62,
11-20.
Artículo
40 - Gonzalez-Franco, D.A., Ramirez-Amaya, V., Joseph-Bravo, P., Prado-Alcala, R.A., Quirarte, G.L. (2017). Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance training.
Neurobiology of Learning and Memory,
140,
17-26.
Artículo
41 - Jaimes-Hoy, L., Gurrola, G.B., Cisneros, M., Joseph-Bravo, P., Possani, L.D., Charli, J.L. (2017). The Kv1.3 channel blocker Vm24 enhances muscle glucose transporter 4 mobilization but does not reduce body-weight gain in diet-induced obese male rats.
Life Sciences,
181,
23-30.
Artículo
42 - Sotelo-Rivera, I., Cote-Velez, A., Uribe, R.M., Charli, J.L., Joseph-Bravo, P. (2017). Glucocorticoids curtail stimuli-induced CREB phosphorylation in TRH neurons through interaction of the glucocorticoid receptor with the catalytic subunit of protein kinase A.
Endocrine,
55 (3),
861-871.
Artículo
43 - Jaimes-Hoy,L., Gutierrez-Mariscal,M., Vargas,Y., Perez-Maldonado,A., Romero,F., Sanchez-Jaramillo,E., Charli,J.L., Joseph-Bravo,P. (2016). Neonatal maternal separation alters, in a sex specific manner, the expression of TRH, of TRH-degrading ectoenzyme in the rat hypothalamus, and the response of the thyroid axis to starvation.
Endocrinology,
157 (8),
3253-3265.
Revisión
44 - Joseph-Bravo,P., Jaimes-Hoy,L., Charli,J.L. (2016). Advances in TRH signaling.
Reviews in Endocrine and Metabolic Disorders,
17 (4),
545-558.
Revisión
45 - Joseph-Bravo,P., Jaimes-Hoy,L., Charli,J. (2015). Regulation of TRH neurons and energy homeostasis related signals under stress.
Journal of Endocrinology,
224 (3),
R139-R159 [erratum en vol 227 (3) X1].
Revisión
46 - Joseph-Bravo,P., Jaimes-Hoy,L., Uribe,R.M., Charli,J.L. (2015). TRH, first hypophysiotropic releasing hormone isolated: its control of pituitary-thyroid axis.
Journal of Endocrinology,
226 (2),
T85-T100 [erratum en vol 227 (3) X3].
Artículo
47 - Lazcano,I., Cabral,A., Uribe,R.M., Jaimes-Hoy,L., Perello,M., Joseph-Bravo,P., Sanchez-Jaramillo,E., Charli,J.L. (2015). Fasting enhances pyroglutamyl peptidase II activity in tanycytes of the mediobasal hypothalamus of male adult rats.
Endocrinology,
156 (7),
2713-2723.
Artículo
48 - Rodriguez-Molina,V., Patino,J., Vargas,Y., Sanchez-Jaramillo,E., Joseph-Bravo,P., Charli,J.L. (2014). TRH regulates action potential shape in cerebral cortex pyramidal neurons.
Brain Research,
1571,
1-11.
Artículo
49 - Sotelo-Rivera,I., Jaimes-Hoy,L., Cote-Velez,A., Espinoza-Ayala,C., Charli,J.L., Joseph-Bravo,P. (2014). An acute injection of corticosterone increases thyrotrophin releasing hormone expression in the paraventricular nucleus of the hypothalamus but interferes with the rapid hypothalamus pituitary thyroid axis response to cold in male rats.
Journal of Neuroendocrinology,
26 (12),
861-869.
Artículo
50 - Uribe,R.M., Jaimes-Hoy,L., Ramirez-Martinez,C., Garcia-Vazquez,A., Romero,F., Cisneros,M., Cote-Velez,A., Charli,J.L., Joseph-Bravo,P. (2014). Voluntary exercise adapts the hypothalamus-pituitary-thyroid axis in male rats.
Endocrinology,
155 (5),
en20131724.
Artículo
51 - Gutierrez-Mariscal,M., Sanchez,E., Rebolledo-Solleiro,D., Garcia-Vazquez,A.I., Cote-Velez,A., Acasuso-Rivero,C., Charli,J.L., Joseph-Bravo,P. (2012). The acute response of the amygdalar TRH system to psychogenic stressors varies dependent on the paradigm and circadian condition.
Brain Research,
1452,
73-84.
Artículo
52 - Gutierrez-Mariscal,M., Sanchez,E., Garcia-Vazquez,A., Rebolledo-Solleiro,D., Charli,J.L., Joseph-Bravo,P. (2012). Acute response of hypophysiotropic thyrotropin releasing hormone neurons and thyrotropin release to behavioural paradigms producing varying intensities of stress and physical activity.
Regulatory Peptides,
179 (1-3),
61-70.
Artículo
53 - Lazcano,I., Uribe,R.M., Martinez-Chavez,Erick, Vargas,M.A., Matziari,M., Joseph-Bravo,P., Charli,J.L. (2012). Pyroglutamyl peptidase II inhibition enhances the analeptic effect of thyrotropin releasing hormone in the rat medial septum.
Journal of Pharmacology and Experimental Therapeutics,
342 (1),
222-231.
Artículo
54 - Cote-Velez,A., Perez-Maldonado,A., Osuna,J., Barrera,B., Charli,J.L., Joseph-Bravo,P. (2011). Creb and Sp/Kruppel response elements cooperate to control rat TRH gene transcription in response to cAMP.
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms,
1809 (3),
191-199.
Artículo
55 - Guerra-Crespo,M., Perez-Monter,C., Janga,S.C., Castillo-Ramirez,S., Gutierrez-Rios,R.M., Joseph-Bravo,P., Perez-Martinez,L., Charli,J.L. (2011). Transcriptional profiling of fetal hypothalamic TRH neurons.
BMC Genomics,
12 (1),
222.
Artículo
56 - Uribe,R.M., Cisneros,M., Vargas,M.A., Lezama,L., Cote-Velez,A., Joseph-Bravo,P., Charli,J.L. (2011). The systemic inhibition of nitric oxide production rapidly regulates TRH mRNA concentration in the paraventricular nucleus of the hypothalamus and serum TSH concentration. Studies in control and cold-stressed rats.
Brain Research,
1367,
188-197.
Artículo
57 - Diaz-Gallardo,M.Y., Cote-Velez,A., Charli,J.L., Joseph-Bravo,P. (2010). A rapid interference between glucocorticoids and cAMP-activated signaling in hypothalamic neurons prevents binding of pCREB and GR at the CRE-like and composite GRE sites of TRH gene promoter.
Journal of Neuroendocrinology,
22 (4),
282-293.
Artículo; Actas Paper
58 - Diaz-Gallardo,M.Y., Cote-Velez,A., Carreon-Rodriguez,A., Charli,J.L., Joseph-Bravo,P. (2010). Phosphorylated Cyclic-AMP-Response Element-Binding Protein and Thyroid Hormone Receptor Have Independent Response Elements in the Rat Thyrotropin-Releasing Hormone Promoter: An Analysis in Hypothalamic Cells.
Neuroendocrinology,
91 (1),
64-76.
Artículo
59 - de Gortari,P., Mancera,K., Cote-Velez,A., Amaya,M.I., Martinez,A., Jaimes-Hoy,L., Joseph-Bravo,P. (2009). Involvement of CRH-R2 receptor in eating behavior and in the response of the HPT axis in rats subjected to dehydration-induced anorexia.
Psychoneuroendocrinology,
34 (2),
259-272.
Artículo
60 - Rodriguez-Molina,V., Vargas,M.A., Joseph-Bravo,P., Charli,J.L. (2009). NMDA receptor up-regulates pyroglutamyl peptidase II activity in the rat hippocampus.
Neuroscience Letters,
449 (3),
211-214.
Artículo
61 - Uribe,R.M., Zacarias,M., Corkidi,G., Cisneros,M., Charli,J.L., Joseph-Bravo,P. (2009). 17beta-oestradiol indirectly inhibits trh expression in the hypothalamic paraventricular nucleus of female rats and blunts thyroid axis response to cold exposure.
Journal of Neuroendocrinology,
21 (5),
439-448.
Artículo
62 - Cote-Velez,A., Perez-Martinez,L., Charli,J.L., Joseph-Bravo,P. (2008). The PKC and ERK/MAPK Pathways Regulate Glucocorticoid Action on TRH Transcription.
Neurochemical Research,
33 (8),
1582-1591.
Artículo
63 - Cruz,R., Vargas,M.A., Uribe,R.M., Pascual,I., Lazcano,I., Yiotakis,A., Matziari,M., Joseph-Bravo,P., Charli,J.L. (2008). Anterior pituitary pyroglutamyl peptidase II activity controls TRH-induced prolactin release.
Peptides,
29 (11),
1953-1964.
Revisión
64 - Gutierrez-Mariscal,M., de Gortari,P., Lopez-Rubalcava,C., Martinez,A., Joseph-Bravo,P. (2008). Analysis of the anxiolytic-like effect of TRH and the response of amygdalar TRHergic neurons in anxiety.
Psychoneuroendocrinology,
33 (2),
198-213.
Artículo
65 - Jaimes-Hoy,L., Joseph-Bravo,P., de Gortari,P. (2008). Differential response of TRHergic neurons of the hypothalamic paraventricular nucleus (PVN) in female animals submitted to food-restriction or dehydration-induced anorexia and cold exposure.
Hormones and Behavior,
53 (2),
366-377.
Revisión
66 - Aguilar-Valles,A., Sanchez,E., de Gortari,P., Garcia-Vazquez,A.I., Ramirez-Amaya,V., Bermudez-Rattoni,F., Joseph-Bravo,P. (2007). The expression of TRH, its receptors and degrading enzyme is differentially modulated in the rat limbic system during training in the Morris water maze.
Neurochemistry International,
50 (2),
404-417.
Artículo
67 - de Gortari,P., Vargas,M.A., Martinez,A., Garcia-Vazquez,A.I., Uribe,R.M., Chavez-Gutierrez,L., Magdaleno,V., Boileau,G., Charli,J.L., Joseph-Bravo,P. (2007). Stage-specific Modulation of Neprilysin and Aminopeptidase N in the Limbic System During Kindling Progression.
Journal of Molecular Neuroscience,
33 (3),
252-261.
Artículo
68 - Sanchez,E., Fekete,C., Lechan,R.M., Joseph-Bravo,P. (2007). Cocaine- and amphetamine-regulated transcript (CART) expression is differentially regulated in the hypothalamic paraventricular nucleus of lactating rats exposed to suckling or cold stimulation.
Brain Research,
1132 (1),
120-128.
Artículo
69 - Ubieta,R., Uribe,R.M., Gonzalez,J.A., Garcia-Vazquez,A., Perez-Monter,C., Perez-Martinez,L., Joseph-Bravo,P., Charli,J.L. (2007). BDNF up-regulates pre-pro-TRH mRNA expression in the fetal/neonatal paraventricular nucleus of the hypothalamus. Properties of the transduction pathway.
Brain Research,
1174,
28-38.
Artículo
70 - Chavez-Gutierrez,L., Matta-Camacho,E., Osuna,J., Horjales,E., Joseph-Bravo,P., Maigret,B., Charli,J.L. (2006). Homology modeling and site directed mutagenesis of pyroglutamyl peptidase II. Insights into omega versus aminopeptidase specificity in the M1 family.
Journal of Biological Chemistry,
281 (27),
18581-18590.
Artículo
71 - de Gortari,P., Uribe,R.M., Garcia-Vazquez,A., Aguilar-Valles,A., Martinez,A., Valdes,A., Charli,J.L., Fernandez-Guardiola,A., Joseph-Bravo,P. (2006). Amygdala kindling differentially regulates the expression of the elements involved in TRH transmission.
Neurochemistry International,
48 (1),
31-42.
Artículo
72 - Aguilar-Valles,A., Sanchez,E., de Gortari,P., Balderas,I., Ramirez-Amaya,V., Bermudez-Rattoni,F., Joseph-Bravo,P. (2005). Analysis of the Stress Response in Rats Trained in the Water-Maze: Differential Expression of Corticotropin-Releasing Hormone, CRH-R1, Glucocorticoid Receptors and Brain-Derived Neurotrophic Factor in Limbic Regions.
Neuroendocrinology,
82 (5-6),
306-319.
Artículo
73 - Chavez-Gutierrez,L., Bourdais,J., Aranda,G., Vargas,M.A., Matta-Camacho,E., Ducancel,F, Segovia,L., Joseph-Bravo,P., Charli,J.L. (2005). A truncated isoform of pyroglutamyl aminopeptidase II produced by exon extension has dominant-negative activity.
Journal of Neurochemistry,
92 (4),
807-817.
Artículo
74 - Cote-Velez,A., Perez-Martinez,L., Diaz-Gallardo,M.Y., Perez-Monter,C., Carreon,A., Charli,J.L., Joseph-Bravo,P. (2005). Dexamethasone repressed cAMP rapid upregulation of TRH gene transcription. Identification of a composite GRE and a CRE in TRH promoter.
Journal of Molecular Endocrinology,
34 (1),
177-197.
Artículo
75 - de Gortari,P., Romero,F., Cisneros,M., Joseph-Bravo,P. (2005). Acute administration of alcohol modulates pyroglutamyl amino peptidase II activity and mRNA levels in rat limbic regions.
Neurochemistry International,
46 (4),
347-356.
Artículo
76 - de Gortari,P., Cisneros,M., Joseph-Bravo,P. (2005). Chronic ethanol or glucose consumption alter TRH content and pyroglutamyl aminopeptidase II activity in rat limbic regions.
Regulatory Peptides,
127 (1-3),
141-150.
Artículo
77 - Cruz,R., Chavez-Gutierrez,L., Joseph-Bravo,P., Charli,J.L. (2004). 3,3',5'-Triiodo-L-Thyronine Reduces Efficiency of mRNA Knockdown by Antisense Oligodeoxynucleotides: A Study with Pyroglutamyl Aminopeptidase II in Adenohypophysis .
Oligonucleotides,
14 (3),
176-190.
Artículo
78 - Pascual,I., Cisneros,M., Lage,J., Diaz,J, Joseph-Bravo,P., Charli,J.L., Chavez,M.A. (2004). Isolation and purification of HcPI, a natural inhibitor of pyroglutamil aminopeptidase II (TRH-degrading ectoenzyme) from extracts of Hermodice carunculata (annelide: Polychaeta).
Revista Biologia,
18 (1),
38-49.
Artículo
79 - Pascual,I., Gil-Parrado,S., Cisneros,M., Joseph-Bravo,P., Diaz,J., Possani,L.D., Charli,J.L., Chavez,M. (2004). Purification of a specific inhibitor of pyroglutamyl aminopeptidase II from the marine annelide Hermodice carunculata. In vivo effects in rodent brain.
International Journal of Biochemistry and Cell Biology,
36 (1),
138-152.
Artículo
80 - de Gortari,P., Cisneros,M., Medellin,M.A., Joseph-Bravo,P. (2002). Chronic ingestion of ethanol or glucose solutions affects hypothalamic and limbic TRH metabolism in dams and their pups.
Neurochemistry International,
41 (4),
237-249.
Artículo
81 - Joseph-Bravo,P., Perez-Martinez,L., Lezama,L., Morales-Chapa,C., Charli,J.L. (2002). An improved method for the expression of TRH in serum-supplemented primary cultures of fetal hypothalamic cells.
Brain Research Protocols,
9 (2),
93-104.
Artículo
82 - Vargas,M.A., Uribe,R.M., Cisneros,M., Romero,F., Gonzalez,S., Joseph-Bravo,P., Charli,J.L. (2002). Thyrotropin-releasing hormone regulates the diurnal variation of pyroglutamyl aminopeptidase II activity in the male rat adenohypophysis.
European Journal of Endocrinology,
147 (3),
363-369.
Artículo
83 - Vargas,M.A., Cisneros,M., Joseph-Bravo,P., Charli,J.L. (2002). Thyrotropin-releasing hormone-induced down-regulation of pyroglutamyl aminopeptidase II activity involves L-type calcium channels and cam kinase activities in cultures of adenohypophyseal cells.
Journal of Neuroendocrinology,
14 (3),
184-193.
Artículo
84 - Baeza,M.A., Ponce,G., Joseph-Bravo,P., Charli,J.L. (2001). Rapid down regulation of pyroglutamyl peptidase II activity by arachidonic acid in primary cultures of adenohypophyseal cells.
Life Sciences,
68 (17),
2051-2060.
Artículo
85 - Guerra-Crespo,M., Ubieta,R., Joseph-Bravo,P., Charli,J.L., Perez-Martinez,L. (2001). BDNF increases the early expression of TRH mRNA in fetal TrkB+ hypothalamic neurons in primary culture.
European Journal of Neuroscience,
14 (3),
483-494.
Artículo
86 - Perez-Martinez,L., Charli,J., Joseph-Bravo,P. (2001). Development of pro-TRH gene expression in primary cultures of fetal hypothalamic cells.
Developmental Brain Research,
130 (1),
73-81.
Artículo
87 - Sanchez,E., Uribe,R.M., Corkidi,G., Zoeller,R.T., Cisneros,M., Zacarias,M., Morales-Chapa,C., Charli,J.L., Joseph-Bravo,P. (2001). Differential Responses of Thyrotropin-Releasing Hormone (TRH) Neurons to Cold Exposure or Suckling Indicate Functional Heterogeneity of the TRH System in the Paraventricular Nucleus of the Rat Hypothalamus.
Neuroendocrinology,
74 (6),
407-422.
Artículo
88 - Bourdais,J., Romero,F., Uriostegui,B., Cisneros,M., Joseph-Bravo,P., Charli,J.L. (2000). [3-Me-His(2)]-TRH combined with dopamine withdrawal rapidly and transiently increases pyroglutamyl aminopeptidase II activity in primary cultures of adenohypophyseal cells.
Neuropeptides,
34 (2),
83-88.
Artículo
89 - de Gortari,P., Gonzalez-Alzati,M.E., Cisneros,M., Joseph-Bravo,P. (2000). Effect of fasting on the content of thyrotropin-releasing hormone and its mRNA in the central nervous system and pyroglutamyl peptidase II activity in the anterior pituitary of post-weaned and adult rats.
Nutritional Neuroscience,
3 (4),
255-265.
Revisión
90 - de Gortari,P., Mendez,M., Rodriguez-Keller,I., Perez-Martinez,L., Joseph-Bravob,P. (2000). Acute ethanol administration induces changes in TRH and proenkephalin expression in hypothalamic and limbic regions of rat brain.
Neurochemistry International,
37 (5-6),
483-496.
Artículo
91 - Niquet,J., Perez-Martinez,L., Guerra,M., Grouselle,D., Joseph-Bravo,P., Charli,J. (2000). Extracellular matrix proteins increase the expression of pro-TRH and pro-protein convertase PC1 in fetal hypothalamic neurons in vitro.
Developmental Brain Research,
120 (1),
49-56.
Artículo
92 - Vargas,M.A., Cisneros,M., Joseph-Bravo,P., Charli,J.L. (2000). Regulation of adenohypophyseal pyroglutamyl aminopeptidase II activity by thyrotropin-releasing hormone and phorbol esters.
Endocrine,
13 (3),
267-272.
Artículo
93 - Mendez,M., Cisneros,M., Baez,A., Joseph-Bravo,P., Charli,J.L. (1999). Three TRH-like molecules are released from rat hypothalamus in vitro.
Neurochemical Research,
24 (7),
815-823.
Artículo
94 - Perez-Martinez,L., Uribe,R.M., Sanchez,E., Carreon-Rodriguez,A., Chavez,L., Zacarias,M., Joseph-Bravo,P., Charli,J.L. (1999). Regulation of TRH biosynthesis in the paraventricular nucleus of rodent hypothalamus.
Current topics in neurochemistry,
2,
79-88.
Artículo; Actas Paper
95 - Charli,J.L., Vargas,M.A., Cisneros,M., de Gortari,P., Baeza,M.A., Jasso,P., Bourdais,J., Perez,L., Uribe,R.M., Joseph-Bravo,P. (1998). TRH inactivation in the extracellular compartment: role of pyroglutamyl peptidase II.
Neurobiology (Bp.),
6 (1),
45-57.
Artículo
96 - de Gortari,P., Joseph-Bravo,P., Monroy-Ruiz,J., Martinez,A., Cisneros,M., Fernandez-Guardiola,A. (1998). Brain thyrotropin-releasing hormone content varies through amygdaloid kindling development according to afterdischarge frequency and propagation.
Epilepsia,
39 (8),
897-903.
Revisión
97 - Joseph-Bravo,P., Uribe,R.M., Vargas,M.A., Perez-Martinez,L., Zoeller,T., Charli,J.L. (1998). Multifactorial modulation of TRH metabolism.
Cellular & Molecular Neurobiology,
18 (2),
231-247.
Artículo
98 - Perez-Martinez,L., Carreon-Rodriguez,A., Gonzalez-Alzati,M.E., Morales,C., Charli,J.L., Joseph-Bravo,P. (1998). Dexamethasone rapidly regulates TRH mRNA levels in hypothalamic cell cultures: interaction with the cAMP pathway.
Neuroendocrinology,
68 (5),
345-354.
Artículo
99 - Vargas,M.A., Bourdais,J., Sanchez,S., Uriostegui,B., Moreno,E., Joseph-Bravo,P., Charli,J.L. (1998). Multiple hypothalamic factors regulate pyroglutamyl peptidase II in cultures of adenohypophyseal cells: role of the cAMP pathway.
Journal of Neuroendocrinology,
10 (3),
199-206.
Artículo
100 - Sanchez,E., Charli,J.L., Morales,C., Corkidi,G., Seidah,N.G., Joseph-Bravo,P., Uribe,R.M. (1997). Expression of the proprotein convertases PC1 and PC2 mRNAs in thyrotropin releasing hormone neurons of the rat paraventricular nucleus of hypothalamus.
Brain Research,
761 (1),
77-86.
Artículo
101 - de Gortari,P., Fernandez-Guardiola,A., Martinez,A., Cisneros,M., Joseph-Bravo,P. (1995). Changes in TRH and its degrading enzyme pyroglutamyl peptidase II, during the development of amygdaloid kindling.
Brain Research,
679 (1),
144-150.
Artículo
102 - Uribe,R.M., Joseph-Bravo,P., Charli,J.L. (1995). Pups removal enhances thyrotropin-releasing hormone mRNA in the hypothalamic paraventricular nucleus.
European Journal of Endocrinology,
133 (3),
354-360.
Artículo
103 - Uribe,R.M., Perez-Martinez,L., Covarrubias,M.D., Gomez,O., Covarrubias,L., Charli,J.L., Joseph-Bravo,P. (1995). Phorbol ester or cAMP enhance thyrotropin-releasing hormone mRNA in primary cultures of hypothalamic cells.
Neuroscience Letters,
201 (1),
41-44.
Artículo
104 - Covarrubias,L., Redondo,J.L., Vargas,M.A., Uribe,R.M., Mendez,M., Joseph-Bravo,P., Charli,J.L. (1994). In vitro TRH release from hypothalamus slices varies during the diurnal cycle.
Neurochemical Research,
19 (7),
845-850.
Carta
Artículo
106 - Joseph-Bravo,P., Fresan,M., Cisneros,M., Vargas,M.A., Charli,J.L. (1994). Pyroglutamyl peptidase II activity is not in the processes of bulbospinal TRHergic neurons.
Neuroscience Letters,
178 (2),
243-246.
Artículo
107 - Uribe,R.M., Joseph-Bravo,P., Ponce,G., Cisneros,M., Aceves,C., Charli,J.L. (1994). Influence of thyroid status on TRH metabolism in rat olfactory bulb.
Peptides,
15 (3),
435-439.
Artículo
108 - Vargas,M.A., Joseph-Bravo,P., Charli,J.L. (1994). Thyrotropin-releasing hormone downregulates pyroglutamyl peptidase II activity in adenohypophyseal cells.
Neuroendocrinology,
60 (3),
323-330.
Artículo
109 - Brakch,N., Boileau,G., Simonetti,M., Nault,C., Joseph-Bravo,P., Rholam,M., Cohen,P. (1993). Prosomatostatin processing in Neuro2A cells. Role of beta-turn structure in the vicinity of the Arg-Lys cleavage site.
European Journal of Biochemistry,
216 (1),
39-47.
*
Artículo
110 - Uribe,R.M., Redondo,J.L., Charli,J.L., Joseph-Bravo,P. (1993). Suckling and cold stress rapidly and transiently increase TRH mRNA in the paraventricular nucleus.
Neuroendocrinology,
58 (1),
140-145.
Artículo
111 - Vargas,M.A., Cisneros,M., Herrera,J., Joseph-Bravo,P., Charli,J.L. (1992). Regional distribution of pyroglutamyl peptidase II in rabbit brain, spinal cord, and organs.
Peptides,
13 (2),
255-260.
Artículo
112 - Cruz,C., Charli,J.L., Vargas,M.A., Joseph-Bravo,P. (1991). Neuronal localization of pyroglutamate aminopeptidase II in primary cultures of fetal mouse brain.
Journal of Neurochemistry,
56 (5),
1594-1601.
Artículo
113 - Lepage-Lezin,A., Joseph-Bravo,P., Devilliers,G., Benedetti,L., Launay,J.M., Gomez,S., Cohen,P. (1991). Prosomatostatin is processed in the Golgi apparatus of rat neural cells.
Journal of Biological Chemistry,
266 (3),
1679-1688.
*
Artículo
114 - Uribe,R.M., Joseph-Bravo,P., Pasten,J., Ponce,G., Mendez,M., Covarrubias,L., Charli,J.L. (1991). Some events of thyrotropin-releasing hormone metabolism are regulated in lactating and cycling rats.
Neuroendocrinology,
54 (5),
493-498.
Artículo
115 - Mendez,M., Cruz,C., Joseph-Bravo,P., Wilk,S., Charli,J.L. (1990). Evaluation of the role of prolyl endopeptidase and pyroglutamyl peptidase I in the metabolism of LHRH and TRH in brain.
Neuropeptides,
17 (2),
55-62.
Artículo
116 - Charli,J.L., Mendez,M., Vargas,M.A., Cisneros,M., Assai,M., Joseph-Bravo,P., Wilk,S. (1989). Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices.
Neuropeptides,
14 (3),
191-196.
Artículo
117 - Charli,J.L., Cruz,C., Ponce,G., Vargas,M.A., Mendez,M., Cisneros,M., Pasten,J., Joseph-Bravo,P. (1989). Physiological relevance of pyroglutamate aminopeptidase II.
Annals of the New York Academy of Sciences,
553,
563-564.
Artículo
118 - Covarrubias,L., Uribe,R.M., Mendez,M., Charli,J.L., Joseph-Bravo,P. (1989). Hypothalamic TRH mRNA regulation under different physiological conditions.
Annals of the New York Academy of Sciences,
553,
476-478.
Artículo
119 - Charli,J.L., Cruz,C., Vargas,M., Joseph-Bravo,P. (1988). The narrow specificity pyroglutamate aminopeptidase degrading TRH in brain is an ectoenzyme.
Neurochemistry International,
13,
237-242.
Artículo
120 - Covarrubias,L., Uribe,R.M., Mendez,M., Charli,J.L., Joseph-Bravo,P. (1988). Neuronal TRH synthesis: developmental and circadian TRH mRNA levels.
Biochemical and Biophysical Research Communications,
151 (1),
615-622.
Artículo
121 - Charli,J.L., Mendez,M., Joseph-Bravo,P., Wilk,S. (1987). Specific inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase do not change the in vitro release of TRH or its content in rodent brain.
Neuropeptides,
9 (4),
373-378.
Artículo
122 - Mendez,M., Joseph-Bravo,P., Cisneros,M., Vargas,M.A., Charli,J.L. (1987). Regional distribution of in vitro release of thyrotropin releasing hormone in rat brain.
Peptides,
8 (2),
291-298.
Artículo
123 - Saavedra,R., Bravo,P.J., Charli,J.L., Herion,P. (1987). Characterization of high affinity monoclonal antibodies against the luteinizing hormone-releasing hormone.
Hybridoma,
6 (6),
663-672.
Artículo
124 - Vargas,M., Mendez,M., Cisneros,M., Joseph-Bravo,P., Charli,J.L. (1987). Regional distribution of the membrane-bound pyroglutamate amino peptidase-degrading thyrotropin-releasing hormone in rat brain.
Neuroscience Letters,
79 (3),
311-314.
Artículo
125 - Cohen,S., Charli,J.L., Diaz de Leon,L., Millar,R.P., Arimura,A., Morrison,M.R., Joseph-Bravo,P. (1986). Attempts to immunoprecipitate the LHRH precursor synthesized in cell free systems.
Brain Research Bulletin,
16 (3),
309-314.
Artículo
126 - Torres,H., Charli,J.L., Vargas,M.A., Gonzalez-Noriega,A., Joseph-Bravo,P. (1986). Subcellular distribution of the enzymes degrading Thyrotropin releasing hormone and metabolites in rat brain.
Neurochemistry International,
9,
103-110.
Artículo
127 - Garat,B., Miranda,J., Charli,J.L., Joseph-Bravo,P. (1985). Presence of a membrane bound pyroglutamyl amino peptidase degrading thyrotropin releasing hormone in rat brain.
Neuropeptides,
6 (1),
27-40.
Artículo
128 - Charli,J.L., Ponce,G., McKelvy,J.F., Joseph-Bravo,P. (1984). Accumulation of thyrotropin releasing hormone by rat hypothalamic slices.
Journal of Neurochemistry,
42 (4),
981-986.
Artículo
129 - Pacheco,M.F., McKelvy,J.F., Woodward,D.J., Loudes,C., Joseph-Bravo,P., Krulich,L., Griffin,W.S. (1981). TRH in the rat cerebellum: I. Distribution and concentration.
Peptides,
2 (3),
277-282.
*
Artículo
130 - Joseph-Bravo,P., Charli,J.L., Sherman,T., Boyer,H., Bolivar,F., McKelvy,J.F. (1980). Identification of a putative hypothalamic mRNA coding for somatostatin and of its product in cell-free translation.
Biochemical and Biophysical Research Communications,
94 (3),
1004-1012.
*
Artículo
131 - Joseph-Bravo,P., Loudes,C., Charli,J.L., Kordon,C. (1979). Subcellular distribution of brain peptidases degrading luteinizing hormone releasing hormone (LHRH) and thyrotropin releasing hormone (TRH).
Brain Research,
166 (2),
321-329.
*
Artículo
132 - Joseph-Bravo,P., Charli,J.L., Palacios,J.M., Kordon,C. (1979). Effect of neurotransmitters on the in vitro release of immunoreactive thyrotropin-releasing hormone from rat mediobasal hypothalamus.
Endocrinology,
104 (3),
801-806.
*
Artículo
133 - Lin,C., Joseph-Bravo,P., Sherman,T., Chan,L., McKelvy,J.F. (1979). Cell-free synthesis of putative neurophysin precursors from rat and mouse hypothalamic poly (A)-RNA.
Biochemical and Biophysical Research Communications,
89 (3),
943-950.
*
Artículo
134 - Loudes,C., Joseph-Bravo,P., Leblanc,P., Kordon,C. (1978). Specific activity of LHRH and TRH degrading enzymes in various tissues of normal and castrated male rats.
Biochemical and Biophysical Research Communications,
83 (3),
921-926.
*
Artículo
135 - Joseph-Bravo,P.I., Findley,M., Newberne,P.M. (1976). Some interactions of light, riboflavin, and aflatoxin B1 in vivo and in vitro.
Journal of Toxicology and Environmental Health,
1 (3),
353-376.
*
Internacional
136 - Joseph-Bravo, P., Gutierrez-Mariscal, M., Jaimes-Hoy, L., Charli, J. L. (2019). Thyroid Axis and Energy Balance: Focus on Animals and Implications for Humankind. Handbook of Famine, Starvation, and Nutrient Deprivation: From Biology to Policy.
1099-1126,
Cham, Suiza: Springer.
Nacional
137 - de Gortari,P., Joseph-Bravo,P. (2010). Regulacion neuroendocrina del apetito. Obesidad. Un enfoque multidisciplinario .
57-71,
Pachuca.
Nacional
138 - Charli,J.L., Joseph-Bravo,P. (2008). El cerebro, la comunicación intercelular y los p?ptidos. Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 5.
53-64,
Mexico, D.F..
Nacional
139 - Joseph-Bravo,P., de Gortari,P. (2008). El estrés y sus efectos en el metabolismo y el aprendizaje. Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 6.
65-76,
Mexico, D.F..
Memoria in extenso
140 - Joseph-Bravo,P., Mariscal,M., Garcia,I., Jaimes-Hoy,L., Charli,J.L., de Gortari,P. (2007). Response of limbic TRH neurons depends on the stress paradigm. Endocrine Regulations. Int. Congress of Stress.
96-.
Internacional
141 - de Gortari,P., Joseph,P. (2006). Neuroendocrine Regulation of Energy Metabolism. Molecular Endocrinology.
65-86,
Kerala, India: Research Signpost.
Internacional
142 - Joseph-Bravo,P., Cote-Velez,A., Perez-Martinez,L. (2006). Integration of Neuroendocrine Signals that Regulate the Activity of Hypophysiotropic Peptides. Molecular Endocrinology.
1-24,
Kerala, India: Research Signpost.
Nacional
143 - Joseph-Bravo,P. (1995). Choques, transtornos y otras caídas. Stress, dolor y p?ptidos. Memoria del Curso Explorando el Cerebro.
35-37,
Mexico,D.F..
Memoria in extenso
144 - Charli,J.L., Garat,B., Martinez-Escalera,G., Ponce,G., Miranda,J., Joseph-Bravo,P. (1984). METABOLISM OF THYROTROPIN RELEASING HORMONE AND ITS POSSIBLE RELEVANCE TO PROLACTIN SECRETION. Prolactin Secretion: a Multidisciplinary Approach.
239-248,
Orlando: Academic Press.
Memoria in extenso
145 - Kordon,C., Enjalbert,A., Hery,M., Joseph-Bravo,P., Rotsztjen,W., Ruberg.M. (1979). Role of neurotransmitters in the control of adenohypophyseal secretion. Handbook of the hypothalamus.
253-306,
2,
New York.
*
Internacional
Nacional
147 - Carreon-Rodriguez,A., Perez-Martinez,L., Joseph-Bravo,P. (2008). La participación de las hormonas tiroideas en el desarrollo y función del sistema nervioso.
Facultad de Medicina. Revista Actualidades de Posgrado para el Médico General,
12 (5),
9-12.
Editorial Material
148 - Joseph-Bravo,P. (2004). Hypophysiotropic thyrotropin-releasing hormone neurons as transducers of energy homeostasis.
Endocrinology,
145 (11),
4813-4815.
Note
149 - Charli,J.L., Cruz,C., Redondo,J.L., Guerra,C., Joseph-Bravo,P. (1995). Homologous conditioned medium enhances expression of TRH in hypothalamic neurons in primary culture.
Developmental Brain Research,
89 (1),
155-160.
Note
150 - Mendez,M., Moran,J., Wilk,S., Joseph-Bravo,P., Charli,J.L. (1993). Assessment of the role of TRH in the release of [3H]-dopamine from rat nucleus accumbens-lateral septum slices.
Brain Research Bulletin,
31 (5),
621-625.
Note
151 - Vargas,M.A., Herrera,J., Uribe,R.M., Charli,J.L., Joseph-Bravo,P. (1992). Ontogenesis of pyroglutamyl peptidase II activity in rat brain, adenohypophysis and pancreas.
Developmental Brain Research,
66 (2),
251-256.
Note
152 - Fuchs,L.Y., Ovando,C., Joseph,P., Soberon,X., Charli,J.L. (1990). Repetitive DNA sequence from the crayfish Procambarus clarkii.
Nucleic Acids Research,
18 (6),
1650.
Note
153 - Ponce,G., Charli,J.L., Pasten,J.A., Aceves,C., Joseph-Bravo,P. (1988). Tissue-specific regulation of pyroglutamate aminopeptidase II activity by thyroid hormones.
Neuroendocrinology,
48 (2),
211-213.
Nacional
154 - Charli,J.L., Ponce,G., Torres,H., Garat,B., Barquin,N., Bravo,P.J. (1983). [Cellular biochemistry of hypophysiotropic peptides. II. Liberation, action and inactivation].
Boletin de estudios medicos y biologicos,
32 (7-8 Suppl 1),
243-252.
Nacional
155 - Joseph-Bravo,P., Theleen,M., de Gortari,P., Shapiro,E., Redondo,J.L., Briones,M., Merchant,H., Charli,J.L. (1983). [Biochemistry of hypophysiotropic peptides. I. Biosynthesis and its regulation].
Boletin de estudios medicos y biologicos,
32 (7-8 Suppl 1),
233-241.
Nacional
156 - Charli,J.L., Joseph-Bravo,P., Robert,M. (1980). Use of synthetic oligonucleotides for identification of messenger RNA for somatostatin.
Boletin de estudios medicos y biologicos,
31 (3-4),
220-221.
*
Note
157 - Charli,J.L., Joseph-Bravo,P., Palacios,J.M., Kordon,C. (1978). Histamine-induced release of thyrotropin releasing hormone from hypothalamic slices.
European Journal of Pharmacology,
52 (3-4),
401-403.
*
158 - Joseph-Bravo, Patricia (1972). Efecto de la melatonina sobre el metabolismo de aminas biogenicas en sistema nervioso central .
Facultad de Quimica,
Quimico,
UNAM.
Artículo
159 - Castillo-Campos,A., Gutierrez-Mata,A., Charli,J.L., Joseph-Bravo,P.. Chronic stress inhibits hypothalamus-pituitary-thyroid axis and brown adipose tissue responses to acute cold exposure in male rats.
Journal of Endocrinological Investigation,
44,
713.
Artículo
160 - Jaimes-Hoy,L., Perez-Maldonado,A., Narvaez-Bahena,E., de la Cruz Guarneros,N., Rodriguez-Rodriguez,A., Charli,J.L., Soberon,X., Joseph-Bravo,P.. Sex dimorphic changes in Trh gene methylation and thyroid-axis response to energy demands in maternally-separated rats.
Endocrinology,
May 27 Online ahead of print [comentario vol 162 (9) pp 1-2].
Revisión
161 - Lazcano,I., Rodriguez-Rodriguez,A., Uribe,R.M., Orozco,A., Joseph-Bravo,P., Charli,J.L.. Evolution of thyrotropin-releasing factor extracellular communication units.
General and Comparative Endocrinology,
305,
113642.
Revisión
162 - Charli,J.L., Rodriguez-Rodriguez,A., Hernandez-Ortega,K., Cote-Velez,A., Uribe,R.M., Jaimes-Hoy,L., Joseph-Bravo,P.. The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target?.
Frontiers in Pharmacology,
11,
640.
Artículo
163 - Farkas,E., Varga,E., Kovacs,B., Szilvasy-Szabo,A., Cote-Velez,A., Peterfi,Z., Matziari,M., Toth,M., Zelena,D., Mezriczky,Z., Kadar,A., Kovari,D., Watanabe,M., Kano,M., Mackie,K., Rozsa,B., Ruska,Y., Toth,B., Mate,Z., Erdelyi,F., Szabo,G., Gereben,B., Lechan,R.M., Charli,J.L., Joseph-Bravo,P., Fekete,C.. A glial-neuronal circuit in the median eminence regulates thyrotropin-releasing hormone-release via the endocannabinoid system.
iScience,
23 (3),
100921.
Artículo
164 - Joseph-Bravo,P., Lazcano,I., Jaimes-Hoy,L., Gutierrez-Mariscal,M., Sanchez-Jaramillo,E., Uribe,R.M., Charli,J.L.. Sexually dimorphic dynamics of thyroid axis activity during fasting in rats.
Frontiers in Bioscience, Landmark,
25 (7),
1305-1323.
Artículo
165 - Jaimes-Hoy,L., Romero,F., Charli,J.L., Joseph-Bravo,P.. Sex Dimorphic Responses of the Hypothalamus-Pituitary-Thyroid Axis to Maternal Separation and Palatable Diet.
Frontiers in Endocrinology,
10,
445.
Artículo
166 - Parra-Montes de Oca, M. A., Gutierrez-Mariscal, M., Salmeron-Jimenez, M. F., Jaimes-Hoy, L., Charli, J. L., Joseph-Bravo, P.. Voluntary Exercise-Induced Activation of Thyroid Axis and Reduction of White Fat Depots Is Attenuated by Chronic Stress in a Sex Dimorphic Pattern in Adult Rats.
Frontiers in Endocrinology,
10,
418.
Revisión
167 - Rodriguez-Rodriguez, A., Lazcano, I., Sanchez-Jaramillo, E., Uribe, R. M., Jaimes-Hoy, L., Joseph-Bravo, P., Charli, J. L.. Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries.
Frontiers in Endocrinology,
10,
401.
Internacional
168 - Joseph-Bravo, P., Gutierrez-Mariscal, M., Jaimes-Hoy, L., Charli, J. L.. Thyroid Axis and Energy Balance: Focus on Animals and Implications for Humankind. Handbook of Famine, Starvation, and Nutrient Deprivation: From Biology to Policy.
1099-1126,
Cham, Suiza: Springer.
Artículo
169 - Cote-Velez, A., Martinez-Baez A., Lezama, L., Uribe, R.M., Joseph-Bravo, P., Charli, J.L.. A screen for modulators reveals that orexin-A rapidly stimulates thyrotropin releasing hormone expression and release in hypothalamic cell culture.
Neuropeptides,
62,
11-20.
Artículo
170 - Gonzalez-Franco, D.A., Ramirez-Amaya, V., Joseph-Bravo, P., Prado-Alcala, R.A., Quirarte, G.L.. Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance training.
Neurobiology of Learning and Memory,
140,
17-26.
Artículo
171 - Jaimes-Hoy, L., Gurrola, G.B., Cisneros, M., Joseph-Bravo, P., Possani, L.D., Charli, J.L.. The Kv1.3 channel blocker Vm24 enhances muscle glucose transporter 4 mobilization but does not reduce body-weight gain in diet-induced obese male rats.
Life Sciences,
181,
23-30.
Artículo
Artículo
173 - Jaimes-Hoy,L., Gutierrez-Mariscal,M., Vargas,Y., Perez-Maldonado,A., Romero,F., Sanchez-Jaramillo,E., Charli,J.L., Joseph-Bravo,P.. Neonatal maternal separation alters, in a sex specific manner, the expression of TRH, of TRH-degrading ectoenzyme in the rat hypothalamus, and the response of the thyroid axis to starvation.
Endocrinology,
157 (8),
3253-3265.
Revisión
174 - Joseph-Bravo,P., Jaimes-Hoy,L., Charli,J.L.. Advances in TRH signaling.
Reviews in Endocrine and Metabolic Disorders,
17 (4),
545-558.
Revisión
175 - Joseph-Bravo,P., Jaimes-Hoy,L., Charli,J.. Regulation of TRH neurons and energy homeostasis related signals under stress.
Journal of Endocrinology,
224 (3),
R139-R159 [erratum en vol 227 (3) X1].
Revisión
176 - Joseph-Bravo,P., Jaimes-Hoy,L., Uribe,R.M., Charli,J.L.. TRH, first hypophysiotropic releasing hormone isolated: its control of pituitary-thyroid axis.
Journal of Endocrinology,
226 (2),
T85-T100 [erratum en vol 227 (3) X3].
Artículo
177 - Lazcano,I., Cabral,A., Uribe,R.M., Jaimes-Hoy,L., Perello,M., Joseph-Bravo,P., Sanchez-Jaramillo,E., Charli,J.L.. Fasting enhances pyroglutamyl peptidase II activity in tanycytes of the mediobasal hypothalamus of male adult rats.
Endocrinology,
156 (7),
2713-2723.
Artículo
178 - Rodriguez-Molina,V., Patino,J., Vargas,Y., Sanchez-Jaramillo,E., Joseph-Bravo,P., Charli,J.L.. TRH regulates action potential shape in cerebral cortex pyramidal neurons.
Brain Research,
1571,
1-11.
Artículo
179 - Sotelo-Rivera,I., Jaimes-Hoy,L., Cote-Velez,A., Espinoza-Ayala,C., Charli,J.L., Joseph-Bravo,P.. An acute injection of corticosterone increases thyrotrophin releasing hormone expression in the paraventricular nucleus of the hypothalamus but interferes with the rapid hypothalamus pituitary thyroid axis response to cold in male rats.
Journal of Neuroendocrinology,
26 (12),
861-869.
Artículo
180 - Uribe,R.M., Jaimes-Hoy,L., Ramirez-Martinez,C., Garcia-Vazquez,A., Romero,F., Cisneros,M., Cote-Velez,A., Charli,J.L., Joseph-Bravo,P.. Voluntary exercise adapts the hypothalamus-pituitary-thyroid axis in male rats.
Endocrinology,
155 (5),
en20131724.
Artículo
181 - Gutierrez-Mariscal,M., Sanchez,E., Rebolledo-Solleiro,D., Garcia-Vazquez,A.I., Cote-Velez,A., Acasuso-Rivero,C., Charli,J.L., Joseph-Bravo,P.. The acute response of the amygdalar TRH system to psychogenic stressors varies dependent on the paradigm and circadian condition.
Brain Research,
1452,
73-84.
Artículo
182 - Gutierrez-Mariscal,M., Sanchez,E., Garcia-Vazquez,A., Rebolledo-Solleiro,D., Charli,J.L., Joseph-Bravo,P.. Acute response of hypophysiotropic thyrotropin releasing hormone neurons and thyrotropin release to behavioural paradigms producing varying intensities of stress and physical activity.
Regulatory Peptides,
179 (1-3),
61-70.
Artículo
183 - Lazcano,I., Uribe,R.M., Martinez-Chavez,Erick, Vargas,M.A., Matziari,M., Joseph-Bravo,P., Charli,J.L.. Pyroglutamyl peptidase II inhibition enhances the analeptic effect of thyrotropin releasing hormone in the rat medial septum.
Journal of Pharmacology and Experimental Therapeutics,
342 (1),
222-231.
Artículo
184 - Cote-Velez,A., Perez-Maldonado,A., Osuna,J., Barrera,B., Charli,J.L., Joseph-Bravo,P.. Creb and Sp/Kruppel response elements cooperate to control rat TRH gene transcription in response to cAMP.
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms,
1809 (3),
191-199.
Artículo
185 - Guerra-Crespo,M., Perez-Monter,C., Janga,S.C., Castillo-Ramirez,S., Gutierrez-Rios,R.M., Joseph-Bravo,P., Perez-Martinez,L., Charli,J.L.. Transcriptional profiling of fetal hypothalamic TRH neurons.
BMC Genomics,
12 (1),
222.
Artículo
186 - Uribe,R.M., Cisneros,M., Vargas,M.A., Lezama,L., Cote-Velez,A., Joseph-Bravo,P., Charli,J.L.. The systemic inhibition of nitric oxide production rapidly regulates TRH mRNA concentration in the paraventricular nucleus of the hypothalamus and serum TSH concentration. Studies in control and cold-stressed rats.
Brain Research,
1367,
188-197.
Artículo
187 - Diaz-Gallardo,M.Y., Cote-Velez,A., Charli,J.L., Joseph-Bravo,P.. A rapid interference between glucocorticoids and cAMP-activated signaling in hypothalamic neurons prevents binding of pCREB and GR at the CRE-like and composite GRE sites of TRH gene promoter.
Journal of Neuroendocrinology,
22 (4),
282-293.
Artículo; Actas Paper
188 - Diaz-Gallardo,M.Y., Cote-Velez,A., Carreon-Rodriguez,A., Charli,J.L., Joseph-Bravo,P.. Phosphorylated Cyclic-AMP-Response Element-Binding Protein and Thyroid Hormone Receptor Have Independent Response Elements in the Rat Thyrotropin-Releasing Hormone Promoter: An Analysis in Hypothalamic Cells.
Neuroendocrinology,
91 (1),
64-76.
Nacional
189 - de Gortari,P., Joseph-Bravo,P.. Regulacion neuroendocrina del apetito. Obesidad. Un enfoque multidisciplinario .
57-71,
Pachuca.
Artículo
190 - de Gortari,P., Mancera,K., Cote-Velez,A., Amaya,M.I., Martinez,A., Jaimes-Hoy,L., Joseph-Bravo,P.. Involvement of CRH-R2 receptor in eating behavior and in the response of the HPT axis in rats subjected to dehydration-induced anorexia.
Psychoneuroendocrinology,
34 (2),
259-272.
Artículo
191 - Rodriguez-Molina,V., Vargas,M.A., Joseph-Bravo,P., Charli,J.L.. NMDA receptor up-regulates pyroglutamyl peptidase II activity in the rat hippocampus.
Neuroscience Letters,
449 (3),
211-214.
Artículo
192 - Uribe,R.M., Zacarias,M., Corkidi,G., Cisneros,M., Charli,J.L., Joseph-Bravo,P.. 17beta-oestradiol indirectly inhibits trh expression in the hypothalamic paraventricular nucleus of female rats and blunts thyroid axis response to cold exposure.
Journal of Neuroendocrinology,
21 (5),
439-448.
Artículo
193 - Cote-Velez,A., Perez-Martinez,L., Charli,J.L., Joseph-Bravo,P.. The PKC and ERK/MAPK Pathways Regulate Glucocorticoid Action on TRH Transcription.
Neurochemical Research,
33 (8),
1582-1591.
Artículo
194 - Cruz,R., Vargas,M.A., Uribe,R.M., Pascual,I., Lazcano,I., Yiotakis,A., Matziari,M., Joseph-Bravo,P., Charli,J.L.. Anterior pituitary pyroglutamyl peptidase II activity controls TRH-induced prolactin release.
Peptides,
29 (11),
1953-1964.
Revisión
195 - Gutierrez-Mariscal,M., de Gortari,P., Lopez-Rubalcava,C., Martinez,A., Joseph-Bravo,P.. Analysis of the anxiolytic-like effect of TRH and the response of amygdalar TRHergic neurons in anxiety.
Psychoneuroendocrinology,
33 (2),
198-213.
Artículo
196 - Jaimes-Hoy,L., Joseph-Bravo,P., de Gortari,P.. Differential response of TRHergic neurons of the hypothalamic paraventricular nucleus (PVN) in female animals submitted to food-restriction or dehydration-induced anorexia and cold exposure.
Hormones and Behavior,
53 (2),
366-377.
Nacional
197 - Charli,J.L., Joseph-Bravo,P.. El cerebro, la comunicación intercelular y los p?ptidos. Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 5.
53-64,
Mexico, D.F..
Nacional
198 - Joseph-Bravo,P., de Gortari,P.. El estrés y sus efectos en el metabolismo y el aprendizaje. Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 6.
65-76,
Mexico, D.F..
Nacional
199 - Carreon-Rodriguez,A., Perez-Martinez,L., Joseph-Bravo,P.. La participación de las hormonas tiroideas en el desarrollo y función del sistema nervioso.
Facultad de Medicina. Revista Actualidades de Posgrado para el Médico General,
12 (5),
9-12.
Revisión
200 - Aguilar-Valles,A., Sanchez,E., de Gortari,P., Garcia-Vazquez,A.I., Ramirez-Amaya,V., Bermudez-Rattoni,F., Joseph-Bravo,P.. The expression of TRH, its receptors and degrading enzyme is differentially modulated in the rat limbic system during training in the Morris water maze.
Neurochemistry International,
50 (2),
404-417.
Artículo
201 - de Gortari,P., Vargas,M.A., Martinez,A., Garcia-Vazquez,A.I., Uribe,R.M., Chavez-Gutierrez,L., Magdaleno,V., Boileau,G., Charli,J.L., Joseph-Bravo,P.. Stage-specific Modulation of Neprilysin and Aminopeptidase N in the Limbic System During Kindling Progression.
Journal of Molecular Neuroscience,
33 (3),
252-261.
Artículo
202 - Sanchez,E., Fekete,C., Lechan,R.M., Joseph-Bravo,P.. Cocaine- and amphetamine-regulated transcript (CART) expression is differentially regulated in the hypothalamic paraventricular nucleus of lactating rats exposed to suckling or cold stimulation.
Brain Research,
1132 (1),
120-128.
Artículo
203 - Ubieta,R., Uribe,R.M., Gonzalez,J.A., Garcia-Vazquez,A., Perez-Monter,C., Perez-Martinez,L., Joseph-Bravo,P., Charli,J.L.. BDNF up-regulates pre-pro-TRH mRNA expression in the fetal/neonatal paraventricular nucleus of the hypothalamus. Properties of the transduction pathway.
Brain Research,
1174,
28-38.
Memoria in extenso
204 - Joseph-Bravo,P., Mariscal,M., Garcia,I., Jaimes-Hoy,L., Charli,J.L., de Gortari,P.. Response of limbic TRH neurons depends on the stress paradigm. Endocrine Regulations. Int. Congress of Stress.
96-.
Artículo
205 - Chavez-Gutierrez,L., Matta-Camacho,E., Osuna,J., Horjales,E., Joseph-Bravo,P., Maigret,B., Charli,J.L.. Homology modeling and site directed mutagenesis of pyroglutamyl peptidase II. Insights into omega versus aminopeptidase specificity in the M1 family.
Journal of Biological Chemistry,
281 (27),
18581-18590.
Artículo
206 - de Gortari,P., Uribe,R.M., Garcia-Vazquez,A., Aguilar-Valles,A., Martinez,A., Valdes,A., Charli,J.L., Fernandez-Guardiola,A., Joseph-Bravo,P.. Amygdala kindling differentially regulates the expression of the elements involved in TRH transmission.
Neurochemistry International,
48 (1),
31-42.
Internacional
207 - de Gortari,P., Joseph,P.. Neuroendocrine Regulation of Energy Metabolism. Molecular Endocrinology.
65-86,
Kerala, India: Research Signpost.
Internacional
208 - Joseph-Bravo,P., Cote-Velez,A., Perez-Martinez,L.. Integration of Neuroendocrine Signals that Regulate the Activity of Hypophysiotropic Peptides. Molecular Endocrinology.
1-24,
Kerala, India: Research Signpost.
Internacional
Artículo
210 - Aguilar-Valles,A., Sanchez,E., de Gortari,P., Balderas,I., Ramirez-Amaya,V., Bermudez-Rattoni,F., Joseph-Bravo,P.. Analysis of the Stress Response in Rats Trained in the Water-Maze: Differential Expression of Corticotropin-Releasing Hormone, CRH-R1, Glucocorticoid Receptors and Brain-Derived Neurotrophic Factor in Limbic Regions.
Neuroendocrinology,
82 (5-6),
306-319.
Artículo
211 - Chavez-Gutierrez,L., Bourdais,J., Aranda,G., Vargas,M.A., Matta-Camacho,E., Ducancel,F, Segovia,L., Joseph-Bravo,P., Charli,J.L.. A truncated isoform of pyroglutamyl aminopeptidase II produced by exon extension has dominant-negative activity.
Journal of Neurochemistry,
92 (4),
807-817.
Artículo
212 - Cote-Velez,A., Perez-Martinez,L., Diaz-Gallardo,M.Y., Perez-Monter,C., Carreon,A., Charli,J.L., Joseph-Bravo,P.. Dexamethasone repressed cAMP rapid upregulation of TRH gene transcription. Identification of a composite GRE and a CRE in TRH promoter.
Journal of Molecular Endocrinology,
34 (1),
177-197.
Artículo
213 - de Gortari,P., Romero,F., Cisneros,M., Joseph-Bravo,P.. Acute administration of alcohol modulates pyroglutamyl amino peptidase II activity and mRNA levels in rat limbic regions.
Neurochemistry International,
46 (4),
347-356.
Artículo
214 - de Gortari,P., Cisneros,M., Joseph-Bravo,P.. Chronic ethanol or glucose consumption alter TRH content and pyroglutamyl aminopeptidase II activity in rat limbic regions.
Regulatory Peptides,
127 (1-3),
141-150.
Artículo
215 - Cruz,R., Chavez-Gutierrez,L., Joseph-Bravo,P., Charli,J.L.. 3,3',5'-Triiodo-L-Thyronine Reduces Efficiency of mRNA Knockdown by Antisense Oligodeoxynucleotides: A Study with Pyroglutamyl Aminopeptidase II in Adenohypophysis .
Oligonucleotides,
14 (3),
176-190.
Artículo
216 - Pascual,I., Cisneros,M., Lage,J., Diaz,J, Joseph-Bravo,P., Charli,J.L., Chavez,M.A.. Isolation and purification of HcPI, a natural inhibitor of pyroglutamil aminopeptidase II (TRH-degrading ectoenzyme) from extracts of Hermodice carunculata (annelide: Polychaeta).
Revista Biologia,
18 (1),
38-49.
Artículo
217 - Pascual,I., Gil-Parrado,S., Cisneros,M., Joseph-Bravo,P., Diaz,J., Possani,L.D., Charli,J.L., Chavez,M.. Purification of a specific inhibitor of pyroglutamyl aminopeptidase II from the marine annelide Hermodice carunculata. In vivo effects in rodent brain.
International Journal of Biochemistry and Cell Biology,
36 (1),
138-152.
Editorial Material
218 - Joseph-Bravo,P.. Hypophysiotropic thyrotropin-releasing hormone neurons as transducers of energy homeostasis.
Endocrinology,
145 (11),
4813-4815.
Artículo
219 - de Gortari,P., Cisneros,M., Medellin,M.A., Joseph-Bravo,P.. Chronic ingestion of ethanol or glucose solutions affects hypothalamic and limbic TRH metabolism in dams and their pups.
Neurochemistry International,
41 (4),
237-249.
Artículo
220 - Joseph-Bravo,P., Perez-Martinez,L., Lezama,L., Morales-Chapa,C., Charli,J.L.. An improved method for the expression of TRH in serum-supplemented primary cultures of fetal hypothalamic cells.
Brain Research Protocols,
9 (2),
93-104.
Artículo
221 - Vargas,M.A., Uribe,R.M., Cisneros,M., Romero,F., Gonzalez,S., Joseph-Bravo,P., Charli,J.L.. Thyrotropin-releasing hormone regulates the diurnal variation of pyroglutamyl aminopeptidase II activity in the male rat adenohypophysis.
European Journal of Endocrinology,
147 (3),
363-369.
Artículo
222 - Vargas,M.A., Cisneros,M., Joseph-Bravo,P., Charli,J.L.. Thyrotropin-releasing hormone-induced down-regulation of pyroglutamyl aminopeptidase II activity involves L-type calcium channels and cam kinase activities in cultures of adenohypophyseal cells.
Journal of Neuroendocrinology,
14 (3),
184-193.
Artículo
223 - Baeza,M.A., Ponce,G., Joseph-Bravo,P., Charli,J.L.. Rapid down regulation of pyroglutamyl peptidase II activity by arachidonic acid in primary cultures of adenohypophyseal cells.
Life Sciences,
68 (17),
2051-2060.
Artículo
224 - Guerra-Crespo,M., Ubieta,R., Joseph-Bravo,P., Charli,J.L., Perez-Martinez,L.. BDNF increases the early expression of TRH mRNA in fetal TrkB+ hypothalamic neurons in primary culture.
European Journal of Neuroscience,
14 (3),
483-494.
Artículo
225 - Perez-Martinez,L., Charli,J., Joseph-Bravo,P.. Development of pro-TRH gene expression in primary cultures of fetal hypothalamic cells.
Developmental Brain Research,
130 (1),
73-81.
Artículo
226 - Sanchez,E., Uribe,R.M., Corkidi,G., Zoeller,R.T., Cisneros,M., Zacarias,M., Morales-Chapa,C., Charli,J.L., Joseph-Bravo,P.. Differential Responses of Thyrotropin-Releasing Hormone (TRH) Neurons to Cold Exposure or Suckling Indicate Functional Heterogeneity of the TRH System in the Paraventricular Nucleus of the Rat Hypothalamus.
Neuroendocrinology,
74 (6),
407-422.
Artículo
227 - Bourdais,J., Romero,F., Uriostegui,B., Cisneros,M., Joseph-Bravo,P., Charli,J.L.. [3-Me-His(2)]-TRH combined with dopamine withdrawal rapidly and transiently increases pyroglutamyl aminopeptidase II activity in primary cultures of adenohypophyseal cells.
Neuropeptides,
34 (2),
83-88.
Artículo
228 - de Gortari,P., Gonzalez-Alzati,M.E., Cisneros,M., Joseph-Bravo,P.. Effect of fasting on the content of thyrotropin-releasing hormone and its mRNA in the central nervous system and pyroglutamyl peptidase II activity in the anterior pituitary of post-weaned and adult rats.
Nutritional Neuroscience,
3 (4),
255-265.
Revisión
229 - de Gortari,P., Mendez,M., Rodriguez-Keller,I., Perez-Martinez,L., Joseph-Bravob,P.. Acute ethanol administration induces changes in TRH and proenkephalin expression in hypothalamic and limbic regions of rat brain.
Neurochemistry International,
37 (5-6),
483-496.
Artículo
230 - Niquet,J., Perez-Martinez,L., Guerra,M., Grouselle,D., Joseph-Bravo,P., Charli,J.. Extracellular matrix proteins increase the expression of pro-TRH and pro-protein convertase PC1 in fetal hypothalamic neurons in vitro.
Developmental Brain Research,
120 (1),
49-56.
Artículo
231 - Vargas,M.A., Cisneros,M., Joseph-Bravo,P., Charli,J.L.. Regulation of adenohypophyseal pyroglutamyl aminopeptidase II activity by thyrotropin-releasing hormone and phorbol esters.
Endocrine,
13 (3),
267-272.
Artículo
232 - Mendez,M., Cisneros,M., Baez,A., Joseph-Bravo,P., Charli,J.L.. Three TRH-like molecules are released from rat hypothalamus in vitro.
Neurochemical Research,
24 (7),
815-823.
Artículo
233 - Perez-Martinez,L., Uribe,R.M., Sanchez,E., Carreon-Rodriguez,A., Chavez,L., Zacarias,M., Joseph-Bravo,P., Charli,J.L.. Regulation of TRH biosynthesis in the paraventricular nucleus of rodent hypothalamus.
Current topics in neurochemistry,
2,
79-88.
Artículo; Actas Paper
234 - Charli,J.L., Vargas,M.A., Cisneros,M., de Gortari,P., Baeza,M.A., Jasso,P., Bourdais,J., Perez,L., Uribe,R.M., Joseph-Bravo,P.. TRH inactivation in the extracellular compartment: role of pyroglutamyl peptidase II.
Neurobiology (Bp.),
6 (1),
45-57.
Artículo
235 - de Gortari,P., Joseph-Bravo,P., Monroy-Ruiz,J., Martinez,A., Cisneros,M., Fernandez-Guardiola,A.. Brain thyrotropin-releasing hormone content varies through amygdaloid kindling development according to afterdischarge frequency and propagation.
Epilepsia,
39 (8),
897-903.
Revisión
236 - Joseph-Bravo,P., Uribe,R.M., Vargas,M.A., Perez-Martinez,L., Zoeller,T., Charli,J.L.. Multifactorial modulation of TRH metabolism.
Cellular & Molecular Neurobiology,
18 (2),
231-247.
Artículo
237 - Perez-Martinez,L., Carreon-Rodriguez,A., Gonzalez-Alzati,M.E., Morales,C., Charli,J.L., Joseph-Bravo,P.. Dexamethasone rapidly regulates TRH mRNA levels in hypothalamic cell cultures: interaction with the cAMP pathway.
Neuroendocrinology,
68 (5),
345-354.
Artículo
238 - Vargas,M.A., Bourdais,J., Sanchez,S., Uriostegui,B., Moreno,E., Joseph-Bravo,P., Charli,J.L.. Multiple hypothalamic factors regulate pyroglutamyl peptidase II in cultures of adenohypophyseal cells: role of the cAMP pathway.
Journal of Neuroendocrinology,
10 (3),
199-206.
Artículo
239 - Sanchez,E., Charli,J.L., Morales,C., Corkidi,G., Seidah,N.G., Joseph-Bravo,P., Uribe,R.M.. Expression of the proprotein convertases PC1 and PC2 mRNAs in thyrotropin releasing hormone neurons of the rat paraventricular nucleus of hypothalamus.
Brain Research,
761 (1),
77-86.
Artículo
240 - de Gortari,P., Fernandez-Guardiola,A., Martinez,A., Cisneros,M., Joseph-Bravo,P.. Changes in TRH and its degrading enzyme pyroglutamyl peptidase II, during the development of amygdaloid kindling.
Brain Research,
679 (1),
144-150.
Artículo
241 - Uribe,R.M., Joseph-Bravo,P., Charli,J.L.. Pups removal enhances thyrotropin-releasing hormone mRNA in the hypothalamic paraventricular nucleus.
European Journal of Endocrinology,
133 (3),
354-360.
Artículo
242 - Uribe,R.M., Perez-Martinez,L., Covarrubias,M.D., Gomez,O., Covarrubias,L., Charli,J.L., Joseph-Bravo,P.. Phorbol ester or cAMP enhance thyrotropin-releasing hormone mRNA in primary cultures of hypothalamic cells.
Neuroscience Letters,
201 (1),
41-44.
Nacional
243 - Joseph-Bravo,P.. Choques, transtornos y otras caídas. Stress, dolor y p?ptidos. Memoria del Curso Explorando el Cerebro.
35-37,
Mexico,D.F..
Note
244 - Charli,J.L., Cruz,C., Redondo,J.L., Guerra,C., Joseph-Bravo,P.. Homologous conditioned medium enhances expression of TRH in hypothalamic neurons in primary culture.
Developmental Brain Research,
89 (1),
155-160.
Artículo
245 - Covarrubias,L., Redondo,J.L., Vargas,M.A., Uribe,R.M., Mendez,M., Joseph-Bravo,P., Charli,J.L.. In vitro TRH release from hypothalamus slices varies during the diurnal cycle.
Neurochemical Research,
19 (7),
845-850.
Carta
Artículo
247 - Joseph-Bravo,P., Fresan,M., Cisneros,M., Vargas,M.A., Charli,J.L.. Pyroglutamyl peptidase II activity is not in the processes of bulbospinal TRHergic neurons.
Neuroscience Letters,
178 (2),
243-246.
Artículo
248 - Uribe,R.M., Joseph-Bravo,P., Ponce,G., Cisneros,M., Aceves,C., Charli,J.L.. Influence of thyroid status on TRH metabolism in rat olfactory bulb.
Peptides,
15 (3),
435-439.
Artículo
249 - Vargas,M.A., Joseph-Bravo,P., Charli,J.L.. Thyrotropin-releasing hormone downregulates pyroglutamyl peptidase II activity in adenohypophyseal cells.
Neuroendocrinology,
60 (3),
323-330.
Artículo
250 - Brakch,N., Boileau,G., Simonetti,M., Nault,C., Joseph-Bravo,P., Rholam,M., Cohen,P.. Prosomatostatin processing in Neuro2A cells. Role of beta-turn structure in the vicinity of the Arg-Lys cleavage site.
European Journal of Biochemistry,
216 (1),
39-47.
*
Artículo
251 - Uribe,R.M., Redondo,J.L., Charli,J.L., Joseph-Bravo,P.. Suckling and cold stress rapidly and transiently increase TRH mRNA in the paraventricular nucleus.
Neuroendocrinology,
58 (1),
140-145.
Note
252 - Mendez,M., Moran,J., Wilk,S., Joseph-Bravo,P., Charli,J.L.. Assessment of the role of TRH in the release of [3H]-dopamine from rat nucleus accumbens-lateral septum slices.
Brain Research Bulletin,
31 (5),
621-625.
Artículo
253 - Vargas,M.A., Cisneros,M., Herrera,J., Joseph-Bravo,P., Charli,J.L.. Regional distribution of pyroglutamyl peptidase II in rabbit brain, spinal cord, and organs.
Peptides,
13 (2),
255-260.
Note
254 - Vargas,M.A., Herrera,J., Uribe,R.M., Charli,J.L., Joseph-Bravo,P.. Ontogenesis of pyroglutamyl peptidase II activity in rat brain, adenohypophysis and pancreas.
Developmental Brain Research,
66 (2),
251-256.
Artículo
255 - Cruz,C., Charli,J.L., Vargas,M.A., Joseph-Bravo,P.. Neuronal localization of pyroglutamate aminopeptidase II in primary cultures of fetal mouse brain.
Journal of Neurochemistry,
56 (5),
1594-1601.
Artículo
256 - Lepage-Lezin,A., Joseph-Bravo,P., Devilliers,G., Benedetti,L., Launay,J.M., Gomez,S., Cohen,P.. Prosomatostatin is processed in the Golgi apparatus of rat neural cells.
Journal of Biological Chemistry,
266 (3),
1679-1688.
*
Artículo
257 - Uribe,R.M., Joseph-Bravo,P., Pasten,J., Ponce,G., Mendez,M., Covarrubias,L., Charli,J.L.. Some events of thyrotropin-releasing hormone metabolism are regulated in lactating and cycling rats.
Neuroendocrinology,
54 (5),
493-498.
Artículo
258 - Mendez,M., Cruz,C., Joseph-Bravo,P., Wilk,S., Charli,J.L.. Evaluation of the role of prolyl endopeptidase and pyroglutamyl peptidase I in the metabolism of LHRH and TRH in brain.
Neuropeptides,
17 (2),
55-62.
Note
259 - Fuchs,L.Y., Ovando,C., Joseph,P., Soberon,X., Charli,J.L.. Repetitive DNA sequence from the crayfish Procambarus clarkii.
Nucleic Acids Research,
18 (6),
1650.
Artículo
260 - Charli,J.L., Mendez,M., Vargas,M.A., Cisneros,M., Assai,M., Joseph-Bravo,P., Wilk,S.. Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices.
Neuropeptides,
14 (3),
191-196.
Artículo
261 - Charli,J.L., Cruz,C., Ponce,G., Vargas,M.A., Mendez,M., Cisneros,M., Pasten,J., Joseph-Bravo,P.. Physiological relevance of pyroglutamate aminopeptidase II.
Annals of the New York Academy of Sciences,
553,
563-564.
Artículo
262 - Covarrubias,L., Uribe,R.M., Mendez,M., Charli,J.L., Joseph-Bravo,P.. Hypothalamic TRH mRNA regulation under different physiological conditions.
Annals of the New York Academy of Sciences,
553,
476-478.
Artículo
263 - Charli,J.L., Cruz,C., Vargas,M., Joseph-Bravo,P.. The narrow specificity pyroglutamate aminopeptidase degrading TRH in brain is an ectoenzyme.
Neurochemistry International,
13,
237-242.
Artículo
264 - Covarrubias,L., Uribe,R.M., Mendez,M., Charli,J.L., Joseph-Bravo,P.. Neuronal TRH synthesis: developmental and circadian TRH mRNA levels.
Biochemical and Biophysical Research Communications,
151 (1),
615-622.
Note
265 - Ponce,G., Charli,J.L., Pasten,J.A., Aceves,C., Joseph-Bravo,P.. Tissue-specific regulation of pyroglutamate aminopeptidase II activity by thyroid hormones.
Neuroendocrinology,
48 (2),
211-213.
Artículo
266 - Charli,J.L., Mendez,M., Joseph-Bravo,P., Wilk,S.. Specific inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase do not change the in vitro release of TRH or its content in rodent brain.
Neuropeptides,
9 (4),
373-378.
Artículo
267 - Mendez,M., Joseph-Bravo,P., Cisneros,M., Vargas,M.A., Charli,J.L.. Regional distribution of in vitro release of thyrotropin releasing hormone in rat brain.
Peptides,
8 (2),
291-298.
Artículo
268 - Saavedra,R., Bravo,P.J., Charli,J.L., Herion,P.. Characterization of high affinity monoclonal antibodies against the luteinizing hormone-releasing hormone.
Hybridoma,
6 (6),
663-672.
Artículo
269 - Vargas,M., Mendez,M., Cisneros,M., Joseph-Bravo,P., Charli,J.L.. Regional distribution of the membrane-bound pyroglutamate amino peptidase-degrading thyrotropin-releasing hormone in rat brain.
Neuroscience Letters,
79 (3),
311-314.
Artículo
270 - Cohen,S., Charli,J.L., Diaz de Leon,L., Millar,R.P., Arimura,A., Morrison,M.R., Joseph-Bravo,P.. Attempts to immunoprecipitate the LHRH precursor synthesized in cell free systems.
Brain Research Bulletin,
16 (3),
309-314.
Artículo
271 - Torres,H., Charli,J.L., Vargas,M.A., Gonzalez-Noriega,A., Joseph-Bravo,P.. Subcellular distribution of the enzymes degrading Thyrotropin releasing hormone and metabolites in rat brain.
Neurochemistry International,
9,
103-110.
Artículo
272 - Garat,B., Miranda,J., Charli,J.L., Joseph-Bravo,P.. Presence of a membrane bound pyroglutamyl amino peptidase degrading thyrotropin releasing hormone in rat brain.
Neuropeptides,
6 (1),
27-40.
Artículo
273 - Charli,J.L., Ponce,G., McKelvy,J.F., Joseph-Bravo,P.. Accumulation of thyrotropin releasing hormone by rat hypothalamic slices.
Journal of Neurochemistry,
42 (4),
981-986.
Memoria in extenso
274 - Charli,J.L., Garat,B., Martinez-Escalera,G., Ponce,G., Miranda,J., Joseph-Bravo,P.. METABOLISM OF THYROTROPIN RELEASING HORMONE AND ITS POSSIBLE RELEVANCE TO PROLACTIN SECRETION. Prolactin Secretion: a Multidisciplinary Approach.
239-248,
Orlando: Academic Press.
Nacional
275 - Charli,J.L., Ponce,G., Torres,H., Garat,B., Barquin,N., Bravo,P.J.. [Cellular biochemistry of hypophysiotropic peptides. II. Liberation, action and inactivation].
Boletin de estudios medicos y biologicos,
32 (7-8 Suppl 1),
243-252.
Nacional
276 - Joseph-Bravo,P., Theleen,M., de Gortari,P., Shapiro,E., Redondo,J.L., Briones,M., Merchant,H., Charli,J.L.. [Biochemistry of hypophysiotropic peptides. I. Biosynthesis and its regulation].
Boletin de estudios medicos y biologicos,
32 (7-8 Suppl 1),
233-241.
Artículo
277 - Pacheco,M.F., McKelvy,J.F., Woodward,D.J., Loudes,C., Joseph-Bravo,P., Krulich,L., Griffin,W.S.. TRH in the rat cerebellum: I. Distribution and concentration.
Peptides,
2 (3),
277-282.
*
Artículo
278 - Joseph-Bravo,P., Charli,J.L., Sherman,T., Boyer,H., Bolivar,F., McKelvy,J.F.. Identification of a putative hypothalamic mRNA coding for somatostatin and of its product in cell-free translation.
Biochemical and Biophysical Research Communications,
94 (3),
1004-1012.
*
Nacional
279 - Charli,J.L., Joseph-Bravo,P., Robert,M.. Use of synthetic oligonucleotides for identification of messenger RNA for somatostatin.
Boletin de estudios medicos y biologicos,
31 (3-4),
220-221.
*
Artículo
280 - Joseph-Bravo,P., Loudes,C., Charli,J.L., Kordon,C.. Subcellular distribution of brain peptidases degrading luteinizing hormone releasing hormone (LHRH) and thyrotropin releasing hormone (TRH).
Brain Research,
166 (2),
321-329.
*
Artículo
281 - Joseph-Bravo,P., Charli,J.L., Palacios,J.M., Kordon,C.. Effect of neurotransmitters on the in vitro release of immunoreactive thyrotropin-releasing hormone from rat mediobasal hypothalamus.
Endocrinology,
104 (3),
801-806.
*
Artículo
282 - Lin,C., Joseph-Bravo,P., Sherman,T., Chan,L., McKelvy,J.F.. Cell-free synthesis of putative neurophysin precursors from rat and mouse hypothalamic poly (A)-RNA.
Biochemical and Biophysical Research Communications,
89 (3),
943-950.
*
Memoria in extenso
283 - Kordon,C., Enjalbert,A., Hery,M., Joseph-Bravo,P., Rotsztjen,W., Ruberg.M.. Role of neurotransmitters in the control of adenohypophyseal secretion. Handbook of the hypothalamus.
253-306,
2,
New York.
*
Artículo
284 - Loudes,C., Joseph-Bravo,P., Leblanc,P., Kordon,C.. Specific activity of LHRH and TRH degrading enzymes in various tissues of normal and castrated male rats.
Biochemical and Biophysical Research Communications,
83 (3),
921-926.
*
Note
285 - Charli,J.L., Joseph-Bravo,P., Palacios,J.M., Kordon,C.. Histamine-induced release of thyrotropin releasing hormone from hypothalamic slices.
European Journal of Pharmacology,
52 (3-4),
401-403.
*
Artículo
286 - Joseph-Bravo,P.I., Findley,M., Newberne,P.M.. Some interactions of light, riboflavin, and aflatoxin B1 in vivo and in vitro.
Journal of Toxicology and Environmental Health,
1 (3),
353-376.
*
287 - Joseph-Bravo, Patricia. Efecto de la melatonina sobre el metabolismo de aminas biogenicas en sistema nervioso central .
Facultad de Quimica,
Quimico,
UNAM.
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