Dr. Lourival Domingos Possani Postay
Investigador Emérito
Biología Molecular y Bioquímica de venenos de animales ponzoñosos
Bioprocesos con aplicaciones biotecnológicas y para la generación de medicamentos biotecnológicos
Bioquímica Estructural de Proteínas
Estructura, Función y Manipulación de Péptidos y Proteínas con énfasis en estudios electrofisiológicos
Estructura, Función y Manipulación de Péptidos y Proteínas con función antimicrobiana
Número de registros: 39
- Activos
- Vencidos
- Estructura y función de componentes del veneno de alacranes, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2023 - 2025
- Estructura y función de componentes del veneno de alacranes mexicanos, incluyendo análisis transcriptomica y proteomica, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2019 - 2021
- Natural agonists of ryanodine receptors: structure-function relationship and antiarrhythmic properties, NATIONAL INSTITUTES OF HEALTH, 2018 - 2020
- Genes y proteínas de alacranes: aislamiento y caracterización, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2016 - 2019
- Proteómica y transcriptómica de las glándulas del veneno de alacranes, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2015 - 2019
- Arácnidos de la biodiversidad mexicana y brasileña: purificación y caracterización de componentes del veneno, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2015 - 2017
- Proteínas, péptidos y genes del veneno de alacranes y anticuerpos protectores, PRESUPUESTO UNAM, 2014 - 2020
- Componentes del veneno de alacranes: aislamiento y caracterización, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2013 - 2016
- Biomedicine for inwardly rectifying potassium channel, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2012 - 2015
- Eventos moleculares asociados a la intoxicación por veneno de alacranes: un análisis por biología de sistemas, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2012 - 2015
- Calcins as membrane-permeable ligands of ryanodine receptors, UNIVERSITY OF MICHIGAN, 2011 - 2016
- Purificación y caracterización de componentes del veneno de arácnidos de la biodiversidad mexicana y brasileña, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2010 - 2013
- Aislamiento y caracterización de componentes del veneno para alacranes, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2010 - 2012
- Una nueva estrategia para generación de vacuna aviar, mediante el uso de anticuerpos contra receptores de células dendríticas, Instituto de Ciencia y Tecnología del Distrito Federal, 2009 - 2011
- K+ channel blockers for malaria control, BILL & MELINDA GATES FOUNDATION, 2009 - 2010
- Toxinas de alacrán y sintéticos análogos que afectan los canales de potasio responsables de las corrientes a del sistema nervioso central, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2009 - 2012
- Desarrollo de mosquitos transgénicos resistentes a la transmisión de malaria y dengue, FONDO DE COOPERACIÓN INTERNACIONAL EN CIENCIA Y TECNOLOGÍA UNIÓN EUROPEA - MÉXICO, 2009 - 2012
- Identificación y caracterización de nuevas toxinas de alacrán inhibidoras de canales iónicos de linfocitos, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2008 - 2011
- Caracterización química-funcional de componentes del veneno de alacranes, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2007 - 2009
- Estudio del veneno de alacrán brasileño opisthacanthus cayaporum: caracterización química-funcional de sus péptidos y generación de una biblioteca de genes para su producción recombinante., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2006 - 2009
- Eventos moleculares asociados a la intoxicación por veneno de alacranes: un análisis por biología de sistemas., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2006 - 2009
- Análisis proteómico de venenos de alacranes mexicanos y latinoamericanos con miras a la identificación de nuevas toxinas que afectan canales iónicos de potasio, responsables de las corrientes tipo-a de células del cerebelo., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2006 - 2009
- Toxinas, antibióticos y defensinas del veneno de alacranes con improtancia en salud pública., FONDO SECTORIAL DE INVESTIGACIÓN EN SALUD Y SEGURIDAD SOCIAL, 2006 - 2010
- Producción de antígenos recombinantes para la obtención de faboterápicos útiles en el tratamiento contra la intoxicación causada por picadura de alacrán., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2005 - 2007
- Identificación y caracterización de nuevas toxinas de alacrán inhibidoras de canales iónicos en linfocitos., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2004 - 2007
- Ligandos naturales de venenos de arañas como herramientas para el estudio de receptores celulares., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2004 - 2005
- Caracterización química y funcional de componentes del veneno y de la hemolinfa de alacranes., DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2004 - 2006
- Componentes del veneno de alacranes: ergtoxinas, defensinas y fosfolipasas, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2003 - 2006
- Caracterización química- funcional de toxinas de arácnidos que actúan sobre canales iónicos de calico y potasio., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2002 - 2004
- Aislamiento del veneno de alacranes y caracterización del papel fisiológico que juegan péptidos específicos en los canales iónicos voltaje y neurotransmisores dependientes., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2002 - 2003
- Ligandos naturales de la biodiversidad mexicana para el desarrollo y diseño de nuevos fármacos., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2000 - 2002
- Estructura de toxinas del veneno de alacrán y estudio de la interacción con canales iónicos., DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2000 - 2003
- Toxinas del veneno de alacranes; ergtoxina y canales de potasio, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 1999 - 2002
- Toxinas de alacrán: herramientas sitio-específico para el estudio de la excitabilidad de las membranas biológicas, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 1999 - 2001
- Aislamiento y caracterización de péptidos tóxicos de venenos de alacranes de baja california: preparación de un banco de cdn y clonaciòn de genes, DIRECCIÓN GENERAL DE INTERCAMBIO ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 1997
- Estudio de la interacción de toxinas de alacranes con canales de potasio, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 1997 - 2000
- Chemical and functional characterization of scorpion toxins, HOWARD HUGHES MEDICAL INSTITUTE, 1997 - 2001
- Toxinas peptídicas de alacranes mexicanos como sondas para el estudio de las funciones de canales iónicos, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 1996 - 1998
- Noxiustoxina y cn5 como modelos de toxinas del veneno de alacranes mexicanos que actúan sobre canales iónicos, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 1995 - 1998
Nivel D del PRIDE
Nivel Investigador Emérito del SNII
Nivel Investigador Emérito del SNII
Doctorado, en Biofísica, Faculte des Sciences DOrsay-Universite de París, Francia (octubre 1968-marzo 1970)
Licenciatura, Historia Natural, Fac. de Filosofía de la Universidad Federal de Río Grande do Sul, Brasil (1966)
Premio Luis Elizondo, Tecnológico de Monterrey, 2017
Premio Heberto Castillo, Secretaria de Ciencia, Tecnologia y Innovación de la ciudad de Mexico, 2017
Premio Nacional de Ciencias, Gobierno Mexicano, 2016
Premio Redi, International Society on Toxinology, 2006
Investigador emérito, UNAM, 2005
Doctor Honoris Causa, Universidad de Debrecen, Hungría, 2005
Miembro de la Academia de Ciencias de America Latina, 1999
Premio Nacional de Investigación Básica, Fundación Glaxo-Wellcome, 1998
Howard Hughes Medical Institute International Research Scholar 1997-2001, 1997
Premio Nacional de Ciencias y Artes, Gobierno de la República, 1995
Premio de Investigacion Medica Dr. Jorge Rosenkran, 1994
Premio Universidad Nacional en el área de Ciencias Naturales, UNAM, 1993
Howard Hughes Medical Institute International Research Scholar 1991-1996, 1991
- Activos
- Graduados
1 - Mendoza Trujillo, Ilse Monserrat (2021). Efecto terapeutico de la benzoquinona azul en un modelo de tuberculosis experimental pulmonar .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Possani, Lourival Domingos
2 - Cid Uribe, Jimena Isaias (2020). Transcriptoma y proteoma de la glandula venenosa del alacran Centruroides limpidus : una aproximacion a la composicion peptidica del veneno.
Instituto de Biotecnologia,
Doctorado en Bioquímicas,
UNAM.
Asesor: Possani, Lourival Domingos
3 - Veytia Bucheli, Jose Ignacio (2019). El bloqueo de los canales de potasio Kv1.3 con la toxina de alacran Vm24 atenua la respuesta de los linfocitos T de memoria efectora CD4+ a la estimulacion a traves del receptor de celulas T .
Instituto de Biotecnologia,
99 paginas,
Doctorado en Bioquimicas,
UNAM.
Asesor: Possani, Lourival D.
4 - Mendonza Luis,Rey Luis (2019). Síntesis química y predicción de estructura secundaria de Cn29, un péptido aislado del veneno del alacrán ?Centruroides noxius.
Facultad de Ciencias Biológicas,
Biólogo,
Benemérita Universidad Autónoma de Puebla.
*
Asesor: Possani Postay, Lourival D.
5 - Romero Gutierrez, Maria Teresa (2018). Caracterizacion del transcriptoma de la glandula venenosa y el proteoma del veneno del alacran Thorellius atrox .
Instituto de Biotecnologia,
Doctorado en Ciencias Biomedicas,
UNAM.
Asesor: Possani, Lourival Domingos
6 - Cid Uribe, Jimena Isaias (2016). Caracterizacion proteomica del veneno y transcriptomica de la glandula venenosa de machos y hembras del alacran centruroides limpidus .
Instituto de Biotecnologia,
84 paginas,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Possani Postay, Lourival D.
7 - Veytia Bucheli, Jose Ignacio (2015). Efecto inmunomodulador de la toxina Vm24 del alacran vaejovis mexicanus en linfocitos T de memoria efectores Cd4+ .
Instituto de Biotecnologia,
38 paginas,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Possani Lourival, D.
8 - Amaro Estrada, Itzel (2015). Obtencion de anticuerpos de origen humano que neutralicen la toxina ts1 del alacran brasileno tityus serrulatus.
Instituto de Biotecnologia,
68 paginas,
Doctorado en Ciencias Bioquimicas,
UNAM.
Asesor: Possani, Lourival Domingos
9 - Luna Ramirez,Karen Sofia (2014). Urodacus yaschenkoi, Autralian scorpion: phylogeny, venom characterization and pharmacology.
Facultad de Medicina, Odontologia y Ciencias de la Salud,
University of Melbourne.
*
Asesor: Possani Postay, Lourival D.
10 - Jimenez Vargas, Juana Maria (2012). Toxinas de alacran que afectan a canales de potasio del tipo herg1 .
Instituto de Biotecnologia,
Doctorado en Ciencias Biomedicas,
UNAM.
Asesor: Possani, Lourival Domingos
11 - Canul Tec, Juan Carlos (2012). Bases estructurales de la neutralizacion de la toxina Cn2 de Centruroides noxius Hoffmann por el anticuerpo scFv 9004G .
Instituto de Biotecnologia,
67 paginas,
Doctorado en Ciencias (Bioquimica),
UNAM.
12 - Rendon Anaya, Martha Rosalia (2011). Analisis del transcriptoma de la glandula de veneno del alacran Centruroides noxius Hoffmann .
Instituto de Biotecnologia,
x, 97 paginas,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Possani Postay, Lourival D., Herrera Estrella,Luis
13 - Espino Solis, Gerardo Pavel (2009). Desarrollo de anticuerpos contra integrinas de celulas dendriticas de caballo con miras a su aplicacion biotecnologica.
Instituto de Biotecnologia,
28, [59] paginas,
Doctorado en Ciencias Bioquimicas,
UNAM.
Asesor: Possani, Lourival D.
14 - Jimenez Vargas, Juana Maria (2006). Expresion heterologa de genes que codifican para toxinas de alacran .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Possani, Lourival Domingos
15 - Diego Garcia, Elia (2005). Analisis proteomico y genomico de los componentes del veneno de alacran Tityus costatus Karsdch : caracterizacion de peptidos y genes que codifican toxinas y componentes antimicrobianos.
Instituto de Biotecnologia,
Doctorado en Ciencias Biomedicas,
UNAM.
Asesor: Possani, Lourival Domingos
16 - Valdez Cruz, Norma Adriana (2004). Caracterizacion bioquimica y funcional de la fosfolipasa a2 heterodimerica Phaidactylipina perteneciente al grupo III .
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
Asesor: Possani, Lourival Domingos
17 - Rodriguez de la Vega Cuellar, Ricardo Canek (2004). Caracterizacion de antibioticos peptidicos involucrados en la respuesta inmune innata del alacran Centruriodes limpidus limpidus .
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
Asesor: Possani, Lourival Domingos
18 - Garcia Valdes, Jose de Jesus (2003). Estudio de la interaccion de toxinas de alacranes mexicanos sobre el maxicanal de potasio activado por calcio.
Instituto de Biotecnologia,
Doctor en Ciencias Bioquimicas,
UNAM.
Asesor: Possani, Lourival Domingos
19 - Ramirez Dominguez, Martha Eugenia (2002). Estudio de la interaccion de toxinas de alacran con canales de sodio.
Instituto de Biotecnologia,
Doctorado en Ciencias Quimicas (Bioquimica),
UNAM.
20 - Pardo Lopez, Liliana (2002). Estudio de la relacion estructurafuncion entre el canal de potasio HERG y una toxina del alacran Centruroides noxius: Ergtoxina.
Instituto de Biotecnologia,
Doctorado en Ciencias Quimicas (Bioquimica),
UNAM.
Asesor: Possani, Lourival Domingos
21 - Conde Baeye, Renaud (2001). Componentes del veneno del alacran Pandinus imperator con actividad enzimatica, antimicrobiana y antiparasitaria.
Instituto de Biotecnologia,
Doctor en Biotecnologia,
UNAM.
Asesor: Possani, Lourival Domingos
22 - Meyer,Lutz (2001). Characterization of the venom of the marine snail Conus delessertii.
Diploma en Biologia, Química y Farmácia,
Universidad Libre de Berlin.
*
Asesor: Possani Postay, Lourival D., Hucho, Ferdinand , Heimer,Edgar
23 - Zamudio Zuniga, Fernando (1999). Purificacion y caracterizacion quimicafuncional de toxinas de veneno del alacran Pardinus imperator que tienen accion sobre canales de calcio .
Instituto de Biotecnologia,
Doctorado en Biotecnologia,
UNAM.
Asesor: Possani, Lourival Domingos
24 - Rodriguez de la Vega Cuellar, Ricardo Canek (1999). Aislamiento y caracterizacion de peptidos antimicrobianos presentes en la hemolinfa del alacran Cetruroides limpidus limpidus Karsch .
Facultad de Quimica,
Quimico,
UNAM.
*
Asesor: Possani, Lourival Domingos
25 - Anguiano Vega, Gerardo Alfonso (1999). Evaluacion de la fraccion CN F.II.5 del alacran mexicano Centruroides noxius (Hoffmann) en la generacion de una respuesta inmune protectora a mamiferos .
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
*
Asesor: Possani, Lourival Domingos
26 - Ferreira Batista,Cesar Vicente (1999). Péptidos antimicrobianos del anfíbio Brasileño Phyllomedusa distincta.
Doctor en Ciencias Biológicas (Biología Molecular),
Universidad de Brasilia.
*
Asesor: Possani Postay,Lourival D., Bloch, Carlos
27 - Torres Larios, Alfredo (1999). Aislamiento y caracterizacion de un peptido antibacteriano del verano del alacran Hadrurus aztecus.
Facultad de Medicina,
Maestría en Ciencias Biomédicas,
UNAM.
*
Asesor: Possani, Lourival Domingos
28 - Pardo Lopez, Liliana (1998). Expresion de la toxina recombinante helotermina (HLTX) del veneno de Heloderma horridum horridum, utilizando dos diferentes sistemas de expresion (procarionte y eucarionte) .
Instituto de Biotecnologia,
Maestro en Ciencias Quimicas (Bioquimica),
UNAM.
29 - Valdez Cruz, Norma Adriana (1998). Análisis morfológico del alacrán Centruroides exilicauda y caracterización de algunas de sus toxinas".
Facultad de Ciencias Químicas,
Licenciado en Químico Farmaco Biólogo,
Universidad Autonoma de Baja California.
*
Asesor: Possani Postay, Lourival D., Licea, Alexei F.
30 - Licea Navarro, Alexei Fedorovish (1997). Clonacion y expresion de la region variable del anticuerpo monoclonal neutralizante BCF2, dirigido contra la toxina 2 del alacran centruroides noxius .
Instituto de Biotecnologia,
Doctorado en Biotecnologia,
UNAM.
31 - Pardo Lopez, Liliana (1995). Secuenciación del cDNA que codifica para la toxina Helotermina del veneno de Heloderma horridum horridum.
Facultad de Biología,
Licenciado en Biología,
Universidad Veracruzana.
*
Asesor: Possani Postay, Lourival D.
32 - Solache Diaz, Ma Emma Alejandra (1994). Efectos de modificaciones quimicas sobre actividades antigenicas y farmacologicas de la noxiustoxina .
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
Asesor: Possani, Lourival Domingos
33 - Ramirez Navarro, Angelina (1994). Determinacion de las constantes de afinidad de toxinas del veneno de alacranes mexicanos a tejidos excitables : cerebro y musculo.
Facultad de Medicina,
Doctorado en Ciencias Biomedicas,
UNAM.
*
Asesor: Possani, Lourival Domingos
34 - Nieto Rodriguez, Alejandro (1994). Aislamiento y caracterizacion de peptidos semejantes a la noxiustoxina del veneno del alacran Centruroides noxius.
Instituto de Biotecnologia,
Maestria en Biotecnologia,
UNAM.
Asesor: Possani, Lourival Domingos
35 - Gurrola Briones, Georgina (1994). Caracterizacion funcional estructural de la noxiustoxina.
Instituto de Biotecnologia,
Doctorado en Investigacion Biomedica Basica,
UNAM.
Asesor: Possani, Lourival Domingos
36 - Muñoz Garay,Roberto Carlos (1994). Determinación del efecto de la toxina 2 de Centruroides noxius sobre la proliferación in vitro de linfocitos murinos.
Licenciado en Biología,
Universidad Autónoma del Estado de Mexico.
*
Asesor: Possani Postay, Lourival D.
37 - Tapia Vieyra,Juana Virginia (1994). Determinación de la secuencia nucleotídica de cDNAs que codifican para toxinas del veneno de alacrán Centruroides noxius Hoffmann.
Licenciado en Biología,
Universidad Autónoma del Estado de México.
*
Asesor: Possani Postay, Lourival D.
38 - Vaca Dominguez, Luis Alfonso (1994). Uso de toxinas como sensores estructurales de canales de potasio.
Facultad de Medicina,
Doctorado en Ciencias Biomédicas,
UNAM.
*
39 - Vazquez Ramos, Alejandra (1993). Determinacion de la estructura primaria y caracterizacion de cDNAs que codifican para toxinas del veneno del alacran Centruroides noxius Hoffmann .
Instituto de Biotecnologia,
Doctorado en Biotecnologia,
UNAM.
40 - Cossio Bayugar, Raquel (1993). Aislamiento y caracterizacion de una fosfolipasa del veneno del alacran Hadrurus concolourus.
Colegio de Ciencias y Humanidades, Unidad Academica de los Ciclos Profesional y de Posgrado,
Licenciatura en Investigación Biomédica Básica,
UNAM.
*
Asesor: Possani, Lourival Domingos
41 - Cuevas Aguirre, Delia Anatolia (1992). Caracterizacion bioquimica de saliva de triatominos mexicanos.
Maestria en Biotecnologia,
UNAM.
42 - Calderon Aranda, Emma Soraida (1992). Estudio de la relacion estructurafuncion y capacidad inmunogenica de neurotoxinas y peptidos analogos sinteticos del veneno del alacran Centruroides noxius Hoffmann .
Instituto de Biotecnologia,
Doctorado en Investigacion Biomedica Basica,
UNAM.
Asesor: Possani, Lourival Domingos
43 - Fernández Aguilar,Juan Antonio (1992). Aislamiento y caracterización química de componentes tóxicos minoritarios del veneno del alacrán Centruroides limpidus limpidus (Alacrán de Guerrero).
Médico Veterinario Zootecnista,
Universidad Autónoma Agrária "Antonio Narro", Torreon, Coahuila.
*
Asesor: Possani Postay, Lourival D.
44 - Valdivia Flores, Hector Horacio (1991). Aislamiento y caracterizacion de toxinas de veneno de alacran que bloquean canales de potasio.
Facultad de Medicina,
Doctorado en Ciencias Biomedicas,
UNAM.
*
Asesor: Possani, Lourival Domingos
45 - Olamendi Portugal, Timoteo Celso (1991). Sintesis quimica y caracterizacion inmunologica de peptidos correspondientes a la secuencia de la toxina II9.2.2 del alacran Centruroides noxius .
Instituto de Biotecnologia,
Especialista en Biotecnologia,
UNAM.
Asesor: Possani, Lourival Domingos
46 - Mocha Morales, Javier (1991). Caracterizacion quimica y funcional de la toxina helotermina del verano de Heloderna horridum.
Facultad de Medicina,
Doctorado en Ciencias Biomedicas,
UNAM.
*
Asesor: Possani, Lourival Domingos
47 - Amezcua Lopez, Jose (1991). Fofolipasa neurotoxica del veneno de la serpiente Oxyuranus scutellatus scutellatus : purificacion, secuencia de aminoacidos y cristalizacion .
Facultad de Ciencias ,
Maestria en Microscopia Cronica,
UNAM.
*
Asesor: Possani, Lourival Domingos
48 - Villarreal Molina, Gilda Maria (1989). Purificación y marcaje de toxinas del alacrán Centruroides noxius para el estudio de canales iónicos de membranas excitables.
Licenciatura en Investigación Biomédica Básica,
UNAM.
*
Asesor: Possani, Lourival Domingos
49 - Vaca Dominguez, Luis Alfonso (1989). Sintesis de peptidos correspondientes a la secuencia de la noxiustoxina : determinantes antigenicos y efectos sobre canales ionicos.
Maestria en Investigacion Biomedica Basica,
UNAM.
*
Asesor: Possani, Lourival Domingos
50 - Zamudio Zuniga, Fernando (1989). Obtencion, caracterizacion y uso de anticuerpos monoclonales para el estudio de estructura y funcion de toxinas de alacranes.
Facultad de Quimica,
Maestría en Ciencias Químicas (Bioquímica),
UNAM.
*
Asesor: Possani Postay, Lourival D.
51 - Mochca Morales, Javier (1988). Aislamiento y caracterizacion de una toxina del veneno del Heloderma horridum horridum.
Maestro en Investigacion Biomedica Basica,
UNAM.
*
Asesor: Possani, Lourival Domingos
52 - Alagon Cano, Alejandro (1988). Enzimas hidroliticas del veneno de heloderma horridum horridum : fosfolipasa A2 y calicreina .
Doctorado en Investigacion Biomedica Basica,
UNAM.
*
Asesor: Possani Postay, Lourival D.
53 - Balderas Altamirano,Cipriano (1988). Aislamiento y caracterizacion de toxinas del alacrán de Morelos Centruroides limpidus limpidus (Karsch).
Biólogo,
Universidad Autonoma del Estado de Morelos.
*
Asesor: Possani Postay, Lourival D.
54 - Ramirez Navarro, Angelina (1987). Aislamiento y caracterizacion de las toxinas del veneno del alacran C. Limpidus tecomanus Hoffmann .
Facultad de Medicina,
Maestria en Ciencias Biomedicas,
UNAM.
*
Asesor: Possani, Lourival Domingos
55 - Dehesa Dávila,Manuel (1987). Aislamiento y caracterización de una toxina del veneno del alacrán Centruroides infamatus infamatus Koch.
Maestro en Investigación Biomédicas,
Universidad de Guanajuato, Léon.
*
Asesor: Possani Postay, Lourival D.
56 - Sanchez Garcia, Maria del Rocio (1986). Purificacion de toxinas del veneno del alacran Centruroides noxius Hoffmann 1932, por medio de inmunoadsorbentes.
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
*
Asesor: Possani, Lourival Domingos
57 - Gurrola Briones, Georgina (1986). Sintesis quimica de peptidos correspondientes a secuencias de aminoacidos de toxinas de alacran y sus propiedades.
Instituto de Biotecnologia,
Maestro en Ciencias Quimicas (Bioquimica),
UNAM.
Asesor: Possani, Lourival Domingos
58 - Colomer Gould, Veronica (1984). Obtencion de anticuerpos monoclonales en contra de toxinas del veneno de alacran centruroides noxius.
Instituto de Investigaciones Biomedicas,
Licenciatura en Investigacion Biomedica Basica,
UNAM.
*
Asesor: Possani, Lourival Domingos, Celis, Esteban
59 - Rode Sanchez, Gustavo Ricardo (1984). Aislamiento y caracterización de los componentes tóxicos del veneno del alacrán sudamericano Tityus serrulatus.
Facultad de Química,
Maestría en Ciencias (Bioquímica),
UNAM.
*
Asesor: Possani, Lourival Domingos
60 - Ramirez Avila, Guillermo Julio (1983). Aislamiento y caracterizacion de proteinasas del veneno de la serpiente mexicana crotalus molossus nigrescens (Gloyd) 1936.
Facultad de Quimica,
Maestro en Ciencias Quimicas (Bioquimica),
UNAM.
*
Asesor: Possani, Lourival Domingos
61 - Dent, Myrna Alexandra Roberta (1983). Aislamiento y caracterizacion quimica de diversas toxinas del veneno del alacran centruroides noxius hoffmann.
Facultad de Química,
Maestría en Ciencias Químicas (Bioquímica),
UNAM.
*
Asesor: Possani, Lourival Domingos
62 - Rode Sanchez, Gustavo Ricardo (1980). Contribucion al estudio de la glutamato descarboxilasa (GAD) de cerebro : Aspectos cineticos y problemas de purificacion .
Facultad de Quimica,
Quimico Farmaceutico Biologo,
UNAM.
*
Asesor: Possani, Lourival Domingos
63 - Alagon Cano, Alejandro (1980). Estudio sobre los venenos de varias especies zoologicas.
Instituto de Investigacions Biomedicas,
Maestria en Investigacion Biomedica Basica,
UNAM.
*
Asesor: Possani Postay, Lourival D.
64 - Molinar Rode, Ricardo Alejandro (1979). Caracterizacion bioquimica del veneno de la serpiente mexicana bothrops asper .
Facultad de Quimica,
Quimico Farmaceutico Biologo,
UNAM.
*
Asesor: Possani, Lourival Domingos
65 - Dent, Myrna Alexandra Roberta (1979). Contribucion al estudio de las toxinas del veneno y ultraestructura del telson del alacran de Nayarit centruroides noxius hoffmann.
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
*
Asesor: Possani, Lourival Domingos
Total de publicaciones: 450
- Tipo
- Fecha
Artículo Short communication
66 - Delgado-Prudencio,G., Becerril,B., Possani,L.D., Ortiz,E. (2025). New proposal for the systematic nomenclature of scorpion peptides.
Toxicon,
253,
108192.
Artículo
67 - Gallegos-Monterrosa,R., Cid-Uribe,J.I., Delgado-Prudencio,G., Perez-Morales,D., Banda,M.M., Tellez-Galvan,A., Carcamo-Noriega,E.N., Garza-Ramos,U., Zare,R.N., Possani,L.D., Bustamante,V.H. (2025). Blue benzoquinone from scorpion venom shows bactericidal activity against drug-resistant strains of the priority pathogen Acinetobacter baumannii.
Journal of Antibiotics (Tokyo),
78,
235-245.
Artículo
68 - Monteiro,I.S., Araujo,I.F.S., Camargos,T.S., Ortiz,E., Souza,A.C.B., Lima,J.D., Possani,L.D., Schwartz,E.F., Tibery,D.V. (2025). The First K(+)-Channel Blocker Described from Tityus fasciolatus Venom: The Purification, Molecular Cloning, and Functional Characterization of a-KTx4.9 (Tf5).
Toxins (Basel),
17 (2),
96.
Revisión
69 - Riano-Umbarila,L., Romero-Moreno,J.A., Possani,L.D., Becerril,B. (2025). State of the art on the development of a recombinant antivenom against Mexican scorpion stings.
Toxicon,
257,
108306.
Artículo
70 - Gonzalez-Santillan,E., Valdez-Velazquez,L.L., Delgado-Hernandez,O., Cid-Uribe,J.I., Romero-Gutierrez,M.T., Possani,L.D. (2024). A multigene approach to identify the scorpion species (Arachnida: Scorpiones) of Colima, Mexico, with comments on their venom diversity.
Revista Mexicana de Biodiversidad,
95,
e955373.
Artículo
71 - Restano-Cassulini,R., Olamendi-Portugal,T., Riano-Umbarila,L., Zamudio,F.Z., Delgado-Prudencio,G., Becerril,B., Possani,L.D. (2024). Characterization of Sodium Channel Peptides Obtained from the Venom of the Scorpion Centruroides bonito.
Toxins (Basel),
16 (3),
125.
Articulo
72 - Riano-Umbarila,L., Olamendi-Portugal,T., Romero-Moreno,J.A., Delgado-Prudencio,G., Zamudio,F.Z., Becerril,B., Possani,L.D. (2024). Toxic Peptides from the Mexican Scorpion Centruroides villegasi: Chemical Structure and Evaluation of Recognition by Human Single-Chain Antibodies.
Toxins (Basel),
16 (7),
301.
Artículo
73 - Garcia-Villalvazo,P.E, Jimenez-Vargas,J.M, Lino-Lopez,G.J, Meneses,E.P, Bermudez-Guzman,M.J, Barajas-Saucedo,C.E, Delgado-Enciso,I., Possani,L.D, Valdez-Velazquez,L.L (2023). Unveiling the Protein Components of the Secretory-Venom Gland and Venom of the Scorpion Centruroides possanii (Buthidae) through Omic Technologies.
Toxins (Basel),
15 (8),
498.
Artículo
74 - Gomez-Ramirez,I.V., Corrales-Garcia,L.L., Possani,L.D., Riano-Umbarila,L., Becerril,B. (2023). Expression in Pichia pastoris of human antibody fragments that neutralize venoms of Mexican scorpions.
Toxicon,
223,
107012.
Artículo
75 - Ibarra-Vega,R., Jimenez-Vargas,J.M., Pineda-Contreras,A., Martinez-Martinez,F.J., Barajas-Saucedo,C.E., Garcia-Ortega,H., Magana-Vergara,N.E., Possani,L.D., Corzo,G., Gaitan-Hinojosa,M.A., Vazquez-Vuelvas,O.F., Zamudio,F., Valdez-Velazquez,L.L. (2023). Indolealkylamines in the venom of the scorpion Thorellius intrepidus.
Toxicon,
233,
107232.
Artículo
76 - Lopez-Giraldo,E., Carrillo,E., Titaux-Delgado,G., Cano-Sanchez,P., Colorado,A., Possani,L.D., Rio-Portilla,F.D. (2023). Structural and functional studies of scorpine: A channel blocker and cytolytic peptide.
Toxicon,
222,
106985
.
Artículo
77 - Naseem,M.U., Gurrola-Briones,G., Romero-Imbachi,M.R., Borrego,J., Carcamo-Noriega,E., Beltran-Vidal,J., Zamudio,F.Z., Shakeel,K., Possani,L.D., Panyi,G. (2023). Characterization and Chemical Synthesis of Cm39 (a-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K(+) Channel K(V)1.2 and Small- and Intermediate-Conductance Ca(2+)-Activated K(+) Channels K(Ca)2.2 and K(Ca)3.1.
Toxins (Basel),
15 (1),
41.
Artículo
78 - Romero-Moreno,J.A., Serrano-Posada,H., Olamendi-Portugal,T., Possani,L.D., Becerril,B., Riano-Umbarila,L. (2023). Development of a human antibody fragment cross-neutralizing scorpion toxins.
Molecular Immunology,
155,
165-174.
Artículo
79 - Salazar,M.H., Ortiz,M.H., Encarnacion,S., Zamudio,F., Possani,L.D., Cleghorn,J., Moran,M., Acosta,H., Corzo,G. (2023). A proteomic overview of the major venom components from Tityus championi from Panama.
Toxicon,
227,
107082.
Artículo
80 - Shakeel,K., Olamendi-Portugal,T., Naseem,M.U., Becerril,B., Zamudio,F.Z., Delgado-Prudencio,G., Possani,L.D., Panyi,G. (2023). Of Seven New K(+) Channel Inhibitor Peptides of Centruroides bonito, a-KTx 2.24 Has a Picomolar Affinity for Kv1.2.
Toxins (Basel),
15 (8),
506.
Artículo
81 - Valencia-Martinez,H., Riano-Umbarila,L., Olamendi-Portugal,T., Romero-Moreno,J.A., Possani,L.D., Becerril,B. (2023). Neutralization of Centruroides tecomanus scorpion venom by the use of two human recombinant antibody fragments.
Molecular Immunology,
164,
79-87.
Artículo
82 - Bermudez-Guzman,M.J., Jimenez-Vargas,J.M., Possani,L.D., Zamudio,F., Ororzco-Gutierrez,G., Oceguera-Contreras,E., Enriquez-Vara,J.N, Vazquez-Vuelvas,O.F., Garcia-Villalvazo,P.E., Valdez-Velazquez,L.L. (2022). Biochemical characterization and insecticidal activity of isolated peptides from the venom of the scorpion Centruroides tecomanus.
Toxicon,
206,
90-102.
Artículo
83 - Csoti,A., Najera-Meza,R.C., Bogar,F., Tajti,G., Szanto,T.G., Varga,Z., Gurrola,G.B., Toth,G.K., Possani,L.D., Panyi,G. (2022). sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity.
Biochemical Pharmacology,
199,
115023.
Artículo
84 - Delgado-Prudencio,G., Cid-Uribe,J.I., Morales,J.A., Possani,L.D., Ortiz,E., Romero-Gutierrez,T. (2022). The Enzymatic Core of Scorpion Venoms.
Toxins,
14 (4),
248.
Artículo
85 - Espinoza-Duarte,M.R., Ortega-Ochoa,C., Baca-Ramirez,A., Possani,L.D., Espino-Solis,G.P. (2022). Flow cytometry analysis of CD11c-positive peripheral blood mononuclear cells in horses.
Veterinary Immunology and Immunopathology,
253 (November),
110504.
Artículo
86 - Naseem,M.U., Carcamo-Noriega,E., Borrego,J., Szanto,T.G., Zamudio,F.Z., Delgado-Prudencio,G., Possani,L.D., Panyi,G. (2022). Cm28, a scorpion toxin having a unique primary structure, inhibits KV1.2 and KV1.3 with high affinity.
Journal of General Physiology,
154 (8),
e202213146.
Artículo
87 - Salazar,M.H., Clement,H., Corrales-Garcia,L.L., Sanchez,J., Cleghorn,J., Zamudio,F., Possani,L.D., Acosta,H., Corzo,G. (2022). Heterologous expression of four recombinant toxins from Panamanian scorpions of the genus Tityus and Centruroides for production of antivenom.
Toxicon: X,
13,
100090.
Artículo
88 - Valencia-Martinez,H., Olamendi-Portugal,T., Restano-Cassulini,R., Serrano-Posada,H., Zamudio,F., Possani,L.D., Riano-Umbarila,L., Becerril,B. (2022). Characterization of Four Medically Important Toxins from Centruroides huichol Scorpion Venom and Its Neutralization by a Single Recombinant Antibody Fragment.
Toxins,
14 (6),
369.
Artículo
89 - Veytia-Bucheli,J.I., Alvarado-Velazquez,D.A., Possani,L.D., Gonzalez-Amaro,R., Rosenstein,Y. (2022). The Ca(2+) Channel Blocker Verapamil Inhibits the In Vitro Activation and Function of T Lymphocytes: A 2022 Reappraisal.
Pharmaceutics,
14 (7).
Artículo
90 - Alamilla,J., Jimenez-Vargas,J.M., Galvan-Hernandez,A.R., Reyes-Mendez,M.E., Bermudez-Guzman,M.J., Restano-Cassulini,R., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D., Valdez-Velazquez,L.L. (2021). Toxin Ct1a, from venom of Centruroides tecomanus, modifies the spontaneous firing frequency of neurons in the suprachiasmatic nucleus.
Toxicon,
197,
114-125.
Artículo
91 - Beltran-Vidal,J., Carcamo-Noriega,E., Pastor,N., Zamudio-Zuniga,F., Guerrero-Vargas,J.A., Castano,S., Possani,L.D., Restano-Cassulini,R. (2021). Colombian Scorpion Centruroides margaritatus: Purification and Characterization of a Gamma Potassium Toxin with Full-Block Activity on the hERG1 Channel.
Toxins (Basel),
13 (6),
407.
Artículo
Artículo
93 - Lopes,K.S., Torres Quintanilha,M.V., Barros de Souza,A.C., Zamudio-Zuniga,F., Possani,L.D., Mortari,M.R. (2021). Antiseizure potential of peptides from the venom of social wasp Chartergellus communis against chemically-induced seizures.
Toxicon,
194,
23.
Artículo
Artículo
95 - Rodriguez-Ravelo,R., Ruiz-Urquiola,A., Possani-Postay,L.D., Morris-Quevedo,H.J., Rodriguez-Ravelo,M., Espinosa-Lopez,G. (2021). Variation of cytochrome oxidase-I gene and venom proteins of Rhopalurus junceus populations in the Moanicum sector: Pharmacological implications.
Journal of Pharmacy and Pharmacognosy Research,
9 (1),
1-12.
Artículo
96 - Vargas-Jaimes,L., Rodriguez,M.C., Argotte-Ramos,R., Juarez-Gonzalez,V.R., Pastor,N., Cesa-Luna,C., Possani,L.D., Quintero-Hernandez,V. (2021). Recombinant C-Terminal Domains from Scorpine-like Peptides Inhibit the Plasmodium berghei Ookinete Development In Vitro.
International Journal of Peptide Research and Therapeutics,
27,
817-829.
Artículo
97 - Benard-Valle,M., Neri-Castro,E.E., Yanez-Mendoza,M.F., Lomonte,B., Olvera,A., Zamudio,F., Restano-Cassulini,R., Possani,L.D., Jimenez-Ferrer,E., Alagon,A. (2020). Functional, proteomic and transcriptomic characterization of the venom from Micrurus browni browni: Identification of the first lethal multimeric neurotoxin in coral snake venom.
Journal of Proteomics,
225,
103863.
Revisión
98 - Cid-Uribe,J.I., Veytia-Bucheli,J.I., Romero-Gutierrez,T., Ortiz,E., Possani,L.D. (2020). Scorpion venomics: a 2019 overview.
Expert Review of Proteomics,
17 (1),
67-83.
Artículo
99 - Cota-Arce,J.M., Zazueta-Favela,D., Diaz-Castillo,F., Jimenez,S., Bernaldez-Sarabia,J., Caram-Salas,N.L., Dan,K.W.L., Escobedo,G., Licea-Navarro,A.F., Possani,L.D., De Leon-Nava,M.A. (2020). Venom components of the scorpion Centruroides limpidus modulate cytokine expression by T helper lymphocytes: Identification of ion channel-related toxins by mass spectrometry.
International Immunopharmacology,
84,
106505.
Artículo
100 - El-Bitar, A. M. H., Sarhan, M., Abdel-Rahman, M. A., Quintero-Hernandez, V., Aoki-Utsubo, C., Moustafa, M. A., Possani, L. D., Hotta, H. (2020). Smp76, a Scorpine-Like Peptide Isolated from the Venom of the Scorpion Scorpio maurus palmatus, with a Potent Antiviral Activity Against Hepatitis C Virus and Dengue Virus.
International Journal of Peptide Research and Therapeutics,
26,
811-821.
Artículo
101 - Garcia-Guerrero,I.A., Carcamo-Noriega,E., Gomez-Lagunas,F., Gonzalez-Santillan,E., Zamudio,F.Z., Gurrola,G.B., Possani,L.D. (2020). Biochemical characterization of the venom from the Mexican scorpion Centruroides ornatus, a dangerous species to humans.
Toxicon,
173,
27-38.
Artículo
102 - Gomez-Ramirez,I.V., Riano-Umbarila,L., Olamendi-Portugal,T., Restano-Cassulini,R., Possani,L.D., Becerril,B. (2020). Biochemical, electrophysiological and immunological characterization of the venom from Centruroides baergi, a new scorpion species of medical importance in Mexico.
Toxicon,
184,
10-18.
Artículo
103 - Lopez-Giraldo,A.E., Olamendi-Portugal,T., Riano-Umbarila,L., Becerril,B., Possani,L.D., Delepierre,M., Rio-Portilla,F.D. (2020). The three-dimensional structure of the toxic peptide Cl13 from the scorpion Centruroides limpidus.
Toxicon,
184,
158-166.
Artículo
104 - Luna-Ramirez,K., Csoti,A., McArthur,J.R., Chin,Y.K.Y., Anangi,R., Najera,R.D.C., Possani,L.D., King,G.F., Panyi,G., Yu,H., Adams,D.J., Finol-Urdaneta,R.K. (2020). Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom.
Biochemical Pharmacology,
174,
113782.
Artículo
105 - Mourao,C.B.F., Brand,G.D., Fernandes,J.P.C., Prates,M.V., Bloch,C., Barbosa,J.A.R.G., Freitas,S.M., Restano-Cassulini,R., Possani,L.D., Schwartz,E.F. (2020). Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom Peptide that Resembles Plant Cyclotides.
Journal of Medicinal Chemistry,
63 (17),
9500?951.
Artículo
106 - Neri-Castro,E., Benard-Valle,M., Paniagua,D., Boyer,L.V., Possani,D., Lopez-Casillas,F., Olvera,A., Romero,C., Zamudio,F., Alagon,A. (2020). Neotropical Rattlesnake (Crotalus simus) Venom Pharmacokinetics in Lymph and Blood Using an Ovine Model.
Toxins (Basel),
12 (7),
455.
Artículo
107 - Riano-Umbarila,L., Rojas-Trejo,V.M., Romero-Moreno,J.A., Costas,M., Utrera-Espindola,I., Olamendi-Portugal,T., Possani,L.D., Becerril,B. (2020). Comparative assessment of the VH-VL and VL-VH orientations of single-chain variable fragments of scorpion toxin-neutralizing antibodies.
Molecular Immunology,
122,
141-147.
Artículo
108 - Valdez-Velazquez,L.L., Cid-Uribe,J., Romero-Gutierrez,M.T., Olamendi-Portugal,T., Jimenez-Vargas,J.M., Possani,L.D. (2020). Transcriptomic and proteomic analyses of the venom and venom glands of Centruroides hirsutipalpus, a dangerous scorpion from Mexico.
Toxicon,
179,
21-32.
Artículo
109 - Bernaldez-Sarabia,J., Figueroa-Montiel,A., Duenas,S., Cervantes-Luevano,K., Beltran,J.A., Ortiz,E., Jimenez,S., Possani,L.D., Paniagua-Solis,J.F., Gonzalez-Canudas,J., Licea-Navarro,A. (2019). The Diversified O-Superfamily in Californiconus californicus Presents a Conotoxin with Antimycobacterial Activity.
Toxins (Basel),
11 (2),
E128.
Artículo
110 - Carcamo-Noriega,E.N., Sathyamoorthi,S., Banerjee,S., Gnanamani,E., Mendoza-Trujillo,Monserrat, Mata-Espinosa,D., Hernandez-Pando,R., Veytia-Bucheli,J.I., Possani,L.D., Zare,R.N. (2019). 1,4-Benzoquinone antimicrobial agents against Staphylococcus aureus and Mycobacterium tuberculosis derived from scorpion venom.
Proceedings of the National Academy of Sciences,
116 (26),
201812334,
12642-12647.
Artículo
Artículo
112 - Cid-Uribe,J.I., Meneses,E.P., Batista,C.V.F., Ortiz,E., Possani,L.D. (2019). Dissecting Toxicity: The Venom Gland Transcriptome and the Venom Proteome of the Highly Venomous Scorpion Centruroides limpidus (Karsch, 1879).
Toxins (Basel),
11 (5),
247.
Artículo
113 - Delgado-Prudencio, G., Possani, L. D., Becerril, B., Ortiz, E. (2019). The Dual alpha-Amidation System in Scorpion Venom Glands.
Toxins (Basel),
11 (7).
Artículo
114 - Gurrola, G. B., Guijarro, J. I., Delepierre, M., Mendoza, R. L. L., Cid-Uribe, J. I., Coronas, F. V., Possani, L. D. (2019). Cn29, a novel orphan peptide found in the venom of the scorpion Centruroides noxius: Structure and function.
Toxicon,
167,
184-191.
Artículo
115 - Jauregui-Zuniga,D., Pedraza-Escalona,M., Merino-Guzman,R., Possani,L.D. (2019). Construction and expression of a single-chain variable fragment antibody against chicken DEC 205 for targeting the bacterial expressed hemagglutinin-neuraminidase of Newcastle disease virus.
Veterinary Immunology and Immunopathology,
212,
9-14.
Artículo
116 - Okada,M., Ortiz,E., Corzo,G., Possani,L.D. (2019). Pore-forming spider venom peptides show cytotoxicity to hyperpolarized cancer cells expressing K+ channels: A lentiviral vector approach.
PLoS ONE,
14 (4),
e0215391.
Artículo
117 - Riano-Umbarila,L., Gomez-Ramirez,I.V., Ledezma-Candanoza,L.M., Olamendi-Portugal,T., Rodriguez-Rodriguez,E.R., Fernandez-Taboada,G., Possani,L.D., Becerril,B. (2019). Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms.
Toxins (Basel),
11 (1),
32.
Artículo
118 - Rincon-Cortes,C.A., Olamendi-Portugal,T., Carcamo-Noriega,E.N., Gonzalez-Santillan,E., Zamudio-Zuniga,F., Reyes-Montano,E.A., Vega Castro,N.A., Possani,L.D. (2019). Structural and functional characterization of toxic peptides purified from the venom of the Colombian scorpion Tityus macrochirus.
Toxicon,
169,
5-11.
Artículo
119 - Santibanez-Lopez,C.E., Graham,M.R., Sharma,P.P., Ortiz,E., Possani,L.D. (2019). Hadrurid Scorpion Toxins: Evolutionary Conservation and Selective Pressures.
Toxins (Basel),
11 (11),
E637,
E637.
Artículo
120 - Arora, A.K., Pesko, K.N., Quintero-Hernandez, V., Possani, L.D., Miller, T.A., Durvasula, R.V. (2018). A paratransgenic strategy to block transmission of Xylella fastidiosa from the glassy-winged sharpshooter Homalodisca vitripennis.
BMC Biotechnology,
18 (1),
50.
Artículo
121 - Banerjee, S., Gnanamani, E., Lynch, S.R., Zamudio-Zuniga, F., Jimenez-Vargas, J.M., Possani, L.D., Zare, R.N. (2018). An Alkaloid from Scorpion Venom: Chemical Structure and Synthesis.
Journal of Natural Products,
81 (8),
1899-1904.
Artículo
122 - Batista, C.V.F., Martins, J.G., Restano-Cassulini, R., Coronas, F.I.V., Zamudio, F.Z., Procopio, R., Possani, L.D. (2018). Venom characterization of the Amazonian scorpion Tityus metuendus.
Toxicon,
143,
51-58.
Artículo
123 - Carcamo-Noriega, E.N., Olamendi-Portugal, T., Restano-Cassulini, R., Rowe, A., Uribe-Romero, S.J., Becerril, B., Possani, L.D. (2018). Intraspecific variation of Centruroides sculpturatus scorpion venom from two regions of Arizona.
Archives of Biochemistry and Biophysics,
638,
52-57.
Artículo
124 - Cid-Uribe, J.I., Santibanez-Lopez, C.E., Meneses, E.P., Batista, C.V.F., Jimenez-Vargas, J.M., Ortiz, E., Possani, L.D. (2018). The diversity of venom components of the scorpion species Paravaejovis schwenkmeyeri (Scorpiones: Vaejovidae) revealed by transcriptome and proteome analyses.
Toxicon,
151,
47-62.
Revisión
125 - Gonzalez-Santillan, E., Possani, L.D. (2018). North American scorpion species of public health importance with a reappraisal of historical epidemiology.
Acta Tropica,
187,
264-274.
Artículo
126 - Olamendi-Portugal, T., Batista, C.V.F., Pedraza-Escalona, M., Restano-Cassulini, R., Zamudio, F.Z., Benard-Valle, M., de Roodt, A.R., Possani, L.D. (2018). New insights into the proteomic characterization of the coral snake Micrurus pyrrhocryptus venom.
Toxicon,
153,
23-31.
Revisión
127 - Ortiz, E., Possani, L.D. (2018). Scorpion toxins to unravel the conundrum of ion channel structure and functioning.
Toxicon,
150,
17-27.
Artículo
Artículo
129 - Salazar, M.H., Arenas, I., Corrales-Garcia, L.L., Miranda, R., Velez, S., Sanchez, J., Mendoza, K., Cleghorn, J., Zamudio, F.Z., Castillo, A., Possani, L.D., Corzo, G., Acosta, H. (2018). Venoms of Centruroides and Tityus species from Panama and their main toxic fractions.
Toxicon,
141,
79-87.
Artículo
130 - Valdez-Velazquez, L.L., Olamendi-Portugal, T., Restano-Cassulini, R., Zamudio, F.Z., Possani, L.D. (2018). Mass fingerprinting and electrophysiological analysis of the venom from the scorpion Centruroides hirsutipalpus (Scorpiones: Buthidae).
Journal of Venomous Animals and Toxins Including Tropical Diseases,
24,
17.
Artículo
131 - Veytia-Bucheli, J.I., Jimenez-Vargas, J.M., Melchy-Perez, E.I., Sandoval-Hernandez, M.A., Possani, L.D., Rosenstein, Y. (2018). Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation.
Cell Communication and Signaling,
16 (1),
45.
Artículo
Artículo
Artículo
134 - Jauregui-Zuniga, D., Pedraza-Escalona, M., Espino-Solis, G.P., Quintero-Hernandez, V., Olvera-Rodriguez, A., Diaz-Salinas, M.A., Lopez, S., Possani, L.D. (2017). Targeting antigens to Dec-205 on dendritic cells induces a higher immune response in chickens: Hemagglutinin of avian influenza virus example.
Research in Veterinary Science,
111,
55-62.
Artículo
135 - Jimenez-Vargas, J.M., Quintero-Hernandez, V., Gonzalez-Morales, L., Ortiz, E., Possani, L.D. (2017). Design and expression of recombinant toxins from Mexican scorpions of the genus Centruroides for production of antivenoms.
Toxicon,
128,
5-14 [Corrigendum 130 (2017) 126].
Revisión
136 - Jimenez-Vargas, J.M., Possani, L.D., Luna-Ramirez, K. (2017). Arthropod toxins acting on neuronal potassium channels.
Neuropharmacology,
127,
139-160.
Artículo
137 - Lopes, K.S., Campos, G.A.A., Camargo, L.C., de Souza, A.C.B., Ibituruna, B.V., Magalhaes, A.C.M., da Rocha, L.F., Garcia, A.B., Rodrigues, M.C., Ribeiro, D.M., Costa, M.C., Lopez, M.H.M., Nolli, L.M., Zamudio-Zuniga, F., Possani, L.D., Schwartz, E.F., Mortari, M.R. (2017). Characterization of two peptides isolated from the venom of social wasp Chartergellus communis (Hymenoptera: Vespidae): Influence of multiple alanine residues and C-terminal amidation on biological effects.
Peptides,
95,
84-93.
Artículo
Artículo
139 - Olamendi-Portugal, T., Csoti, A., Jimenez-Vargas, J.M., Gomez-Lagunas, F., Panyi, G., Possani, L.D. (2017). Pi5 and Pi6, two undescribed peptides from the venom of the scorpion Pandinus imperator and their effects on K+-channels.
Toxicon,
133,
136-144.
Artículo
140 - Restano-Cassulini, R., Garcia, W., Paniagua-Solis, J.F., Possani, L.D. (2017). Antivenom Evaluation by Electrophysiological Analysis.
Toxins (Basel),
9 (3),
74.
Artículo
Artículo
142 - Romero-Gutierrez, T., Peguero-Sanchez, E., Cevallos, M.A., Batista, C.V.F., Ortiz, E., Possani, L.D. (2017). A Deeper Examination of Thorellius atrox Scorpion Venom Components with Omic Techonologies.
Toxins (Basel),
9 (12),
399.
Artículo
Artículo
144 - Vargas-Jaimes, L., Xiao, L., Zhang, J., Possani, L.D., Valdivia, H.H., Quintero-Hernandez, V. (2017). Recombinant expression of Intrepicalcin from the scorpion Vaejovis intrepidus and its effect on skeletal ryanodine receptors.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1861 (4),
936-946.
Artículo
145 - Figueroa-Montiel,A., Ramos,M.A., Mares,R.E., Duenas,S., Pimienta,G., Ortiz,E., Possani,L.D., Licea-Navarro,A.F. (2016). In Silico Identification of Protein Disulfide Isomerase Gene Families in the De Novo Assembled Transcriptomes of Four Different Species of the Genus Conus.
PLoS ONE,
11 (2),
e0148390.
Revisión
146 - Luna-Martinez,K., Jimenez-Vargas,J.M., Possani,L.D. (2016). Scorpine-Like Peptides.
Single Cell Biology,
5 (138).
Artículo
147 - Olamendi-Portugal,T., Bartok,A., Zamudio-Zuniga,F., Balajthy,A., Becerril,B., Panyi,G., Possani,L.D. (2016). Isolation, chemical and functional characterization of several new K-channel blocking peptides from the venom of the scorpion Centruroides tecomanus.
Toxicon,
115,
1-12.
Artículo
148 - Osnaya-Romero N., Acosta-Saavedra,L.C., Goytia-Acevedo,R., Lares-Asseff,I., Basurto-Celaya,G., Perez-Guille,G., Possani,L.D., Calderon-Aranda,E.S. (2016). Serum level of scorpion toxins, electrolytes and electrocardiogram alterations in Mexican children envenomed by scorpion sting.
Toxicon,
122,
103-108.
Artículo
149 - Riano-Umbarila,L., Ledezma-Candanoza,L.M., Serrano-Posada,H., Fernandez-Taboada,G., Olamendi-Portugal,T., Rojas-Trejo,S., Gomez-Ramirez,I.V., Rudino-Pinera,E., Possani,L.D., Becerril,B. (2016). Optimal neutralization of Centruroides noxius venom is understood through a structural complex between two antibody fragments and the Cn2 toxin.
Journal of Biological Chemistry,
291 (4),
1619-1630.
Artículo
150 - Rodriguez-Rodriguez,E.R., Olamendi-Portugal,T., Serrano-Posada,H., Arredondo-Lopez,J.N., Gomez-Ramirez,I., Fernandez-Taboada,G., Possani,L.D., Vega,G.A., Riano-Umbarila,L., Becerril,B. (2016). Broadening the neutralizing capacity of a family of antibody fragments against different toxins from Mexican scorpions.
Toxicon,
119,
52-63.
Artículo
151 - Santibanez-Lopez,C.E., Cid-Uribe,J.I., Batista,C.V., Ortiz,E., Possani,L.D. (2016). Venom Gland Transcriptomic and Proteomic Analyses of the Enigmatic Scorpion Superstitionia donensis (Scorpiones: Superstitioniidae), with Insights on the Evolution of Its Venom Components.
Toxins (Basel),
8 (12),
367.
Revisión
152 - Santibanez-Lopez,C.E., Francke,O.F., Ureta,C., Possani,L.D. (2016). Scorpions from Mexico: From Species Diversity to Venom Complexity.
Toxins (Basel),
8 (1).
Artículo
153 - Valdez-Velazquez,L.L., Romero-Gutierrez,M.T., Delgado-Enciso,I., Dobrovinskaya,O., Melnikov,V., Quintero-Hernandez,V., Ceballos-Magana,S.G., Gaitan-Hinojosa,M.A., Coronas,F.I., Puebla-Perez,A.M., Zamudio,F., De la Cruz-Garcia,I, Vazquez-Vuelvas,O.F., Soriano-Hernandez,A.D., Possani,L.D. (2016). Comprehensive analysis of venom from the scorpion Centruroides tecomanus reveals compounds with antimicrobial, cytotoxic, and insecticidal activities.
Toxicon,
118,
95-103.
Artículo
154 - Xiao,L., Gurrola,G.B., Zhang,J., Valdivia,C.R., SanMartin,M., Zamudio,F.Z., Zhang,L., Possani,L.D., Valdivia,H.H. (2016). Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands.
Journal of General Physiology,
147 (5),
375-394.
Artículo
155 - Zhang,H., Du,M., Xie,J., Liu,X., Sun,J., Wang,W., Xin,X., Possani,L.D., Yea,K., Lerner,R.A. (2016). Autocrine-Based Selection of Drugs that Target Ion Channels from Combinatorial Venom Peptide Libraries.
Angewandte Chemie International Edition,
55 (32),
9306-9310.
Artículo
156 - Coronas,F.I., Diego-Garcia,E., Restano-Cassulini,R., de Roodt,A.R., Possani,L.D. (2015). Biochemical and physiological characterization of a new Na-channel specific peptide from the venom of the Argentinean scorpion Tityus trivittatus.
Peptides,
68,
11-16.
Artículo
157 - Espino-Solis,G.P., Quintero-Hernandez,V., Olvera-Rodriguez,A., Calderon-Amador,J., Pedraza-Escalona,M., Licea-Navarro,A., Flores-Romo,L., Possani,L.D. (2015). Novel monoclonal antibody against alphaX subunit from horse CD11c/CD18 integrin.
Veterinary Immunology and Immunopathology,
164 (3-4),
220-226.
Artículo
158 - Luna-Ramirez,K., Quintero-Hernandez,V., Juarez-Gonzalez,V.R., Possani,L.D. (2015). Whole Transcriptome of the Venom Gland from Urodacus yaschenkoi Scorpion.
PLoS ONE,
10 (5),
e0127883.
Artículo
159 - Okada,M., Corzo,G., Romero-Perez,G.A., Coronas,F., Matsuda,H., Possani,L.D. (2015). A pore forming peptide from spider Lachesana sp. venom induced neuronal depolarization and pain.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1850 (4),
657-666.
Revisión
160 - Ortiz,E., Possani,L.D. (2015). The unfulfilled promises of scorpion insectotoxins.
Journal of Venomous Animals and Toxins Including Tropical Diseases,
21,
16.
Revisión
161 - Ortiz,E., Gurrola,G.B., Schwartz,E.F., Possani,L.D. (2015). Scorpion venom components as potential candidates for drug development.
Toxicon,
93,
125-135.
Artículo
162 - Quintero-Hernandez,V., Ramirez-Carreto,S., Romero-Gutierrez,M.T., Valdez-Velazquez,L.L., Becerril,B., Possani,L.D., Ortiz,E. (2015). Transcriptome Analysis of Scorpion Species Belonging to the Vaejovis Genus.
PLoS ONE,
10 (2),
e0117188.
Artículo
163 - Ramirez-Carreto,S., Jimenez-Vargas,J.M., Rivas-Santiago,B., Corzo,G., Possani,L.D., Becerril,B., Ortiz,E. (2015). Peptides from the scorpion Vaejovis punctatus with broad antimicrobial activity.
Peptides,
73,
51-59.
Artículo
164 - Rodriguez-Ravelo,R., Batista,C.V., Coronas,F.I., Zamudio,F.Z., Hernandez-Orihuela,L., Espinosa-Lopez,G., Ruiz-Urquiola,A., Possani,L.D. (2015). Comparative proteomic analysis of male and female venoms from the Cuban scorpion Rhopalurus junceus.
Toxicon,
107 (B),
327-334.
Artículo
165 - Santibanez-Lopez,C.E., Possani,L.D. (2015). Overview of the Knottin scorpion toxin-like peptides in scorpion venoms: Insights on their classification and evolution.
Toxicon,
107 (B),
317-326.
Artículo
166 - Gonzalez-Morales,L., Pedraza-Escalona,M., Diego-Garcia,E., Restano-Cassulini,R., Batista,C.V., Gutierrez,M.C., Possani,L.D. (2014). Proteomic characterization of the venom and transcriptomic analysis of the venomous gland from the Mexican centipede Scolopendra viridis.
Journal of Proteomics,
111,
224-237.
Artículo
167 - Luna-Ramirez,K., Bartok,A., Restano-Cassulini,R., Quintero-Hernandez,V., Coronas,F., Christensen,J., Wright,C.E., Panyi,G., Possani,L.D. (2014). Structure, Molecular Modeling and Function of the First Potassium Channel Blocker, Urotoxin, Isolated from the Venom of the Australian Scorpion Urodacus Yaschenkoi.
Molecular Pharmacology,
86 (1),
28-41.
Artículo
168 - Luna-Ramirez,K., Sani,M.A., Silva-Sanchez,J., Jimenez-Vargas,J.M., Reyna-Flores,F., Winkel,K.D., Wright,C.E., Possani,L.D., Separovic,F. (2014). Membrane Interactions and Biological Activity of Antimicrobial Peptides from Australian Scorpion.
Biochimica et Biophysica Acta (BBA) - Biomembranes,
1838 (9),
2140-2148.
Artículo
169 - Ortiz,E., Rendon-Anaya,M., Rego,S.C., Schwartz,E.F., Possani,L.D. (2014). Antarease-like Zn-metalloproteases are ubiquitous in the venom of different scorpion genera.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1840 (6),
1738-1746.
Artículo
170 - Pedraza-Escalona,M., Batista,C.V., Restano-Cassulini,R., Sandoval-Rios,M., Coronas,F.I., Possani,L.D. (2014). A proteomic analysis of the early secondary molecular effects caused by Cn2 scorpion toxin on neuroblastoma cells.
Journal of Proteomics,
111,
212-223.
Artículo
171 - Picco,C., Corzo,G., Possani,L.D., Prestipino,G. (2014). Interaction of the scorpion toxin Discrepin with Kv4.3 channels and A-type K channels in cerebellum granular cells.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1840 (9),
2744-2751.
Artículo
172 - Rodriguez-Ravelo,R., Restano-Cassulini,R., Zamudio,F.Z., Coronas,F.I.V., Espinosa-Lopez,G., Possani,L.D. (2014). A K+ channel blocking peptide from the Cuban scorpion Rhopalurus garridoi.
Peptides,
53,
42-47.
Artículo
173 - Vergara,I., Pedraza-Escalona,M., Paniagua,D., Restano-Cassulini,R., Zamudio,F., Batista,C.V., Possani,L.D., Alagon,A. (2014). Eastern coral snake Micrurus fulvius venom toxicity in mice is mainly determined by neurotoxic phospholipases A.
Journal of Proteomics,
105,
295-306.
Artículo
174 - Abdel-Rahman,M.A., Quintero-Hernandez,V., Possani,L.D. (2013). Venom proteomic and venomous glands transcriptomic analysis of the Egyptian scorpion Scorpio maurus palmatus (Arachnida: Scorpionidae).
Toxicon,
74,
193-207.
Artículo; Actas Paper
175 - Aguilar,M.B., Ortiz,E., Kaas,Q., Lopez-Vera,E., Becerril,B., Possani,L.D., de la Cotera,E.P. (2013). Precursor De13.1 from Conus delessertii defines the novel G gene superfamily.
Peptides,
41,
17-20.
Artículo
176 - Bernaldez,J., Roman-Gonzalez,S.A., Martinez,O., Jimenez,S., Vivas,O., Arenas,I., Corzo,G., Arreguin,R., Garcia,D.E., Possani,L.D., Licea,A. (2013). A Conus regularis Conotoxin with a Novel Eight-Cysteine Framework Inhibits CaV2.2 Channels and Displays an Anti-Nociceptive Activity.
Marine Drugs,
11 (4),
1188-1202.
Artículo
177 - Caliskan,F., Quintero-Hernandez,V., Restano-Cassulini,R., Coronas-Valderrama,F.I., Corzo,G., Possani,L.D. (2013). Molecular cloning and biochemical characterization of the first Na+-channel alpha-type toxin peptide (Acra4) from Androctonus crassicauda scorpion venom.
Biochimie,
95 (6),
1216-1222.
Artículo
178 - Deuis,J.R., Zimmermann,K., Romanovsky,A.A., Possani,L.D., Cabot,P.J., Lewis,R.J., Vetter,I. (2013). An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na1.6 in peripheral pain pathways.
Pain,
154 (9),
1749-1757.
Artículo
179 - Garcia,F., Villegas,E., Espino-Solis,G.P., Rodriguez,A., Paniagua-Solis,J.F., Sandoval-Lopez,G., Possani,L.D., Corzo,G. (2013). Antimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics.
Journal of Antibiotics,
66 (1),
3-10.
Artículo
180 - Luna-Ramirez,K., Quintero-Hernandez,V., Vargas-Jaimes,L., Batista,C.V., Winkel,K., Possani,L.D. (2013). Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity.
Toxicon,
63 (1),
44-54.
Artículo
181 - Mourao,C.B., Heghinian,M.D., Barbosa,E.A., Mari,F., Bloch,C.,Jr., Restano-Cassulini,R., Possani,L.D., Schwartz,E.F. (2013). Characterization of a novel peptide toxin from Acanthoscurria paulensis spider venom: a distinct cysteine assignment into the HWTX-II family.
Biochemistry,
52 (14),
2440-2452.
Artículo
182 - Pedraza-Escalona,M., Possani,L.D. (2013). Scorpion beta-toxins and voltage-gated sodium channels: interactions and effects.
Frontiers in Bioscience,
18 (2),
572-587.
Revisión
183 - Quintero-Hernandez,V., Jimenez-Vargas,J.M., Gurrola,G.B., Valdivia,H.H., Possani,L.D. (2013). Scorpion venom components that affect ion-channels function.
Toxicon,
76,
328-342.
Artículo
184 - Riano-Umbarila,L., Olamendi-Portugal,T., Morelos-Juarez,C., Gurrola,G.B., Possani,L.D., Becerril,B. (2013). A novel human recombinant antibody fragment capable of neutralizing Mexican scorpion toxins.
Toxicon,
76,
370-376.
Artículo
185 - Rodriguez-Ravelo,R., Coronas,F.I., Zamudio,F.Z., Gonzalez-Morales,L., Lopez,G.E., Urquiola,A.R., Possani,L.D. (2013). The Cuban scorpion Rhopalurus junceus (Scorpiones, Buthidae): component variations in venom samples collected in different geographical areas.
Journal of Venomous Animals and Toxins Including Tropical Diseases,
19 (1),
13.
Artículo
186 - Sanchez-Vasquez,L., Silva-Sanchez,J., Jimenez-Vargas,J.M., Rodriguez-Romero,A., Munoz-Garay,C., Rodriguez,M.C., Gurrola,G.B., Possani,L.D. (2013). Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1830 (6),
3427-3436.
Artículo
187 - Schwartz,E.F., Bartok,A., Schwartz,C.A., Papp,F., Gomez-Lagunas,F., Panyi,G., Possani,L.D. (2013). OcyKTx2, a new K-channel toxin characterized from the venom of the scorpion Opisthacanthus cayaporum.
Peptides,
46,
40-46.
Artículo
188 - Valdez-Velazquez,L.L., Quintero-Hernandez,V., Romero-Gutierrez,M.T., Coronas,F.I.V., Possani,L.D. (2013). Mass Fingerprinting of the Venom and Transcriptome of Venom Gland of Scorpion Centruroides tecomanus.
PLoS ONE,
8 (6),
e66486.
Artículo
189 - Caliskan,F., Garcia,B.I., Coronas,F.I., Restano-Cassulini,R., Korkmaz,F., Sahin,Y., Corzo,G., Possani,L.D. (2012). Purification and cDNA cloning of a novel neurotoxic peptide (Acra3) from the scorpion Androctonus crassicauda.
Peptides,
37 (1),
106-112.
Artículo
190 - Caliskan,F., Quintero-Hernandez,V., Restano-Cassulini,R., Batista,C.V.F., Zamudio,F.Z., Coronas,F.I., Possani,L.D. (2012). Turkish scorpion Buthacus macrocentrus: General characterization of the venom and description of Bu1, a potent mammalian Na+-channel à-toxin.
Toxicon,
59 (3),
408-415.
Artículo
191 - Clement,H., Costa de Oliveira,V, Zamudio,F.Z., Lago,N.R., Valdez-Cruz,N.A., Valle,M.B., Alagon,A.C., Possani,L.D., de Roodt,A.R. (2012). Isolation, amino acid sequence and biological characterization of an "aspartic-49" phospholipase A(2) from Bothrops (Rhinocerophis) ammodytoides Venom.
Toxicon,
60 (7),
1314-1323.
Artículo
192 - Clement,H., Olvera,A., Rodriguez,M., Zamudio,F., Palomares,L.A., Possani,L.D., Odell,G.V., Alagon,A., Sanchez-Lopez,R. (2012). Identification, cDNA cloning and heterologous expression of a hyaluronidase from the tarantula Brachypelma vagans venom.
Toxicon,
60 (7),
1223-1227.
Artículo
193 - Guerrero-Vargas,J.A., Mourao,C.B., Quintero-Hernandez,V., Possani,L.D., Schwartz,E.F. (2012). Identification and Phylogenetic Analysis of Tityus pachyurus and Tityus obscurus Novel Putative Na-Channel Scorpion Toxins.
PLoS ONE,
7 (2),
e30478.
Artículo
194 - Gurrola,G.B., Hernandez-Lopez,R.A., Rodriguez de la Vega,R.C., Varga,Z., Batista,C.V., Salas-Castillo,S.P., Panyi,G., del Rio-Portilla,F., Possani,L.D. (2012). Structure, function and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes.
Biochemistry,
51 (19),
4049-4061.
Artículo
195 - Jimenez-Vargas,J.M., Restano-Cassulini,R., Possani,L.D. (2012). Interacting sites of scorpion toxin ErgTx1 with hERG1 K(+) channels.
Toxicon,
59 (6),
633-641.
Artículo
196 - Jimenez-Vargas,J.M., Restano-Cassulini,R., Possani,L.D. (2012). Toxin modulators and blockers of hERG K(+) channels.
Toxicon,
60 (4),
492-501.
Artículo
197 - Quintero-Hernandez,V., Del Pozo-Yauner,L., Pedraza-Escalona,M., Juarez-Gonzalez,V.R., Alcantara-Recillas,I., Possani,L.D., Becerril,B. (2012). Evaluation of three different formats of a neutralizing single chain human antibody against toxin Cn2: Neutralization capacity versus thermodynamic stability.
Immunology Letters,
143 (2),
152-160.
Artículo
Artículo
199 - Rendon-Anaya,M., Delaye,L., Possani,L.D., Herrera-Estrella,A. (2012). Global Transcriptome Analysis of the Scorpion Centruroides noxius: New Toxin Families and Evolutionary Insights from an Ancestral Scorpion Species.
PLoS ONE,
7 (8),
e43331.
Artículo
200 - Rodriguez-Rodriguez,E.R., Ledezma-Candanoza,L.M., Contreras-Ferrat,L.G., Olamendi-Portugal,T., Possani,L.D., Becerril,B., Riano-Umbarila,L. (2012). A Single Mutation in Framework 2 of the Heavy Variable Domain Improves the Properties of a Diabody and a Related Single-Chain Antibody.
Journal of Molecular Biology,
423 (3),
337-350.
Artículo
201 - Saucedo,A.L., Flores-Solis,D., Rodriguez de la Vega,R.C., Ramirez-Cordero,B., Hernandez-Lopez,R., Cano-Sanchez,P., Noriega-Navarro,R., Garcia-Valdes,J., Coronas-Valderrama,F., de Roodt,A., Brieba,L.G., Possani,L.D., del Rio-Portilla,F. (2012). New tricks of an old pattern: structural versatility of scorpion toxins with common cysteine spacing.
Journal of Biological Chemistry,
287 (15),
12321-12330.
Artículo
202 - Saucedo,A.L., Del Rio,F., Picco,C., Estrada,G., Prestipino,G., Possani,L.D., Delepierre,M., Corzo,G. (2012). Solution structure of native and recombinant expressed toxin CssII from the venom of the scorpion suffusus, and their effects on Nav1.5 Sodium channels.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1824 (3),
478-487.
Artículo
203 - Schiavon,E., Pedraza-Escalona,M., Gurrola,G.B., Olamendi-Portugal,T., Corzo,G., Wanke,E., Possani,L.D. (2012). Negative-shift activation, current reduction and resurgent currents induced by beta-toxins from Centruroides scorpions in sodium channels.
Toxicon,
59 (2),
283-293.
Artículo
204 - Varga,Z., Gurrola-Briones,G., Papp,F., Rodriguez de la Vega,R.C., Pedraza-Alva,G., Tajhya,R.B., Gaspar,R., Cardenas,L., Rosenstein,Y., Beeton,C., Possani,L.D., Panyi,G. (2012). Vm24, a Natural Immunosuppressant Peptide Potently and Selectively Blocks Kv1.3 Potassium Channels of Human T Cells.
Molecular Pharmacology,
82 (3),
372-382.
Artículo
205 - Wang,X., Jimenez-Vargas,J.M., Xu,C., Possani,L.D., Zhu,S. (2012). Positive selection-guided mutational analysis revealing two key functional sites of scorpion ERG K(+) channel toxins.
Biochemical and Biophysical Research Communications,
429 (1-2),
111-116.
Artículo
206 - Amaro,I., Riano-Umbarila,L., Becerril,B., Possani,L.D. (2011). Isolation and characterization of a human antibody fragment specific for Ts1 toxin from Tityus serrulatus scorpion.
Immunology Letters,
139 (1-2),
73-79.
Artículo
207 - Camargos,T.S., Restano-Cassulini,R., Possani,L.D., Peigneur,S., Tytgat,J., Schwartz,C.A., de Freitas,S.M., Schwartz,E.F. (2011). The new kappa-KTx 2.5 from the scorpion Opisthacanthus cayaporum.
Peptides,
32 (7),
1509-1517.
Artículo
208 - Canul-Tec,J.C., Riano-Umbarila,L., Rudino-Pinera,E., Becerril,B., Possani,L.D., Torres-Larios,A. (2011). Structural basis of neutralization of the major toxic component from the scorpion centruroides noxius hoffmann by a human-derived single chain antibody fragment.
Journal of Biological Chemistry,
286 (23),
20892-20900.
Revisión
209 - Corrales-Garcia,L.L., Possani,L.D., Corzo,G. (2011). Expression systems of human beta-defensins: vectors, purification and biological activities.
Amino Acids,
40 (1),
5-13.
Artículo
210 - Espino-Solis,G.P., Estrada,G., Olamendi-Portugal,T., Villegas,E., Zamudio,F., Cestele,S., Possani,L.D., Corzo,G. (2011). Isolation and molecular cloning of beta-neurotoxins from the venom of the scorpion Centruroides suffusus suffusus.
Toxicon,
57 (5),
739-746.
Artículo
Artículo
212 - Garcia-Gomez,B.I., Coronas,F.I., Restano-Cassulini,R., Rodriguez,R.R., Possani,L.D. (2011). Biochemical and molecular characterization of the venom from the Cuban scorpion Rhopalurus junceus.
Toxicon,
58 (1),
18-27.
Artículo
213 - Hernandez-Aponte,C.A., Silva-Sanchez,J., Quintero-Hernandez,V., Rodriguez-Romero,A., Balderas,C., Possani,L.D., Gurrola,G.B. (2011). Vejovine, a new antibiotic from the scorpion venom of Vaejovis mexicanus.
Toxicon,
57 (1),
84-92.
Artículo; Actas Paper
214 - Jimenez-Vargas,J.M., Restano-Cassulini,R., Quintero-Hernandez,V., Gurrola,G.B., Possani,L.D. (2011). Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function.
Peptides,
32 (3),
560-567.
Revisión
215 - Quintero-Hernandez,V., Ortiz,E., Rendon,M.R., Schwartz,E.F., Becerril,B., Corzo,G., Possani,L.D. (2011). Scorpion and spider venom peptides: Gene cloning and peptide expression.
Toxicon,
58 (8),
644-663.
Artículo
216 - Riano-Umbarila,L., Contreras-Ferrat,G., Olamendi-Portugal,T., Morelos-Juarez,C., Corzo,G., Possani,L.D., Becerril,B. (2011). Exploiting cross-reactivity to neutralize two different scorpion venoms with one single-chain antibody fragment.
Journal of Biological Chemistry,
286 (8),
6143-6151.
Artículo
217 - Rodriguez,A., Villegas,E., Satake,H., Possani,L.D., Corzo,G. (2011). Amino acid substitutions in an alpha-helical antimicrobial arachnid peptide affect its chemical properties and biological activity towards pathogenic bacteria but improves its therapeutic index.
Amino Acids,
40 (1),
61-68.
Artículo
218 - de Roodt,A.R., Coronas,F.I., Lago,N., Gonzalez,M.E., Laskowicz,R.D., Beltramino,J.C., Saavedra,S., Lopez,R.A., Reati,G., Vucharchuk,M.G., Bazan,E., Varni,L., Salomon,O.D., Possani,L.D. (2010). General biochemical and immunological characterization of the venom from the scorpion Tityus trivittatus of Argentina.
Toxicon,
55 (2-3),
307-319.
Artículo
219 - Gurrola,G.B., Capes,E.M., Zamudio,F.Z., Possani,L.D., Valdivia,H.H. (2010). Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors.
Pharmaceuticals.(Basel),
3 (4),
1093-1107.
Artículo
220 - Redaelli,E., Restano-Cassulini,R., Fuentes-Silva,D., Clement,H., Schiavon,E., Zamudio,F.Z., Odell,G., Arcangeli,A., Clare,J.J., Alagon,A., Rodriguez de la Vega,R.C., Possani,L.D., Wanke,E. (2010). Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels.
Journal of Biological Chemistry,
285 (6),
4130-4142 .
Artículo; Actas Paper
221 - Rodriguez de la Vega,R.C., Schwartz,E.F., Possani,L.D. (2010). Mining on scorpion venom biodiversity.
Toxicon,
56 (7),
1155-1161.
Artículo
222 - Vandendriessche,T., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D., Tytgat,J. (2010). Isolation and characterization of two novel scorpion toxins: the alpha-toxin-like CeII8, specific for Na(v)1.7 channels and the classical anti-mammalian CeII9, specific for Na(v)1.4 channels.
Toxicon,
56 (4),
613-623.
Artículo
223 - Zhu,S., Gao,B., Aumelas,A., Rodriguez,M.D., Lanz-Mendoza,H., Peigneur,S., Diego-Garcia,E., Martin-Eauclaire,M.F., Tytgat,J., Possani,L.D. (2010). MeuTXKbeta1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1804 (4),
872-883.
Artículo
224 - Corzo,G., Bernard,C., Clement,H., Villegas,E., Bosmans,F., Tytgat,J., Possani,L.D., Darbon,H., Alagon,A. (2009). Insecticidal peptides from the theraposid spider Brachypelma albiceps: A NMR-based model of Ba2.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1794 (8),
1190-1196.
Artículo
225 - Corzo,G., Prochnicka-Chalufour,A., Garcia,B.I., Possani,L.D., Delepierre,M. (2009). Solution structure of Cn5, a crustacean toxin found in the venom of the scorpions Centruroides noxius and Centruroides suffusus suffusus.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1794 (11),
1591-1598.
Artículo
226 - D'Suze,G., Schwartz,E.F., Garcia,B.I., Sevcik,C., Possani,L.D. (2009). Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans.
Biochimie,
91 (8),
1010-1019.
Revisión
227 - Espino-Solis,G.P., Riano-Umbarila,L., Becerril,B., Possani,L.D. (2009). Antidotes against venomous animals: State of the art and prospectives.
Journal of Proteomics,
72 (2),
183-199.
Artículo
228 - Espino-Solis,G.P., Calderon-Amador,J., Calderon-Aranda,E.S., Licea,A.F., Donis-Maturano,L., Flores-Romo,L., Possani,L.D. (2009). Rational design of synthetic peptides to generate antibodies that recognize in situ CD11c+ putative dendritic cells in horse lymph nodes.
Veterinary Immunology and Immunopathology,
132 (2-4),
181-190.
Artículo
229 - Garcia-Gomez,B.I., Olamendi-Portugal,T.C., Paniagua,J., van der Walt,J., Dyason,K., Possani,L.D. (2009). Heterologous expression of a gene that codes for Pg8, a scorpion toxin of Parabuthus granulatus, capable of generating protecting antibodies in mice.
Toxicon,
53 (7-8),
770-778.
Artículo
230 - Gonzalez-Morales,L., Diego-Garcia,E., Segovia,L., Gutierrez,M.C., Possani,L.D. (2009). Venom from the centipede Scolopendra viridis Say: purification, gene cloning and phylogenetic analysis of a phospholipase A2.
Toxicon,
54 (1),
8-15.
Artículo
231 - Hernandez-Salgado,K., Estrada,G., Olvera,A., Coronas,F.I., Possani,L.D., Corzo,G. (2009). Heterologous expressed toxic and non-toxic peptide variants of toxin CssII are capable to produce neutralizing antibodies against the venom of the scorpion Centruroides suffusus suffusus.
Immunology Letters,
125 (2),
93-99.
Artículo
232 - Kauferstein,S., Kendel,Y., Nicke,A., Coronas,F.I., Possani,L.D., Favreau,P., Krizaj,I., Wunder,C., Kauert,G., Mebs,D. (2009). New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptors.
Toxicon,
54 (3),
295-301.
Artículo
233 - Papp,F., Batista,C.V., Varga,Z., Herceg,M., Roman-Gonzalez,S.A., Gaspar,R., Possani,L.D., Panyi,G. (2009). Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus.
Toxicon,
54 (4),
379-389.
Revisión
234 - Prestipino,G., Corzo,G., Romeo,S., Murgia,A.R., Zanardi,I., Gurrola,G., Possani,L.D. (2009). Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells.
Toxicology Letters,
187 (1),
1-9.
Artículo
235 - Schwartz,E.F., Capes,E.M., Diego-Garcia,E., Zamudio,F.Z., Fuentes,O., Possani,L.D., Valdivia,H.H. (2009). Characterization of hadrucalcin, a peptide from Hadrurus gertschi scorpion venom with pharmacological activity on ryanodine receptors.
British Journal of Pharmacology,
157 (3),
392-403.
Artículo
236 - Silva,E.C., Camargos,T.S., Maranhao,A.Q., Silva-Pereira,I., Silva,L.P., Possani,L.D., Schwartz,E.F. (2009). Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum.
Toxicon,
54 (3),
252-261.
Artículo
237 - Abdel-Mottaleb,Y., Corzo,G., Martin-Eauclaire,M.F., Satake,H., Ceard,B., Peigneur,S., Nambaru,P., Bougis,P.E., Possani,L.D., Tytgat,J. (2008). A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K(+) channels.
Biochemical Pharmacology,
76 (6),
805-815.
Artículo
238 - Carballar-Lejarazu,R., Rodriguez,M.H., De La Cruz Hernandez-Hernandez,F., Ramos-Castaneda,J., Possani,L.D., Zurita-Ortega,M., Reynaud-Garza,E., Hernandez-Rivas,R., Loukeris,T., Lycett,G., Lanz-Mendoza,H. (2008). Recombinant scorpine: a multifunctional antimicrobial peptide with activity against different pathogens.
Cellular and Molecular Life Sciences,
65 (19),
3081-3092.
Artículo
239 - Corzo,G., Papp,F., Varga,Z., Barraza,O., Espino-Solis,P.G., Rodriguez de la Vega,R.C., Gaspar,R., Panyi,G., Possani,L.D. (2008). A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus.
Biochemical Pharmacology,
76 (9),
1142-1154.
Artículo
240 - Corzo,G., Diego-Garcia,E., Clement,H., Peigneur,S., Odell,G., Tytgat,J., Possani,L.D., Alagon,A. (2008). An insecticidal peptide from the theraposid Brachypelma smithi spider venom reveals common molecular features among spider species from different genera.
Peptides,
29 (11),
1901-1908.
Artículo
241 - Diego-Garcia,E., Abdel-Mottaleb,Y., Schwartz,E.F., de la Vega RC, Tytgat,J., Possani,L.D. (2008). Cytolytic and K(+) channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms.
Cellular and Molecular Life Sciences,
65 (1),
187-200.
Artículo
242 - Espino-Solis,G.P., Osuna-Quintero,J., Possani,L.D. (2008). Molecular cloning and characterization of the alphaX subunit from CD11c/CD18 horse integrin.
Veterinary Immunology and Immunopathology,
122 (3-4),
326-334.
Artículo
243 - Olamendi-Portugal,T., Batista,C.V., Restano-Cassulini,R., Pando,V., Villa-Hernandez,O., Zavaleta-Martinez-Vargas,A., Salas-Arruz,M.C., de la Vega RC, Becerril,B., Possani,L.D. (2008). Proteomic analysis of the venom from the fish eating coral snake Micrurus surinamensis: Novel toxins, their function and phylogeny.
Proteomics,
8 (9),
1919-1932.
Artículo
244 - Petricevich,V.L., Reynaud,E., Cruz,A.H., Possani,L.D. (2008). Macrophage activation, phagocytosis and intracellular calcium oscillations induced by scorpion toxins from Tityus serrulatus.
Clinical and Experimental Immunology,
154 (3),
415-423.
Artículo
245 - Restano-Cassulini,R., Olamendi-Portugal,T., Zamudio,F., Becerril,B., Possani,L.D. (2008). Two Novel Ergtoxins, Blockers of K(+)-channels, Purified from the Mexican Scorpion Centruroides elegans elegans.
Neurochemical Research,
33 (8),
1525-1533.
Artículo
246 - Romeo,S., Corzo,G., Vasile,A., Satake,H., Prestipino,G., Possani,L.D. (2008). A positive charge at the N-terminal segment of Discrepin increases the blocking effect of K(+) channels responsible for the I(A) currents in cerebellum granular cells.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1780 (4),
750-755.
Artículo
247 - Schwartz,E.F., Camargos,T.S., Zamudio,F.Z., Silva,L.P., Bloch,C.,Jr., Caixeta,F., Schwartz,C.A., Possani,L.D. (2008). Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum.
Toxicon,
51 (8),
1499-1508.
Artículo
248 - Batista,C.V., Roman-Gonzalez,S.A., Salas-Castillo,S.P., Zamudio,F.Z., Gomez-Lagunas,F., Possani,L.D. (2007). Proteomic analysis of the venom from the scorpion Tityus stigmurus: Biochemical and physiological comparison with other Tityus species.
Comparative Biochemistry and Physiology - C Toxicology and Pharmacology,
146 (1-2),
147-157.
Artículo
249 - Clement,H., Odell,G., Zamudio,F.Z., Redaelli,E., Wanke,E., Alagon,A., Possani,L.D. (2007). Isolation and characterization of a novel toxin from the venom of the spider Grammostola rosea that blocks sodium channels.
Toxicon,
50 (1),
65-74.
Artículo; Actas Paper
250 - Diego-Garcia,E., Schwartz,E.F., D'Suze,G., Roman-Gonzalez,S.A., Batista,C.V., Garcia,B.I., Rodriguez de la Vega,R.C., Possani,L.D. (2007). Wide phylogenetic distribution of Scorpine and long-chain beta-KTx-like peptides in scorpion venoms: Identification of "orphan" components.
Peptides,
28 (1),
31-37.
Artículo
251 - Estrada,G., Garcia,B.I., Schiavon,E., Ortiz,E., Cestele,S., Wanke,E., Possani,L.D., Corzo,G. (2007). Four disulfide-bridged scorpion beta neurotoxin CssII: Heterologous expression and proper folding in vitro.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1770 (8),
1161-1168.
Artículo
252 - Lopez-Vera,E., Aguilar,M.B., Schiavon,E., Marinzi,C., Ortiz,E., Restano-Cassulini,R., Batista,C.V.F., Possani,L.D., Heimer de la Cotera,E.P., Peri,F., Becerril,B., Wanke,E. (2007). Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors.
Febs Journal,
274 (15),
3972-3985.
Artículo
253 - Petricevich,V.L., Hernandez-Cruz,A., Coronas,F.I., Possani,L.D. (2007). Toxin gamma from Tityus serrulatus scorpion venom plays an essential role in immunomodulation of macrophages.
Toxicon,
50 (5),
666-675.
Artículo
254 - Quintero-Hernandez,V., Juarez-Gonzalez,V.R., Ortiz-Leon,M., Sanchez,R., Possani,L.D., Becerril,B. (2007). The change of the scFv into the Fab format improves the stability and in vivo toxin neutralization capacity of recombinant antibodies.
Molecular Immunology,
44 (6),
1307-1315.
Artículo
255 - Rodriguez de la Vega,R.C., Possani,L.D. (2007). Novel paradigms on scorpion toxins that affect the activating mechanism of sodium channels.
Toxicon,
49 (2),
171-180.
Artículo
256 - Schwartz,E.F., Diego-Garcia,E., Rodriguez de la Vega,R.C., Possani,L.D. (2007). Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones).
BMC Genomics,
8 (1),
119.
Artículo
257 - Valdez-Cruz,N.A., Segovia,L., Corona,M., Possani,L.D. (2007). Sequence analysis and phylogenetic relationship of genes encoding heterodimeric Phospholipases A2 from the venom of the scorpion Anuroctonus phaiodactylus.
Gene,
396 (1),
149-158.
Artículo
258 - Abdel-Mottaleb,Y., Coronas,F.V., de Roodt,A.R., Possani,L.D., Tytgat,J. (2006). A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new alpha-KTX subfamily.
FEBS Letters,
580 (2),
592-596.
Artículo
259 - Barona,J., Batista,C.V., Zamudio,F.Z., Gomez-Lagunas,F., Wanke,E., Otero,R., Possani,L.D. (2006). Proteomic analysis of the venom and characterization of toxins specific for Na(+)- and K(+)-channels from the Colombian scorpion Tityus pachyurus.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1764 (1),
76-84.
Artículo
260 - Batista,C.V., D'Suze,G., Gomez-Lagunas,F., Zamudio,F.Z., Encarnacion,S., Sevcik,C., Possani,L.D. (2006). Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins.
Proteomics,
6 (12),
3718-3727.
Artículo
261 - Caliskan,F., Garcia,B.I., Coronas,F.I., Batista,C.V., Zamudio,F.Z., Possani,L.D. (2006). Characterization of venom components from the scorpion Androctonus crassicauda of Turkey: Peptides and genes.
Toxicon,
48 (1),
12-22.
Artículo
262 - Mebs,D., Kuch,U., Coronas,F.I., Batista,C.V., Gumprecht,A., Possani,L.D. (2006). Biochemical and biological activities of the venom of the Chinese pitviper Zhaoermia mangshanensis, with the complete amino acid sequence and phylogenetic analysis of a novel Arg49 phospholipase A(2) myotoxin.
Toxicon,
47 (7),
797-811.
Revisión
263 - Panyi,G., Possani,L.D., Rodriguez de la Vega,R.C., Gaspar,R., Varga,Z. (2006). K+ Channel Blockers: Novel Tools to Inhibit T Cell Activation Leading to Specific Immunosuppression.
Current Pharmaceutical Design,
12 (18),
2199-2220.
Artículo
264 - Prochnicka-Chalufour,A., Corzo,G., Satake,H., Martin-Eauclaire,M.F., Murgia,A.R., Prestipino,G., D'Suze,G., Possani,L.D., Delepierre,M. (2006). Solution Structure of Discrepin, a New K(+)-Channel Blocking Peptide from the alpha-KTx15 Subfamily(,).
Biochemistry,
45 (6),
1795-1804.
Artículo; Actas Paper
265 - Restano-Cassulini,R., Korolkova,Y.V., Diochot,S., Gurrola,G., Guasti,L., Possani,L., Lazdunski,M., Grishin,E., Arcangeli,A., Wanke,E. (2006). Species Diversity and Peptide Toxins Blocking Selectivity of ERG Subfamily K+ Channels in CNS.
Molecular Pharmacology,
69 (5),
1673-1683.
Artículo
266 - Schiavon,E., Sacco,T., Restano-Cassulini,R., Gurrola,G., Tempia,F., Possani,L.D., Wanke,E. (2006). Resurgent current and voltage sensor-trapping enhanced activation by a {beta}-scorpion toxin solely in nav1.6 channel: Significance in Mice Purkinje Neurons.
Journal of Biological Chemistry,
281 (29),
20326-20337.
Artículo
267 - Schwartz,E.F., Schwartz,C.A., Gomez-Lagunas,F., Zamudio,F.Z., Possani,L.D. (2006). HgeTx1, the first K(+)-channel specific toxin characterized from the venom of the scorpion Hadrurus gertschi Soleglad.
Toxicon,
48 (8),
1046-1053.
Artículo
268 - Aguilar,M.B., Lopez-Vera,E., Ortiz,E., Becerril,B., Possani,L.D., Olivera,B.M., Heimer de la Cotera,E.P. (2005). A Novel Conotoxin from Conus delessertii with Posttranslationally Modified Lysine Residues.
Biochemistry,
44 (33),
11130-11136.
Artículo
269 - Bagdaany,M., Batista,C.V., Valdez-Cruz,N.A., Somodi,S., Rodriguez de la Vega,R.C., Licea,A.F., Varga,Z., Gaspar,R., Possani,L.D., Panyi,G. (2005). Anuroctoxin, a new scorpion toxin of the {alpha}-KTx 6 subfamily is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes.
Molecular Pharmacology,
67 (4),
1034-1044.
Artículo
270 - Coronas,F.I., Balderas,C., Lopez,L.P., Possani,L.D., Gurrola,G.B. (2005). Amino acid sequence determination and chemical synthesis of CllErg1 (gamma-KTx1.5), a K+ channel blocker peptide isolated from the scorpion Centruroides limpidus limpidus.
Journal of the Brazilian Chemical Society,
16 (3A),
404-411.
Artículo
271 - Diego-Garcia,E., Batista,C.V., Garcia-Gomez,B.I., Lucas,S., Candido,D.M., Gomez-Lagunas,F., Possani,L.D. (2005). The Brazilian scorpion Tityus costatus Karsch: genes, peptides and function.
Toxicon,
45 (3),
273-283.
Revisión
272 - Gazarian,K.G., Gazarian,T., Hernandez,R., Possani,L.D. (2005). Immunology of scorpion toxins and perspectives for generation of anti-venom vaccines.
Vaccine,
23 (26),
3357-3368.
Artículo
273 - Juarez-Gonzalez,V.R., Riano-Umbarila,L., Quintero-Hernandez,V., Olamendi-Portugal,T., Ortiz-Leon,M., Ortiz,E., Possani,L.D., Becerril,B. (2005). Directed Evolution, Phage Display and Combination of Evolved Mutants: A Strategy to Recover the Neutralization Properties of the scFv Version of BCF2 a Neutralizing Monoclonal Antibody Specific to Scorpion Toxin Cn2.
Journal of Molecular Biology,
346 (5),
1287-1297.
Artículo
274 - Olamendi-Portugal,T., Somodi,S., Fernandez,J.A., Zamudio,F.Z., Becerril,B., Varga,Z., Panyi,G., Gaspar,R., Possani,L.D. (2005). Novel alpha-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockage Kv1.3 over IKCa1 K(+) channels of T cells.
Toxicon,
46 (4),
418-429.
Artículo
275 - Padilla,A., Govezensky,T., Possani,L.D., Larralde,C. (2005). Mortality and antibody responses of mice to three successive episodes of experimental scorpion (Centruroides limpidus limpidus) envenomation and immunological rescue.
Toxicon,
46 (2),
142-149.
Artículo
276 - Possani,L.D. (2005). Insecticidal peptide from scorpion venom.
Industrial Bioprocessing,
27 (2),
9-10.
Artículo
277 - Riano-Umbarila,L., Juarez-Gonzalez,V.R., Olamendi-Portugal,T., Ortiz-Leon,M., Possani,L.D., Becerril,B. (2005). A strategy for the generation of specific human antibodies by directed evolution and phage display.
Febs Journal,
272 (10),
2591-2601.
Revisión
278 - Rodriguez de la Vega,R.C., Possani,L.D. (2005). Overview of scorpion toxins specific for Na(+) channels and related peptides: biodiversity, structure-function relationships and evolution.
Toxicon,
46 (8),
831-844.
Carta
279 - Rodriguez de la Vega,R.C., Possani,L.D. (2005). On the evolution of invertebrate defensins.
Trends in Genetics,
21 (6),
330-332.
Artículo
280 - Batista,C.V., Del Pozo,L., Zamudio,F.Z., Contreras,S., Becerril,B., Wanke,E., Possani,L.D. (2004). Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins.
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences,
803 (1),
55-66.
Artículo
281 - D'Suze,G., Sevcik,C., Corona,M., Zamudio,F.Z., Batista,C.V., Coronas,F.I., Possani,L.D. (2004). Ardiscretin a novel arthropod-selective toxin from Tityus discrepans scorpion venom.
Toxicon,
43 (3),
263-272.
Artículo
282 - D'Suze,G., Batista,C.V., Frau,A., Murgia,A.R., Zamudio,F.Z., Sevcik,C., Possani,L.D., Prestipino,G. (2004). Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K(+)-channels (I(A) currents) of cerebellum granular cells.
Archives of Biochemistry and Biophysics,
430 (2),
256-263.
Artículo
283 - Frenal,K., Xu,C.Q., Wolff,N., Wecker,K., Gurrola,G.B., Zhu,S.Y., Chi,C.W., Possani,L.D., Tytgat,J., Delepierre,M. (2004). Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K(+) channels.
Proteins,
56 (2),
367-375.
Artículo
284 - Gomez-Lagunas,F., Batista,C.V., Olamendi-Portugal,T., Ramirez-Dominguez,M.E., Possani,L.D. (2004). Inhibition of the collapse of the shaker k+ conductance by specific scorpion toxins.
Journal of General Physiology,
123 (3),
265-279.
Artículo
285 - Huys,I., Olamendi-Portugal,T., Garcia-Gomez,B.I., Vandenberghe,I., Van Beeumen,J., Dyason,K., Clynen,E., Zhu,S., van der Walt,J., Possani,L., Tytgat,J. (2004). A subfamily of acidic alpha -K+ toxins.
Journal of Biological Chemistry,
279 (4),
2781-2789.
Artículo
286 - Montero-Solis,C., Gonzalez-Ceron,L., Rodriguez,M.H., Cirerol,B.E., Zamudio,F., Possanni,L.D., James,A.A., De La Cruz Hernandez-Hernandez,F. (2004). Identification and characterization of gp65, a salivary-gland-specific molecule expressed in the malaria vector Anopheles albimanus.
Insect Molecular Biology,
13 (2),
155-164.
Artículo
287 - Murgia,A.R., Batista,C.V., Prestipino,G., Possani,L.D. (2004). Amino acid sequence and function of a new alpha-toxin from the Amazonian scorpion Tityus cambridgei.
Toxicon,
43 (6),
737-740.
Artículo
288 - Pascual,I., Gil-Parrado,S., Cisneros,M., Joseph-Bravo,P., Diaz,J., Possani,L.D., Charli,J.L., Chavez,M. (2004). Purification of a specific inhibitor of pyroglutamyl aminopeptidase II from the marine annelide Hermodice carunculata. In vivo effects in rodent brain.
International Journal of Biochemistry and Cell Biology,
36 (1),
138-152.
Artículo
289 - Rio-Portilla,F., Hernandez-Marin,E., Pimienta,G., Coronas,F.V., Zamudio,F.Z., Rodriguez de la Vega,R.C., Wanke,E., Possani,L.D. (2004). NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical beta-toxin sequence but with alpha-like physiological activity.
European Journal of Biochemistry,
271 (12),
2504-2516.
Artículo
290 - Rodriguez de la Vega,R.C., Garcia,B.I., D'Ambrosio,C, Diego-Garcia,E., Scaloni,A., Possani,L.D. (2004). Antimicrobial peptide induction in the haemolymph of the Mexican scorpion Centruroides limpidus limpidus in response to septic injury.
Cellular and Molecular Life Sciences,
61 (12),
1507-1519.
Revisión
291 - Rodriguez de la Vega,R.C., Possani,L.D. (2004). Current views on scorpion toxins specific for K(+)-channels.
Toxicon,
43 (8),
865-875.
Artículo
292 - Selisko,B., Cosio,G., Garcia,C., Becerril,B., Possani,L.D., Horjales,E. (2004). Bacterial expression, purification and functional characterization of a recombinant chimeric Fab derived from murine mAb BCF2 that neutralizes the venom of the scorpion Centruroides noxius hoffmann.
Toxicon,
43 (1),
43-51.
Artículo
293 - Shalabi,A., Zamudio,F., Wu,X., Scaloni,A., Possani,L., Villereal,M.L. (2004). Tetrapandins, a new class of scorpion toxins that specifically inhibit store-operated calcium entry in HEK-293 cells.
Journal of Biological Chemistry,
279 (2),
1040-1049.
Artículo
294 - Valdez-Cruz,N.A., Batista,C.V., Possani,L.D. (2004). Phaiodactylipin, a glycosylated heterodimeric phospholipase A from the venom of the scorpion Anuroctonus phaiodactylus.
European Journal of Biochemistry,
271 (8),
1453-1464.
Artículo
295 - Valdez-Cruz,N.A., Batista,C.V., Zamudio,F.Z., Bosmans,F., Tytgat,J., Possani,L.D. (2004). Phaiodotoxin, a novel structural class of insect-toxin isolated from the venom of the Mexican scorpion Anuroctonus phaiodactylus.
European Journal of Biochemistry,
271 (23-24),
4753-4761.
Artículo
296 - Valdez-Cruz,N.A., Davila,S., Licea,A., Corona,M., Zamudio,F.Z., Garcia-Valdes,J., Boyer,L., Possani,L.D. (2004). Biochemical, genetic and physiological characterization of venom components from two species of scorpions: Centruroides exilicauda Wood and Centruroides sculpturatus Ewing.
Biochimie,
86 (6),
387-396.
Artículo
297 - Zhu,X., Zamudio,F.Z., Olbinski,B.A., Possani,L.D., Valdivia,H.H. (2004). Activation of skeletal ryanodine receptors by two novel scorpion toxins from buthotus judaicus.
Journal of Biological Chemistry,
279 (25),
26588-26596.
Artículo
298 - Corona,M., Coronas,F.V., Merino,E., Becerril,B., Gutierrez,R., Rebolledo-Antunez,S., Garcia,D.E., Possani,L.D. (2003). A novel class of peptide found in scorpion venom with neurodepressant effects in peripheral and central nervous system of the rat.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1649 (1),
58-67.
Artículo
299 - Coronas,F.V., de Roodt,A.R., Portugal,T.O., Zamudio,F.Z., Batista,C.V., Gomez-Lagunas,F., Possani,L.D. (2003). Disulfide bridges and blockage of Shaker B K(+)-channels by another butantoxin peptide purified from the Argentinean scorpion Tityus trivittatus.
Toxicon,
41 (2),
173-179.
Artículo
300 - Coronas,F.V., Stankiewicz,M., Batista,C.V., Giraud,S., Alam,J.M., Possani,L.D., Mebs,D., Pelhate,M. (2003). Primary structure and electrophysiological characterization of two almost identical isoforms of toxin from Isometrus vittatus (family: Buthidae) scorpion venom.
Toxicon,
41 (8),
989-997.
Artículo
301 - Garcia,C., Calderon-Aranda,E.S., Anguiano,G.A., Becerril,B., Possani,L.D. (2003). Analysis of the immune response induced by a scorpion venom sub-fraction, a pure peptide and a recombinant peptide, against toxin Cn2 of Centruroides noxius Hoffmann.
Toxicon,
41 (4),
417-427.
Artículo
302 - Gazarian,T.G., Selisko,B., Gurrola,G.B., Possani,L.D., Gazarian,K.G. (2003). Potential of Peptides Selected from Random Phage-Displayed Libraries to Mimic Conformational Epitopes: A Study on Scorpion Toxin Cn2 and the Neutralizing Monoclonal Antibody BCF2.
Combinatorial Chemistry & High Throughput Screening,
6 (2),
119-132.
Artículo
303 - Guijarro,J.I., M'Barek,S., Gomez-Lagunas,F., Garnier,D., Rochat,H., Sabatier,J.M., Possani,L.D., Delepierre,M. (2003). Solution structure of Pi4, a short four-disulfide-bridged scorpion toxin specific of potassium channels.
Protein Science,
12 (9),
1844-1854.
Artículo
304 - Gutierrez,M.C., Abarca,C., Possani,L.D. (2003). A toxic fraction from scolopendra venom increases the basal release of neurotransmitters in the ventral ganglia of crustaceans.
Comparative Biochemistry and Physiology - C Toxicology and Pharmacology,
135 (2),
205-214.
Artículo
305 - Lopez-Gonzalez,I., Olamendi-Portugal,T., de la Vega-Beltran,J.L., van der Walt,J., Dyason,K., Possani,L.D., Felix,R., Darszon,A. (2003). Scorpion toxins that block T-type Ca(2+) channels in spermatogenic cells inhibit the sperm acrosome reaction.
Biochemical and Biophysical Research Communications,
300 (2),
408-414.
Artículo
306 - Padilla,A., Govezensky,T., Possani,L.D., Larralde,C. (2003). Experimental envenoming of mice with venom from the scorpion Centruroides limpidus limpidus: differences in mortality and symptoms with and without antibody therapy relating to differences in age, sex and strain of mouse.
Toxicon,
41 (8),
959-965.
Carta
307 - Xu,C.Q., Zhu,S.Y., Chi,C.W., Tytgat,J., Possani,L.D., Rodriguez de la Vega,R.C. (2003). Turret and pore block of K+ channels: What is the difference? (multiple letters).
Trends in Pharmacological Sciences,
24 (9),
446-449.
Artículo
308 - Angulo,Y., Olamendi-Portugal,T., Alape-Giron,A., Possani,L.D., Lomonte,B. (2002). Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A(2) homologue.
International Journal of Biochemistry and Cell Biology,
34 (10),
1268-1278.
Artículo
309 - Batista,C.V., Gomez-Lagunas,F., Rodriguez de la Vega,R.C., Hajdu,P., Panyi,G., Gaspar,R., Possani,L.D. (2002). Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1601 (2),
123-131.
Artículo
310 - Batista,C.V., Zamudio,F.Z., Lucas,S., Fox,J.W., Frau,A., Prestipino,G., Possani,L.D. (2002). Scorpion toxins from Tityus cambridgei that affect Na(+)-channels.
Toxicon,
40 (5),
557-562.
Artículo
311 - Corona,M., Gurrola,G.B., Merino,E., Cassulini,R.R., Valdez-Cruz,N.A., Garcia,B, Ramirez-Dominguez,M.E., Coronas,F.I., Zamudio,F.Z., Wanke,E., Possani,L.D. (2002). A large number of novel Ergtoxin-like genes and ERG K(+)-channels blocking peptides from scorpions of the genus Centruroides.
FEBS Letters,
532 (1-2),
121-126.
Artículo
312 - Corzo,G., Villegas,E., Gomez-Lagunas,F., Possani,L.D., Belokoneva,O.S., Nakajima,T. (2002). Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins.
Journal of Biological Chemistry,
277 (26),
23627-23637.
Artículo
313 - Lecchi,M., Redaelli,E., Rosati,B., Gurrola,G., Florio,T., Crociani,O., Curia,G., Cassulini,R.R., Masi,A., Arcangeli,A., Olivotto,M., Schettini,G., Possani,L.D., Wanke,E. (2002). Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release.
Journal of Neuroscience,
22 (9),
3414-3425.
Artículo
314 - Olamendi-Portugal,T., Garcia,B.I., Lopez-Gonzalez,I., van der Walt,J., Dyason,K., Ulens,C., Tytgat,J., Felix,R., Darszon,A., Possani,L.D. (2002). Two new scorpion toxins that target voltage-gated Ca(2+) and Na(+) channels.
Biochemical and Biophysical Research Communications,
299 (4),
562-568.
Artículo
315 - Pardo-Lopez,L., Garcia-Valdes,J., Gurrola,G.B., Robertson,G.A., Possani,L.D. (2002). Mapping the receptor site for ergtoxin, a specific blocker of ERG channels.
FEBS Letters,
510 (1-2),
45-49.
Artículo
316 - Pardo-Lopez,L., Zhang,M., Liu,J., Jiang,M., Possani,L.D., Tseng,G.N. (2002). Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel's outer vestibule.
Journal of Biological Chemistry,
277 (19),
16403-16411.
Artículo
317 - Possani,L.D., Corona,M., Zurita,M., Rodriguez,M.H. (2002). From Noxiustoxin to Scorpine and Possible Transgenic Mosquitoes Resistant to Malaria.
Archives of Medical Research,
33 (4),
398-404.
Artículo
318 - Ramirez-Dominguez,M.E., Olamendi-Portugal,T., Garcia,U., Garcia,C., Arechiga,H., Possani,L.D. (2002). Cn11, the first example of a scorpion toxin that is a true blocker of Na(+) currents in crayfish neurons.
Journal of Experimental Biology,
205 (Pt 6),
869-876.
Artículo
319 - Vacher,H., Alami,M., Crest,M., Possani,L.D., Bougis,P.E., Martin-Eauclaire,M.F. (2002). Expanding the scorpion toxin alpha-KTX 15 family with AmmTX3 from Androctonus mauretanicus.
European Journal of Biochemistry,
269 (24),
6037-6041.
Artículo
320 - Corona,M., Valdez-Cruz,N.A., Merino,E., Zurita,M., Possani,L.D. (2001). Genes and peptides from the scorpion Centruroides sculpturatus Ewing, that recognize Na(+)-channels.
Toxicon,
39 (12),
1893-1898.
Artículo
321 - Frau,A., Pisciotta,M., Gurrola,G.B., Possani,L.D., Prestipino,G. (2001). Synthetic undecapeptide (NTX10-20) of noxiustoxin blocks completely the I(A) potassium currents of cerebellum granular cells.
European Biophysics Journal,
29 (8),
569-573.
Artículo
322 - Garcia-Valdes,J., Zamudio,F.Z., Toro,L., Possan,L.D. (2001). Slotoxin, alphaKTx1.11, a new scorpion peptide blocker of MaxiK channels that differentiates between alpha and alpha+beta (beta1 or beta4) complexes.
FEBS Letters,
505 (3),
369-373. .
Artículo
323 - Goudet,C., Ferrer,T., Galan,L., Artiles,A., Batista,C.F., Possani,L.D., Alvarez,J., Aneiros,A., Tytgat,J. (2001). Characterization of two Bunodosoma granulifera toxins active on cardiac sodium channels.
British Journal of Pharmacology,
134 (6),
1195-1206.
Artículo
324 - Nishigaki,T., Zamudio,F.Z., Possani,L.D., Darszon,A. (2001). Time-Resolved Sperm Responses to an Egg Peptide Measured by Stopped-Flow Fluorometry.
Biochemical and Biophysical Research Communications,
284 (2),
531-535.
Artículo
325 - Peter,M.,Jr, Varga,Z., Hajdu,P., Gaspar,R., Damjanovich,S., Horjales,E., Possani,L.D., Panyi,G. (2001). Effects of toxins Pi2 and Pi3 on human T lymphocyte Kv1.3 channels: the role of Glu7 and Lys24.
Journal of Membrane Biology,
179 (1),
13-25.
Artículo
326 - Rocchetti,M., Besana,A., Gurrola,G.B., Possani,L.D., Zaza,A. (2001). Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential.
Journal of Physiology,
534 (Pt 3),
721-732.
Artículo
327 - Angulo,Y., Olamendi-Portugal,T., Possani,L.D., Lomonte,B. (2000). Isolation and characterization of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a new Lys49 phospholipase A2 homologue.
International Journal of Biochemistry and Cell Biology,
32 (1),
63-71.
Artículo
328 - Batista,C.V., Gomez-Lagunas,F., Lucas,S., Possani,L.D. (2000). Tc1, from Tityus cambridgei, is the first member of a new subfamily of scorpion toxin that blocks K(+)-channels.
FEBS Letters,
486 (2),
117-120.
Carta
329 - Bottiglieri,C., Ferrara,L., Corona,M., Gurrola,G.B., Batista,C., Wanke,E., Possani,L.D. (2000). Disulfide bridges of ergtoxin, a member of a new sub-family of peptide blockers of the ether-a-go-go-related K+ channel.
FEBS Letters,
479 (3),
156-157 .
Artículo
330 - Conde,R., Zamudio,F.Z., Rodriguez,M.H., Possani,L.D. (2000). Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion venom.
FEBS Letters,
471 (2-3),
165-168.
Artículo
331 - Peter,M.,Jr, Hajdu,P., Varga,Z., Damjanovich,S., Possani,L.D., Panyi,G., Gaspar,R. (2000). Blockage of human T lymphocyte Kv1.3 channels by Pi1, a novel class of scorpion toxin.
Biochemical and Biophysical Research Communications,
278 (1),
34-37.
Artículo
332 - Pisciotta,M., Coronas,F.I., Bloch,C., Prestipino,G., Possani,L.D. (2000). Fast K(+) currents from cerebellum granular cells are completely blocked by a peptide purified from Androctonus australis Garzoni scorpion venom.
Biochimica et Biophysica Acta (BBA) - Biomembranes,
1468 (1-2),
203-212.
Artículo
333 - Possani,L.D., Merino,E., Corona,M., Bolivar,F., Becerril,B. (2000). Peptides and genes coding for scorpion toxins that affect ion-channels.
Biochimie,
82 (9-10),
861-868.
Carta
Artículo
335 - Torres-Larios,A., Gurrola,G.B., Zamudio,F.Z., Possani,L.D. (2000). Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus.
European Journal of Biochemistry,
267 (16),
5023-5031.
Artículo
336 - Altamirano,M.M., Garcia,C., Possani,L.D., Fersht,A.R. (1999). Oxidative refolding chromatography: folding of the scorpion toxin Cn5.
Nature Biotechnology,
17 (2),
187-191.
Artículo
337 - Batista,C.V., da Silva,L.R., Sebben,A., Scaloni,A., Ferrara,L., Paiva,G.R., Olamendi-Portugal,T., Possani,L.D., Bloch,C. (1999). Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.
Peptides,
20 (6),
679-686.
Artículo
338 - Calderon-Aranda,E.S., Riviere,G., Choumet,V., Possani,L.D., Bon,C. (1999). Pharmacokinetics of the toxic fraction of Centruroides limpidus limpidus venom in experimentally envenomed rabbits and effects of immunotherapy with specific F(ab')2.
Toxicon,
37 (5),
771-782.
Artículo
339 - Calderon-Aranda,E.S., Selisko,B., York,E.J., Gurrola,G.B., Stewart,J.M., Possani,L.D. (1999). Mapping of an epitope recognized by a neutralizing monoclonal antibody specific to toxin Cn2 from the scorpion Centruroides noxius, using discontinuous synthetic peptides.
European Journal of Biochemistry,
264 (3),
746-755.
Artículo
340 - Conde,R., Zamudio,F.Z., Becerril,B., Possani,L.D. (1999). Phospholipin, a novel heterodimeric phospholipase A2 from Pandinus imperator scp6pion venom.
FEBS Letters,
460 (3),
447-450.
Artículo
341 - Delepierre,M., Prochnicka-Chalufour,A., Boisbouvier,J., Possani,L.D. (1999). Pi7, an orphan peptide from the scorpion Pandinus imperator: a 1H-NMR analysis using a nano-NMR Probe.
Biochemistry,
38 (51),
16756-16765.
Artículo
342 - D'Suze,G., Zamudio,F., Gomez-Lagunas,F., Possani,L.D. (1999). A novel K+ channel blocking toxin from Tityus discrepans scorpion venom.
FEBS Letters,
456 (1),
146-148.
Artículo
343 - Gurrola,G.B., Rosati,B., Rocchetti,M., Pimienta,G., Zaza,A., Arcangeli,A., Olivotto,M., Possani,L.D., Wanke,E. (1999). A toxin to nervous, cardiac, and endocrine ERG K+ channels isolated from Centruroides noxius scorpion venom.
FASEB Journal,
13 (8),
953-962.
Artículo
344 - Ottolia,M., Babini,E., Gazzotti,P., Possani,L.D., Prestipino,G. (1999). Reconstitution of a voltage and calcium dependent potassium channel from rat cerebellum.
Brain Research,
815 (2),
410-413.
Artículo
345 - Pintar,A., Possani,L.D., Delepierre,M. (1999). Solution structure of toxin 2 from centruroides noxius Hoffmann, a beta-scorpion neurotoxin acting on sodium channels.
Journal of Molecular Biology,
287 (2),
359-367.
Revisión
346 - Possani,L.D., Selisko,B., Gurrola,G.B. (1999). Structure and function of scorpion toxins affecting K+-channels.
Perspectives In Drug Discovery And Design,
16,
15-40.
Revisión
347 - Possani,L.D., Becerril,B., Delepierre,M., Tytgat,J. (1999). Scorpion toxins specific for Na+-channels.
European Journal of Biochemistry,
264 (2),
287-300.
Artículo
Artículo
349 - Tytgat,J., Chandy,K.G., Garcia,M.L., Gutman,G.A., Martin-Eauclaire,M.F., van der Walt,J.J., Possani,L.D. (1999). A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies.
Trends in Pharmacological Sciences,
20 (11),
444-447.
Artículo
350 - Yamamoto,H., Sejbal,J., York,E., Stewart,J.M., Possani,L.D., Kotovych,G. (1999). An nmr conformational analysis of a synthetic peptide Cn2(1-15)NH2-S-S-acetyl-Cn2(52-66)NH2 from the New World Centruroides noxius 2 (Cn2) scorpion toxin: comparison of the structure with those of the Centruroides scorpion toxins.
Biopolymers,
49 (4),
277-286.
Artículo
351 - Boisbouvier,J., Prochnicka-Chalufour,A., Nieto,A.R., Torres,J.A., Nanard,N., Rodriguez,M.H., Possani,L.D., Delepierre,M. (1998). Structural information on a cecropin-like synthetic peptide, Shiva-3 toxic to the sporogonic development of Plasmodium berghei.
European Journal of Biochemistry,
257 (1),
263-273.
Artículo
352 - Delepierre,M., Prochnicka-Chalufour,A., Possani,L.D. (1998). 1H NMR structural analysis of novel potassium blocking toxins using a nano-NMR probe.
Toxicon,
36 (11),
1599-1608.
Artículo
353 - Licea,A.F., Gutierrez,M.C., Esparza,J., Estrada-Parra,S., Estrada,G.I., Quesada-Pascual,F., Possani,L.D. (1998). Enhancement of the immunogenicity of Mycobacterium leprae peptides by means of polymerization.
Asia-Pacific Journal Of Molecular Biology And Biotechnology,
6 (2),
89-95.
Artículo
354 - Martinez,F., Munoz-Garay,C., Gurrola,G., Darszon,A., Possani,L.D., Becerril,B. (1998). Site directed mutants of Noxiustoxin reveal specific interactions with potassium channels.
FEBS Letters,
429 (3),
381-384.
Artículo
Artículo
356 - Peter,M.,Jr, Varga,Z., Panyi,G., Bene,L., Damjanovich,S., Pieri,C., Possani,L.D., Gaspar,R. (1998). Pandinus imperator scorpion venom blocks voltage-gated K+ channels in human lymphocytes.
Biochemical and Biophysical Research Communications,
242 (3),
621-625.
Artículo
357 - Pisciotta,M., Ottolia,M., Possani,L.D., Prestipino,G. (1998). A novel toxin form the scorpion Androctonus australis blocks Shaker K+ channels expressed in Xenopus oocytes.
Biochemical and Biophysical Research Communications,
242 (2),
287-291.
Artículo
358 - Pisciotta,M., Coronas,F.I., Possani,L.D., Prestipino,G. (1998). The Androctonus australis garzoni scorpion venom contains toxins that selectively affect voltage-dependent K(+)-channels in cerebellum granular cells.
European Biophysics Journal,
27 (1),
69-73.
Artículo
359 - Possani,L.D., Zurita,M., Delepierre,M., Hernandez,F.H., Rodriguez,M.H. (1998). From noxiustoxin to Shiva-3, a peptide toxic to the sporogonic development of Plasmodium berghei.
Toxicon,
36 (11),
1683-1692.
Revisión
360 - Selisko,B., Garcia,C., Becerril,B., Gomez-Lagunas,F., Garay,C., Possani,L.D. (1998). Cobatoxins 1 and 2 from Centruroides noxius Hoffmann constitute a subfamily of potassium-channel-blocking scorpion toxins.
European Journal of Biochemistry,
254 (3),
468-479.
Artículo
361 - Tytgat,J., Debont,T., Rostoll,K., Muller,G.J., Verdonck,F., Daenens,P., van der Walt,J.J., Possani,L.D. (1998). Purification and partial characterization of a 'short' insectotoxin-like peptide from the venom of the scorpion Parabuthus schlechteri.
FEBS Letters,
441 (3),
387-391.
Artículo
362 - Valdivia,H.H., Possani,L.D. (1998). Peptide toxins as probes of ryanodine receptor structure and function.
Trends in Cardiovascular Medicine,
8 (3),
111-118.
Revisión
363 - Becerril,B., Marangoni,S., Possani,L.D. (1997). Toxins and genes isolated from scorpions of the genus Tityus.
Toxicon,
35 (6),
821-835.
Artículo
364 - Ben Khalifa,R., Stankiewicz,M., Pelhate,M., Serrano-Hernandez,S.E., Possani,L.D., Hinkel,H., Mebs,D. (1997). Action of babycurus-toxin 1 from the east African scorpion Babycurus centrurimorphus on the isolated cockroach giant axon.
Toxicon,
35 (7),
1069-1080.
Artículo
365 - Delepierre,M., Prochnicka-Chalufour,A., Possani,L.D. (1997). A novel potassium channel blocking toxin from the scorpion Pandinus imperator: A 1H NMR analysis using a nano-NMR probe.
Biochemistry,
36 (9),
2649-2658.
Artículo
366 - Garcia,C., Becerril,B., Selisko,B., Delepierre,M., Possani,L.D. (1997). Isolation, characterization and comparison of a novel crustacean toxin with a mammalian toxin from the venom of the scorpion Centruroides noxius Hoffmann.
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology,
116 (3),
315-322.
Artículo
367 - Gomez-Lagunas,F., Olamendi-Portugal,T., Possani,L.D. (1997). Block of ShakerB K+ channels by Pi1, a novel class of scorpion toxin.
FEBS Letters,
400 (2),
197-200.
Artículo
368 - Higareda,A.E., Possani,L.D., Ramirez,O.T. (1997). The use of culture redox potential and oxygen uptake rate for assessing glucose and glutamine depletion in hybridoma cultures.
Biotechnology and Bioengineering,
56 (5),
555-563.
Artículo
369 - Zamudio,F.Z., Gurrola,G.B., Arevalo,C., Sreekumar,R., Walker,J.W., Valdivia,H.H., Possani,L.D. (1997). Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptors.
FEBS Letters,
405 (3),
385-389.
Artículo
370 - Zamudio,F.Z., Conde,R., Arevalo,C., Becerril,B., Martin,B.M., Valdivia,H.H., Possani,L.D. (1997). The mechanism of inhibition of ryanodine receptor channels by imperatoxin I, a heterodimeric protein from the scorpion Pandinus imperator.
Journal of Biological Chemistry,
272 (18),
11886-11894.
Artículo
371 - Becerril,B., Corona,M., Coronas,F.I., Zamudio,F., Calderon-Aranda,E.S., Fletcher,P.L., Martin,B.M., Possani,L.D. (1996). Toxic peptides and genes encoding toxin gamma of the Brazilian scorpions Tityus bahiensis and Tityus stigmurus.
Biochemical Journal,
313 (Pt 3),
753-760.
Artículo
372 - Corona,M., Zurita,M., Possani,L.D., Becerril,B. (1996). Cloning and characterization of the genomic region encoding toxin IV-5 from the scorpion Tityus serrulatus Lutz and Mello.
Toxicon,
34 (2),
251-256.
Artículo
373 - Dehesa-Davila,M., Ramirez,A.N., Zamudio,F.Z., Gurrola-Briones,G., Lievano,A., Darszon,A., Possani,L.D. (1996). Structural and functional comparison of toxins from the venom of the scorpions Centruroides infamatus infamatus, Centruroides limpidus limpidus and Centruroides noxius.
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology,
113 (2),
331-339.
Artículo
374 - D'Suze,G., Corona,F., Possani,L.D., Sevcik,C. (1996). High performance liquid chromatography purification and amino acid sequence of toxins from the muscarinic fraction of Tityus discrepans scorpion venom.
Toxicon,
34 (5),
591-598.
Artículo
375 - Gomez-Lagunas,F., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D. (1996). Two novel toxins from the venom of the scorpion Pandinus imperator show that the N-terminal amino acid sequence is important for their affinities towards Shaker B K+ channels.
Journal of Membrane Biology,
152 (1),
49-56.
Artículo
376 - Licea,A.F., Becerril,B., Possani,L.D. (1996). Fab fragments of the monoclonal antibody BCF2 are capable of neutralizing the whole soluble venom from the scorpion Centruroides noxius Hoffmann.
Toxicon,
34 (8),
843-847.
Artículo
377 - Martinez,F., Becerril,B., Gurrola,G.B., Martin,B.M., Possani,L.D. (1996). Synthesis and expression of the gene coding for noxiustoxin, a K+ channel-blocking peptide from the venom of the scorpion Centruroides noxius.
Toxicon,
34 (11-12),
1413-1419.
Artículo
378 - Nieto,A.R., Gurrola,G.B., Vaca,L., Possani,L.D. (1996). Noxiustoxin 2, a novel K+ channel blocking peptide from the venom of the scorpion Centruroides noxius Hoffmann.
Toxicon,
34 (8),
913-922.
Artículo
379 - Nobile,M., Noceti,F., Prestipino,G., Possani,L.D. (1996). Helothermine, a lizard venom toxin, inhibits calcium current in cerebellar granules.
Experimental Brain Research,
110 (1),
15-20.
Artículo
380 - Olamendi-Portugal,T., Gomez-Lagunas,F., Gurrola,G.B., Possani,L.D. (1996). A novel structural class of K+-channel blocking toxin from the scorpion Pandinus imperator.
Biochemical Journal,
315 (Pt 3),
977-981.
Artículo
381 - Selisko,B., Garcia,C., Becerril,B., Delepierre,M., Possani,L.D. (1996). An insect-specific toxin from Centruroides noxius Hoffmann. cDNA, primary structure, three-dimensional model and electrostatic surface potentials in comparison with other toxin variants.
European Journal of Biochemistry,
242 (2),
235-242.
Artículo
382 - Vaca,L., Licea,A., Possani,L.D. (1996). Modulation of cell membrane potential in cultured vascular endothelium.
American Journal of Physiology - Cell Physiology,
270 (3 Pt 1),
C819-C824.
Artículo
383 - Zamudio,F., Wolf,K.M., Martin,B.M., Possani,L.D., Chiappinelli,V.A. (1996). Two novel alpha-neurotoxins isolated from the taipan snake, Oxyuranus scutellatus, exhibit reduced affinity for nicotinic acetylcholine receptors in brain and skeletal muscle.
Biochemistry,
35 (24),
7910-7916.
Artículo
384 - Becerril,B., Corona,M., Garcia,C., Bolivar,F., Possani,L.D. (1995). Cloning of genes encoding scorpion toxins: An interpretative review.
Journal Of Toxicology-Toxin Reviews,
14 (3),
339-357.
Artículo
385 - Calderon-Aranda,E.S., Olamendi-Portugal,T., Possani,L.D. (1995). The use of synthetic peptides can be a misleading approach to generate vaccines against scorpion toxins.
Vaccine,
13 (13),
1198-1206.
Artículo
386 - Dauplais,M., Gilquin,B., Possani,L.D., Gurrola-Briones,G., Roumestand,C., Menez,A. (1995). Determination of the three-dimensional solution structure of noxiustoxin: analysis of structural differences with related short-chain scorpion toxins.
Biochemistry,
34 (51),
16563-16573.
Artículo
387 - Drakopoulou,E., Cotton,J., Virelizier,H., Bernardi,E., Schoofs,A.R., Partiseti,M., Choquet,D., Gurrola,G., Possani,L.D., Vita,C. (1995). Chemical synthesis, structural and functional characterisation of noxiustoxin, a powerful blocker of lymphocyte voltage-dependent K+ channels.
Biochemical and Biophysical Research Communications,
213 (3),
901-907.
Artículo
388 - Gaspar,R., Bene,L., Damjanovich,S., Munoz-Garay,C., Calderon-Aranda,E.S., Possani,L.D. (1995). Beta-scorpion toxin 2 from Centruroides noxius blocks voltage-gated K+ channels in human lymphocytes.
Biochemical and Biophysical Research Communications,
213 (2),
419-423.
Artículo
389 - Gurrola,G.B., Possani,L.D. (1995). Structural and functional features of noxiustoxin: a K+ channel blocker.
Biochemistry and Molecular Biology International,
37 (3),
527-535.
Artículo
390 - Herion,P., Gurrola-Briones,G., Sanchez,M.D.R., Saavedra,R., Possani,L.D. (1995). Monoclonal antibodies against noxiustoxin.
Hybridoma,
14 (3),
247-251.
Artículo
391 - Morrissette,J., Kratzschmar,J., Haendler,B., Elhayek,R., Mochca-Morales,J., Martin,B.M., Patel,J.R., Moss,R.L., Schleuning,W.D., Coronado,R., Possani,L.D. (1995). Primary Structure and Properties of Helothermine, A Peptide Toxin That Blocks Ryanodine Receptors.
Biophysical Journal,
68 (6),
2280-2288.
Artículo
392 - Noceti,F., Ramirez,A.N., Possani,L.D., Prestipino,G. (1995). Characterization of a voltage-dependent potassium channel in squid Schwann cells reconstituted in planar lipid bilayers.
Glia,
15 (1),
33-42.
Artículo
393 - Noeske-Jungblut,C., Haendler,B., Donner,P., Alagon,A., Possani,L., Schleuning,W.D. (1995). Triabin, a highly potent exosite inhibitor of thrombin.
Journal of Biological Chemistry,
270 (48),
28629-28634.
Note
Note
Note
Note
Note
Note
Artículo
400 - Rodriguez,M.C., Zamudio,F., Torres,J.A., Gonzalez-Ceron,L., Possani,L.D., Rodriguez,M.H. (1995). Effect of a cecropin-like synthetic peptide (Shiva-3) on the sporogonic development of Plasmodium berghei.
Experimental Parasitology,
80 (4),
596-604.
Artículo
401 - Trequattrini,C., Zamudio,F.Z., Petris,A., Prestipino,G., Possani,L.D., Franciolini,F. (1995). Tityus bahiensis toxin IV-5b selectively affects Na channel inactivation in chick dorsal root ganglion neurons.
Comparative Biochemistry and Physiology -- Part A: Physiology,
112 (1),
21-28.
Artículo
402 - Vazquez,A., Tapia,J.V., Eliason,W.K., Martin,B.M., Lebreton,F., Delepierre,M., Possani,L.D., Becerril,B. (1995). Cloning and characterization of the cDNAs encoding Na+ channel-specific toxins 1 and 2 of the scorpion Centruroides noxius Hoffmann.
Toxicon,
33 (9),
1161-1170.
Artículo
403 - Dehesa-Davila,M., Martin,B.M., Nobile,M., Prestipino,G., Possani,L.D. (1994). Isolation of a toxin from Centruroides infamatus infamatus Koch scorpion venom that modifies Na+ permeability on chick dorsal root ganglion cells.
Toxicon,
32 (12),
1487-1493.
Artículo
404 - Dehesa-Davila,M., Possani,L.D. (1994). Scorpionism and serotherapy in Mexico.
Toxicon,
32 (9),
1015-1018.
Artículo
405 - Fletcher,M.D., Possani,L.D., Fletcher,P.L. (1994). Morphological studies by light and electron microscopy of pancreatic acinar cells under the effect of Tityus serrulatus venom.
Cell and Tissue Research,
278 (2),
255-264.
Artículo
406 - Gurrola,G.B., Moreno-Hagelsieb,G., Zamudio,F.Z., Garcia,M., Soberon,X., Possani,L.D. (1994). The disulfide bridges of toxin 2 from the scorpion Centruroides noxius Hoffmann and its three-dimensional structure calculated using the coordinates of variant 3 from Centruroides sculpturatus.
FEBS Letters,
347 (1),
59-62.
Artículo
407 - Gutierrez,M.C., ESTRADA,I.C.E., Estrada-Parra,S., Quesada-Pascual,F., Licea,A.F., Possani,L.D. (1994). The imunogenetic activity of synthetic peptides corresponding to M. Leprae protein sequences.
Asia-Pacific Journal Of Molecular Biology And Biotechnology,
2,
143-150.
Artículo; Actas Paper
408 - Higareda,A.E., Possani,L.D., Ramirez,O.T. (1994). Metabolic and kinetic studies of hybridomas in exponentially fed-batch cultures using T-flasks.
Cytotechnology,
15 (1-3),
73-86.
Artículo
409 - Lebreton,F., Delepierre,M., Ramirez,A.N., Balderas,C., Possani,L.D. (1994). Primary and NMR three-dimensional structure determination of a novel crustacean toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch.
Biochemistry,
33 (37),
11135-11149.
Artículo
410 - Martin,B.M., Ramirez,A.N., Gurrola,G.B., Nobile,M., Prestipino,G., Possani,L.D. (1994). Novel K(+)-channel-blocking toxins from the venom of the scorpion Centruroides limpidus limpidus Karsch.
Biochemical Journal,
304 (Pt 1),
51-56.
Artículo
411 - Nobile,M., Magnelli,V., Lagostena,L., Mochca-Morales,J., Possani,L.D., Prestipino,G. (1994). The toxin helothermine affects potassium currents in newborn rat cerebellar granule cells.
Journal of Membrane Biology,
139 (1),
49-55.
Artículo
412 - Noeske-Jungblut,C., Kratzschmar,J., Haendler,B., Alagon,A., Possani,L., Verhallen,P., Donner,P., Schleuning,W.D. (1994). An inhibitor of collagen-induced platelet aggregation from the saliva of Triatoma pallidipennis.
Journal of Biological Chemistry,
269 (7),
5050-5053.
Artículo
413 - Ramirez,A.N., Martin,B.M., Gurrola,G.B., Possani,L.D. (1994). Isolation and characterization of a novel toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch.
Toxicon,
32 (4),
479-490.
Artículo
414 - Sacile,R., Ruggiero,C., Ballestrero,R., Possani,L.D., Prestipino,G., Rauch,G. (1994). Secondary structure of noxiustoxin and charybdotoxin from hydropathy power spectra.
Biochemical and Biophysical Research Communications,
201 (1),
186-193.
Artículo
415 - Valdivia,H.H., Martin,B.M., Ramirez,A.N., Fletcher,P.L., Possani,L.D. (1994). Isolation and pharmacological characterization of four novel Na+ channel-blocking toxins from the scorpion Centruroides noxius Hoffmann.
Journal of Biochemistry,
116 (6),
1383-1391.
Artículo
416 - Becerril,B., Corona,M., Mejia,M.C., Martin,B.M., Lucas,S., Bolivar,F., Possani,L.D. (1993). The genomic region encoding toxin gamma from the scorpion Tityus serrulatus contains an intron.
FEBS Letters,
335 (1),
6-8.
Artículo
417 - Becerril,B., Vazquez,A., Garcia,C., Corona,M., Bolivar,F., Possam,L.D. (1993). Cloning and characterization of cDNAs that code for Na(+)-channel-blocking toxins of the scorpion Centruroides noxius Hoffmann.
Gene,
128 (2),
165-171.
Artículo
418 - Calderon-Aranda,E.S., Hozbor,D., Possani,L.D. (1993). Neutralizing capacity of murine sera induced by different antigens of scorpion venom.
Toxicon,
31 (3),
327-337.
Artículo
419 - Vaca,L., Gurrola,G.B., Possani,L.D., Kunze,D.L. (1993). Blockade of a KCa channel with synthetic peptides from noxiustoxin: a K+ channel blocker.
Journal of Membrane Biology,
134 (2),
123-129.
Artículo
420 - Vazquez,A., Becerril,B., Martin,B.M., Zamudio,F., Bolivar,F., Possani,L.D. (1993). Primary structure determination and cloning of the cDNA encoding toxin 4 of the scorpion Centruroides noxius Hoffmann.
FEBS Letters,
320 (1),
43-46.
Artículo
421 - Estrada,I.C., Gutierrez,M.C., Esparza,J., Quesada-Pascual,F., Estrada-Parra,S., Possani,L.D. (1992). Use of synthetic peptides corresponding to sequences of Mycobacterium leprae proteins to study delayed-type hypersensitivity response in sensitized guinea pigs.
International Journal of Leprosy,
60 (1),
18-27.
Artículo
422 - Fletcher,P.L., Fletcher,M.D., Possani,L.D. (1992). Characteristics of pancreatic exocrine secretion produced by venom from the Brazilian scorpion, Tityus serrulatus.
European Journal of Cell Biology,
58 (2),
259-270.
Note
423 - Harvey,A.L., Marshall,D.L., Possani,L.D. (1992). Dendrotoxin-like effects of noxiustoxin.
Toxicon,
30 (11),
1497-1500.
Artículo
424 - Possani,L.D., Fletcher,P.L., Fletcher,M.D., Rode,G.S., Mochca-Morales,J., Lucas,S., Coronas,F.V., Alagon,A.C., Martin,B.M. (1992). Structural and functional characteristics of toxins purified from the venom of the Brazilian scorpion Tityus serrulatus Lutz and Mello.
Memorias do Instituto Butantan,
54 (2),
35-52.
Artículo
425 - Possani,L.D., Mochca-Morales,J., Amezcua,J., Martin,B.M., Prestipino,G., Nobile,M. (1992). Anionic currents of chick sensory neurons are affected by a phospholipase A2 purified from the venom of the taipan snake.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research,
1134 (3),
210-216.
Artículo
426 - Possani,L.D., Martin,B.M., Yatani,A., Mochca-Morales,J., Zamudio,F.Z., Gurrola,G.B., Brown,A.M. (1992). Isolation and physiological characterization of taicatoxin, a complex toxin with specific effects on calcium channels.
Toxicon,
30 (11),
1343-1364.
Artículo
427 - Valdivia,H.H., Martin,B.M., Escobar,L., Possani,L.D. (1992). Noxiustoxin and leiurutoxin III, two homologous peptide toxins with binding properties to synaptosomal membrane K+ channels.
Biochemistry International,
27 (6),
953-962.
Artículo
428 - Zamudio,F., Saavedra,R., Martin,B.M., Gurrola-Briones,G., Herion,P., Possani,L.D. (1992). Amino acid sequence and immunological characterization with monoclonal antibodies of two toxins from the venom of the scorpion Centruroides noxius Hoffmann.
European Journal of Biochemistry,
204 (1),
281-292.
Artículo
429 - Possani,L.D., Martin,B.M., Fletcher,M.D., Fletcher,P.L. (1991). Discharge effect on pancreatic exocrine secretion produced by toxins purified from Tityus serrulatus scorpion venom.
Journal of Biological Chemistry,
266 (5),
3178-3185.
Artículo
430 - Colden-Stanfield,M., Schilling,W.P., Possani,L.D., Kunze,D.L. (1990). Bradykinin-induced potassium current in cultured bovine aortic endothelial cells.
Journal of Membrane Biology,
116 (3),
227-238.
*
Artículo
431 - Mochca-Morales,J., Martin,B.M., Possani,L.D. (1990). Isolation and characterization of helothermine, a novel toxin from Heloderma horridum horridum (Mexican beaded lizard) venom.
Toxicon,
28 (3),
299-309.
Artículo
432 - Possani,L.D. (1990). 3Rd Pan-American Symposium on Animal, Plant and Microbial Toxins, Oaxtepec, Morelos-State, Mexico - 9-12 January 1990.
Toxicon,
28 (6),
597-597.
Artículo
433 - Ramirez,G.A., Fletcher,P.L., Possani,L.D. (1990). Characterization of the venom from Crotalus molossus nigrescens Gloyd (black tail rattlesnake): isolation of two proteases.
Toxicon,
28 (3),
285-297.
Artículo
434 - Gurrola,G.B., Molinar-Rode,R., Sitges,M., Bayon,A., Possani,L.D. (1989). Synthetic peptides corresponding to the sequence of noxiustoxin indicate that the active site of this K+ channel blocker is located on its amino-terminal portion.
Journal of Neural Transmission,
77 (1),
11-20.
Artículo
435 - Kirsch,G.E., Skattebol,A., Possani,L.D., Brown,A.M. (1989). Modification of Na channel gating by an alpha scorpion toxin from Tityus serrulatus.
Journal of General Physiology,
93 (1),
67-83.
Artículo
436 - Prestipino,G., Valdivia,H.H., Lievano,A., Darszon,A., Ramirez,A.N., Possani,L.D. (1989). Purification and reconstitution of potassium channel proteins from squid axon membranes.
FEBS Letters,
250 (2),
570-574.
Artículo
437 - Alagon,A.C., Guzman,H.S., Martin,B.M., Ramirez,A.N., Carbone,E., Possani,L.D. (1988). Isolation and characterization of two toxins from the Mexican scorpion Centruroides limpidus limpidus Karsch.
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology,
89 (1),
153-161.
Artículo
438 - Martin,B.M., Carbone,E., Yatani,A., Brown,A.M., Ramirez,A.N., Gurrola,G.B., Possani,L.D. (1988). Amino acid sequence and physiological characterization of toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann.
Toxicon,
26 (9),
785-794.
Artículo
439 - Ramirez,A.N., Gurrola,G.B., Martin,B.M., Possani,L.D. (1988). Isolation of several toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann.
Toxicon,
26 (9),
773-783.
Artículo
440 - Valdivia,H.H., Smith,J.S., Martin,B.M., Coronado,R., Possani,L.D. (1988). Charybdotoxin and noxiustoxin, two homologous peptide inhibitors of the K+ (Ca2+) channel.
FEBS Letters,
226 (2),
280-284.
Artículo
441 - Yatani,A., Kirsch,G.E., Possani,L.D., Brown,A.M. (1988). Effects of New World scorpion toxins on single-channel and whole cell cardiac sodium currents.
American Journal of Physiology Heart and Circulatory Physiology,
254 (3 Pt 2),
H443-H451.
Artículo
442 - Brown,A.M., Yatani,A., Lacerda,A.E., Gurrola,G.B., Possani,L.D. (1987). Neurotoxins that act selectively on voltage-dependent cardiac calcium channels.
Circulation Research,
61 (4 Pt 2),
I6-I9.
Artículo
443 - Carbone,E., Prestipino,G., Spadavecchia,L., Franciolini,F., Possani,L.D. (1987). Blocking of the squid axon K+ channel by noxiustoxin: a toxin from the venom of the scorpion Centruroides noxius.
Pflugers Archiv European Journal of Physiology,
408 (5),
423-431.
Artículo
444 - Sitges,M., Possani,L.D., Bayon,A. (1987). Characterization of the actions of toxins II-9.2.2 and II-10 from the venom of the scorpion Centruroides noxius on transmitter release from mouse brain synaptosomes.
Journal of Neurochemistry,
48 (6),
1745-1752.
Artículo
445 - Alagon,A., Possani,L.D., Smart,J., Schleuning,W.D. (1986). Helodermatine, a kallikrein-like, hypotensive enzyme from the venom of Heloderma horridum horridum (Mexican beaded lizard).
Journal of Experimental Medicine,
164 (6),
1835-1845.
Artículo
446 - Rodriguez,A., Tablero,M., Barragan,B., Lara,P., Rangel,M., Arreguin,B., Possani,L., Soriano-Garcia,M. (1986). Crystallization of Hevein - A Protein from Latex of Hevea-Brasiliensis (Rubber Tree).
Journal of Crystal Growth,
76 (3),
710-714.
*
Artículo
447 - Sitges,M., Possani,L.D., Bayon,A. (1986). Noxiustoxin, a short-chain toxin from the Mexican scorpion Centruroides noxius, induces transmitter release by blocking K+ permeability.
Journal of Neuroscience,
6 (6),
1570-1574.
*
Artículo
448 - Sosa,B.P., Alagon,A.C., Martin,B.M., Possani,L.D. (1986). Biochemical characterization of the phospholipase A2 purified from the venom of the Mexican beaded lizard (Heloderma horridum horridum Wiegmann).
Biochemistry,
25 (10),
2927-2933.
*
Artículo
449 - Possani,L.D., Martin,B.M., Svendsen,I., Rode,G.S., Erickson,B.W. (1985). Scorpion toxins from Centruroides noxius and Tityus serrulatus. Primary structures and sequence comparison by metric analysis.
Biochemical Journal,
229 (3),
739-750.
*
Artículo
450 - Carbone,E., Prestipino,G., Franciolini,F., Dent,M.A., Possani,L.D. (1984). Selective modification of the squid axon Na currents by Centruroides noxius toxin II-10.
Journal de Physiologie,
79 (4),
179-184.
*
Artículo
451 - Alagon,A.C., Maldonado,M.E., Julia,J.Z., Sanchez,C.R., Possani,L.D. (1982). Venom from two sub-species of Heloderma horridum (Mexican beaded lizard): general characterization and purification of N-benzoyl-L-arginine ethyl ester hydrolase.
Toxicon,
20 (2),
463-475.
*
Artículo
452 - Carbone,E., Wanke,E., Prestipino,G., Possani,L.D., Maelicke,A. (1982). Selective blockage of voltage-dependent K+ channels by a novel scorpion toxin.
Nature,
296 (5852),
90-91.
*
Artículo
453 - Carbone,E., Wanke,E., Prestipino,G., Possani,L.D., Maelicke,A. (1982). Selective Action of Purified Scorpion Neurotoxins on the Ionic Currents of the Squid Giant-Axon.
Hoppe-Seylers Zeitschrift fur Physiologische Chemie,
363 (2),
1299-1300.
*
Artículo
454 - Possani,L.D., Martin,B.M., Svendsen,I.B. (1982). The Primary Structure of Noxiustoxin - A K+-Channel Blocking Peptide, Purified from the Venom of the Scorpion Centruroides-Noxius Hoffmann.
Carlsberg Research Communications,
47 (5),
285-289.
*
Artículo
455 - Trejo,A.C., Possani,L.D. (1982). Electron microscopic evidence for scorpion toxin binding to synapses of rat brain cortex.
Neuroscience Letters,
32 (2),
103-108.
*
Artículo
456 - Perez de la Mora,M., Possani,L.D., Tapia,R., Teran,L., Palacios,R., Fuxe,K., Hokfelt,T., Ljungdahl,A. (1981). Demonstration of central gamma-aminobutyrate-containing nerve terminals by means of antibodies against glutamate decarboxylase.
Neuroscience,
6 (5),
875-895.
*
Artículo
457 - Possani,L., Steinmetz,W.E., Dent,M.A., Alagon,A.C., Wuthrich,K. (1981). Preliminary spectroscopic characterization of six toxins from Latin American scorpions.
Biochimica et Biophysica Acta (BBA) - Protein Structure,
669 (2),
183-192.
*
Artículo
458 - Possani,L.D., Dent,M.A.R., Martin,B.M., Maelicke,A., Svendsen,I. (1981). The Amino Terminal Sequence of Several Toxins from the Venom of the Mexican Scorpion Centruroides Noxius Hoffmann.
Carlsberg Research Communications,
46 (4),
207-214.
*
Artículo
459 - Possani,L.D., Martin,B.M., Mochcamorales,J., Svendsen,I. (1981). Purification and Chemical Characterization of the Major Toxins from the Venom of the Brazilian Scorpion Tityus Serrulatus Lutz and Mello.
Carlsberg Research Communications,
46 (4),
195-205.
*
Note
460 - Possani,L.D., Fernandez de Castro,J., Julia,J.Z. (1981). Detoxification with glutaraldehyde of purified scorpion (Centruroides noxius Hoffmann) venom.
Toxicon,
19 (2),
323-329.
*
Artículo
461 - Alagon,A.C., Molinar,R.R., Possani,L.D., Fletcher,P.L., Cronan,J.E., Julia,J.Z. (1980). Venom from the snake Bothrops asper Garman. Purification and characterization of three phospholipases A2.
Biochemical Journal,
185 (3),
695-704.
*
Note
462 - Dent,M.A., Possani,L.D., Ramirez,G.A., Fletcher,P.L. (1980). Purification and characterization of two mammalian toxins from the venom of the Mexican scorpion Centruroides noxius Hoffmann.
Toxicon,
18 (3),
343-350.
*
Artículo
463 - Possani,L.D., Fletcher,P.L., Alagon,A.B., Alagon,A.C., Julia,J.Z. (1980). Purification and characterization of a mammalian toxin from venom of the Mexican scorpion, Centruroides limpidus tecomanus Hoffmann.
Toxicon,
18 (2),
175-183.
*
Note
464 - Possani,L.D., Sosa,B.P., Alagon,A.C., Burchfield,P.M. (1980). The venom from the snakes Agkistrodon bilineatus Taylori and Crotalus durissus Totonacus: lethality, biochemical and immunological properties.
Toxicon,
18 (3),
356-360.
*
Artículo
465 - Possani,L.D., Alagon,A.C., Fletcher,P.L., Varela,M.J., Julia,J.Z. (1979). Purification and characterization of a phospholipase A2 from the venom of the coral snake, Micrurus fulvius microgalbineus (Brown and Smith).
Biochemical Journal,
179 (3),
603-606.
*
Artículo
466 - Sosa,B.P., Alagon,A.C., Possani,L.D., Julia,J.Z. (1979). Comparison of phospholipase activity with direct and indirect lytic effects of animal venoms upon human red cells.
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry,
64 (2),
231-234.
*
Note
467 - Bayon,A., Possani,L.D., Rode,G., Tapia,R. (1978). Kinetics of brain glutamate decarboxylase. Dead-end and product inhibition studies.
Journal of Neurochemistry,
30 (6),
1629-1631.
*
Artículo
468 - Hokfelt,T., Elde,R., Fuxe,K., Johansson,O., Ljungdahl,A., Goldstein,M., Luft,R., Efendic,S., Nilsson,G., Terenius,L., Ganten,D., Jeffcoate,S.L., Rehfeld,J., Said,S., Perez de la Mora,M., Possani,L., Tapia,R., Teran,L., Palacios,R. (1978). Aminergic and peptidergic pathways in the nervous system with special reference to the hypothalamus.
Research publications - Association for Research in Nervous and Mental Disease,
56,
69-135.
*
Artículo
469 - Possani,L.D., Ramirez,G.A., Fletcher,P.L., Gurrola,M.A. (1978). Isolation of two mammalian toxins from the venom of the Mexican scorpion Centruroides elegans (Thorell).
FEBS Letters,
91 (2),
261-264.
*
Artículo
470 - Bayon,A., Possani,L.D., Tapia,M., Tapia,R. (1977). Kinetics of brain glutamate decarboxylase. Interactions with glutamate, pyridoxal 5'-phosphate and glutamate-pyridoxal 5'-phosphate Schiff base.
Journal of Neurochemistry,
29 (3),
519-525.
*
Artículo
471 - Bayon,A., Possani,L.D., Tapia,R. (1977). Kinetics of brain glutamate decarboxylase. Inhibition studies with N-(5'-phosphopyridoxyl) amino acids.
Journal of Neurochemistry,
29 (3),
513-517.
*
Artículo
472 - Possani,L.D., Bayon,A., Tapia,R. (1977). Synthesis of affinity chromatography resins for the purification of brain glutamate decarboxylase.
Neurochemical Research,
2 (1),
51-57.
*
Artículo
473 - Possani,L.D., Alagon,A.C., Fletcher,P.L., Erickson,B.W. (1977). Purification and properties of mammalian toxins from the venom of Brazilian Scorpion Tityus serrulatus Lutz and Mello.
Archives of Biochemistry and Biophysics,
180 (2),
394-403.
*
Artículo
474 - Klett,R.P., Fulpius,B.W., Cooper,D., Smith,M., Reich,E., Possani,L.D. (1973). The acetylcholine receptor. I. Purification and characterization of a macromolecule isolated from Electrophorus electricus.
Journal of Biological Chemistry,
248 (19),
6841-6853.
*
Artículo
475 - Possani,L.D. (1973). GABA effects and GABA receptors in neuromuscular junctions of crustaceans: analysis of some stereochemical models.
Revista brasileira de pesquisas medicas e biologicas,
6 (1),
31-42.
*
Artículo
476 - Tondo,C.V., Possani,L.D. (1972). Study of the bimodal frequency distribution of the relative concentration of hemoglobin S in heterozygous carriers.
Revista brasileira de pesquisas medicas e biologicas,
5 (1-2),
47-56.
*
Artículo
477 - Possani,L.D., Banerjee,R., Balny,C., Douzou,P. (1970). Oxidation of haemoglobin by oxygen in light: possible role of singlet oxygen.
Nature,
226 (248),
861-862.
*
Internacional
478 - Abdel-Rahman,M.A., Quintero-Hernandez,V., Possani,L.D. (2014). Scorpion Venom Gland Transcriptomics and Proteomics: An Overview. Venom Genomics and Proteomics.
105-124.
Internacional
479 - Rodriguez de la Vega,R.C., Corzo,G., Possani,L.D. (2014). Scorpion Venoms as a Platform for Drug Development. Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics.
204-220,
Cambridge: Royal Society of Chemistry.
Internacional
480 - Rodriguez-Rodriguez,E.R., Riano-Umbarila,L., Possani,L.D., Becerril,B. (2014). Recombinant neutralizing antibodies, a new generation of scorpion anti-venoms. Scorpion Venoms.
Toxinology,
139-159,
4,
Dordrecht: Springer.
Internacional
481 - Petricevich,V.L., Barbosa-Navarro,L., Possani,L.D. (2013). Therapeutic use of scorpion venom. Molecular aspects of inflammation.
209-231,
Kerala: Research Signpost.
Internacional
482 - Rodriguez-de-la-Vega,R., Vidal,N., Possani,L.D. (2013). Scorpion Peptides. Handbook of Biologically Active Peptides, second edition .
423-429.
Internacional
483 - Possani,L.D., Gurrola,G.B., Schwartz,E., Restano,R. (2011). Bioquimica y biologia molecular de los venenos de escorpiones de importancia medica en el continente americano. Emergencias por Animales Ponzonosos en las Americas .
147-180,
Mexico.
Internacional
484 - Valdez-Cruz,N.A., Conde,R., Zamudio,F., Possani,L.D. (2011). Anticoagulants from scorpion venoms. Toxins and Hemostasis: From Bench to Bedside .
255-266.
Internacional
485 - Rodriguez-de-la-Vega,R., Barraza,R., Restano,R., Possani,L.D. (2009). Toxins active on Herg channel: structure and function. Animal toxins: State of the Art. Perspectives in Health and Biotechnology .
193-204,
Belo Horizonte: EditoraUFMG.
Nacional
486 - Possani-Postay,L.D. (2008). El estudio de los componentes del veneno de alacranes en el contexto de la biología molecular, la farmacología y la medicina. Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 16.
179-187,
Mexico, D.F..
Internacional
487 - Delepierre,M., Possani,L.D. (2006). Pharmaceutical Applications of Ion Channel Blockers: Use of NMR to Determine the Structure of Scorpion Toxins. Modern Magnetic Resonance.
1325-1330,
2,
Dordrecht: Springer.
Internacional
488 - Possani,L.D., Rodriguez de la Vega,R.C. (2006). Scorpion venom peptides. Handbook of Biologically Active Peptides.
339-354,
San Diego.
Nacional
489 - Alagon,A., Possani,L.D. (2003). Desarrollo de nuevos f rmacos a partir de la fauna tropical. Fronteras de la Biología en los Inicios del Siglo XXI, Módulo VII .
123-160,
Mexico,D.F..
Internacional
490 - Possani,L.D., Merino,E., Corona,M., Becerril,B. (2002). Scorpion genes and peptides specific for potassium channels: Structure, function and evolution. Perspectives in Molecular Toxinology.
201-214.
Internacional
491 - Possani,L.D., Becerril,B., Tytgat,J., Delepierre,M. (2001). High Affinity Scorpion Toxins for Studying Potassium and Sodium Channels. Ion Channel Localization Methods and Protocols: Methods and Protocols.
145-165.
Internacional
492 - Calderon-Aranda,E.S., Dehesa-Davila,M., Chavez-Haro,A., Possani,L.D. (1996). Scorpion stings and their treatment in Mexico. Envenomings and their treatment.
311-320,
Lyon.
Internacional
493 - Dehesa-Davila,M., Alagon,A.C., Possani,L.D. (1995). Clinical toxicology of scorpion stings. Handbook of clinical toxicology of animal venoms and poisons.
221-238,
New York.
Memoria in extenso
494 - Gutierrez,M.C., Estrada,G.I., Estrada-Parra,S., Gurrola,G.B., Possani,L.D. (1991). Synthetic peptides as skin test reagents in leprosy. Proceedings Leprosy Research in Latin America.
7 p,
Caracas.
Memoria in extenso
495 - Possani,L.D., Gurrola,G.B., Portugal,T.O., Zamudio,F.Z., Vaca,L.D., Calderon,S.A., Kirsch,G.E. (1991). Scorpion toxins: a model for peptide synthesis of new drugs. Proceedings First Brazilian Congress on Proteins.
352-367,
Brasil.
Nacional
496 - Gurrola,G.B., Molina-Rode,R., Zentella,A.D., Possani,L.D. (1984). Sintesis de peptidos y su posible utilizacion como vacuna contra toxinas de alacran. Avances en el mecanismo de accion de farmacos.
35-50.
Internacional
497 - Possani,L.D. (1984). Structure of scorpion toxins. Handbook of natural toxins.
513-550,
New York.
*
Memoria in extenso
498 - Perez de la Mora,M., Fuxe,K., Hokfelt,T., Anderson,K., Possani,L., Tapia,R. (1981). Gabaergic synapses: distribution and interaction with other Neurotransmitter systems in the brain. Regulatory Mechanisms of Synaptic Transmission.
71-101,
Boston,MA.
*
Internacional
499 - Fuxe,K., Andersson,K., Schwarcz,R., Agnati,L.F., Perez de la Mora,M., Hokfelt,T., Goldstein,M., Ferland,L., Possani,L., Tapia,L. (1979). Studies on different types of dopamine nerve terminals in the forebrain adn their possible interactions with neurons. Advances in neurology.
Advances in neurology,
199-216,
New York.
*
Memoria in extenso
500 - Perez de la Mora,M., Fuxe,K., Andersson,K., Hokfelt,T., Ljungdahl,A., Possani,L., Tapia,R. (1979). STUDIES ON GABA-MONOAMINE AND GABA-ENDORPHIN INTERACTIONS. Catecholamines: Basic and Clinical Frontiers Proceedings of the Fourth International Catecholamine Symposium, Pacific Grove, California, September 17-22, 1978.
1032-1034.
*
Internacional
501 - Alagon,A.C., Possani,L.D., Erickson,B.W. (1978). ISOLATION AND CHARACTERIZATION OF SEVERAL PROTEINS FROM TITYUS SERRULATUS SCORPION VENOM. Toxins Animal, Plant and Microbial.
609-618.
*
Internacional
502 - Fuxe,K., Hokfelt,T., Agnati,L.F., Johansson,O., Goldstein,M., Perez de la Mora,M., Possani,L., Tapia,R., Teran,L., Palacios,R. (1978). Mapping out central catecholamine synthesizing neurons: immunohistochemical studies on catecholamine-synthesizing enzymes. Psychopharmacology: a Generation of Progress.
67-94,
New York.
*
Internacional
503 - Gopalakrishnakone, P., Possani, L. D., Schwartz, E., Rodriguez-de-la-Vega, R. (2014). Scorpion Venoms.
Toxinology,
Dordrecht: Springer.
Divulgación
Nacional
505 - Alagon,A., Carillo,C., Chavez-Haro,A., De la Mora-Zerpa,C., Larralde,C., Lamas,N, Martin,E, Osnaya-Romero,N., Perez,Y, Possani,L.D., Romero-Zamora,L. (2003). Práctica Médica Efectiva- Alacranismo (T63.2, X22).
Mexico.
nacional divulgacion
506 - Possani Postay,L.D. (2023). Un interés dedicado al conocimiento y las tecnologías para la salud a partir de venenos de alacranes.
Biotecnología en Movimiento. Revista de divulgación del Instituto de Biotecnología de la UNAM,
9 (32).
Divulgación
507 - Carcamo-Noriega,E.N., Possani-Postay,L.D. (2019). Veneno rojo: un potencial antibiotico contra la tuberculosis obtenido del veneno del alacran.
Biotecnología en Movimiento. Revista de divulgación del Instituto de Biotecnología de la UNAM,
18,
20-23.
Divulgación
508 - Becerril-Lujan,B., Riano,L., Possani,L (2014). Bancos de anticuerpos recombinantes de origen humano: una fuente ideal de antivenenos modernos contra la picadura de alacrán.
Revista Digital Universitaria,
15 (11),
art 84.
Editorial Material
509 - Garcia,M.L., Possani,L.D. (2007). Gating modifier peptides of ion channels.
Toxicon,
49 (2),
123.
Editorial Material
510 - Possani,L.D., Rodriguez de la Vega,R.C. (2003). Response to Xu et al.: Hypothesis-driven science paves the way for new discoveries.
Trends in Pharmacological Sciences,
24 (9),
448-449.
Editorial Material
511 - Possani,L.D. (2003). The past, present, and future of biotechnology in Mexico.
Nature Biotechnology,
21 (5),
582-583.
Editorial Material
512 - Rodriguez de la Vega,R.C., Merino,E., Becerril,B., Possani,L.D. (2003). Novel interactions between K(+) channels and scorpion toxins.
Trends in Pharmacological Sciences,
24 (5),
222-227.
Nacional
Nacional
514 - Domingos Possani,L. (1983). The toxins of scorpion venom: structure and function.
Boletin de estudios medicos y biologicos,
32 (7-8 Suppl 1),
285-297.
515 - Possani Postay, Lourival, D. (2024). Caracterización del veneno de alacrán Hoffmannihadrurus aztecus.
Dirección de Ingenieria en Biotecnología y Tecnologia Ambiental,
Licenciatura,
Universidad Politécnica del Estado de Morelos.
*
Asesor: Ortega Catalan, Angel Salvador
Artículo Short communication
516 - Delgado-Prudencio,G., Becerril,B., Possani,L.D., Ortiz,E.. New proposal for the systematic nomenclature of scorpion peptides.
Toxicon,
253,
108192.
Artículo
517 - Gallegos-Monterrosa,R., Cid-Uribe,J.I., Delgado-Prudencio,G., Perez-Morales,D., Banda,M.M., Tellez-Galvan,A., Carcamo-Noriega,E.N., Garza-Ramos,U., Zare,R.N., Possani,L.D., Bustamante,V.H.. Blue benzoquinone from scorpion venom shows bactericidal activity against drug-resistant strains of the priority pathogen Acinetobacter baumannii.
Journal of Antibiotics (Tokyo),
78,
235-245.
Artículo
518 - Monteiro,I.S., Araujo,I.F.S., Camargos,T.S., Ortiz,E., Souza,A.C.B., Lima,J.D., Possani,L.D., Schwartz,E.F., Tibery,D.V.. The First K(+)-Channel Blocker Described from Tityus fasciolatus Venom: The Purification, Molecular Cloning, and Functional Characterization of a-KTx4.9 (Tf5).
Toxins (Basel),
17 (2),
96.
Revisión
Artículo
520 - Gonzalez-Santillan,E., Valdez-Velazquez,L.L., Delgado-Hernandez,O., Cid-Uribe,J.I., Romero-Gutierrez,M.T., Possani,L.D.. A multigene approach to identify the scorpion species (Arachnida: Scorpiones) of Colima, Mexico, with comments on their venom diversity.
Revista Mexicana de Biodiversidad,
95,
e955373.
Artículo
521 - Restano-Cassulini,R., Olamendi-Portugal,T., Riano-Umbarila,L., Zamudio,F.Z., Delgado-Prudencio,G., Becerril,B., Possani,L.D.. Characterization of Sodium Channel Peptides Obtained from the Venom of the Scorpion Centruroides bonito.
Toxins (Basel),
16 (3),
125.
Articulo
522 - Riano-Umbarila,L., Olamendi-Portugal,T., Romero-Moreno,J.A., Delgado-Prudencio,G., Zamudio,F.Z., Becerril,B., Possani,L.D.. Toxic Peptides from the Mexican Scorpion Centruroides villegasi: Chemical Structure and Evaluation of Recognition by Human Single-Chain Antibodies.
Toxins (Basel),
16 (7),
301.
523 - Possani Postay, Lourival, D.. Caracterización del veneno de alacrán Hoffmannihadrurus aztecus.
Dirección de Ingenieria en Biotecnología y Tecnologia Ambiental,
Licenciatura,
Universidad Politécnica del Estado de Morelos.
*
Asesor: Ortega Catalan, Angel Salvador
Artículo
524 - Garcia-Villalvazo,P.E, Jimenez-Vargas,J.M, Lino-Lopez,G.J, Meneses,E.P, Bermudez-Guzman,M.J, Barajas-Saucedo,C.E, Delgado-Enciso,I., Possani,L.D, Valdez-Velazquez,L.L. Unveiling the Protein Components of the Secretory-Venom Gland and Venom of the Scorpion Centruroides possanii (Buthidae) through Omic Technologies.
Toxins (Basel),
15 (8),
498.
Artículo
525 - Gomez-Ramirez,I.V., Corrales-Garcia,L.L., Possani,L.D., Riano-Umbarila,L., Becerril,B.. Expression in Pichia pastoris of human antibody fragments that neutralize venoms of Mexican scorpions.
Toxicon,
223,
107012.
Artículo
526 - Ibarra-Vega,R., Jimenez-Vargas,J.M., Pineda-Contreras,A., Martinez-Martinez,F.J., Barajas-Saucedo,C.E., Garcia-Ortega,H., Magana-Vergara,N.E., Possani,L.D., Corzo,G., Gaitan-Hinojosa,M.A., Vazquez-Vuelvas,O.F., Zamudio,F., Valdez-Velazquez,L.L.. Indolealkylamines in the venom of the scorpion Thorellius intrepidus.
Toxicon,
233,
107232.
Artículo
527 - Lopez-Giraldo,E., Carrillo,E., Titaux-Delgado,G., Cano-Sanchez,P., Colorado,A., Possani,L.D., Rio-Portilla,F.D.. Structural and functional studies of scorpine: A channel blocker and cytolytic peptide.
Toxicon,
222,
106985
.
Artículo
528 - Naseem,M.U., Gurrola-Briones,G., Romero-Imbachi,M.R., Borrego,J., Carcamo-Noriega,E., Beltran-Vidal,J., Zamudio,F.Z., Shakeel,K., Possani,L.D., Panyi,G.. Characterization and Chemical Synthesis of Cm39 (a-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K(+) Channel K(V)1.2 and Small- and Intermediate-Conductance Ca(2+)-Activated K(+) Channels K(Ca)2.2 and K(Ca)3.1.
Toxins (Basel),
15 (1),
41.
Artículo
529 - Romero-Moreno,J.A., Serrano-Posada,H., Olamendi-Portugal,T., Possani,L.D., Becerril,B., Riano-Umbarila,L.. Development of a human antibody fragment cross-neutralizing scorpion toxins.
Molecular Immunology,
155,
165-174.
Artículo
530 - Salazar,M.H., Ortiz,M.H., Encarnacion,S., Zamudio,F., Possani,L.D., Cleghorn,J., Moran,M., Acosta,H., Corzo,G.. A proteomic overview of the major venom components from Tityus championi from Panama.
Toxicon,
227,
107082.
Artículo
531 - Shakeel,K., Olamendi-Portugal,T., Naseem,M.U., Becerril,B., Zamudio,F.Z., Delgado-Prudencio,G., Possani,L.D., Panyi,G.. Of Seven New K(+) Channel Inhibitor Peptides of Centruroides bonito, a-KTx 2.24 Has a Picomolar Affinity for Kv1.2.
Toxins (Basel),
15 (8),
506.
Artículo
532 - Valencia-Martinez,H., Riano-Umbarila,L., Olamendi-Portugal,T., Romero-Moreno,J.A., Possani,L.D., Becerril,B.. Neutralization of Centruroides tecomanus scorpion venom by the use of two human recombinant antibody fragments.
Molecular Immunology,
164,
79-87.
nacional divulgacion
533 - Possani Postay,L.D.. Un interés dedicado al conocimiento y las tecnologías para la salud a partir de venenos de alacranes.
Biotecnología en Movimiento. Revista de divulgación del Instituto de Biotecnología de la UNAM,
9 (32).
Artículo
534 - Bermudez-Guzman,M.J., Jimenez-Vargas,J.M., Possani,L.D., Zamudio,F., Ororzco-Gutierrez,G., Oceguera-Contreras,E., Enriquez-Vara,J.N, Vazquez-Vuelvas,O.F., Garcia-Villalvazo,P.E., Valdez-Velazquez,L.L.. Biochemical characterization and insecticidal activity of isolated peptides from the venom of the scorpion Centruroides tecomanus.
Toxicon,
206,
90-102.
Artículo
535 - Csoti,A., Najera-Meza,R.C., Bogar,F., Tajti,G., Szanto,T.G., Varga,Z., Gurrola,G.B., Toth,G.K., Possani,L.D., Panyi,G.. sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity.
Biochemical Pharmacology,
199,
115023.
Artículo
536 - Delgado-Prudencio,G., Cid-Uribe,J.I., Morales,J.A., Possani,L.D., Ortiz,E., Romero-Gutierrez,T.. The Enzymatic Core of Scorpion Venoms.
Toxins,
14 (4),
248.
Artículo
537 - Espinoza-Duarte,M.R., Ortega-Ochoa,C., Baca-Ramirez,A., Possani,L.D., Espino-Solis,G.P.. Flow cytometry analysis of CD11c-positive peripheral blood mononuclear cells in horses.
Veterinary Immunology and Immunopathology,
253 (November),
110504.
Artículo
538 - Naseem,M.U., Carcamo-Noriega,E., Borrego,J., Szanto,T.G., Zamudio,F.Z., Delgado-Prudencio,G., Possani,L.D., Panyi,G.. Cm28, a scorpion toxin having a unique primary structure, inhibits KV1.2 and KV1.3 with high affinity.
Journal of General Physiology,
154 (8),
e202213146.
Artículo
539 - Salazar,M.H., Clement,H., Corrales-Garcia,L.L., Sanchez,J., Cleghorn,J., Zamudio,F., Possani,L.D., Acosta,H., Corzo,G.. Heterologous expression of four recombinant toxins from Panamanian scorpions of the genus Tityus and Centruroides for production of antivenom.
Toxicon: X,
13,
100090.
Artículo
540 - Valencia-Martinez,H., Olamendi-Portugal,T., Restano-Cassulini,R., Serrano-Posada,H., Zamudio,F., Possani,L.D., Riano-Umbarila,L., Becerril,B.. Characterization of Four Medically Important Toxins from Centruroides huichol Scorpion Venom and Its Neutralization by a Single Recombinant Antibody Fragment.
Toxins,
14 (6),
369.
Artículo
541 - Veytia-Bucheli,J.I., Alvarado-Velazquez,D.A., Possani,L.D., Gonzalez-Amaro,R., Rosenstein,Y.. The Ca(2+) Channel Blocker Verapamil Inhibits the In Vitro Activation and Function of T Lymphocytes: A 2022 Reappraisal.
Pharmaceutics,
14 (7).
Artículo
542 - Alamilla,J., Jimenez-Vargas,J.M., Galvan-Hernandez,A.R., Reyes-Mendez,M.E., Bermudez-Guzman,M.J., Restano-Cassulini,R., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D., Valdez-Velazquez,L.L.. Toxin Ct1a, from venom of Centruroides tecomanus, modifies the spontaneous firing frequency of neurons in the suprachiasmatic nucleus.
Toxicon,
197,
114-125.
Artículo
543 - Beltran-Vidal,J., Carcamo-Noriega,E., Pastor,N., Zamudio-Zuniga,F., Guerrero-Vargas,J.A., Castano,S., Possani,L.D., Restano-Cassulini,R.. Colombian Scorpion Centruroides margaritatus: Purification and Characterization of a Gamma Potassium Toxin with Full-Block Activity on the hERG1 Channel.
Toxins (Basel),
13 (6),
407.
Artículo
544 - Jimenez-Vargas,J.M., Ramirez-Carreto,S., Corzo,G., Possani,L.D., Becerril,B., Ortiz,E.. Structural and functional characterization of NDBP-4 family antimicrobial peptides from the scorpion Mesomexovis variegatus.
Peptides,
141,
170553.
Artículo
545 - Lopes,K.S., Torres Quintanilha,M.V., Barros de Souza,A.C., Zamudio-Zuniga,F., Possani,L.D., Mortari,M.R.. Antiseizure potential of peptides from the venom of social wasp Chartergellus communis against chemically-induced seizures.
Toxicon,
194,
23.
Artículo
546 - Riano-Umbarila,L., Romero-Moreno,J.A., Ledezma-Candanoza,L.M., Olamendi-Portugal,T., Possani,L.D., Becerril,B.. Full Neutralization of Centruroides sculpturatus Scorpion Venom by Combining Two Human Antibody Fragments.
Toxins,
13 (10),
708.
Artículo
547 - Rodriguez-Ravelo,R., Ruiz-Urquiola,A., Possani-Postay,L.D., Morris-Quevedo,H.J., Rodriguez-Ravelo,M., Espinosa-Lopez,G.. Variation of cytochrome oxidase-I gene and venom proteins of Rhopalurus junceus populations in the Moanicum sector: Pharmacological implications.
Journal of Pharmacy and Pharmacognosy Research,
9 (1),
1-12.
Artículo
548 - Vargas-Jaimes,L., Rodriguez,M.C., Argotte-Ramos,R., Juarez-Gonzalez,V.R., Pastor,N., Cesa-Luna,C., Possani,L.D., Quintero-Hernandez,V.. Recombinant C-Terminal Domains from Scorpine-like Peptides Inhibit the Plasmodium berghei Ookinete Development In Vitro.
International Journal of Peptide Research and Therapeutics,
27,
817-829.
Artículo
549 - Benard-Valle,M., Neri-Castro,E.E., Yanez-Mendoza,M.F., Lomonte,B., Olvera,A., Zamudio,F., Restano-Cassulini,R., Possani,L.D., Jimenez-Ferrer,E., Alagon,A.. Functional, proteomic and transcriptomic characterization of the venom from Micrurus browni browni: Identification of the first lethal multimeric neurotoxin in coral snake venom.
Journal of Proteomics,
225,
103863.
Revisión
550 - Cid-Uribe,J.I., Veytia-Bucheli,J.I., Romero-Gutierrez,T., Ortiz,E., Possani,L.D.. Scorpion venomics: a 2019 overview.
Expert Review of Proteomics,
17 (1),
67-83.
Artículo
551 - Cota-Arce,J.M., Zazueta-Favela,D., Diaz-Castillo,F., Jimenez,S., Bernaldez-Sarabia,J., Caram-Salas,N.L., Dan,K.W.L., Escobedo,G., Licea-Navarro,A.F., Possani,L.D., De Leon-Nava,M.A.. Venom components of the scorpion Centruroides limpidus modulate cytokine expression by T helper lymphocytes: Identification of ion channel-related toxins by mass spectrometry.
International Immunopharmacology,
84,
106505.
Artículo
552 - El-Bitar, A. M. H., Sarhan, M., Abdel-Rahman, M. A., Quintero-Hernandez, V., Aoki-Utsubo, C., Moustafa, M. A., Possani, L. D., Hotta, H.. Smp76, a Scorpine-Like Peptide Isolated from the Venom of the Scorpion Scorpio maurus palmatus, with a Potent Antiviral Activity Against Hepatitis C Virus and Dengue Virus.
International Journal of Peptide Research and Therapeutics,
26,
811-821.
Artículo
553 - Garcia-Guerrero,I.A., Carcamo-Noriega,E., Gomez-Lagunas,F., Gonzalez-Santillan,E., Zamudio,F.Z., Gurrola,G.B., Possani,L.D.. Biochemical characterization of the venom from the Mexican scorpion Centruroides ornatus, a dangerous species to humans.
Toxicon,
173,
27-38.
Artículo
554 - Gomez-Ramirez,I.V., Riano-Umbarila,L., Olamendi-Portugal,T., Restano-Cassulini,R., Possani,L.D., Becerril,B.. Biochemical, electrophysiological and immunological characterization of the venom from Centruroides baergi, a new scorpion species of medical importance in Mexico.
Toxicon,
184,
10-18.
Artículo
555 - Lopez-Giraldo,A.E., Olamendi-Portugal,T., Riano-Umbarila,L., Becerril,B., Possani,L.D., Delepierre,M., Rio-Portilla,F.D.. The three-dimensional structure of the toxic peptide Cl13 from the scorpion Centruroides limpidus.
Toxicon,
184,
158-166.
Artículo
556 - Luna-Ramirez,K., Csoti,A., McArthur,J.R., Chin,Y.K.Y., Anangi,R., Najera,R.D.C., Possani,L.D., King,G.F., Panyi,G., Yu,H., Adams,D.J., Finol-Urdaneta,R.K.. Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom.
Biochemical Pharmacology,
174,
113782.
Artículo
557 - Mourao,C.B.F., Brand,G.D., Fernandes,J.P.C., Prates,M.V., Bloch,C., Barbosa,J.A.R.G., Freitas,S.M., Restano-Cassulini,R., Possani,L.D., Schwartz,E.F.. Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom Peptide that Resembles Plant Cyclotides.
Journal of Medicinal Chemistry,
63 (17),
9500?951.
Artículo
558 - Neri-Castro,E., Benard-Valle,M., Paniagua,D., Boyer,L.V., Possani,D., Lopez-Casillas,F., Olvera,A., Romero,C., Zamudio,F., Alagon,A.. Neotropical Rattlesnake (Crotalus simus) Venom Pharmacokinetics in Lymph and Blood Using an Ovine Model.
Toxins (Basel),
12 (7),
455.
Artículo
559 - Riano-Umbarila,L., Rojas-Trejo,V.M., Romero-Moreno,J.A., Costas,M., Utrera-Espindola,I., Olamendi-Portugal,T., Possani,L.D., Becerril,B.. Comparative assessment of the VH-VL and VL-VH orientations of single-chain variable fragments of scorpion toxin-neutralizing antibodies.
Molecular Immunology,
122,
141-147.
Artículo
560 - Valdez-Velazquez,L.L., Cid-Uribe,J., Romero-Gutierrez,M.T., Olamendi-Portugal,T., Jimenez-Vargas,J.M., Possani,L.D.. Transcriptomic and proteomic analyses of the venom and venom glands of Centruroides hirsutipalpus, a dangerous scorpion from Mexico.
Toxicon,
179,
21-32.
Artículo
561 - Bernaldez-Sarabia,J., Figueroa-Montiel,A., Duenas,S., Cervantes-Luevano,K., Beltran,J.A., Ortiz,E., Jimenez,S., Possani,L.D., Paniagua-Solis,J.F., Gonzalez-Canudas,J., Licea-Navarro,A.. The Diversified O-Superfamily in Californiconus californicus Presents a Conotoxin with Antimycobacterial Activity.
Toxins (Basel),
11 (2),
E128.
Artículo
562 - Carcamo-Noriega,E.N., Sathyamoorthi,S., Banerjee,S., Gnanamani,E., Mendoza-Trujillo,Monserrat, Mata-Espinosa,D., Hernandez-Pando,R., Veytia-Bucheli,J.I., Possani,L.D., Zare,R.N.. 1,4-Benzoquinone antimicrobial agents against Staphylococcus aureus and Mycobacterium tuberculosis derived from scorpion venom.
Proceedings of the National Academy of Sciences,
116 (26),
201812334,
12642-12647.
Artículo
563 - Carcamo-Noriega,E.N., Possani,L.D., Ortiz,E.. Venom content and toxicity regeneration after venom gland depletion by electrostimulation in the scorpion Centruroides limpidus.
Toxicon,
157,
87-92.
Artículo
564 - Cid-Uribe,J.I., Meneses,E.P., Batista,C.V.F., Ortiz,E., Possani,L.D.. Dissecting Toxicity: The Venom Gland Transcriptome and the Venom Proteome of the Highly Venomous Scorpion Centruroides limpidus (Karsch, 1879).
Toxins (Basel),
11 (5),
247.
Artículo
565 - Delgado-Prudencio, G., Possani, L. D., Becerril, B., Ortiz, E.. The Dual alpha-Amidation System in Scorpion Venom Glands.
Toxins (Basel),
11 (7).
Artículo
566 - Gurrola, G. B., Guijarro, J. I., Delepierre, M., Mendoza, R. L. L., Cid-Uribe, J. I., Coronas, F. V., Possani, L. D.. Cn29, a novel orphan peptide found in the venom of the scorpion Centruroides noxius: Structure and function.
Toxicon,
167,
184-191.
Artículo
567 - Jauregui-Zuniga,D., Pedraza-Escalona,M., Merino-Guzman,R., Possani,L.D.. Construction and expression of a single-chain variable fragment antibody against chicken DEC 205 for targeting the bacterial expressed hemagglutinin-neuraminidase of Newcastle disease virus.
Veterinary Immunology and Immunopathology,
212,
9-14.
Artículo
568 - Okada,M., Ortiz,E., Corzo,G., Possani,L.D.. Pore-forming spider venom peptides show cytotoxicity to hyperpolarized cancer cells expressing K+ channels: A lentiviral vector approach.
PLoS ONE,
14 (4),
e0215391.
Artículo
569 - Riano-Umbarila,L., Gomez-Ramirez,I.V., Ledezma-Candanoza,L.M., Olamendi-Portugal,T., Rodriguez-Rodriguez,E.R., Fernandez-Taboada,G., Possani,L.D., Becerril,B.. Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms.
Toxins (Basel),
11 (1),
32.
Artículo
570 - Rincon-Cortes,C.A., Olamendi-Portugal,T., Carcamo-Noriega,E.N., Gonzalez-Santillan,E., Zamudio-Zuniga,F., Reyes-Montano,E.A., Vega Castro,N.A., Possani,L.D.. Structural and functional characterization of toxic peptides purified from the venom of the Colombian scorpion Tityus macrochirus.
Toxicon,
169,
5-11.
Artículo
571 - Santibanez-Lopez,C.E., Graham,M.R., Sharma,P.P., Ortiz,E., Possani,L.D.. Hadrurid Scorpion Toxins: Evolutionary Conservation and Selective Pressures.
Toxins (Basel),
11 (11),
E637,
E637.
Divulgación
572 - Carcamo-Noriega,E.N., Possani-Postay,L.D.. Veneno rojo: un potencial antibiotico contra la tuberculosis obtenido del veneno del alacran.
Biotecnología en Movimiento. Revista de divulgación del Instituto de Biotecnología de la UNAM,
18,
20-23.
Artículo
573 - Arora, A.K., Pesko, K.N., Quintero-Hernandez, V., Possani, L.D., Miller, T.A., Durvasula, R.V.. A paratransgenic strategy to block transmission of Xylella fastidiosa from the glassy-winged sharpshooter Homalodisca vitripennis.
BMC Biotechnology,
18 (1),
50.
Artículo
574 - Banerjee, S., Gnanamani, E., Lynch, S.R., Zamudio-Zuniga, F., Jimenez-Vargas, J.M., Possani, L.D., Zare, R.N.. An Alkaloid from Scorpion Venom: Chemical Structure and Synthesis.
Journal of Natural Products,
81 (8),
1899-1904.
Artículo
575 - Batista, C.V.F., Martins, J.G., Restano-Cassulini, R., Coronas, F.I.V., Zamudio, F.Z., Procopio, R., Possani, L.D.. Venom characterization of the Amazonian scorpion Tityus metuendus.
Toxicon,
143,
51-58.
Artículo
576 - Carcamo-Noriega, E.N., Olamendi-Portugal, T., Restano-Cassulini, R., Rowe, A., Uribe-Romero, S.J., Becerril, B., Possani, L.D.. Intraspecific variation of Centruroides sculpturatus scorpion venom from two regions of Arizona.
Archives of Biochemistry and Biophysics,
638,
52-57.
Artículo
577 - Cid-Uribe, J.I., Santibanez-Lopez, C.E., Meneses, E.P., Batista, C.V.F., Jimenez-Vargas, J.M., Ortiz, E., Possani, L.D.. The diversity of venom components of the scorpion species Paravaejovis schwenkmeyeri (Scorpiones: Vaejovidae) revealed by transcriptome and proteome analyses.
Toxicon,
151,
47-62.
Revisión
578 - Gonzalez-Santillan, E., Possani, L.D.. North American scorpion species of public health importance with a reappraisal of historical epidemiology.
Acta Tropica,
187,
264-274.
Artículo
579 - Olamendi-Portugal, T., Batista, C.V.F., Pedraza-Escalona, M., Restano-Cassulini, R., Zamudio, F.Z., Benard-Valle, M., de Roodt, A.R., Possani, L.D.. New insights into the proteomic characterization of the coral snake Micrurus pyrrhocryptus venom.
Toxicon,
153,
23-31.
Revisión
580 - Ortiz, E., Possani, L.D.. Scorpion toxins to unravel the conundrum of ion channel structure and functioning.
Toxicon,
150,
17-27.
Artículo
581 - Romero-Gutierrez, M. T., Santibanez-Lopez, C. E., Jimenez-Vargas, J. M., Batista, C. V. F., Ortiz, E., Possani, L. D.. Transcriptomic and Proteomic Analyses Reveal the Diversity of Venom Components from the Vaejovid Scorpion Serradigitus gertschi.
Toxins (Basel),
10 (9),
359.
Artículo
582 - Salazar, M.H., Arenas, I., Corrales-Garcia, L.L., Miranda, R., Velez, S., Sanchez, J., Mendoza, K., Cleghorn, J., Zamudio, F.Z., Castillo, A., Possani, L.D., Corzo, G., Acosta, H.. Venoms of Centruroides and Tityus species from Panama and their main toxic fractions.
Toxicon,
141,
79-87.
Artículo
583 - Valdez-Velazquez, L.L., Olamendi-Portugal, T., Restano-Cassulini, R., Zamudio, F.Z., Possani, L.D.. Mass fingerprinting and electrophysiological analysis of the venom from the scorpion Centruroides hirsutipalpus (Scorpiones: Buthidae).
Journal of Venomous Animals and Toxins Including Tropical Diseases,
24,
17.
Artículo
584 - Veytia-Bucheli, J.I., Jimenez-Vargas, J.M., Melchy-Perez, E.I., Sandoval-Hernandez, M.A., Possani, L.D., Rosenstein, Y.. Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation.
Cell Communication and Signaling,
16 (1),
45.
Artículo
585 - Cid Uribe, J.I., Jimenez Vargas, J.M., Ferreira Batista, C.V., Zamudio-Zuniga, F., Possani, L.D.. Comparative proteomic analysis of female and male venoms from the Mexican scorpion Centruroides limpidus: Novel components found.
Toxicon,
125,
91-98.
Artículo
586 - Jaimes-Hoy, L., Gurrola, G.B., Cisneros, M., Joseph-Bravo, P., Possani, L.D., Charli, J.L.. The Kv1.3 channel blocker Vm24 enhances muscle glucose transporter 4 mobilization but does not reduce body-weight gain in diet-induced obese male rats.
Life Sciences,
181,
23-30.
Artículo
587 - Jauregui-Zuniga, D., Pedraza-Escalona, M., Espino-Solis, G.P., Quintero-Hernandez, V., Olvera-Rodriguez, A., Diaz-Salinas, M.A., Lopez, S., Possani, L.D.. Targeting antigens to Dec-205 on dendritic cells induces a higher immune response in chickens: Hemagglutinin of avian influenza virus example.
Research in Veterinary Science,
111,
55-62.
Artículo
588 - Jimenez-Vargas, J.M., Quintero-Hernandez, V., Gonzalez-Morales, L., Ortiz, E., Possani, L.D.. Design and expression of recombinant toxins from Mexican scorpions of the genus Centruroides for production of antivenoms.
Toxicon,
128,
5-14 [Corrigendum 130 (2017) 126].
Revisión
589 - Jimenez-Vargas, J.M., Possani, L.D., Luna-Ramirez, K.. Arthropod toxins acting on neuronal potassium channels.
Neuropharmacology,
127,
139-160.
Artículo
590 - Lopes, K.S., Campos, G.A.A., Camargo, L.C., de Souza, A.C.B., Ibituruna, B.V., Magalhaes, A.C.M., da Rocha, L.F., Garcia, A.B., Rodrigues, M.C., Ribeiro, D.M., Costa, M.C., Lopez, M.H.M., Nolli, L.M., Zamudio-Zuniga, F., Possani, L.D., Schwartz, E.F., Mortari, M.R.. Characterization of two peptides isolated from the venom of social wasp Chartergellus communis (Hymenoptera: Vespidae): Influence of multiple alanine residues and C-terminal amidation on biological effects.
Peptides,
95,
84-93.
Artículo
591 - Olamendi-Portugal, T., Restano-Cassulini, R., Riano-Umbarila, L., Becerril, B., Possani, L.D.. Functional and immuno-reactive characterization of a previously undescribed peptide from the venom of the scorpion centruroides limpidus.
Peptides,
87,
34-40.
Artículo
592 - Olamendi-Portugal, T., Csoti, A., Jimenez-Vargas, J.M., Gomez-Lagunas, F., Panyi, G., Possani, L.D.. Pi5 and Pi6, two undescribed peptides from the venom of the scorpion Pandinus imperator and their effects on K+-channels.
Toxicon,
133,
136-144.
Artículo
593 - Restano-Cassulini, R., Garcia, W., Paniagua-Solis, J.F., Possani, L.D.. Antivenom Evaluation by Electrophysiological Analysis.
Toxins (Basel),
9 (3),
74.
Artículo
594 - Riano-Umbarila, L., Rodriguez-Rodriguez, E.R., Santibanez-Lopez, C.E., Guereca, L., Uribe-Romero, S.J., Gomez-Ramirez, I.V., Carcamo-Noriega, E.N., Possani, L.D., Becerril, B.. Updating knowledge on new medically important scorpion species in Mexico.
Toxicon,
138,
130-137.
Artículo
595 - Romero-Gutierrez, T., Peguero-Sanchez, E., Cevallos, M.A., Batista, C.V.F., Ortiz, E., Possani, L.D.. A Deeper Examination of Thorellius atrox Scorpion Venom Components with Omic Techonologies.
Toxins (Basel),
9 (12),
399.
Artículo
596 - Santibanez-Lopez, C.E., Cid-Uribe, J.I., Zamudio, F.Z., Batista, C.V.F., Ortiz, E., Possani, L.D.. Venom gland transcriptomic and venom proteomic analyses of the scorpion Megacormus gertschi Diaz-Najera, 1966 (Scorpiones: Euscorpiidae: Megacorminae).
Toxicon,
133,
95-109.
Artículo
597 - Vargas-Jaimes, L., Xiao, L., Zhang, J., Possani, L.D., Valdivia, H.H., Quintero-Hernandez, V.. Recombinant expression of Intrepicalcin from the scorpion Vaejovis intrepidus and its effect on skeletal ryanodine receptors.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1861 (4),
936-946.
Artículo
598 - Figueroa-Montiel,A., Ramos,M.A., Mares,R.E., Duenas,S., Pimienta,G., Ortiz,E., Possani,L.D., Licea-Navarro,A.F.. In Silico Identification of Protein Disulfide Isomerase Gene Families in the De Novo Assembled Transcriptomes of Four Different Species of the Genus Conus.
PLoS ONE,
11 (2),
e0148390.
Revisión
599 - Luna-Martinez,K., Jimenez-Vargas,J.M., Possani,L.D.. Scorpine-Like Peptides.
Single Cell Biology,
5 (138).
Artículo
600 - Olamendi-Portugal,T., Bartok,A., Zamudio-Zuniga,F., Balajthy,A., Becerril,B., Panyi,G., Possani,L.D.. Isolation, chemical and functional characterization of several new K-channel blocking peptides from the venom of the scorpion Centruroides tecomanus.
Toxicon,
115,
1-12.
Artículo
601 - Osnaya-Romero N., Acosta-Saavedra,L.C., Goytia-Acevedo,R., Lares-Asseff,I., Basurto-Celaya,G., Perez-Guille,G., Possani,L.D., Calderon-Aranda,E.S.. Serum level of scorpion toxins, electrolytes and electrocardiogram alterations in Mexican children envenomed by scorpion sting.
Toxicon,
122,
103-108.
Artículo
602 - Riano-Umbarila,L., Ledezma-Candanoza,L.M., Serrano-Posada,H., Fernandez-Taboada,G., Olamendi-Portugal,T., Rojas-Trejo,S., Gomez-Ramirez,I.V., Rudino-Pinera,E., Possani,L.D., Becerril,B.. Optimal neutralization of Centruroides noxius venom is understood through a structural complex between two antibody fragments and the Cn2 toxin.
Journal of Biological Chemistry,
291 (4),
1619-1630.
Artículo
603 - Rodriguez-Rodriguez,E.R., Olamendi-Portugal,T., Serrano-Posada,H., Arredondo-Lopez,J.N., Gomez-Ramirez,I., Fernandez-Taboada,G., Possani,L.D., Vega,G.A., Riano-Umbarila,L., Becerril,B.. Broadening the neutralizing capacity of a family of antibody fragments against different toxins from Mexican scorpions.
Toxicon,
119,
52-63.
Artículo
604 - Santibanez-Lopez,C.E., Cid-Uribe,J.I., Batista,C.V., Ortiz,E., Possani,L.D.. Venom Gland Transcriptomic and Proteomic Analyses of the Enigmatic Scorpion Superstitionia donensis (Scorpiones: Superstitioniidae), with Insights on the Evolution of Its Venom Components.
Toxins (Basel),
8 (12),
367.
Revisión
605 - Santibanez-Lopez,C.E., Francke,O.F., Ureta,C., Possani,L.D.. Scorpions from Mexico: From Species Diversity to Venom Complexity.
Toxins (Basel),
8 (1).
Artículo
606 - Valdez-Velazquez,L.L., Romero-Gutierrez,M.T., Delgado-Enciso,I., Dobrovinskaya,O., Melnikov,V., Quintero-Hernandez,V., Ceballos-Magana,S.G., Gaitan-Hinojosa,M.A., Coronas,F.I., Puebla-Perez,A.M., Zamudio,F., De la Cruz-Garcia,I, Vazquez-Vuelvas,O.F., Soriano-Hernandez,A.D., Possani,L.D.. Comprehensive analysis of venom from the scorpion Centruroides tecomanus reveals compounds with antimicrobial, cytotoxic, and insecticidal activities.
Toxicon,
118,
95-103.
Artículo
607 - Xiao,L., Gurrola,G.B., Zhang,J., Valdivia,C.R., SanMartin,M., Zamudio,F.Z., Zhang,L., Possani,L.D., Valdivia,H.H.. Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands.
Journal of General Physiology,
147 (5),
375-394.
Artículo
608 - Zhang,H., Du,M., Xie,J., Liu,X., Sun,J., Wang,W., Xin,X., Possani,L.D., Yea,K., Lerner,R.A.. Autocrine-Based Selection of Drugs that Target Ion Channels from Combinatorial Venom Peptide Libraries.
Angewandte Chemie International Edition,
55 (32),
9306-9310.
Artículo
609 - Coronas,F.I., Diego-Garcia,E., Restano-Cassulini,R., de Roodt,A.R., Possani,L.D.. Biochemical and physiological characterization of a new Na-channel specific peptide from the venom of the Argentinean scorpion Tityus trivittatus.
Peptides,
68,
11-16.
Artículo
610 - Espino-Solis,G.P., Quintero-Hernandez,V., Olvera-Rodriguez,A., Calderon-Amador,J., Pedraza-Escalona,M., Licea-Navarro,A., Flores-Romo,L., Possani,L.D.. Novel monoclonal antibody against alphaX subunit from horse CD11c/CD18 integrin.
Veterinary Immunology and Immunopathology,
164 (3-4),
220-226.
Artículo
611 - Luna-Ramirez,K., Quintero-Hernandez,V., Juarez-Gonzalez,V.R., Possani,L.D.. Whole Transcriptome of the Venom Gland from Urodacus yaschenkoi Scorpion.
PLoS ONE,
10 (5),
e0127883.
Artículo
612 - Okada,M., Corzo,G., Romero-Perez,G.A., Coronas,F., Matsuda,H., Possani,L.D.. A pore forming peptide from spider Lachesana sp. venom induced neuronal depolarization and pain.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1850 (4),
657-666.
Revisión
613 - Ortiz,E., Possani,L.D.. The unfulfilled promises of scorpion insectotoxins.
Journal of Venomous Animals and Toxins Including Tropical Diseases,
21,
16.
Revisión
614 - Ortiz,E., Gurrola,G.B., Schwartz,E.F., Possani,L.D.. Scorpion venom components as potential candidates for drug development.
Toxicon,
93,
125-135.
Artículo
615 - Quintero-Hernandez,V., Ramirez-Carreto,S., Romero-Gutierrez,M.T., Valdez-Velazquez,L.L., Becerril,B., Possani,L.D., Ortiz,E.. Transcriptome Analysis of Scorpion Species Belonging to the Vaejovis Genus.
PLoS ONE,
10 (2),
e0117188.
Artículo
616 - Ramirez-Carreto,S., Jimenez-Vargas,J.M., Rivas-Santiago,B., Corzo,G., Possani,L.D., Becerril,B., Ortiz,E.. Peptides from the scorpion Vaejovis punctatus with broad antimicrobial activity.
Peptides,
73,
51-59.
Artículo
617 - Rodriguez-Ravelo,R., Batista,C.V., Coronas,F.I., Zamudio,F.Z., Hernandez-Orihuela,L., Espinosa-Lopez,G., Ruiz-Urquiola,A., Possani,L.D.. Comparative proteomic analysis of male and female venoms from the Cuban scorpion Rhopalurus junceus.
Toxicon,
107 (B),
327-334.
Artículo
618 - Santibanez-Lopez,C.E., Possani,L.D.. Overview of the Knottin scorpion toxin-like peptides in scorpion venoms: Insights on their classification and evolution.
Toxicon,
107 (B),
317-326.
Artículo
619 - Gonzalez-Morales,L., Pedraza-Escalona,M., Diego-Garcia,E., Restano-Cassulini,R., Batista,C.V., Gutierrez,M.C., Possani,L.D.. Proteomic characterization of the venom and transcriptomic analysis of the venomous gland from the Mexican centipede Scolopendra viridis.
Journal of Proteomics,
111,
224-237.
Artículo
620 - Luna-Ramirez,K., Bartok,A., Restano-Cassulini,R., Quintero-Hernandez,V., Coronas,F., Christensen,J., Wright,C.E., Panyi,G., Possani,L.D.. Structure, Molecular Modeling and Function of the First Potassium Channel Blocker, Urotoxin, Isolated from the Venom of the Australian Scorpion Urodacus Yaschenkoi.
Molecular Pharmacology,
86 (1),
28-41.
Artículo
621 - Luna-Ramirez,K., Sani,M.A., Silva-Sanchez,J., Jimenez-Vargas,J.M., Reyna-Flores,F., Winkel,K.D., Wright,C.E., Possani,L.D., Separovic,F.. Membrane Interactions and Biological Activity of Antimicrobial Peptides from Australian Scorpion.
Biochimica et Biophysica Acta (BBA) - Biomembranes,
1838 (9),
2140-2148.
Artículo
622 - Ortiz,E., Rendon-Anaya,M., Rego,S.C., Schwartz,E.F., Possani,L.D.. Antarease-like Zn-metalloproteases are ubiquitous in the venom of different scorpion genera.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1840 (6),
1738-1746.
Artículo
623 - Pedraza-Escalona,M., Batista,C.V., Restano-Cassulini,R., Sandoval-Rios,M., Coronas,F.I., Possani,L.D.. A proteomic analysis of the early secondary molecular effects caused by Cn2 scorpion toxin on neuroblastoma cells.
Journal of Proteomics,
111,
212-223.
Artículo
624 - Picco,C., Corzo,G., Possani,L.D., Prestipino,G.. Interaction of the scorpion toxin Discrepin with Kv4.3 channels and A-type K channels in cerebellum granular cells.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1840 (9),
2744-2751.
Artículo
625 - Rodriguez-Ravelo,R., Restano-Cassulini,R., Zamudio,F.Z., Coronas,F.I.V., Espinosa-Lopez,G., Possani,L.D.. A K+ channel blocking peptide from the Cuban scorpion Rhopalurus garridoi.
Peptides,
53,
42-47.
Artículo
626 - Vergara,I., Pedraza-Escalona,M., Paniagua,D., Restano-Cassulini,R., Zamudio,F., Batista,C.V., Possani,L.D., Alagon,A.. Eastern coral snake Micrurus fulvius venom toxicity in mice is mainly determined by neurotoxic phospholipases A.
Journal of Proteomics,
105,
295-306.
Internacional
627 - Abdel-Rahman,M.A., Quintero-Hernandez,V., Possani,L.D.. Scorpion Venom Gland Transcriptomics and Proteomics: An Overview. Venom Genomics and Proteomics.
105-124.
Internacional
628 - Rodriguez de la Vega,R.C., Corzo,G., Possani,L.D.. Scorpion Venoms as a Platform for Drug Development. Venoms to Drugs: Venom as a Source for the Development of Human Therapeutics.
204-220,
Cambridge: Royal Society of Chemistry.
Internacional
629 - Rodriguez-Rodriguez,E.R., Riano-Umbarila,L., Possani,L.D., Becerril,B.. Recombinant neutralizing antibodies, a new generation of scorpion anti-venoms. Scorpion Venoms.
Toxinology,
139-159,
4,
Dordrecht: Springer.
Internacional
630 - Gopalakrishnakone, P., Possani, L. D., Schwartz, E., Rodriguez-de-la-Vega, R.. Scorpion Venoms.
Toxinology,
Dordrecht: Springer.
Divulgación
631 - Becerril-Lujan,B., Riano,L., Possani,L. Bancos de anticuerpos recombinantes de origen humano: una fuente ideal de antivenenos modernos contra la picadura de alacrán.
Revista Digital Universitaria,
15 (11),
art 84.
Artículo
632 - Abdel-Rahman,M.A., Quintero-Hernandez,V., Possani,L.D.. Venom proteomic and venomous glands transcriptomic analysis of the Egyptian scorpion Scorpio maurus palmatus (Arachnida: Scorpionidae).
Toxicon,
74,
193-207.
Artículo; Actas Paper
633 - Aguilar,M.B., Ortiz,E., Kaas,Q., Lopez-Vera,E., Becerril,B., Possani,L.D., de la Cotera,E.P.. Precursor De13.1 from Conus delessertii defines the novel G gene superfamily.
Peptides,
41,
17-20.
Artículo
634 - Bernaldez,J., Roman-Gonzalez,S.A., Martinez,O., Jimenez,S., Vivas,O., Arenas,I., Corzo,G., Arreguin,R., Garcia,D.E., Possani,L.D., Licea,A.. A Conus regularis Conotoxin with a Novel Eight-Cysteine Framework Inhibits CaV2.2 Channels and Displays an Anti-Nociceptive Activity.
Marine Drugs,
11 (4),
1188-1202.
Artículo
635 - Caliskan,F., Quintero-Hernandez,V., Restano-Cassulini,R., Coronas-Valderrama,F.I., Corzo,G., Possani,L.D.. Molecular cloning and biochemical characterization of the first Na+-channel alpha-type toxin peptide (Acra4) from Androctonus crassicauda scorpion venom.
Biochimie,
95 (6),
1216-1222.
Artículo
636 - Deuis,J.R., Zimmermann,K., Romanovsky,A.A., Possani,L.D., Cabot,P.J., Lewis,R.J., Vetter,I.. An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na1.6 in peripheral pain pathways.
Pain,
154 (9),
1749-1757.
Artículo
637 - Garcia,F., Villegas,E., Espino-Solis,G.P., Rodriguez,A., Paniagua-Solis,J.F., Sandoval-Lopez,G., Possani,L.D., Corzo,G.. Antimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics.
Journal of Antibiotics,
66 (1),
3-10.
Artículo
638 - Luna-Ramirez,K., Quintero-Hernandez,V., Vargas-Jaimes,L., Batista,C.V., Winkel,K., Possani,L.D.. Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity.
Toxicon,
63 (1),
44-54.
Artículo
639 - Mourao,C.B., Heghinian,M.D., Barbosa,E.A., Mari,F., Bloch,C.,Jr., Restano-Cassulini,R., Possani,L.D., Schwartz,E.F.. Characterization of a novel peptide toxin from Acanthoscurria paulensis spider venom: a distinct cysteine assignment into the HWTX-II family.
Biochemistry,
52 (14),
2440-2452.
Artículo
640 - Pedraza-Escalona,M., Possani,L.D.. Scorpion beta-toxins and voltage-gated sodium channels: interactions and effects.
Frontiers in Bioscience,
18 (2),
572-587.
Revisión
641 - Quintero-Hernandez,V., Jimenez-Vargas,J.M., Gurrola,G.B., Valdivia,H.H., Possani,L.D.. Scorpion venom components that affect ion-channels function.
Toxicon,
76,
328-342.
Artículo
642 - Riano-Umbarila,L., Olamendi-Portugal,T., Morelos-Juarez,C., Gurrola,G.B., Possani,L.D., Becerril,B.. A novel human recombinant antibody fragment capable of neutralizing Mexican scorpion toxins.
Toxicon,
76,
370-376.
Artículo
643 - Rodriguez-Ravelo,R., Coronas,F.I., Zamudio,F.Z., Gonzalez-Morales,L., Lopez,G.E., Urquiola,A.R., Possani,L.D.. The Cuban scorpion Rhopalurus junceus (Scorpiones, Buthidae): component variations in venom samples collected in different geographical areas.
Journal of Venomous Animals and Toxins Including Tropical Diseases,
19 (1),
13.
Artículo
644 - Sanchez-Vasquez,L., Silva-Sanchez,J., Jimenez-Vargas,J.M., Rodriguez-Romero,A., Munoz-Garay,C., Rodriguez,M.C., Gurrola,G.B., Possani,L.D.. Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1830 (6),
3427-3436.
Artículo
645 - Schwartz,E.F., Bartok,A., Schwartz,C.A., Papp,F., Gomez-Lagunas,F., Panyi,G., Possani,L.D.. OcyKTx2, a new K-channel toxin characterized from the venom of the scorpion Opisthacanthus cayaporum.
Peptides,
46,
40-46.
Artículo
646 - Valdez-Velazquez,L.L., Quintero-Hernandez,V., Romero-Gutierrez,M.T., Coronas,F.I.V., Possani,L.D.. Mass Fingerprinting of the Venom and Transcriptome of Venom Gland of Scorpion Centruroides tecomanus.
PLoS ONE,
8 (6),
e66486.
Internacional
647 - Petricevich,V.L., Barbosa-Navarro,L., Possani,L.D.. Therapeutic use of scorpion venom. Molecular aspects of inflammation.
209-231,
Kerala: Research Signpost.
Internacional
648 - Rodriguez-de-la-Vega,R., Vidal,N., Possani,L.D.. Scorpion Peptides. Handbook of Biologically Active Peptides, second edition .
423-429.
Artículo
649 - Caliskan,F., Garcia,B.I., Coronas,F.I., Restano-Cassulini,R., Korkmaz,F., Sahin,Y., Corzo,G., Possani,L.D.. Purification and cDNA cloning of a novel neurotoxic peptide (Acra3) from the scorpion Androctonus crassicauda.
Peptides,
37 (1),
106-112.
Artículo
650 - Caliskan,F., Quintero-Hernandez,V., Restano-Cassulini,R., Batista,C.V.F., Zamudio,F.Z., Coronas,F.I., Possani,L.D.. Turkish scorpion Buthacus macrocentrus: General characterization of the venom and description of Bu1, a potent mammalian Na+-channel à-toxin.
Toxicon,
59 (3),
408-415.
Artículo
651 - Clement,H., Costa de Oliveira,V, Zamudio,F.Z., Lago,N.R., Valdez-Cruz,N.A., Valle,M.B., Alagon,A.C., Possani,L.D., de Roodt,A.R.. Isolation, amino acid sequence and biological characterization of an "aspartic-49" phospholipase A(2) from Bothrops (Rhinocerophis) ammodytoides Venom.
Toxicon,
60 (7),
1314-1323.
Artículo
652 - Clement,H., Olvera,A., Rodriguez,M., Zamudio,F., Palomares,L.A., Possani,L.D., Odell,G.V., Alagon,A., Sanchez-Lopez,R.. Identification, cDNA cloning and heterologous expression of a hyaluronidase from the tarantula Brachypelma vagans venom.
Toxicon,
60 (7),
1223-1227.
Artículo
653 - Guerrero-Vargas,J.A., Mourao,C.B., Quintero-Hernandez,V., Possani,L.D., Schwartz,E.F.. Identification and Phylogenetic Analysis of Tityus pachyurus and Tityus obscurus Novel Putative Na-Channel Scorpion Toxins.
PLoS ONE,
7 (2),
e30478.
Artículo
654 - Gurrola,G.B., Hernandez-Lopez,R.A., Rodriguez de la Vega,R.C., Varga,Z., Batista,C.V., Salas-Castillo,S.P., Panyi,G., del Rio-Portilla,F., Possani,L.D.. Structure, function and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes.
Biochemistry,
51 (19),
4049-4061.
Artículo
655 - Jimenez-Vargas,J.M., Restano-Cassulini,R., Possani,L.D.. Interacting sites of scorpion toxin ErgTx1 with hERG1 K(+) channels.
Toxicon,
59 (6),
633-641.
Artículo
656 - Jimenez-Vargas,J.M., Restano-Cassulini,R., Possani,L.D.. Toxin modulators and blockers of hERG K(+) channels.
Toxicon,
60 (4),
492-501.
Artículo
657 - Quintero-Hernandez,V., Del Pozo-Yauner,L., Pedraza-Escalona,M., Juarez-Gonzalez,V.R., Alcantara-Recillas,I., Possani,L.D., Becerril,B.. Evaluation of three different formats of a neutralizing single chain human antibody against toxin Cn2: Neutralization capacity versus thermodynamic stability.
Immunology Letters,
143 (2),
152-160.
Artículo
658 - Ramirez-Carreto,S., Quintero-Hernandez,V., Jimenez-Vargas,J.M., Corzo,G., Possani,L.D., Becerril,B., Ortiz,E.. Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae.
Peptides,
34 (2),
290-295.
Artículo
659 - Rendon-Anaya,M., Delaye,L., Possani,L.D., Herrera-Estrella,A.. Global Transcriptome Analysis of the Scorpion Centruroides noxius: New Toxin Families and Evolutionary Insights from an Ancestral Scorpion Species.
PLoS ONE,
7 (8),
e43331.
Artículo
660 - Rodriguez-Rodriguez,E.R., Ledezma-Candanoza,L.M., Contreras-Ferrat,L.G., Olamendi-Portugal,T., Possani,L.D., Becerril,B., Riano-Umbarila,L.. A Single Mutation in Framework 2 of the Heavy Variable Domain Improves the Properties of a Diabody and a Related Single-Chain Antibody.
Journal of Molecular Biology,
423 (3),
337-350.
Artículo
661 - Saucedo,A.L., Flores-Solis,D., Rodriguez de la Vega,R.C., Ramirez-Cordero,B., Hernandez-Lopez,R., Cano-Sanchez,P., Noriega-Navarro,R., Garcia-Valdes,J., Coronas-Valderrama,F., de Roodt,A., Brieba,L.G., Possani,L.D., del Rio-Portilla,F.. New tricks of an old pattern: structural versatility of scorpion toxins with common cysteine spacing.
Journal of Biological Chemistry,
287 (15),
12321-12330.
Artículo
662 - Saucedo,A.L., Del Rio,F., Picco,C., Estrada,G., Prestipino,G., Possani,L.D., Delepierre,M., Corzo,G.. Solution structure of native and recombinant expressed toxin CssII from the venom of the scorpion suffusus, and their effects on Nav1.5 Sodium channels.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1824 (3),
478-487.
Artículo
663 - Schiavon,E., Pedraza-Escalona,M., Gurrola,G.B., Olamendi-Portugal,T., Corzo,G., Wanke,E., Possani,L.D.. Negative-shift activation, current reduction and resurgent currents induced by beta-toxins from Centruroides scorpions in sodium channels.
Toxicon,
59 (2),
283-293.
Artículo
664 - Varga,Z., Gurrola-Briones,G., Papp,F., Rodriguez de la Vega,R.C., Pedraza-Alva,G., Tajhya,R.B., Gaspar,R., Cardenas,L., Rosenstein,Y., Beeton,C., Possani,L.D., Panyi,G.. Vm24, a Natural Immunosuppressant Peptide Potently and Selectively Blocks Kv1.3 Potassium Channels of Human T Cells.
Molecular Pharmacology,
82 (3),
372-382.
Artículo
665 - Wang,X., Jimenez-Vargas,J.M., Xu,C., Possani,L.D., Zhu,S.. Positive selection-guided mutational analysis revealing two key functional sites of scorpion ERG K(+) channel toxins.
Biochemical and Biophysical Research Communications,
429 (1-2),
111-116.
Artículo
666 - Amaro,I., Riano-Umbarila,L., Becerril,B., Possani,L.D.. Isolation and characterization of a human antibody fragment specific for Ts1 toxin from Tityus serrulatus scorpion.
Immunology Letters,
139 (1-2),
73-79.
Artículo
667 - Camargos,T.S., Restano-Cassulini,R., Possani,L.D., Peigneur,S., Tytgat,J., Schwartz,C.A., de Freitas,S.M., Schwartz,E.F.. The new kappa-KTx 2.5 from the scorpion Opisthacanthus cayaporum.
Peptides,
32 (7),
1509-1517.
Artículo
668 - Canul-Tec,J.C., Riano-Umbarila,L., Rudino-Pinera,E., Becerril,B., Possani,L.D., Torres-Larios,A.. Structural basis of neutralization of the major toxic component from the scorpion centruroides noxius hoffmann by a human-derived single chain antibody fragment.
Journal of Biological Chemistry,
286 (23),
20892-20900.
Revisión
669 - Corrales-Garcia,L.L., Possani,L.D., Corzo,G.. Expression systems of human beta-defensins: vectors, purification and biological activities.
Amino Acids,
40 (1),
5-13.
Artículo
670 - Espino-Solis,G.P., Estrada,G., Olamendi-Portugal,T., Villegas,E., Zamudio,F., Cestele,S., Possani,L.D., Corzo,G.. Isolation and molecular cloning of beta-neurotoxins from the venom of the scorpion Centruroides suffusus suffusus.
Toxicon,
57 (5),
739-746.
Artículo
671 - Estrada,G., Restano-Cassulini,R., Ortiz,E., Possani,L.D., Corzo,G.. Addition of positive charges at the C-terminal peptide region of CssII; a mammalian scorpion peptide toxin; improves its affinity for sodium channels Nav1.6.
Peptides,
32 (1),
75-79 .
Artículo
672 - Garcia-Gomez,B.I., Coronas,F.I., Restano-Cassulini,R., Rodriguez,R.R., Possani,L.D.. Biochemical and molecular characterization of the venom from the Cuban scorpion Rhopalurus junceus.
Toxicon,
58 (1),
18-27.
Artículo
673 - Hernandez-Aponte,C.A., Silva-Sanchez,J., Quintero-Hernandez,V., Rodriguez-Romero,A., Balderas,C., Possani,L.D., Gurrola,G.B.. Vejovine, a new antibiotic from the scorpion venom of Vaejovis mexicanus.
Toxicon,
57 (1),
84-92.
Artículo; Actas Paper
674 - Jimenez-Vargas,J.M., Restano-Cassulini,R., Quintero-Hernandez,V., Gurrola,G.B., Possani,L.D.. Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function.
Peptides,
32 (3),
560-567.
Revisión
675 - Quintero-Hernandez,V., Ortiz,E., Rendon,M.R., Schwartz,E.F., Becerril,B., Corzo,G., Possani,L.D.. Scorpion and spider venom peptides: Gene cloning and peptide expression.
Toxicon,
58 (8),
644-663.
Artículo
676 - Riano-Umbarila,L., Contreras-Ferrat,G., Olamendi-Portugal,T., Morelos-Juarez,C., Corzo,G., Possani,L.D., Becerril,B.. Exploiting cross-reactivity to neutralize two different scorpion venoms with one single-chain antibody fragment.
Journal of Biological Chemistry,
286 (8),
6143-6151.
Artículo
677 - Rodriguez,A., Villegas,E., Satake,H., Possani,L.D., Corzo,G.. Amino acid substitutions in an alpha-helical antimicrobial arachnid peptide affect its chemical properties and biological activity towards pathogenic bacteria but improves its therapeutic index.
Amino Acids,
40 (1),
61-68.
Internacional
678 - Possani,L.D., Gurrola,G.B., Schwartz,E., Restano,R.. Bioquimica y biologia molecular de los venenos de escorpiones de importancia medica en el continente americano. Emergencias por Animales Ponzonosos en las Americas .
147-180,
Mexico.
Internacional
679 - Valdez-Cruz,N.A., Conde,R., Zamudio,F., Possani,L.D.. Anticoagulants from scorpion venoms. Toxins and Hemostasis: From Bench to Bedside .
255-266.
Artículo
680 - de Roodt,A.R., Coronas,F.I., Lago,N., Gonzalez,M.E., Laskowicz,R.D., Beltramino,J.C., Saavedra,S., Lopez,R.A., Reati,G., Vucharchuk,M.G., Bazan,E., Varni,L., Salomon,O.D., Possani,L.D.. General biochemical and immunological characterization of the venom from the scorpion Tityus trivittatus of Argentina.
Toxicon,
55 (2-3),
307-319.
Artículo
681 - Gurrola,G.B., Capes,E.M., Zamudio,F.Z., Possani,L.D., Valdivia,H.H.. Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors.
Pharmaceuticals.(Basel),
3 (4),
1093-1107.
Artículo
682 - Redaelli,E., Restano-Cassulini,R., Fuentes-Silva,D., Clement,H., Schiavon,E., Zamudio,F.Z., Odell,G., Arcangeli,A., Clare,J.J., Alagon,A., Rodriguez de la Vega,R.C., Possani,L.D., Wanke,E.. Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels.
Journal of Biological Chemistry,
285 (6),
4130-4142 .
Artículo; Actas Paper
683 - Rodriguez de la Vega,R.C., Schwartz,E.F., Possani,L.D.. Mining on scorpion venom biodiversity.
Toxicon,
56 (7),
1155-1161.
Artículo
684 - Vandendriessche,T., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D., Tytgat,J.. Isolation and characterization of two novel scorpion toxins: the alpha-toxin-like CeII8, specific for Na(v)1.7 channels and the classical anti-mammalian CeII9, specific for Na(v)1.4 channels.
Toxicon,
56 (4),
613-623.
Artículo
685 - Zhu,S., Gao,B., Aumelas,A., Rodriguez,M.D., Lanz-Mendoza,H., Peigneur,S., Diego-Garcia,E., Martin-Eauclaire,M.F., Tytgat,J., Possani,L.D.. MeuTXKbeta1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1804 (4),
872-883.
Artículo
686 - Corzo,G., Bernard,C., Clement,H., Villegas,E., Bosmans,F., Tytgat,J., Possani,L.D., Darbon,H., Alagon,A.. Insecticidal peptides from the theraposid spider Brachypelma albiceps: A NMR-based model of Ba2.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1794 (8),
1190-1196.
Artículo
687 - Corzo,G., Prochnicka-Chalufour,A., Garcia,B.I., Possani,L.D., Delepierre,M.. Solution structure of Cn5, a crustacean toxin found in the venom of the scorpions Centruroides noxius and Centruroides suffusus suffusus.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1794 (11),
1591-1598.
Artículo
688 - D'Suze,G., Schwartz,E.F., Garcia,B.I., Sevcik,C., Possani,L.D.. Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans.
Biochimie,
91 (8),
1010-1019.
Revisión
689 - Espino-Solis,G.P., Riano-Umbarila,L., Becerril,B., Possani,L.D.. Antidotes against venomous animals: State of the art and prospectives.
Journal of Proteomics,
72 (2),
183-199.
Artículo
690 - Espino-Solis,G.P., Calderon-Amador,J., Calderon-Aranda,E.S., Licea,A.F., Donis-Maturano,L., Flores-Romo,L., Possani,L.D.. Rational design of synthetic peptides to generate antibodies that recognize in situ CD11c+ putative dendritic cells in horse lymph nodes.
Veterinary Immunology and Immunopathology,
132 (2-4),
181-190.
Artículo
691 - Garcia-Gomez,B.I., Olamendi-Portugal,T.C., Paniagua,J., van der Walt,J., Dyason,K., Possani,L.D.. Heterologous expression of a gene that codes for Pg8, a scorpion toxin of Parabuthus granulatus, capable of generating protecting antibodies in mice.
Toxicon,
53 (7-8),
770-778.
Artículo
692 - Gonzalez-Morales,L., Diego-Garcia,E., Segovia,L., Gutierrez,M.C., Possani,L.D.. Venom from the centipede Scolopendra viridis Say: purification, gene cloning and phylogenetic analysis of a phospholipase A2.
Toxicon,
54 (1),
8-15.
Artículo
693 - Hernandez-Salgado,K., Estrada,G., Olvera,A., Coronas,F.I., Possani,L.D., Corzo,G.. Heterologous expressed toxic and non-toxic peptide variants of toxin CssII are capable to produce neutralizing antibodies against the venom of the scorpion Centruroides suffusus suffusus.
Immunology Letters,
125 (2),
93-99.
Artículo
694 - Kauferstein,S., Kendel,Y., Nicke,A., Coronas,F.I., Possani,L.D., Favreau,P., Krizaj,I., Wunder,C., Kauert,G., Mebs,D.. New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptors.
Toxicon,
54 (3),
295-301.
Artículo
695 - Papp,F., Batista,C.V., Varga,Z., Herceg,M., Roman-Gonzalez,S.A., Gaspar,R., Possani,L.D., Panyi,G.. Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus.
Toxicon,
54 (4),
379-389.
Revisión
696 - Prestipino,G., Corzo,G., Romeo,S., Murgia,A.R., Zanardi,I., Gurrola,G., Possani,L.D.. Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells.
Toxicology Letters,
187 (1),
1-9.
Artículo
697 - Schwartz,E.F., Capes,E.M., Diego-Garcia,E., Zamudio,F.Z., Fuentes,O., Possani,L.D., Valdivia,H.H.. Characterization of hadrucalcin, a peptide from Hadrurus gertschi scorpion venom with pharmacological activity on ryanodine receptors.
British Journal of Pharmacology,
157 (3),
392-403.
Artículo
698 - Silva,E.C., Camargos,T.S., Maranhao,A.Q., Silva-Pereira,I., Silva,L.P., Possani,L.D., Schwartz,E.F.. Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum.
Toxicon,
54 (3),
252-261.
Internacional
699 - Rodriguez-de-la-Vega,R., Barraza,R., Restano,R., Possani,L.D.. Toxins active on Herg channel: structure and function. Animal toxins: State of the Art. Perspectives in Health and Biotechnology .
193-204,
Belo Horizonte: EditoraUFMG.
Artículo
700 - Abdel-Mottaleb,Y., Corzo,G., Martin-Eauclaire,M.F., Satake,H., Ceard,B., Peigneur,S., Nambaru,P., Bougis,P.E., Possani,L.D., Tytgat,J.. A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K(+) channels.
Biochemical Pharmacology,
76 (6),
805-815.
Artículo
701 - Carballar-Lejarazu,R., Rodriguez,M.H., De La Cruz Hernandez-Hernandez,F., Ramos-Castaneda,J., Possani,L.D., Zurita-Ortega,M., Reynaud-Garza,E., Hernandez-Rivas,R., Loukeris,T., Lycett,G., Lanz-Mendoza,H.. Recombinant scorpine: a multifunctional antimicrobial peptide with activity against different pathogens.
Cellular and Molecular Life Sciences,
65 (19),
3081-3092.
Artículo
702 - Corzo,G., Papp,F., Varga,Z., Barraza,O., Espino-Solis,P.G., Rodriguez de la Vega,R.C., Gaspar,R., Panyi,G., Possani,L.D.. A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus.
Biochemical Pharmacology,
76 (9),
1142-1154.
Artículo
703 - Corzo,G., Diego-Garcia,E., Clement,H., Peigneur,S., Odell,G., Tytgat,J., Possani,L.D., Alagon,A.. An insecticidal peptide from the theraposid Brachypelma smithi spider venom reveals common molecular features among spider species from different genera.
Peptides,
29 (11),
1901-1908.
Artículo
704 - Diego-Garcia,E., Abdel-Mottaleb,Y., Schwartz,E.F., de la Vega RC, Tytgat,J., Possani,L.D.. Cytolytic and K(+) channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms.
Cellular and Molecular Life Sciences,
65 (1),
187-200.
Artículo
705 - Espino-Solis,G.P., Osuna-Quintero,J., Possani,L.D.. Molecular cloning and characterization of the alphaX subunit from CD11c/CD18 horse integrin.
Veterinary Immunology and Immunopathology,
122 (3-4),
326-334.
Artículo
706 - Olamendi-Portugal,T., Batista,C.V., Restano-Cassulini,R., Pando,V., Villa-Hernandez,O., Zavaleta-Martinez-Vargas,A., Salas-Arruz,M.C., de la Vega RC, Becerril,B., Possani,L.D.. Proteomic analysis of the venom from the fish eating coral snake Micrurus surinamensis: Novel toxins, their function and phylogeny.
Proteomics,
8 (9),
1919-1932.
Artículo
707 - Petricevich,V.L., Reynaud,E., Cruz,A.H., Possani,L.D.. Macrophage activation, phagocytosis and intracellular calcium oscillations induced by scorpion toxins from Tityus serrulatus.
Clinical and Experimental Immunology,
154 (3),
415-423.
Artículo
708 - Restano-Cassulini,R., Olamendi-Portugal,T., Zamudio,F., Becerril,B., Possani,L.D.. Two Novel Ergtoxins, Blockers of K(+)-channels, Purified from the Mexican Scorpion Centruroides elegans elegans.
Neurochemical Research,
33 (8),
1525-1533.
Artículo
709 - Romeo,S., Corzo,G., Vasile,A., Satake,H., Prestipino,G., Possani,L.D.. A positive charge at the N-terminal segment of Discrepin increases the blocking effect of K(+) channels responsible for the I(A) currents in cerebellum granular cells.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1780 (4),
750-755.
Artículo
710 - Schwartz,E.F., Camargos,T.S., Zamudio,F.Z., Silva,L.P., Bloch,C.,Jr., Caixeta,F., Schwartz,C.A., Possani,L.D.. Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum.
Toxicon,
51 (8),
1499-1508.
Nacional
711 - Possani-Postay,L.D.. El estudio de los componentes del veneno de alacranes en el contexto de la biología molecular, la farmacología y la medicina. Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 16.
179-187,
Mexico, D.F..
Artículo
712 - Batista,C.V., Roman-Gonzalez,S.A., Salas-Castillo,S.P., Zamudio,F.Z., Gomez-Lagunas,F., Possani,L.D.. Proteomic analysis of the venom from the scorpion Tityus stigmurus: Biochemical and physiological comparison with other Tityus species.
Comparative Biochemistry and Physiology - C Toxicology and Pharmacology,
146 (1-2),
147-157.
Artículo
713 - Clement,H., Odell,G., Zamudio,F.Z., Redaelli,E., Wanke,E., Alagon,A., Possani,L.D.. Isolation and characterization of a novel toxin from the venom of the spider Grammostola rosea that blocks sodium channels.
Toxicon,
50 (1),
65-74.
Artículo; Actas Paper
714 - Diego-Garcia,E., Schwartz,E.F., D'Suze,G., Roman-Gonzalez,S.A., Batista,C.V., Garcia,B.I., Rodriguez de la Vega,R.C., Possani,L.D.. Wide phylogenetic distribution of Scorpine and long-chain beta-KTx-like peptides in scorpion venoms: Identification of "orphan" components.
Peptides,
28 (1),
31-37.
Artículo
715 - Estrada,G., Garcia,B.I., Schiavon,E., Ortiz,E., Cestele,S., Wanke,E., Possani,L.D., Corzo,G.. Four disulfide-bridged scorpion beta neurotoxin CssII: Heterologous expression and proper folding in vitro.
Biochimica et Biophysica Acta (BBA) - General Subjects,
1770 (8),
1161-1168.
Artículo
716 - Lopez-Vera,E., Aguilar,M.B., Schiavon,E., Marinzi,C., Ortiz,E., Restano-Cassulini,R., Batista,C.V.F., Possani,L.D., Heimer de la Cotera,E.P., Peri,F., Becerril,B., Wanke,E.. Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors.
Febs Journal,
274 (15),
3972-3985.
Artículo
717 - Petricevich,V.L., Hernandez-Cruz,A., Coronas,F.I., Possani,L.D.. Toxin gamma from Tityus serrulatus scorpion venom plays an essential role in immunomodulation of macrophages.
Toxicon,
50 (5),
666-675.
Artículo
718 - Quintero-Hernandez,V., Juarez-Gonzalez,V.R., Ortiz-Leon,M., Sanchez,R., Possani,L.D., Becerril,B.. The change of the scFv into the Fab format improves the stability and in vivo toxin neutralization capacity of recombinant antibodies.
Molecular Immunology,
44 (6),
1307-1315.
Artículo
719 - Rodriguez de la Vega,R.C., Possani,L.D.. Novel paradigms on scorpion toxins that affect the activating mechanism of sodium channels.
Toxicon,
49 (2),
171-180.
Artículo
720 - Schwartz,E.F., Diego-Garcia,E., Rodriguez de la Vega,R.C., Possani,L.D.. Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones).
BMC Genomics,
8 (1),
119.
Artículo
721 - Valdez-Cruz,N.A., Segovia,L., Corona,M., Possani,L.D.. Sequence analysis and phylogenetic relationship of genes encoding heterodimeric Phospholipases A2 from the venom of the scorpion Anuroctonus phaiodactylus.
Gene,
396 (1),
149-158.
Editorial Material
Artículo
723 - Abdel-Mottaleb,Y., Coronas,F.V., de Roodt,A.R., Possani,L.D., Tytgat,J.. A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new alpha-KTX subfamily.
FEBS Letters,
580 (2),
592-596.
Artículo
724 - Barona,J., Batista,C.V., Zamudio,F.Z., Gomez-Lagunas,F., Wanke,E., Otero,R., Possani,L.D.. Proteomic analysis of the venom and characterization of toxins specific for Na(+)- and K(+)-channels from the Colombian scorpion Tityus pachyurus.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1764 (1),
76-84.
Artículo
725 - Batista,C.V., D'Suze,G., Gomez-Lagunas,F., Zamudio,F.Z., Encarnacion,S., Sevcik,C., Possani,L.D.. Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins.
Proteomics,
6 (12),
3718-3727.
Artículo
726 - Caliskan,F., Garcia,B.I., Coronas,F.I., Batista,C.V., Zamudio,F.Z., Possani,L.D.. Characterization of venom components from the scorpion Androctonus crassicauda of Turkey: Peptides and genes.
Toxicon,
48 (1),
12-22.
Artículo
727 - Mebs,D., Kuch,U., Coronas,F.I., Batista,C.V., Gumprecht,A., Possani,L.D.. Biochemical and biological activities of the venom of the Chinese pitviper Zhaoermia mangshanensis, with the complete amino acid sequence and phylogenetic analysis of a novel Arg49 phospholipase A(2) myotoxin.
Toxicon,
47 (7),
797-811.
Revisión
728 - Panyi,G., Possani,L.D., Rodriguez de la Vega,R.C., Gaspar,R., Varga,Z.. K+ Channel Blockers: Novel Tools to Inhibit T Cell Activation Leading to Specific Immunosuppression.
Current Pharmaceutical Design,
12 (18),
2199-2220.
Artículo
729 - Prochnicka-Chalufour,A., Corzo,G., Satake,H., Martin-Eauclaire,M.F., Murgia,A.R., Prestipino,G., D'Suze,G., Possani,L.D., Delepierre,M.. Solution Structure of Discrepin, a New K(+)-Channel Blocking Peptide from the alpha-KTx15 Subfamily(,).
Biochemistry,
45 (6),
1795-1804.
Artículo; Actas Paper
730 - Restano-Cassulini,R., Korolkova,Y.V., Diochot,S., Gurrola,G., Guasti,L., Possani,L., Lazdunski,M., Grishin,E., Arcangeli,A., Wanke,E.. Species Diversity and Peptide Toxins Blocking Selectivity of ERG Subfamily K+ Channels in CNS.
Molecular Pharmacology,
69 (5),
1673-1683.
Artículo
731 - Schiavon,E., Sacco,T., Restano-Cassulini,R., Gurrola,G., Tempia,F., Possani,L.D., Wanke,E.. Resurgent current and voltage sensor-trapping enhanced activation by a {beta}-scorpion toxin solely in nav1.6 channel: Significance in Mice Purkinje Neurons.
Journal of Biological Chemistry,
281 (29),
20326-20337.
Artículo
732 - Schwartz,E.F., Schwartz,C.A., Gomez-Lagunas,F., Zamudio,F.Z., Possani,L.D.. HgeTx1, the first K(+)-channel specific toxin characterized from the venom of the scorpion Hadrurus gertschi Soleglad.
Toxicon,
48 (8),
1046-1053.
Internacional
733 - Delepierre,M., Possani,L.D.. Pharmaceutical Applications of Ion Channel Blockers: Use of NMR to Determine the Structure of Scorpion Toxins. Modern Magnetic Resonance.
1325-1330,
2,
Dordrecht: Springer.
Internacional
734 - Possani,L.D., Rodriguez de la Vega,R.C.. Scorpion venom peptides. Handbook of Biologically Active Peptides.
339-354,
San Diego.
Artículo
735 - Aguilar,M.B., Lopez-Vera,E., Ortiz,E., Becerril,B., Possani,L.D., Olivera,B.M., Heimer de la Cotera,E.P.. A Novel Conotoxin from Conus delessertii with Posttranslationally Modified Lysine Residues.
Biochemistry,
44 (33),
11130-11136.
Artículo
736 - Bagdaany,M., Batista,C.V., Valdez-Cruz,N.A., Somodi,S., Rodriguez de la Vega,R.C., Licea,A.F., Varga,Z., Gaspar,R., Possani,L.D., Panyi,G.. Anuroctoxin, a new scorpion toxin of the {alpha}-KTx 6 subfamily is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes.
Molecular Pharmacology,
67 (4),
1034-1044.
Artículo
737 - Coronas,F.I., Balderas,C., Lopez,L.P., Possani,L.D., Gurrola,G.B.. Amino acid sequence determination and chemical synthesis of CllErg1 (gamma-KTx1.5), a K+ channel blocker peptide isolated from the scorpion Centruroides limpidus limpidus.
Journal of the Brazilian Chemical Society,
16 (3A),
404-411.
Artículo
738 - Diego-Garcia,E., Batista,C.V., Garcia-Gomez,B.I., Lucas,S., Candido,D.M., Gomez-Lagunas,F., Possani,L.D.. The Brazilian scorpion Tityus costatus Karsch: genes, peptides and function.
Toxicon,
45 (3),
273-283.
Revisión
739 - Gazarian,K.G., Gazarian,T., Hernandez,R., Possani,L.D.. Immunology of scorpion toxins and perspectives for generation of anti-venom vaccines.
Vaccine,
23 (26),
3357-3368.
Artículo
740 - Juarez-Gonzalez,V.R., Riano-Umbarila,L., Quintero-Hernandez,V., Olamendi-Portugal,T., Ortiz-Leon,M., Ortiz,E., Possani,L.D., Becerril,B.. Directed Evolution, Phage Display and Combination of Evolved Mutants: A Strategy to Recover the Neutralization Properties of the scFv Version of BCF2 a Neutralizing Monoclonal Antibody Specific to Scorpion Toxin Cn2.
Journal of Molecular Biology,
346 (5),
1287-1297.
Artículo
741 - Olamendi-Portugal,T., Somodi,S., Fernandez,J.A., Zamudio,F.Z., Becerril,B., Varga,Z., Panyi,G., Gaspar,R., Possani,L.D.. Novel alpha-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockage Kv1.3 over IKCa1 K(+) channels of T cells.
Toxicon,
46 (4),
418-429.
Artículo
742 - Padilla,A., Govezensky,T., Possani,L.D., Larralde,C.. Mortality and antibody responses of mice to three successive episodes of experimental scorpion (Centruroides limpidus limpidus) envenomation and immunological rescue.
Toxicon,
46 (2),
142-149.
Artículo
743 - Possani,L.D.. Insecticidal peptide from scorpion venom.
Industrial Bioprocessing,
27 (2),
9-10.
Artículo
744 - Riano-Umbarila,L., Juarez-Gonzalez,V.R., Olamendi-Portugal,T., Ortiz-Leon,M., Possani,L.D., Becerril,B.. A strategy for the generation of specific human antibodies by directed evolution and phage display.
Febs Journal,
272 (10),
2591-2601.
Revisión
745 - Rodriguez de la Vega,R.C., Possani,L.D.. Overview of scorpion toxins specific for Na(+) channels and related peptides: biodiversity, structure-function relationships and evolution.
Toxicon,
46 (8),
831-844.
Carta
746 - Rodriguez de la Vega,R.C., Possani,L.D.. On the evolution of invertebrate defensins.
Trends in Genetics,
21 (6),
330-332.
Divulgación
Artículo
748 - Batista,C.V., Del Pozo,L., Zamudio,F.Z., Contreras,S., Becerril,B., Wanke,E., Possani,L.D.. Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins.
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences,
803 (1),
55-66.
Artículo
749 - D'Suze,G., Sevcik,C., Corona,M., Zamudio,F.Z., Batista,C.V., Coronas,F.I., Possani,L.D.. Ardiscretin a novel arthropod-selective toxin from Tityus discrepans scorpion venom.
Toxicon,
43 (3),
263-272.
Artículo
750 - D'Suze,G., Batista,C.V., Frau,A., Murgia,A.R., Zamudio,F.Z., Sevcik,C., Possani,L.D., Prestipino,G.. Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K(+)-channels (I(A) currents) of cerebellum granular cells.
Archives of Biochemistry and Biophysics,
430 (2),
256-263.
Artículo
751 - Frenal,K., Xu,C.Q., Wolff,N., Wecker,K., Gurrola,G.B., Zhu,S.Y., Chi,C.W., Possani,L.D., Tytgat,J., Delepierre,M.. Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K(+) channels.
Proteins,
56 (2),
367-375.
Artículo
752 - Gomez-Lagunas,F., Batista,C.V., Olamendi-Portugal,T., Ramirez-Dominguez,M.E., Possani,L.D.. Inhibition of the collapse of the shaker k+ conductance by specific scorpion toxins.
Journal of General Physiology,
123 (3),
265-279.
Artículo
753 - Huys,I., Olamendi-Portugal,T., Garcia-Gomez,B.I., Vandenberghe,I., Van Beeumen,J., Dyason,K., Clynen,E., Zhu,S., van der Walt,J., Possani,L., Tytgat,J.. A subfamily of acidic alpha -K+ toxins.
Journal of Biological Chemistry,
279 (4),
2781-2789.
Artículo
754 - Montero-Solis,C., Gonzalez-Ceron,L., Rodriguez,M.H., Cirerol,B.E., Zamudio,F., Possanni,L.D., James,A.A., De La Cruz Hernandez-Hernandez,F.. Identification and characterization of gp65, a salivary-gland-specific molecule expressed in the malaria vector Anopheles albimanus.
Insect Molecular Biology,
13 (2),
155-164.
Artículo
755 - Murgia,A.R., Batista,C.V., Prestipino,G., Possani,L.D.. Amino acid sequence and function of a new alpha-toxin from the Amazonian scorpion Tityus cambridgei.
Toxicon,
43 (6),
737-740.
Artículo
756 - Pascual,I., Gil-Parrado,S., Cisneros,M., Joseph-Bravo,P., Diaz,J., Possani,L.D., Charli,J.L., Chavez,M.. Purification of a specific inhibitor of pyroglutamyl aminopeptidase II from the marine annelide Hermodice carunculata. In vivo effects in rodent brain.
International Journal of Biochemistry and Cell Biology,
36 (1),
138-152.
Artículo
757 - Rio-Portilla,F., Hernandez-Marin,E., Pimienta,G., Coronas,F.V., Zamudio,F.Z., Rodriguez de la Vega,R.C., Wanke,E., Possani,L.D.. NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical beta-toxin sequence but with alpha-like physiological activity.
European Journal of Biochemistry,
271 (12),
2504-2516.
Artículo
758 - Rodriguez de la Vega,R.C., Garcia,B.I., D'Ambrosio,C, Diego-Garcia,E., Scaloni,A., Possani,L.D.. Antimicrobial peptide induction in the haemolymph of the Mexican scorpion Centruroides limpidus limpidus in response to septic injury.
Cellular and Molecular Life Sciences,
61 (12),
1507-1519.
Revisión
759 - Rodriguez de la Vega,R.C., Possani,L.D.. Current views on scorpion toxins specific for K(+)-channels.
Toxicon,
43 (8),
865-875.
Artículo
760 - Selisko,B., Cosio,G., Garcia,C., Becerril,B., Possani,L.D., Horjales,E.. Bacterial expression, purification and functional characterization of a recombinant chimeric Fab derived from murine mAb BCF2 that neutralizes the venom of the scorpion Centruroides noxius hoffmann.
Toxicon,
43 (1),
43-51.
Artículo
761 - Shalabi,A., Zamudio,F., Wu,X., Scaloni,A., Possani,L., Villereal,M.L.. Tetrapandins, a new class of scorpion toxins that specifically inhibit store-operated calcium entry in HEK-293 cells.
Journal of Biological Chemistry,
279 (2),
1040-1049.
Artículo
762 - Valdez-Cruz,N.A., Batista,C.V., Possani,L.D.. Phaiodactylipin, a glycosylated heterodimeric phospholipase A from the venom of the scorpion Anuroctonus phaiodactylus.
European Journal of Biochemistry,
271 (8),
1453-1464.
Artículo
763 - Valdez-Cruz,N.A., Batista,C.V., Zamudio,F.Z., Bosmans,F., Tytgat,J., Possani,L.D.. Phaiodotoxin, a novel structural class of insect-toxin isolated from the venom of the Mexican scorpion Anuroctonus phaiodactylus.
European Journal of Biochemistry,
271 (23-24),
4753-4761.
Artículo
764 - Valdez-Cruz,N.A., Davila,S., Licea,A., Corona,M., Zamudio,F.Z., Garcia-Valdes,J., Boyer,L., Possani,L.D.. Biochemical, genetic and physiological characterization of venom components from two species of scorpions: Centruroides exilicauda Wood and Centruroides sculpturatus Ewing.
Biochimie,
86 (6),
387-396.
Artículo
765 - Zhu,X., Zamudio,F.Z., Olbinski,B.A., Possani,L.D., Valdivia,H.H.. Activation of skeletal ryanodine receptors by two novel scorpion toxins from buthotus judaicus.
Journal of Biological Chemistry,
279 (25),
26588-26596.
Artículo
766 - Corona,M., Coronas,F.V., Merino,E., Becerril,B., Gutierrez,R., Rebolledo-Antunez,S., Garcia,D.E., Possani,L.D.. A novel class of peptide found in scorpion venom with neurodepressant effects in peripheral and central nervous system of the rat.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1649 (1),
58-67.
Artículo
767 - Coronas,F.V., de Roodt,A.R., Portugal,T.O., Zamudio,F.Z., Batista,C.V., Gomez-Lagunas,F., Possani,L.D.. Disulfide bridges and blockage of Shaker B K(+)-channels by another butantoxin peptide purified from the Argentinean scorpion Tityus trivittatus.
Toxicon,
41 (2),
173-179.
Artículo
768 - Coronas,F.V., Stankiewicz,M., Batista,C.V., Giraud,S., Alam,J.M., Possani,L.D., Mebs,D., Pelhate,M.. Primary structure and electrophysiological characterization of two almost identical isoforms of toxin from Isometrus vittatus (family: Buthidae) scorpion venom.
Toxicon,
41 (8),
989-997.
Artículo
769 - Garcia,C., Calderon-Aranda,E.S., Anguiano,G.A., Becerril,B., Possani,L.D.. Analysis of the immune response induced by a scorpion venom sub-fraction, a pure peptide and a recombinant peptide, against toxin Cn2 of Centruroides noxius Hoffmann.
Toxicon,
41 (4),
417-427.
Artículo
770 - Gazarian,T.G., Selisko,B., Gurrola,G.B., Possani,L.D., Gazarian,K.G.. Potential of Peptides Selected from Random Phage-Displayed Libraries to Mimic Conformational Epitopes: A Study on Scorpion Toxin Cn2 and the Neutralizing Monoclonal Antibody BCF2.
Combinatorial Chemistry & High Throughput Screening,
6 (2),
119-132.
Artículo
771 - Guijarro,J.I., M'Barek,S., Gomez-Lagunas,F., Garnier,D., Rochat,H., Sabatier,J.M., Possani,L.D., Delepierre,M.. Solution structure of Pi4, a short four-disulfide-bridged scorpion toxin specific of potassium channels.
Protein Science,
12 (9),
1844-1854.
Artículo
772 - Gutierrez,M.C., Abarca,C., Possani,L.D.. A toxic fraction from scolopendra venom increases the basal release of neurotransmitters in the ventral ganglia of crustaceans.
Comparative Biochemistry and Physiology - C Toxicology and Pharmacology,
135 (2),
205-214.
Artículo
773 - Lopez-Gonzalez,I., Olamendi-Portugal,T., de la Vega-Beltran,J.L., van der Walt,J., Dyason,K., Possani,L.D., Felix,R., Darszon,A.. Scorpion toxins that block T-type Ca(2+) channels in spermatogenic cells inhibit the sperm acrosome reaction.
Biochemical and Biophysical Research Communications,
300 (2),
408-414.
Artículo
774 - Padilla,A., Govezensky,T., Possani,L.D., Larralde,C.. Experimental envenoming of mice with venom from the scorpion Centruroides limpidus limpidus: differences in mortality and symptoms with and without antibody therapy relating to differences in age, sex and strain of mouse.
Toxicon,
41 (8),
959-965.
Carta
775 - Xu,C.Q., Zhu,S.Y., Chi,C.W., Tytgat,J., Possani,L.D., Rodriguez de la Vega,R.C.. Turret and pore block of K+ channels: What is the difference? (multiple letters).
Trends in Pharmacological Sciences,
24 (9),
446-449.
Nacional
776 - Alagon,A., Possani,L.D.. Desarrollo de nuevos f rmacos a partir de la fauna tropical. Fronteras de la Biología en los Inicios del Siglo XXI, Módulo VII .
123-160,
Mexico,D.F..
Nacional
777 - Alagon,A., Carillo,C., Chavez-Haro,A., De la Mora-Zerpa,C., Larralde,C., Lamas,N, Martin,E, Osnaya-Romero,N., Perez,Y, Possani,L.D., Romero-Zamora,L.. Práctica Médica Efectiva- Alacranismo (T63.2, X22).
Mexico.
Editorial Material
778 - Possani,L.D., Rodriguez de la Vega,R.C.. Response to Xu et al.: Hypothesis-driven science paves the way for new discoveries.
Trends in Pharmacological Sciences,
24 (9),
448-449.
Editorial Material
779 - Possani,L.D.. The past, present, and future of biotechnology in Mexico.
Nature Biotechnology,
21 (5),
582-583.
Editorial Material
780 - Rodriguez de la Vega,R.C., Merino,E., Becerril,B., Possani,L.D.. Novel interactions between K(+) channels and scorpion toxins.
Trends in Pharmacological Sciences,
24 (5),
222-227.
Artículo
781 - Angulo,Y., Olamendi-Portugal,T., Alape-Giron,A., Possani,L.D., Lomonte,B.. Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A(2) homologue.
International Journal of Biochemistry and Cell Biology,
34 (10),
1268-1278.
Artículo
782 - Batista,C.V., Gomez-Lagunas,F., Rodriguez de la Vega,R.C., Hajdu,P., Panyi,G., Gaspar,R., Possani,L.D.. Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1601 (2),
123-131.
Artículo
783 - Batista,C.V., Zamudio,F.Z., Lucas,S., Fox,J.W., Frau,A., Prestipino,G., Possani,L.D.. Scorpion toxins from Tityus cambridgei that affect Na(+)-channels.
Toxicon,
40 (5),
557-562.
Artículo
784 - Corona,M., Gurrola,G.B., Merino,E., Cassulini,R.R., Valdez-Cruz,N.A., Garcia,B, Ramirez-Dominguez,M.E., Coronas,F.I., Zamudio,F.Z., Wanke,E., Possani,L.D.. A large number of novel Ergtoxin-like genes and ERG K(+)-channels blocking peptides from scorpions of the genus Centruroides.
FEBS Letters,
532 (1-2),
121-126.
Artículo
785 - Corzo,G., Villegas,E., Gomez-Lagunas,F., Possani,L.D., Belokoneva,O.S., Nakajima,T.. Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins.
Journal of Biological Chemistry,
277 (26),
23627-23637.
Artículo
786 - Lecchi,M., Redaelli,E., Rosati,B., Gurrola,G., Florio,T., Crociani,O., Curia,G., Cassulini,R.R., Masi,A., Arcangeli,A., Olivotto,M., Schettini,G., Possani,L.D., Wanke,E.. Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release.
Journal of Neuroscience,
22 (9),
3414-3425.
Artículo
787 - Olamendi-Portugal,T., Garcia,B.I., Lopez-Gonzalez,I., van der Walt,J., Dyason,K., Ulens,C., Tytgat,J., Felix,R., Darszon,A., Possani,L.D.. Two new scorpion toxins that target voltage-gated Ca(2+) and Na(+) channels.
Biochemical and Biophysical Research Communications,
299 (4),
562-568.
Artículo
788 - Pardo-Lopez,L., Garcia-Valdes,J., Gurrola,G.B., Robertson,G.A., Possani,L.D.. Mapping the receptor site for ergtoxin, a specific blocker of ERG channels.
FEBS Letters,
510 (1-2),
45-49.
Artículo
789 - Pardo-Lopez,L., Zhang,M., Liu,J., Jiang,M., Possani,L.D., Tseng,G.N.. Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel's outer vestibule.
Journal of Biological Chemistry,
277 (19),
16403-16411.
Artículo
790 - Possani,L.D., Corona,M., Zurita,M., Rodriguez,M.H.. From Noxiustoxin to Scorpine and Possible Transgenic Mosquitoes Resistant to Malaria.
Archives of Medical Research,
33 (4),
398-404.
Artículo
791 - Ramirez-Dominguez,M.E., Olamendi-Portugal,T., Garcia,U., Garcia,C., Arechiga,H., Possani,L.D.. Cn11, the first example of a scorpion toxin that is a true blocker of Na(+) currents in crayfish neurons.
Journal of Experimental Biology,
205 (Pt 6),
869-876.
Artículo
792 - Vacher,H., Alami,M., Crest,M., Possani,L.D., Bougis,P.E., Martin-Eauclaire,M.F.. Expanding the scorpion toxin alpha-KTX 15 family with AmmTX3 from Androctonus mauretanicus.
European Journal of Biochemistry,
269 (24),
6037-6041.
Internacional
793 - Possani,L.D., Merino,E., Corona,M., Becerril,B.. Scorpion genes and peptides specific for potassium channels: Structure, function and evolution. Perspectives in Molecular Toxinology.
201-214.
Artículo
794 - Corona,M., Valdez-Cruz,N.A., Merino,E., Zurita,M., Possani,L.D.. Genes and peptides from the scorpion Centruroides sculpturatus Ewing, that recognize Na(+)-channels.
Toxicon,
39 (12),
1893-1898.
Artículo
795 - Frau,A., Pisciotta,M., Gurrola,G.B., Possani,L.D., Prestipino,G.. Synthetic undecapeptide (NTX10-20) of noxiustoxin blocks completely the I(A) potassium currents of cerebellum granular cells.
European Biophysics Journal,
29 (8),
569-573.
Artículo
796 - Garcia-Valdes,J., Zamudio,F.Z., Toro,L., Possan,L.D.. Slotoxin, alphaKTx1.11, a new scorpion peptide blocker of MaxiK channels that differentiates between alpha and alpha+beta (beta1 or beta4) complexes.
FEBS Letters,
505 (3),
369-373. .
Artículo
797 - Goudet,C., Ferrer,T., Galan,L., Artiles,A., Batista,C.F., Possani,L.D., Alvarez,J., Aneiros,A., Tytgat,J.. Characterization of two Bunodosoma granulifera toxins active on cardiac sodium channels.
British Journal of Pharmacology,
134 (6),
1195-1206.
Artículo
798 - Nishigaki,T., Zamudio,F.Z., Possani,L.D., Darszon,A.. Time-Resolved Sperm Responses to an Egg Peptide Measured by Stopped-Flow Fluorometry.
Biochemical and Biophysical Research Communications,
284 (2),
531-535.
Artículo
799 - Peter,M.,Jr, Varga,Z., Hajdu,P., Gaspar,R., Damjanovich,S., Horjales,E., Possani,L.D., Panyi,G.. Effects of toxins Pi2 and Pi3 on human T lymphocyte Kv1.3 channels: the role of Glu7 and Lys24.
Journal of Membrane Biology,
179 (1),
13-25.
Artículo
800 - Rocchetti,M., Besana,A., Gurrola,G.B., Possani,L.D., Zaza,A.. Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential.
Journal of Physiology,
534 (Pt 3),
721-732.
Internacional
801 - Possani,L.D., Becerril,B., Tytgat,J., Delepierre,M.. High Affinity Scorpion Toxins for Studying Potassium and Sodium Channels. Ion Channel Localization Methods and Protocols: Methods and Protocols.
145-165.
Artículo
802 - Angulo,Y., Olamendi-Portugal,T., Possani,L.D., Lomonte,B.. Isolation and characterization of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a new Lys49 phospholipase A2 homologue.
International Journal of Biochemistry and Cell Biology,
32 (1),
63-71.
Artículo
803 - Batista,C.V., Gomez-Lagunas,F., Lucas,S., Possani,L.D.. Tc1, from Tityus cambridgei, is the first member of a new subfamily of scorpion toxin that blocks K(+)-channels.
FEBS Letters,
486 (2),
117-120.
Carta
804 - Bottiglieri,C., Ferrara,L., Corona,M., Gurrola,G.B., Batista,C., Wanke,E., Possani,L.D.. Disulfide bridges of ergtoxin, a member of a new sub-family of peptide blockers of the ether-a-go-go-related K+ channel.
FEBS Letters,
479 (3),
156-157 .
Artículo
805 - Conde,R., Zamudio,F.Z., Rodriguez,M.H., Possani,L.D.. Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion venom.
FEBS Letters,
471 (2-3),
165-168.
Artículo
806 - Peter,M.,Jr, Hajdu,P., Varga,Z., Damjanovich,S., Possani,L.D., Panyi,G., Gaspar,R.. Blockage of human T lymphocyte Kv1.3 channels by Pi1, a novel class of scorpion toxin.
Biochemical and Biophysical Research Communications,
278 (1),
34-37.
Artículo
807 - Pisciotta,M., Coronas,F.I., Bloch,C., Prestipino,G., Possani,L.D.. Fast K(+) currents from cerebellum granular cells are completely blocked by a peptide purified from Androctonus australis Garzoni scorpion venom.
Biochimica et Biophysica Acta (BBA) - Biomembranes,
1468 (1-2),
203-212.
Artículo
808 - Possani,L.D., Merino,E., Corona,M., Bolivar,F., Becerril,B.. Peptides and genes coding for scorpion toxins that affect ion-channels.
Biochimie,
82 (9-10),
861-868.
Carta
Artículo
810 - Torres-Larios,A., Gurrola,G.B., Zamudio,F.Z., Possani,L.D.. Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus.
European Journal of Biochemistry,
267 (16),
5023-5031.
Nacional
Artículo
812 - Altamirano,M.M., Garcia,C., Possani,L.D., Fersht,A.R.. Oxidative refolding chromatography: folding of the scorpion toxin Cn5.
Nature Biotechnology,
17 (2),
187-191.
Artículo
813 - Batista,C.V., da Silva,L.R., Sebben,A., Scaloni,A., Ferrara,L., Paiva,G.R., Olamendi-Portugal,T., Possani,L.D., Bloch,C.. Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.
Peptides,
20 (6),
679-686.
Artículo
814 - Calderon-Aranda,E.S., Riviere,G., Choumet,V., Possani,L.D., Bon,C.. Pharmacokinetics of the toxic fraction of Centruroides limpidus limpidus venom in experimentally envenomed rabbits and effects of immunotherapy with specific F(ab')2.
Toxicon,
37 (5),
771-782.
Artículo
815 - Calderon-Aranda,E.S., Selisko,B., York,E.J., Gurrola,G.B., Stewart,J.M., Possani,L.D.. Mapping of an epitope recognized by a neutralizing monoclonal antibody specific to toxin Cn2 from the scorpion Centruroides noxius, using discontinuous synthetic peptides.
European Journal of Biochemistry,
264 (3),
746-755.
Artículo
816 - Conde,R., Zamudio,F.Z., Becerril,B., Possani,L.D.. Phospholipin, a novel heterodimeric phospholipase A2 from Pandinus imperator scp6pion venom.
FEBS Letters,
460 (3),
447-450.
Artículo
817 - Delepierre,M., Prochnicka-Chalufour,A., Boisbouvier,J., Possani,L.D.. Pi7, an orphan peptide from the scorpion Pandinus imperator: a 1H-NMR analysis using a nano-NMR Probe.
Biochemistry,
38 (51),
16756-16765.
Artículo
818 - D'Suze,G., Zamudio,F., Gomez-Lagunas,F., Possani,L.D.. A novel K+ channel blocking toxin from Tityus discrepans scorpion venom.
FEBS Letters,
456 (1),
146-148.
Artículo
819 - Gurrola,G.B., Rosati,B., Rocchetti,M., Pimienta,G., Zaza,A., Arcangeli,A., Olivotto,M., Possani,L.D., Wanke,E.. A toxin to nervous, cardiac, and endocrine ERG K+ channels isolated from Centruroides noxius scorpion venom.
FASEB Journal,
13 (8),
953-962.
Artículo
820 - Ottolia,M., Babini,E., Gazzotti,P., Possani,L.D., Prestipino,G.. Reconstitution of a voltage and calcium dependent potassium channel from rat cerebellum.
Brain Research,
815 (2),
410-413.
Artículo
821 - Pintar,A., Possani,L.D., Delepierre,M.. Solution structure of toxin 2 from centruroides noxius Hoffmann, a beta-scorpion neurotoxin acting on sodium channels.
Journal of Molecular Biology,
287 (2),
359-367.
Revisión
822 - Possani,L.D., Selisko,B., Gurrola,G.B.. Structure and function of scorpion toxins affecting K+-channels.
Perspectives In Drug Discovery And Design,
16,
15-40.
Revisión
823 - Possani,L.D., Becerril,B., Delepierre,M., Tytgat,J.. Scorpion toxins specific for Na+-channels.
European Journal of Biochemistry,
264 (2),
287-300.
Artículo
824 - Selisko,B., Licea,A.F., Becerril,B., Zamudio,F., Possani,L.D., Horjales,E.. Antibody BCF2 against scorpion toxin Cn2 from Centuroides noxius Hoffmann: primary structure and three-dimensional model as free Fv fragment and complexed with its antigen.
Proteins,
37 (1),
130-143.
Artículo
825 - Tytgat,J., Chandy,K.G., Garcia,M.L., Gutman,G.A., Martin-Eauclaire,M.F., van der Walt,J.J., Possani,L.D.. A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies.
Trends in Pharmacological Sciences,
20 (11),
444-447.
Artículo
826 - Yamamoto,H., Sejbal,J., York,E., Stewart,J.M., Possani,L.D., Kotovych,G.. An nmr conformational analysis of a synthetic peptide Cn2(1-15)NH2-S-S-acetyl-Cn2(52-66)NH2 from the New World Centruroides noxius 2 (Cn2) scorpion toxin: comparison of the structure with those of the Centruroides scorpion toxins.
Biopolymers,
49 (4),
277-286.
Artículo
827 - Boisbouvier,J., Prochnicka-Chalufour,A., Nieto,A.R., Torres,J.A., Nanard,N., Rodriguez,M.H., Possani,L.D., Delepierre,M.. Structural information on a cecropin-like synthetic peptide, Shiva-3 toxic to the sporogonic development of Plasmodium berghei.
European Journal of Biochemistry,
257 (1),
263-273.
Artículo
828 - Delepierre,M., Prochnicka-Chalufour,A., Possani,L.D.. 1H NMR structural analysis of novel potassium blocking toxins using a nano-NMR probe.
Toxicon,
36 (11),
1599-1608.
Artículo
829 - Licea,A.F., Gutierrez,M.C., Esparza,J., Estrada-Parra,S., Estrada,G.I., Quesada-Pascual,F., Possani,L.D.. Enhancement of the immunogenicity of Mycobacterium leprae peptides by means of polymerization.
Asia-Pacific Journal Of Molecular Biology And Biotechnology,
6 (2),
89-95.
Artículo
830 - Martinez,F., Munoz-Garay,C., Gurrola,G., Darszon,A., Possani,L.D., Becerril,B.. Site directed mutants of Noxiustoxin reveal specific interactions with potassium channels.
FEBS Letters,
429 (3),
381-384.
Artículo
831 - Olamendi-Portugal,T., Gomez-Lagunas,F.G., Gurrola,G.B., Possani,L.D.. Two similar peptides from the venom of the scorpion Pandinus imperator, one highly effective blocker and the other inactive on K+ channels.
Toxicon,
36 (5),
759-770.
Artículo
832 - Peter,M.,Jr, Varga,Z., Panyi,G., Bene,L., Damjanovich,S., Pieri,C., Possani,L.D., Gaspar,R.. Pandinus imperator scorpion venom blocks voltage-gated K+ channels in human lymphocytes.
Biochemical and Biophysical Research Communications,
242 (3),
621-625.
Artículo
833 - Pisciotta,M., Ottolia,M., Possani,L.D., Prestipino,G.. A novel toxin form the scorpion Androctonus australis blocks Shaker K+ channels expressed in Xenopus oocytes.
Biochemical and Biophysical Research Communications,
242 (2),
287-291.
Artículo
834 - Pisciotta,M., Coronas,F.I., Possani,L.D., Prestipino,G.. The Androctonus australis garzoni scorpion venom contains toxins that selectively affect voltage-dependent K(+)-channels in cerebellum granular cells.
European Biophysics Journal,
27 (1),
69-73.
Artículo
835 - Possani,L.D., Zurita,M., Delepierre,M., Hernandez,F.H., Rodriguez,M.H.. From noxiustoxin to Shiva-3, a peptide toxic to the sporogonic development of Plasmodium berghei.
Toxicon,
36 (11),
1683-1692.
Revisión
836 - Selisko,B., Garcia,C., Becerril,B., Gomez-Lagunas,F., Garay,C., Possani,L.D.. Cobatoxins 1 and 2 from Centruroides noxius Hoffmann constitute a subfamily of potassium-channel-blocking scorpion toxins.
European Journal of Biochemistry,
254 (3),
468-479.
Artículo
837 - Tytgat,J., Debont,T., Rostoll,K., Muller,G.J., Verdonck,F., Daenens,P., van der Walt,J.J., Possani,L.D.. Purification and partial characterization of a 'short' insectotoxin-like peptide from the venom of the scorpion Parabuthus schlechteri.
FEBS Letters,
441 (3),
387-391.
Artículo
838 - Valdivia,H.H., Possani,L.D.. Peptide toxins as probes of ryanodine receptor structure and function.
Trends in Cardiovascular Medicine,
8 (3),
111-118.
Revisión
839 - Becerril,B., Marangoni,S., Possani,L.D.. Toxins and genes isolated from scorpions of the genus Tityus.
Toxicon,
35 (6),
821-835.
Artículo
840 - Ben Khalifa,R., Stankiewicz,M., Pelhate,M., Serrano-Hernandez,S.E., Possani,L.D., Hinkel,H., Mebs,D.. Action of babycurus-toxin 1 from the east African scorpion Babycurus centrurimorphus on the isolated cockroach giant axon.
Toxicon,
35 (7),
1069-1080.
Artículo
841 - Delepierre,M., Prochnicka-Chalufour,A., Possani,L.D.. A novel potassium channel blocking toxin from the scorpion Pandinus imperator: A 1H NMR analysis using a nano-NMR probe.
Biochemistry,
36 (9),
2649-2658.
Artículo
842 - Garcia,C., Becerril,B., Selisko,B., Delepierre,M., Possani,L.D.. Isolation, characterization and comparison of a novel crustacean toxin with a mammalian toxin from the venom of the scorpion Centruroides noxius Hoffmann.
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology,
116 (3),
315-322.
Artículo
843 - Gomez-Lagunas,F., Olamendi-Portugal,T., Possani,L.D.. Block of ShakerB K+ channels by Pi1, a novel class of scorpion toxin.
FEBS Letters,
400 (2),
197-200.
Artículo
844 - Higareda,A.E., Possani,L.D., Ramirez,O.T.. The use of culture redox potential and oxygen uptake rate for assessing glucose and glutamine depletion in hybridoma cultures.
Biotechnology and Bioengineering,
56 (5),
555-563.
Artículo
845 - Zamudio,F.Z., Gurrola,G.B., Arevalo,C., Sreekumar,R., Walker,J.W., Valdivia,H.H., Possani,L.D.. Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptors.
FEBS Letters,
405 (3),
385-389.
Artículo
846 - Zamudio,F.Z., Conde,R., Arevalo,C., Becerril,B., Martin,B.M., Valdivia,H.H., Possani,L.D.. The mechanism of inhibition of ryanodine receptor channels by imperatoxin I, a heterodimeric protein from the scorpion Pandinus imperator.
Journal of Biological Chemistry,
272 (18),
11886-11894.
Artículo
847 - Becerril,B., Corona,M., Coronas,F.I., Zamudio,F., Calderon-Aranda,E.S., Fletcher,P.L., Martin,B.M., Possani,L.D.. Toxic peptides and genes encoding toxin gamma of the Brazilian scorpions Tityus bahiensis and Tityus stigmurus.
Biochemical Journal,
313 (Pt 3),
753-760.
Artículo
848 - Corona,M., Zurita,M., Possani,L.D., Becerril,B.. Cloning and characterization of the genomic region encoding toxin IV-5 from the scorpion Tityus serrulatus Lutz and Mello.
Toxicon,
34 (2),
251-256.
Artículo
849 - Dehesa-Davila,M., Ramirez,A.N., Zamudio,F.Z., Gurrola-Briones,G., Lievano,A., Darszon,A., Possani,L.D.. Structural and functional comparison of toxins from the venom of the scorpions Centruroides infamatus infamatus, Centruroides limpidus limpidus and Centruroides noxius.
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology,
113 (2),
331-339.
Artículo
850 - D'Suze,G., Corona,F., Possani,L.D., Sevcik,C.. High performance liquid chromatography purification and amino acid sequence of toxins from the muscarinic fraction of Tityus discrepans scorpion venom.
Toxicon,
34 (5),
591-598.
Artículo
851 - Gomez-Lagunas,F., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D.. Two novel toxins from the venom of the scorpion Pandinus imperator show that the N-terminal amino acid sequence is important for their affinities towards Shaker B K+ channels.
Journal of Membrane Biology,
152 (1),
49-56.
Artículo
852 - Licea,A.F., Becerril,B., Possani,L.D.. Fab fragments of the monoclonal antibody BCF2 are capable of neutralizing the whole soluble venom from the scorpion Centruroides noxius Hoffmann.
Toxicon,
34 (8),
843-847.
Artículo
853 - Martinez,F., Becerril,B., Gurrola,G.B., Martin,B.M., Possani,L.D.. Synthesis and expression of the gene coding for noxiustoxin, a K+ channel-blocking peptide from the venom of the scorpion Centruroides noxius.
Toxicon,
34 (11-12),
1413-1419.
Artículo
854 - Nieto,A.R., Gurrola,G.B., Vaca,L., Possani,L.D.. Noxiustoxin 2, a novel K+ channel blocking peptide from the venom of the scorpion Centruroides noxius Hoffmann.
Toxicon,
34 (8),
913-922.
Artículo
855 - Nobile,M., Noceti,F., Prestipino,G., Possani,L.D.. Helothermine, a lizard venom toxin, inhibits calcium current in cerebellar granules.
Experimental Brain Research,
110 (1),
15-20.
Artículo
856 - Olamendi-Portugal,T., Gomez-Lagunas,F., Gurrola,G.B., Possani,L.D.. A novel structural class of K+-channel blocking toxin from the scorpion Pandinus imperator.
Biochemical Journal,
315 (Pt 3),
977-981.
Artículo
857 - Selisko,B., Garcia,C., Becerril,B., Delepierre,M., Possani,L.D.. An insect-specific toxin from Centruroides noxius Hoffmann. cDNA, primary structure, three-dimensional model and electrostatic surface potentials in comparison with other toxin variants.
European Journal of Biochemistry,
242 (2),
235-242.
Artículo
858 - Vaca,L., Licea,A., Possani,L.D.. Modulation of cell membrane potential in cultured vascular endothelium.
American Journal of Physiology - Cell Physiology,
270 (3 Pt 1),
C819-C824.
Artículo
859 - Zamudio,F., Wolf,K.M., Martin,B.M., Possani,L.D., Chiappinelli,V.A.. Two novel alpha-neurotoxins isolated from the taipan snake, Oxyuranus scutellatus, exhibit reduced affinity for nicotinic acetylcholine receptors in brain and skeletal muscle.
Biochemistry,
35 (24),
7910-7916.
Internacional
860 - Calderon-Aranda,E.S., Dehesa-Davila,M., Chavez-Haro,A., Possani,L.D.. Scorpion stings and their treatment in Mexico. Envenomings and their treatment.
311-320,
Lyon.
Artículo
861 - Becerril,B., Corona,M., Garcia,C., Bolivar,F., Possani,L.D.. Cloning of genes encoding scorpion toxins: An interpretative review.
Journal Of Toxicology-Toxin Reviews,
14 (3),
339-357.
Artículo
862 - Calderon-Aranda,E.S., Olamendi-Portugal,T., Possani,L.D.. The use of synthetic peptides can be a misleading approach to generate vaccines against scorpion toxins.
Vaccine,
13 (13),
1198-1206.
Artículo
863 - Dauplais,M., Gilquin,B., Possani,L.D., Gurrola-Briones,G., Roumestand,C., Menez,A.. Determination of the three-dimensional solution structure of noxiustoxin: analysis of structural differences with related short-chain scorpion toxins.
Biochemistry,
34 (51),
16563-16573.
Artículo
864 - Drakopoulou,E., Cotton,J., Virelizier,H., Bernardi,E., Schoofs,A.R., Partiseti,M., Choquet,D., Gurrola,G., Possani,L.D., Vita,C.. Chemical synthesis, structural and functional characterisation of noxiustoxin, a powerful blocker of lymphocyte voltage-dependent K+ channels.
Biochemical and Biophysical Research Communications,
213 (3),
901-907.
Artículo
865 - Gaspar,R., Bene,L., Damjanovich,S., Munoz-Garay,C., Calderon-Aranda,E.S., Possani,L.D.. Beta-scorpion toxin 2 from Centruroides noxius blocks voltage-gated K+ channels in human lymphocytes.
Biochemical and Biophysical Research Communications,
213 (2),
419-423.
Artículo
866 - Gurrola,G.B., Possani,L.D.. Structural and functional features of noxiustoxin: a K+ channel blocker.
Biochemistry and Molecular Biology International,
37 (3),
527-535.
Artículo
867 - Herion,P., Gurrola-Briones,G., Sanchez,M.D.R., Saavedra,R., Possani,L.D.. Monoclonal antibodies against noxiustoxin.
Hybridoma,
14 (3),
247-251.
Artículo
868 - Morrissette,J., Kratzschmar,J., Haendler,B., Elhayek,R., Mochca-Morales,J., Martin,B.M., Patel,J.R., Moss,R.L., Schleuning,W.D., Coronado,R., Possani,L.D.. Primary Structure and Properties of Helothermine, A Peptide Toxin That Blocks Ryanodine Receptors.
Biophysical Journal,
68 (6),
2280-2288.
Artículo
869 - Noceti,F., Ramirez,A.N., Possani,L.D., Prestipino,G.. Characterization of a voltage-dependent potassium channel in squid Schwann cells reconstituted in planar lipid bilayers.
Glia,
15 (1),
33-42.
Artículo
870 - Noeske-Jungblut,C., Haendler,B., Donner,P., Alagon,A., Possani,L., Schleuning,W.D.. Triabin, a highly potent exosite inhibitor of thrombin.
Journal of Biological Chemistry,
270 (48),
28629-28634.
Note
Note
Note
Note
Note
Note
Artículo
877 - Rodriguez,M.C., Zamudio,F., Torres,J.A., Gonzalez-Ceron,L., Possani,L.D., Rodriguez,M.H.. Effect of a cecropin-like synthetic peptide (Shiva-3) on the sporogonic development of Plasmodium berghei.
Experimental Parasitology,
80 (4),
596-604.
Artículo
878 - Trequattrini,C., Zamudio,F.Z., Petris,A., Prestipino,G., Possani,L.D., Franciolini,F.. Tityus bahiensis toxin IV-5b selectively affects Na channel inactivation in chick dorsal root ganglion neurons.
Comparative Biochemistry and Physiology -- Part A: Physiology,
112 (1),
21-28.
Artículo
879 - Vazquez,A., Tapia,J.V., Eliason,W.K., Martin,B.M., Lebreton,F., Delepierre,M., Possani,L.D., Becerril,B.. Cloning and characterization of the cDNAs encoding Na+ channel-specific toxins 1 and 2 of the scorpion Centruroides noxius Hoffmann.
Toxicon,
33 (9),
1161-1170.
Internacional
880 - Dehesa-Davila,M., Alagon,A.C., Possani,L.D.. Clinical toxicology of scorpion stings. Handbook of clinical toxicology of animal venoms and poisons.
221-238,
New York.
Artículo
881 - Dehesa-Davila,M., Martin,B.M., Nobile,M., Prestipino,G., Possani,L.D.. Isolation of a toxin from Centruroides infamatus infamatus Koch scorpion venom that modifies Na+ permeability on chick dorsal root ganglion cells.
Toxicon,
32 (12),
1487-1493.
Artículo
882 - Dehesa-Davila,M., Possani,L.D.. Scorpionism and serotherapy in Mexico.
Toxicon,
32 (9),
1015-1018.
Artículo
883 - Fletcher,M.D., Possani,L.D., Fletcher,P.L.. Morphological studies by light and electron microscopy of pancreatic acinar cells under the effect of Tityus serrulatus venom.
Cell and Tissue Research,
278 (2),
255-264.
Artículo
884 - Gurrola,G.B., Moreno-Hagelsieb,G., Zamudio,F.Z., Garcia,M., Soberon,X., Possani,L.D.. The disulfide bridges of toxin 2 from the scorpion Centruroides noxius Hoffmann and its three-dimensional structure calculated using the coordinates of variant 3 from Centruroides sculpturatus.
FEBS Letters,
347 (1),
59-62.
Artículo
885 - Gutierrez,M.C., ESTRADA,I.C.E., Estrada-Parra,S., Quesada-Pascual,F., Licea,A.F., Possani,L.D.. The imunogenetic activity of synthetic peptides corresponding to M. Leprae protein sequences.
Asia-Pacific Journal Of Molecular Biology And Biotechnology,
2,
143-150.
Artículo; Actas Paper
886 - Higareda,A.E., Possani,L.D., Ramirez,O.T.. Metabolic and kinetic studies of hybridomas in exponentially fed-batch cultures using T-flasks.
Cytotechnology,
15 (1-3),
73-86.
Artículo
887 - Lebreton,F., Delepierre,M., Ramirez,A.N., Balderas,C., Possani,L.D.. Primary and NMR three-dimensional structure determination of a novel crustacean toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch.
Biochemistry,
33 (37),
11135-11149.
Artículo
888 - Martin,B.M., Ramirez,A.N., Gurrola,G.B., Nobile,M., Prestipino,G., Possani,L.D.. Novel K(+)-channel-blocking toxins from the venom of the scorpion Centruroides limpidus limpidus Karsch.
Biochemical Journal,
304 (Pt 1),
51-56.
Artículo
889 - Nobile,M., Magnelli,V., Lagostena,L., Mochca-Morales,J., Possani,L.D., Prestipino,G.. The toxin helothermine affects potassium currents in newborn rat cerebellar granule cells.
Journal of Membrane Biology,
139 (1),
49-55.
Artículo
890 - Noeske-Jungblut,C., Kratzschmar,J., Haendler,B., Alagon,A., Possani,L., Verhallen,P., Donner,P., Schleuning,W.D.. An inhibitor of collagen-induced platelet aggregation from the saliva of Triatoma pallidipennis.
Journal of Biological Chemistry,
269 (7),
5050-5053.
Artículo
891 - Ramirez,A.N., Martin,B.M., Gurrola,G.B., Possani,L.D.. Isolation and characterization of a novel toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch.
Toxicon,
32 (4),
479-490.
Artículo
892 - Sacile,R., Ruggiero,C., Ballestrero,R., Possani,L.D., Prestipino,G., Rauch,G.. Secondary structure of noxiustoxin and charybdotoxin from hydropathy power spectra.
Biochemical and Biophysical Research Communications,
201 (1),
186-193.
Artículo
893 - Valdivia,H.H., Martin,B.M., Ramirez,A.N., Fletcher,P.L., Possani,L.D.. Isolation and pharmacological characterization of four novel Na+ channel-blocking toxins from the scorpion Centruroides noxius Hoffmann.
Journal of Biochemistry,
116 (6),
1383-1391.
Artículo
894 - Becerril,B., Corona,M., Mejia,M.C., Martin,B.M., Lucas,S., Bolivar,F., Possani,L.D.. The genomic region encoding toxin gamma from the scorpion Tityus serrulatus contains an intron.
FEBS Letters,
335 (1),
6-8.
Artículo
895 - Becerril,B., Vazquez,A., Garcia,C., Corona,M., Bolivar,F., Possam,L.D.. Cloning and characterization of cDNAs that code for Na(+)-channel-blocking toxins of the scorpion Centruroides noxius Hoffmann.
Gene,
128 (2),
165-171.
Artículo
896 - Calderon-Aranda,E.S., Hozbor,D., Possani,L.D.. Neutralizing capacity of murine sera induced by different antigens of scorpion venom.
Toxicon,
31 (3),
327-337.
Artículo
897 - Vaca,L., Gurrola,G.B., Possani,L.D., Kunze,D.L.. Blockade of a KCa channel with synthetic peptides from noxiustoxin: a K+ channel blocker.
Journal of Membrane Biology,
134 (2),
123-129.
Artículo
898 - Vazquez,A., Becerril,B., Martin,B.M., Zamudio,F., Bolivar,F., Possani,L.D.. Primary structure determination and cloning of the cDNA encoding toxin 4 of the scorpion Centruroides noxius Hoffmann.
FEBS Letters,
320 (1),
43-46.
Artículo
899 - Estrada,I.C., Gutierrez,M.C., Esparza,J., Quesada-Pascual,F., Estrada-Parra,S., Possani,L.D.. Use of synthetic peptides corresponding to sequences of Mycobacterium leprae proteins to study delayed-type hypersensitivity response in sensitized guinea pigs.
International Journal of Leprosy,
60 (1),
18-27.
Artículo
900 - Fletcher,P.L., Fletcher,M.D., Possani,L.D.. Characteristics of pancreatic exocrine secretion produced by venom from the Brazilian scorpion, Tityus serrulatus.
European Journal of Cell Biology,
58 (2),
259-270.
Note
901 - Harvey,A.L., Marshall,D.L., Possani,L.D.. Dendrotoxin-like effects of noxiustoxin.
Toxicon,
30 (11),
1497-1500.
Artículo
902 - Possani,L.D., Fletcher,P.L., Fletcher,M.D., Rode,G.S., Mochca-Morales,J., Lucas,S., Coronas,F.V., Alagon,A.C., Martin,B.M.. Structural and functional characteristics of toxins purified from the venom of the Brazilian scorpion Tityus serrulatus Lutz and Mello.
Memorias do Instituto Butantan,
54 (2),
35-52.
Artículo
903 - Possani,L.D., Mochca-Morales,J., Amezcua,J., Martin,B.M., Prestipino,G., Nobile,M.. Anionic currents of chick sensory neurons are affected by a phospholipase A2 purified from the venom of the taipan snake.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research,
1134 (3),
210-216.
Artículo
904 - Possani,L.D., Martin,B.M., Yatani,A., Mochca-Morales,J., Zamudio,F.Z., Gurrola,G.B., Brown,A.M.. Isolation and physiological characterization of taicatoxin, a complex toxin with specific effects on calcium channels.
Toxicon,
30 (11),
1343-1364.
Artículo
905 - Valdivia,H.H., Martin,B.M., Escobar,L., Possani,L.D.. Noxiustoxin and leiurutoxin III, two homologous peptide toxins with binding properties to synaptosomal membrane K+ channels.
Biochemistry International,
27 (6),
953-962.
Artículo
906 - Zamudio,F., Saavedra,R., Martin,B.M., Gurrola-Briones,G., Herion,P., Possani,L.D.. Amino acid sequence and immunological characterization with monoclonal antibodies of two toxins from the venom of the scorpion Centruroides noxius Hoffmann.
European Journal of Biochemistry,
204 (1),
281-292.
Artículo
907 - Possani,L.D., Martin,B.M., Fletcher,M.D., Fletcher,P.L.. Discharge effect on pancreatic exocrine secretion produced by toxins purified from Tityus serrulatus scorpion venom.
Journal of Biological Chemistry,
266 (5),
3178-3185.
Memoria in extenso
908 - Gutierrez,M.C., Estrada,G.I., Estrada-Parra,S., Gurrola,G.B., Possani,L.D.. Synthetic peptides as skin test reagents in leprosy. Proceedings Leprosy Research in Latin America.
7 p,
Caracas.
Memoria in extenso
909 - Possani,L.D., Gurrola,G.B., Portugal,T.O., Zamudio,F.Z., Vaca,L.D., Calderon,S.A., Kirsch,G.E.. Scorpion toxins: a model for peptide synthesis of new drugs. Proceedings First Brazilian Congress on Proteins.
352-367,
Brasil.
Artículo
910 - Colden-Stanfield,M., Schilling,W.P., Possani,L.D., Kunze,D.L.. Bradykinin-induced potassium current in cultured bovine aortic endothelial cells.
Journal of Membrane Biology,
116 (3),
227-238.
*
Artículo
911 - Mochca-Morales,J., Martin,B.M., Possani,L.D.. Isolation and characterization of helothermine, a novel toxin from Heloderma horridum horridum (Mexican beaded lizard) venom.
Toxicon,
28 (3),
299-309.
Artículo
912 - Possani,L.D.. 3Rd Pan-American Symposium on Animal, Plant and Microbial Toxins, Oaxtepec, Morelos-State, Mexico - 9-12 January 1990.
Toxicon,
28 (6),
597-597.
Artículo
913 - Ramirez,G.A., Fletcher,P.L., Possani,L.D.. Characterization of the venom from Crotalus molossus nigrescens Gloyd (black tail rattlesnake): isolation of two proteases.
Toxicon,
28 (3),
285-297.
Artículo
914 - Gurrola,G.B., Molinar-Rode,R., Sitges,M., Bayon,A., Possani,L.D.. Synthetic peptides corresponding to the sequence of noxiustoxin indicate that the active site of this K+ channel blocker is located on its amino-terminal portion.
Journal of Neural Transmission,
77 (1),
11-20.
Artículo
915 - Kirsch,G.E., Skattebol,A., Possani,L.D., Brown,A.M.. Modification of Na channel gating by an alpha scorpion toxin from Tityus serrulatus.
Journal of General Physiology,
93 (1),
67-83.
Artículo
916 - Prestipino,G., Valdivia,H.H., Lievano,A., Darszon,A., Ramirez,A.N., Possani,L.D.. Purification and reconstitution of potassium channel proteins from squid axon membranes.
FEBS Letters,
250 (2),
570-574.
Artículo
917 - Alagon,A.C., Guzman,H.S., Martin,B.M., Ramirez,A.N., Carbone,E., Possani,L.D.. Isolation and characterization of two toxins from the Mexican scorpion Centruroides limpidus limpidus Karsch.
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology,
89 (1),
153-161.
Artículo
918 - Martin,B.M., Carbone,E., Yatani,A., Brown,A.M., Ramirez,A.N., Gurrola,G.B., Possani,L.D.. Amino acid sequence and physiological characterization of toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann.
Toxicon,
26 (9),
785-794.
Artículo
919 - Ramirez,A.N., Gurrola,G.B., Martin,B.M., Possani,L.D.. Isolation of several toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann.
Toxicon,
26 (9),
773-783.
Artículo
920 - Valdivia,H.H., Smith,J.S., Martin,B.M., Coronado,R., Possani,L.D.. Charybdotoxin and noxiustoxin, two homologous peptide inhibitors of the K+ (Ca2+) channel.
FEBS Letters,
226 (2),
280-284.
Artículo
921 - Yatani,A., Kirsch,G.E., Possani,L.D., Brown,A.M.. Effects of New World scorpion toxins on single-channel and whole cell cardiac sodium currents.
American Journal of Physiology Heart and Circulatory Physiology,
254 (3 Pt 2),
H443-H451.
Artículo
922 - Brown,A.M., Yatani,A., Lacerda,A.E., Gurrola,G.B., Possani,L.D.. Neurotoxins that act selectively on voltage-dependent cardiac calcium channels.
Circulation Research,
61 (4 Pt 2),
I6-I9.
Artículo
923 - Carbone,E., Prestipino,G., Spadavecchia,L., Franciolini,F., Possani,L.D.. Blocking of the squid axon K+ channel by noxiustoxin: a toxin from the venom of the scorpion Centruroides noxius.
Pflugers Archiv European Journal of Physiology,
408 (5),
423-431.
Artículo
924 - Sitges,M., Possani,L.D., Bayon,A.. Characterization of the actions of toxins II-9.2.2 and II-10 from the venom of the scorpion Centruroides noxius on transmitter release from mouse brain synaptosomes.
Journal of Neurochemistry,
48 (6),
1745-1752.
Artículo
925 - Alagon,A., Possani,L.D., Smart,J., Schleuning,W.D.. Helodermatine, a kallikrein-like, hypotensive enzyme from the venom of Heloderma horridum horridum (Mexican beaded lizard).
Journal of Experimental Medicine,
164 (6),
1835-1845.
Artículo
926 - Rodriguez,A., Tablero,M., Barragan,B., Lara,P., Rangel,M., Arreguin,B., Possani,L., Soriano-Garcia,M.. Crystallization of Hevein - A Protein from Latex of Hevea-Brasiliensis (Rubber Tree).
Journal of Crystal Growth,
76 (3),
710-714.
*
Artículo
927 - Sitges,M., Possani,L.D., Bayon,A.. Noxiustoxin, a short-chain toxin from the Mexican scorpion Centruroides noxius, induces transmitter release by blocking K+ permeability.
Journal of Neuroscience,
6 (6),
1570-1574.
*
Artículo
928 - Sosa,B.P., Alagon,A.C., Martin,B.M., Possani,L.D.. Biochemical characterization of the phospholipase A2 purified from the venom of the Mexican beaded lizard (Heloderma horridum horridum Wiegmann).
Biochemistry,
25 (10),
2927-2933.
*
Artículo
929 - Possani,L.D., Martin,B.M., Svendsen,I., Rode,G.S., Erickson,B.W.. Scorpion toxins from Centruroides noxius and Tityus serrulatus. Primary structures and sequence comparison by metric analysis.
Biochemical Journal,
229 (3),
739-750.
*
Artículo
930 - Carbone,E., Prestipino,G., Franciolini,F., Dent,M.A., Possani,L.D.. Selective modification of the squid axon Na currents by Centruroides noxius toxin II-10.
Journal de Physiologie,
79 (4),
179-184.
*
Nacional
931 - Gurrola,G.B., Molina-Rode,R., Zentella,A.D., Possani,L.D.. Sintesis de peptidos y su posible utilizacion como vacuna contra toxinas de alacran. Avances en el mecanismo de accion de farmacos.
35-50.
Internacional
Nacional
933 - Domingos Possani,L.. The toxins of scorpion venom: structure and function.
Boletin de estudios medicos y biologicos,
32 (7-8 Suppl 1),
285-297.
Artículo
934 - Alagon,A.C., Maldonado,M.E., Julia,J.Z., Sanchez,C.R., Possani,L.D.. Venom from two sub-species of Heloderma horridum (Mexican beaded lizard): general characterization and purification of N-benzoyl-L-arginine ethyl ester hydrolase.
Toxicon,
20 (2),
463-475.
*
Artículo
935 - Carbone,E., Wanke,E., Prestipino,G., Possani,L.D., Maelicke,A.. Selective blockage of voltage-dependent K+ channels by a novel scorpion toxin.
Nature,
296 (5852),
90-91.
*
Artículo
936 - Carbone,E., Wanke,E., Prestipino,G., Possani,L.D., Maelicke,A.. Selective Action of Purified Scorpion Neurotoxins on the Ionic Currents of the Squid Giant-Axon.
Hoppe-Seylers Zeitschrift fur Physiologische Chemie,
363 (2),
1299-1300.
*
Artículo
937 - Possani,L.D., Martin,B.M., Svendsen,I.B.. The Primary Structure of Noxiustoxin - A K+-Channel Blocking Peptide, Purified from the Venom of the Scorpion Centruroides-Noxius Hoffmann.
Carlsberg Research Communications,
47 (5),
285-289.
*
Artículo
938 - Trejo,A.C., Possani,L.D.. Electron microscopic evidence for scorpion toxin binding to synapses of rat brain cortex.
Neuroscience Letters,
32 (2),
103-108.
*
Artículo
939 - Perez de la Mora,M., Possani,L.D., Tapia,R., Teran,L., Palacios,R., Fuxe,K., Hokfelt,T., Ljungdahl,A.. Demonstration of central gamma-aminobutyrate-containing nerve terminals by means of antibodies against glutamate decarboxylase.
Neuroscience,
6 (5),
875-895.
*
Artículo
940 - Possani,L., Steinmetz,W.E., Dent,M.A., Alagon,A.C., Wuthrich,K.. Preliminary spectroscopic characterization of six toxins from Latin American scorpions.
Biochimica et Biophysica Acta (BBA) - Protein Structure,
669 (2),
183-192.
*
Artículo
941 - Possani,L.D., Dent,M.A.R., Martin,B.M., Maelicke,A., Svendsen,I.. The Amino Terminal Sequence of Several Toxins from the Venom of the Mexican Scorpion Centruroides Noxius Hoffmann.
Carlsberg Research Communications,
46 (4),
207-214.
*
Artículo
942 - Possani,L.D., Martin,B.M., Mochcamorales,J., Svendsen,I.. Purification and Chemical Characterization of the Major Toxins from the Venom of the Brazilian Scorpion Tityus Serrulatus Lutz and Mello.
Carlsberg Research Communications,
46 (4),
195-205.
*
Note
943 - Possani,L.D., Fernandez de Castro,J., Julia,J.Z.. Detoxification with glutaraldehyde of purified scorpion (Centruroides noxius Hoffmann) venom.
Toxicon,
19 (2),
323-329.
*
Memoria in extenso
944 - Perez de la Mora,M., Fuxe,K., Hokfelt,T., Anderson,K., Possani,L., Tapia,R.. Gabaergic synapses: distribution and interaction with other Neurotransmitter systems in the brain. Regulatory Mechanisms of Synaptic Transmission.
71-101,
Boston,MA.
*
Artículo
945 - Alagon,A.C., Molinar,R.R., Possani,L.D., Fletcher,P.L., Cronan,J.E., Julia,J.Z.. Venom from the snake Bothrops asper Garman. Purification and characterization of three phospholipases A2.
Biochemical Journal,
185 (3),
695-704.
*
Note
946 - Dent,M.A., Possani,L.D., Ramirez,G.A., Fletcher,P.L.. Purification and characterization of two mammalian toxins from the venom of the Mexican scorpion Centruroides noxius Hoffmann.
Toxicon,
18 (3),
343-350.
*
Artículo
947 - Possani,L.D., Fletcher,P.L., Alagon,A.B., Alagon,A.C., Julia,J.Z.. Purification and characterization of a mammalian toxin from venom of the Mexican scorpion, Centruroides limpidus tecomanus Hoffmann.
Toxicon,
18 (2),
175-183.
*
Note
948 - Possani,L.D., Sosa,B.P., Alagon,A.C., Burchfield,P.M.. The venom from the snakes Agkistrodon bilineatus Taylori and Crotalus durissus Totonacus: lethality, biochemical and immunological properties.
Toxicon,
18 (3),
356-360.
*
Artículo
949 - Possani,L.D., Alagon,A.C., Fletcher,P.L., Varela,M.J., Julia,J.Z.. Purification and characterization of a phospholipase A2 from the venom of the coral snake, Micrurus fulvius microgalbineus (Brown and Smith).
Biochemical Journal,
179 (3),
603-606.
*
Artículo
950 - Sosa,B.P., Alagon,A.C., Possani,L.D., Julia,J.Z.. Comparison of phospholipase activity with direct and indirect lytic effects of animal venoms upon human red cells.
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry,
64 (2),
231-234.
*
Internacional
951 - Fuxe,K., Andersson,K., Schwarcz,R., Agnati,L.F., Perez de la Mora,M., Hokfelt,T., Goldstein,M., Ferland,L., Possani,L., Tapia,L.. Studies on different types of dopamine nerve terminals in the forebrain adn their possible interactions with neurons. Advances in neurology.
Advances in neurology,
199-216,
New York.
*
Memoria in extenso
952 - Perez de la Mora,M., Fuxe,K., Andersson,K., Hokfelt,T., Ljungdahl,A., Possani,L., Tapia,R.. STUDIES ON GABA-MONOAMINE AND GABA-ENDORPHIN INTERACTIONS. Catecholamines: Basic and Clinical Frontiers Proceedings of the Fourth International Catecholamine Symposium, Pacific Grove, California, September 17-22, 1978.
1032-1034.
*
Note
953 - Bayon,A., Possani,L.D., Rode,G., Tapia,R.. Kinetics of brain glutamate decarboxylase. Dead-end and product inhibition studies.
Journal of Neurochemistry,
30 (6),
1629-1631.
*
Artículo
954 - Hokfelt,T., Elde,R., Fuxe,K., Johansson,O., Ljungdahl,A., Goldstein,M., Luft,R., Efendic,S., Nilsson,G., Terenius,L., Ganten,D., Jeffcoate,S.L., Rehfeld,J., Said,S., Perez de la Mora,M., Possani,L., Tapia,R., Teran,L., Palacios,R.. Aminergic and peptidergic pathways in the nervous system with special reference to the hypothalamus.
Research publications - Association for Research in Nervous and Mental Disease,
56,
69-135.
*
Artículo
955 - Possani,L.D., Ramirez,G.A., Fletcher,P.L., Gurrola,M.A.. Isolation of two mammalian toxins from the venom of the Mexican scorpion Centruroides elegans (Thorell).
FEBS Letters,
91 (2),
261-264.
*
Internacional
956 - Alagon,A.C., Possani,L.D., Erickson,B.W.. ISOLATION AND CHARACTERIZATION OF SEVERAL PROTEINS FROM TITYUS SERRULATUS SCORPION VENOM. Toxins Animal, Plant and Microbial.
609-618.
*
Internacional
957 - Fuxe,K., Hokfelt,T., Agnati,L.F., Johansson,O., Goldstein,M., Perez de la Mora,M., Possani,L., Tapia,R., Teran,L., Palacios,R.. Mapping out central catecholamine synthesizing neurons: immunohistochemical studies on catecholamine-synthesizing enzymes. Psychopharmacology: a Generation of Progress.
67-94,
New York.
*
Artículo
958 - Bayon,A., Possani,L.D., Tapia,M., Tapia,R.. Kinetics of brain glutamate decarboxylase. Interactions with glutamate, pyridoxal 5'-phosphate and glutamate-pyridoxal 5'-phosphate Schiff base.
Journal of Neurochemistry,
29 (3),
519-525.
*
Artículo
959 - Bayon,A., Possani,L.D., Tapia,R.. Kinetics of brain glutamate decarboxylase. Inhibition studies with N-(5'-phosphopyridoxyl) amino acids.
Journal of Neurochemistry,
29 (3),
513-517.
*
Artículo
960 - Possani,L.D., Bayon,A., Tapia,R.. Synthesis of affinity chromatography resins for the purification of brain glutamate decarboxylase.
Neurochemical Research,
2 (1),
51-57.
*
Artículo
961 - Possani,L.D., Alagon,A.C., Fletcher,P.L., Erickson,B.W.. Purification and properties of mammalian toxins from the venom of Brazilian Scorpion Tityus serrulatus Lutz and Mello.
Archives of Biochemistry and Biophysics,
180 (2),
394-403.
*
Artículo
962 - Klett,R.P., Fulpius,B.W., Cooper,D., Smith,M., Reich,E., Possani,L.D.. The acetylcholine receptor. I. Purification and characterization of a macromolecule isolated from Electrophorus electricus.
Journal of Biological Chemistry,
248 (19),
6841-6853.
*
Artículo
963 - Possani,L.D.. GABA effects and GABA receptors in neuromuscular junctions of crustaceans: analysis of some stereochemical models.
Revista brasileira de pesquisas medicas e biologicas,
6 (1),
31-42.
*
Artículo
964 - Tondo,C.V., Possani,L.D.. Study of the bimodal frequency distribution of the relative concentration of hemoglobin S in heterozygous carriers.
Revista brasileira de pesquisas medicas e biologicas,
5 (1-2),
47-56.
*
Artículo
965 - Possani,L.D., Banerjee,R., Balny,C., Douzou,P.. Oxidation of haemoglobin by oxygen in light: possible role of singlet oxygen.
Nature,
226 (248),
861-862.
*
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