M.B. Timoteo Celso Olamendi Portugal
Técnico Académico Titular C Tiempo Completo
Biología Molecular y Bioquímica de venenos de animales ponzoñosos
Premio a la Innovación Mexicana 2025, categoría 1, otorgado por el IMPI a la patente "Nuevos anticuerpos recombinantes y composiciones neutralizantes del veneno del alacrán Centruroides huichol, Instituto Mexicano de la Propiedad Intelectual, 2025
* Indica publicación con otra institución de adscripción
Total de publicaciones: 61
- Tipo
- Fecha
Artículo
1 - Mejia-Sanchez,M.A., Cardoso-Arenas,S., Miranda-Blancas,R., Franco-Vasquez,A.M., Carbajal-Saucedo,A., Olamendi-Portugal,T., Zamudio,F., Arreguin-Espinosa,R., Corzo,G. (2025). Isolation, purification, structure elucidation, and antibody recognition of two phospholipases A(2) and Crotoxin variation in the venom of the Tamaulipan rattlesnake Crotalus morulus.
Acta Tropica,
267,
107690.
Artículo
Artículo
3 - Shakeel,K., Naseem,M.U., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D., Panyi,G. (2025). Cvill6 and Cvill7: Potent and Selective Peptide Blockers of Kv1.2 Ion Channel Isolated from Mexican Scorpion Centruroides villegasi.
Toxins (Basel),
17 (6),
279.
Artículo
4 - Valdez-Velazquez,L.L., Olamendi-Portugal,T., Restano-Cassulini,R., Riano-Umbarila,L., Jimenez-Vargas,J.M., Zamudio,F., Salazar-Monge,H., Becerril,B., Possani,L.D. (2025). Beta Toxins Isolated from the Scorpion Centruroides hirsutipalpus (Scorpiones; Buthidae) Affect the Function of Sodium Channels of Mammals.
Toxins (Basel),
17 (12),
584.
Artículo
5 - Restano-Cassulini,R., Olamendi-Portugal,T., Riano-Umbarila,L., Zamudio,F.Z., Delgado-Prudencio,G., Becerril,B., Possani,L.D. (2024). Characterization of Sodium Channel Peptides Obtained from the Venom of the Scorpion Centruroides bonito.
Toxins (Basel),
16 (3),
125.
Articulo
6 - Riano-Umbarila,L., Olamendi-Portugal,T., Romero-Moreno,J.A., Delgado-Prudencio,G., Zamudio,F.Z., Becerril,B., Possani,L.D. (2024). Toxic Peptides from the Mexican Scorpion Centruroides villegasi: Chemical Structure and Evaluation of Recognition by Human Single-Chain Antibodies.
Toxins (Basel),
16 (7),
301.
Artículo
7 - Romero-Moreno,J.A., Serrano-Posada,H., Olamendi-Portugal,T., Possani,L.D., Becerril,B., Riano-Umbarila,L. (2023). Development of a human antibody fragment cross-neutralizing scorpion toxins.
Molecular Immunology,
155,
165-174.
Artículo
8 - Shakeel,K., Olamendi-Portugal,T., Naseem,M.U., Becerril,B., Zamudio,F.Z., Delgado-Prudencio,G., Possani,L.D., Panyi,G. (2023). Of Seven New K(+) Channel Inhibitor Peptides of Centruroides bonito, a-KTx 2.24 Has a Picomolar Affinity for Kv1.2.
Toxins (Basel),
15 (8),
506.
Artículo
9 - Valencia-Martinez,H., Riano-Umbarila,L., Olamendi-Portugal,T., Romero-Moreno,J.A., Possani,L.D., Becerril,B. (2023). Neutralization of Centruroides tecomanus scorpion venom by the use of two human recombinant antibody fragments.
Molecular Immunology,
164,
79-87.
Artículo
10 - Mejia-Sanchez,M.A., Clement, H., Corrales-Garcia,L.L., Olamendi-Portugal,T., Carbajal,A., Corzo,G. (2022). Crotoxin B: Heterologous Expression, Protein Folding, Immunogenic Properties, and Irregular Presence in Crotalid Venoms.
Toxins,
14 (6),
382.
Artículo
11 - Valencia-Martinez,H., Olamendi-Portugal,T., Restano-Cassulini,R., Serrano-Posada,H., Zamudio,F., Possani,L.D., Riano-Umbarila,L., Becerril,B. (2022). Characterization of Four Medically Important Toxins from Centruroides huichol Scorpion Venom and Its Neutralization by a Single Recombinant Antibody Fragment.
Toxins,
14 (6),
369.
Artículo
12 - Alamilla,J., Jimenez-Vargas,J.M., Galvan-Hernandez,A.R., Reyes-Mendez,M.E., Bermudez-Guzman,M.J., Restano-Cassulini,R., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D., Valdez-Velazquez,L.L. (2021). Toxin Ct1a, from venom of Centruroides tecomanus, modifies the spontaneous firing frequency of neurons in the suprachiasmatic nucleus.
Toxicon,
197,
114-125.
Artículo
13 - Alvarado,D., Cardoso-Arenas,S., Corrales-Garcia,L.L., Clement,H., Arenas,I., Montero-Dominguez,P.A., Olamendi-Portugal,T., Zamudio,F., Agota,C., Borrego,J., Panyi,G., Papp,F., Corzo,G. (2021). A Novel Insecticidal Spider Peptide that Affects the Mammalian Voltage-Gated Ion Channel hKv1.5.
Frontiers in Pharmacology,
11,
563858.
Artículo
Artículo
15 - Gomez-Ramirez,I.V., Riano-Umbarila,L., Olamendi-Portugal,T., Restano-Cassulini,R., Possani,L.D., Becerril,B. (2020). Biochemical, electrophysiological and immunological characterization of the venom from Centruroides baergi, a new scorpion species of medical importance in Mexico.
Toxicon,
184,
10-18.
Artículo
16 - Lopez-Giraldo,A.E., Olamendi-Portugal,T., Riano-Umbarila,L., Becerril,B., Possani,L.D., Delepierre,M., Rio-Portilla,F.D. (2020). The three-dimensional structure of the toxic peptide Cl13 from the scorpion Centruroides limpidus.
Toxicon,
184,
158-166.
Artículo
17 - Riano-Umbarila,L., Rojas-Trejo,V.M., Romero-Moreno,J.A., Costas,M., Utrera-Espindola,I., Olamendi-Portugal,T., Possani,L.D., Becerril,B. (2020). Comparative assessment of the VH-VL and VL-VH orientations of single-chain variable fragments of scorpion toxin-neutralizing antibodies.
Molecular Immunology,
122,
141-147.
Artículo
18 - Valdez-Velazquez,L.L., Cid-Uribe,J., Romero-Gutierrez,M.T., Olamendi-Portugal,T., Jimenez-Vargas,J.M., Possani,L.D. (2020). Transcriptomic and proteomic analyses of the venom and venom glands of Centruroides hirsutipalpus, a dangerous scorpion from Mexico.
Toxicon,
179,
21-32.
Artículo
19 - Riano-Umbarila,L., Gomez-Ramirez,I.V., Ledezma-Candanoza,L.M., Olamendi-Portugal,T., Rodriguez-Rodriguez,E.R., Fernandez-Taboada,G., Possani,L.D., Becerril,B. (2019). Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms.
Toxins (Basel),
11 (1),
32.
Artículo
20 - Rincon-Cortes,C.A., Olamendi-Portugal,T., Carcamo-Noriega,E.N., Gonzalez-Santillan,E., Zamudio-Zuniga,F., Reyes-Montano,E.A., Vega Castro,N.A., Possani,L.D. (2019). Structural and functional characterization of toxic peptides purified from the venom of the Colombian scorpion Tityus macrochirus.
Toxicon,
169,
5-11.
Artículo
21 - Carcamo-Noriega, E.N., Olamendi-Portugal, T., Restano-Cassulini, R., Rowe, A., Uribe-Romero, S.J., Becerril, B., Possani, L.D. (2018). Intraspecific variation of Centruroides sculpturatus scorpion venom from two regions of Arizona.
Archives of Biochemistry and Biophysics,
638,
52-57.
Artículo
22 - Olamendi-Portugal, T., Batista, C.V.F., Pedraza-Escalona, M., Restano-Cassulini, R., Zamudio, F.Z., Benard-Valle, M., de Roodt, A.R., Possani, L.D. (2018). New insights into the proteomic characterization of the coral snake Micrurus pyrrhocryptus venom.
Toxicon,
153,
23-31.
Artículo
23 - Valdez-Velazquez, L.L., Olamendi-Portugal, T., Restano-Cassulini, R., Zamudio, F.Z., Possani, L.D. (2018). Mass fingerprinting and electrophysiological analysis of the venom from the scorpion Centruroides hirsutipalpus (Scorpiones: Buthidae).
Journal of Venomous Animals and Toxins Including Tropical Diseases,
24,
17.
Artículo
24 - Garcia-Garcia, F., Corrales-Garcia, L.L., Olamendi-Portugal, T., Restano-Cassulini, R., Vega, R., Vega, M., Ortiz, E., Sandoval-Lopez, G., Soto, E., Corzo, G. (2017). Identification, chemical synthesis and heterologous expression of an antinociceptive peptide from the veined tree frog Trachycephalus typhonius.
Process Biochemistry,
62,
205-214.
Artículo
Artículo
26 - Olamendi-Portugal, T., Csoti, A., Jimenez-Vargas, J.M., Gomez-Lagunas, F., Panyi, G., Possani, L.D. (2017). Pi5 and Pi6, two undescribed peptides from the venom of the scorpion Pandinus imperator and their effects on K+-channels.
Toxicon,
133,
136-144.
Artículo
27 - Olamendi-Portugal,T., Bartok,A., Zamudio-Zuniga,F., Balajthy,A., Becerril,B., Panyi,G., Possani,L.D. (2016). Isolation, chemical and functional characterization of several new K-channel blocking peptides from the venom of the scorpion Centruroides tecomanus.
Toxicon,
115,
1-12.
Artículo
28 - Riano-Umbarila,L., Ledezma-Candanoza,L.M., Serrano-Posada,H., Fernandez-Taboada,G., Olamendi-Portugal,T., Rojas-Trejo,S., Gomez-Ramirez,I.V., Rudino-Pinera,E., Possani,L.D., Becerril,B. (2016). Optimal neutralization of Centruroides noxius venom is understood through a structural complex between two antibody fragments and the Cn2 toxin.
Journal of Biological Chemistry,
291 (4),
1619-1630.
Artículo
29 - Rodriguez-Rodriguez,E.R., Olamendi-Portugal,T., Serrano-Posada,H., Arredondo-Lopez,J.N., Gomez-Ramirez,I., Fernandez-Taboada,G., Possani,L.D., Vega,G.A., Riano-Umbarila,L., Becerril,B. (2016). Broadening the neutralizing capacity of a family of antibody fragments against different toxins from Mexican scorpions.
Toxicon,
119,
52-63.
Artículo
30 - Villalba,M.I., Canul-Tec,J.C., Luna-Martinez,O.D., Sanchez-Alcala,R., Olamendi-Portugal,T., Rudino-Pinera,E., Rojas,S., Sanchez-Lopez,R., Fernandez-Velasco,D.A., Becerril,B. (2015). Site-directed Mutagenesis Reveals Regions Implicated in the Stability and Fiber Formation of Human lambda3r Light Chains.
Journal of Biological Chemistry,
290,
2577-2592 .
Artículo
31 - Riano-Umbarila,L., Olamendi-Portugal,T., Morelos-Juarez,C., Gurrola,G.B., Possani,L.D., Becerril,B. (2013). A novel human recombinant antibody fragment capable of neutralizing Mexican scorpion toxins.
Toxicon,
76,
370-376.
Artículo
32 - Rodriguez-Rodriguez,E.R., Ledezma-Candanoza,L.M., Contreras-Ferrat,L.G., Olamendi-Portugal,T., Possani,L.D., Becerril,B., Riano-Umbarila,L. (2012). A Single Mutation in Framework 2 of the Heavy Variable Domain Improves the Properties of a Diabody and a Related Single-Chain Antibody.
Journal of Molecular Biology,
423 (3),
337-350.
Artículo
33 - Schiavon,E., Pedraza-Escalona,M., Gurrola,G.B., Olamendi-Portugal,T., Corzo,G., Wanke,E., Possani,L.D. (2012). Negative-shift activation, current reduction and resurgent currents induced by beta-toxins from Centruroides scorpions in sodium channels.
Toxicon,
59 (2),
283-293.
Artículo
34 - Espino-Solis,G.P., Estrada,G., Olamendi-Portugal,T., Villegas,E., Zamudio,F., Cestele,S., Possani,L.D., Corzo,G. (2011). Isolation and molecular cloning of beta-neurotoxins from the venom of the scorpion Centruroides suffusus suffusus.
Toxicon,
57 (5),
739-746.
Artículo
35 - Olivares,J.E., Diaz-Camino,C., Estrada-Navarrete,G., Alvarado-Affantranger,X., Rodriguez-Kessler,M., Zamudio,F.Z., Olamendi-Portugal,T., Marquez,Y., Servin,L.E., Sanchez,F. (2011). Nodulin 41, a novel late nodulin of common bean with peptidase activity.
BMC Plant Biology,
11 (1),
134.
Artículo
36 - Riano-Umbarila,L., Contreras-Ferrat,G., Olamendi-Portugal,T., Morelos-Juarez,C., Corzo,G., Possani,L.D., Becerril,B. (2011). Exploiting cross-reactivity to neutralize two different scorpion venoms with one single-chain antibody fragment.
Journal of Biological Chemistry,
286 (8),
6143-6151.
Artículo
37 - Vandendriessche,T., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D., Tytgat,J. (2010). Isolation and characterization of two novel scorpion toxins: the alpha-toxin-like CeII8, specific for Na(v)1.7 channels and the classical anti-mammalian CeII9, specific for Na(v)1.4 channels.
Toxicon,
56 (4),
613-623.
Artículo
38 - Garcia-Gomez,B.I., Olamendi-Portugal,T.C., Paniagua,J., van der Walt,J., Dyason,K., Possani,L.D. (2009). Heterologous expression of a gene that codes for Pg8, a scorpion toxin of Parabuthus granulatus, capable of generating protecting antibodies in mice.
Toxicon,
53 (7-8),
770-778.
Artículo
39 - Olamendi-Portugal,T., Batista,C.V., Restano-Cassulini,R., Pando,V., Villa-Hernandez,O., Zavaleta-Martinez-Vargas,A., Salas-Arruz,M.C., de la Vega RC, Becerril,B., Possani,L.D. (2008). Proteomic analysis of the venom from the fish eating coral snake Micrurus surinamensis: Novel toxins, their function and phylogeny.
Proteomics,
8 (9),
1919-1932.
Artículo
40 - Restano-Cassulini,R., Olamendi-Portugal,T., Zamudio,F., Becerril,B., Possani,L.D. (2008). Two Novel Ergtoxins, Blockers of K(+)-channels, Purified from the Mexican Scorpion Centruroides elegans elegans.
Neurochemical Research,
33 (8),
1525-1533.
Artículo
41 - Juarez-Gonzalez,V.R., Riano-Umbarila,L., Quintero-Hernandez,V., Olamendi-Portugal,T., Ortiz-Leon,M., Ortiz,E., Possani,L.D., Becerril,B. (2005). Directed Evolution, Phage Display and Combination of Evolved Mutants: A Strategy to Recover the Neutralization Properties of the scFv Version of BCF2 a Neutralizing Monoclonal Antibody Specific to Scorpion Toxin Cn2.
Journal of Molecular Biology,
346 (5),
1287-1297.
Artículo
42 - Olamendi-Portugal,T., Somodi,S., Fernandez,J.A., Zamudio,F.Z., Becerril,B., Varga,Z., Panyi,G., Gaspar,R., Possani,L.D. (2005). Novel alpha-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockage Kv1.3 over IKCa1 K(+) channels of T cells.
Toxicon,
46 (4),
418-429.
Artículo
43 - Riano-Umbarila,L., Juarez-Gonzalez,V.R., Olamendi-Portugal,T., Ortiz-Leon,M., Possani,L.D., Becerril,B. (2005). A strategy for the generation of specific human antibodies by directed evolution and phage display.
Febs Journal,
272 (10),
2591-2601.
Artículo
44 - Gomez-Lagunas,F., Batista,C.V., Olamendi-Portugal,T., Ramirez-Dominguez,M.E., Possani,L.D. (2004). Inhibition of the collapse of the shaker k+ conductance by specific scorpion toxins.
Journal of General Physiology,
123 (3),
265-279.
Artículo
45 - Huys,I., Olamendi-Portugal,T., Garcia-Gomez,B.I., Vandenberghe,I., Van Beeumen,J., Dyason,K., Clynen,E., Zhu,S., van der Walt,J., Possani,L., Tytgat,J. (2004). A subfamily of acidic alpha -K+ toxins.
Journal of Biological Chemistry,
279 (4),
2781-2789.
Artículo
46 - Coronas,F.V., de Roodt,A.R., Portugal,T.O., Zamudio,F.Z., Batista,C.V., Gomez-Lagunas,F., Possani,L.D. (2003). Disulfide bridges and blockage of Shaker B K(+)-channels by another butantoxin peptide purified from the Argentinean scorpion Tityus trivittatus.
Toxicon,
41 (2),
173-179.
Artículo
47 - Lopez-Gonzalez,I., Olamendi-Portugal,T., de la Vega-Beltran,J.L., van der Walt,J., Dyason,K., Possani,L.D., Felix,R., Darszon,A. (2003). Scorpion toxins that block T-type Ca(2+) channels in spermatogenic cells inhibit the sperm acrosome reaction.
Biochemical and Biophysical Research Communications,
300 (2),
408-414.
Artículo
48 - M'Barek,S., Mosbah,A., Sandoz,G., Fajloun,Z., Olamendi-Portugal,T., Rochat,H., Sampieri,F., Guijarro,J.I., Mansuelle,P., Delepierre,M., De Waard,M., Sabatier,J.M. (2003). Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels.
European Journal of Biochemistry,
270 (17),
3583-3592.
Artículo
49 - Angulo,Y., Olamendi-Portugal,T., Alape-Giron,A., Possani,L.D., Lomonte,B. (2002). Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A(2) homologue.
International Journal of Biochemistry and Cell Biology,
34 (10),
1268-1278.
Artículo
50 - Olamendi-Portugal,T., Garcia,B.I., Lopez-Gonzalez,I., van der Walt,J., Dyason,K., Ulens,C., Tytgat,J., Felix,R., Darszon,A., Possani,L.D. (2002). Two new scorpion toxins that target voltage-gated Ca(2+) and Na(+) channels.
Biochemical and Biophysical Research Communications,
299 (4),
562-568.
Artículo
51 - Ramirez-Dominguez,M.E., Olamendi-Portugal,T., Garcia,U., Garcia,C., Arechiga,H., Possani,L.D. (2002). Cn11, the first example of a scorpion toxin that is a true blocker of Na(+) currents in crayfish neurons.
Journal of Experimental Biology,
205 (Pt 6),
869-876.
Artículo
52 - Angulo,Y., Olamendi-Portugal,T., Possani,L.D., Lomonte,B. (2000). Isolation and characterization of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a new Lys49 phospholipase A2 homologue.
International Journal of Biochemistry and Cell Biology,
32 (1),
63-71.
Artículo
53 - Batista,C.V., da Silva,L.R., Sebben,A., Scaloni,A., Ferrara,L., Paiva,G.R., Olamendi-Portugal,T., Possani,L.D., Bloch,C. (1999). Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.
Peptides,
20 (6),
679-686.
Artículo
Artículo
55 - Gomez-Lagunas,F., Olamendi-Portugal,T., Possani,L.D. (1997). Block of ShakerB K+ channels by Pi1, a novel class of scorpion toxin.
FEBS Letters,
400 (2),
197-200.
Artículo
56 - Gomez-Lagunas,F., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D. (1996). Two novel toxins from the venom of the scorpion Pandinus imperator show that the N-terminal amino acid sequence is important for their affinities towards Shaker B K+ channels.
Journal of Membrane Biology,
152 (1),
49-56.
Artículo
57 - Olamendi-Portugal,T., Gomez-Lagunas,F., Gurrola,G.B., Possani,L.D. (1996). A novel structural class of K+-channel blocking toxin from the scorpion Pandinus imperator.
Biochemical Journal,
315 (Pt 3),
977-981.
Artículo
58 - Calderon-Aranda,E.S., Olamendi-Portugal,T., Possani,L.D. (1995). The use of synthetic peptides can be a misleading approach to generate vaccines against scorpion toxins.
Vaccine,
13 (13),
1198-1206.
Memoria in extenso
59 - Possani,L.D., Gurrola,G.B., Portugal,T.O., Zamudio,F.Z., Vaca,L.D., Calderon,S.A., Kirsch,G.E. (1991). Scorpion toxins: a model for peptide synthesis of new drugs. Proceedings First Brazilian Congress on Proteins.
352-367,
Brasil.
Preprint
60 - Salceda,E., Arenas,I., Olamendi-Portugal,T., Reyes,A., Corzo,G., Soto,E., Villegas,E. (2025). Isolation, synthesis, and pharmacological characterization of a short-structured peptide from the venom of Phidippus audax that affects potassium currents.
Research Square.
61 - Olamendi Portugal, Timoteo Celso (1991). Sintesis quimica y caracterizacion inmunologica de peptidos correspondientes a la secuencia de la toxina II9.2.2 del alacran Centruroides noxius .
Instituto de Biotecnologia,
Especialista en Biotecnologia,
UNAM.
Asesor: Possani, Lourival Domingos
Artículo
62 - Mejia-Sanchez,M.A., Cardoso-Arenas,S., Miranda-Blancas,R., Franco-Vasquez,A.M., Carbajal-Saucedo,A., Olamendi-Portugal,T., Zamudio,F., Arreguin-Espinosa,R., Corzo,G.. Isolation, purification, structure elucidation, and antibody recognition of two phospholipases A(2) and Crotoxin variation in the venom of the Tamaulipan rattlesnake Crotalus morulus.
Acta Tropica,
267,
107690.
Artículo
63 - Olamendi-Portugal,T., Delgado-Prudencio,G., Restano-Cassulini,R., Zamudio,F.Z., Meneses-Romero,E.P., Becerril,B., Possani,L.D.. Isolation and Characterization of Three Lethal Toxins from the Mexican Scorpion Centruroides mascota.
Toxicon,
266,
108498.
Artículo
64 - Shakeel,K., Naseem,M.U., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D., Panyi,G.. Cvill6 and Cvill7: Potent and Selective Peptide Blockers of Kv1.2 Ion Channel Isolated from Mexican Scorpion Centruroides villegasi.
Toxins (Basel),
17 (6),
279.
Artículo
65 - Valdez-Velazquez,L.L., Olamendi-Portugal,T., Restano-Cassulini,R., Riano-Umbarila,L., Jimenez-Vargas,J.M., Zamudio,F., Salazar-Monge,H., Becerril,B., Possani,L.D.. Beta Toxins Isolated from the Scorpion Centruroides hirsutipalpus (Scorpiones; Buthidae) Affect the Function of Sodium Channels of Mammals.
Toxins (Basel),
17 (12),
584.
Preprint
66 - Salceda,E., Arenas,I., Olamendi-Portugal,T., Reyes,A., Corzo,G., Soto,E., Villegas,E.. Isolation, synthesis, and pharmacological characterization of a short-structured peptide from the venom of Phidippus audax that affects potassium currents.
Research Square.
Artículo
67 - Restano-Cassulini,R., Olamendi-Portugal,T., Riano-Umbarila,L., Zamudio,F.Z., Delgado-Prudencio,G., Becerril,B., Possani,L.D.. Characterization of Sodium Channel Peptides Obtained from the Venom of the Scorpion Centruroides bonito.
Toxins (Basel),
16 (3),
125.
Articulo
68 - Riano-Umbarila,L., Olamendi-Portugal,T., Romero-Moreno,J.A., Delgado-Prudencio,G., Zamudio,F.Z., Becerril,B., Possani,L.D.. Toxic Peptides from the Mexican Scorpion Centruroides villegasi: Chemical Structure and Evaluation of Recognition by Human Single-Chain Antibodies.
Toxins (Basel),
16 (7),
301.
Artículo
69 - Romero-Moreno,J.A., Serrano-Posada,H., Olamendi-Portugal,T., Possani,L.D., Becerril,B., Riano-Umbarila,L.. Development of a human antibody fragment cross-neutralizing scorpion toxins.
Molecular Immunology,
155,
165-174.
Artículo
70 - Shakeel,K., Olamendi-Portugal,T., Naseem,M.U., Becerril,B., Zamudio,F.Z., Delgado-Prudencio,G., Possani,L.D., Panyi,G.. Of Seven New K(+) Channel Inhibitor Peptides of Centruroides bonito, a-KTx 2.24 Has a Picomolar Affinity for Kv1.2.
Toxins (Basel),
15 (8),
506.
Artículo
71 - Valencia-Martinez,H., Riano-Umbarila,L., Olamendi-Portugal,T., Romero-Moreno,J.A., Possani,L.D., Becerril,B.. Neutralization of Centruroides tecomanus scorpion venom by the use of two human recombinant antibody fragments.
Molecular Immunology,
164,
79-87.
Artículo
72 - Mejia-Sanchez,M.A., Clement, H., Corrales-Garcia,L.L., Olamendi-Portugal,T., Carbajal,A., Corzo,G.. Crotoxin B: Heterologous Expression, Protein Folding, Immunogenic Properties, and Irregular Presence in Crotalid Venoms.
Toxins,
14 (6),
382.
Artículo
73 - Valencia-Martinez,H., Olamendi-Portugal,T., Restano-Cassulini,R., Serrano-Posada,H., Zamudio,F., Possani,L.D., Riano-Umbarila,L., Becerril,B.. Characterization of Four Medically Important Toxins from Centruroides huichol Scorpion Venom and Its Neutralization by a Single Recombinant Antibody Fragment.
Toxins,
14 (6),
369.
Artículo
74 - Alamilla,J., Jimenez-Vargas,J.M., Galvan-Hernandez,A.R., Reyes-Mendez,M.E., Bermudez-Guzman,M.J., Restano-Cassulini,R., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D., Valdez-Velazquez,L.L.. Toxin Ct1a, from venom of Centruroides tecomanus, modifies the spontaneous firing frequency of neurons in the suprachiasmatic nucleus.
Toxicon,
197,
114-125.
Artículo
75 - Alvarado,D., Cardoso-Arenas,S., Corrales-Garcia,L.L., Clement,H., Arenas,I., Montero-Dominguez,P.A., Olamendi-Portugal,T., Zamudio,F., Agota,C., Borrego,J., Panyi,G., Papp,F., Corzo,G.. A Novel Insecticidal Spider Peptide that Affects the Mammalian Voltage-Gated Ion Channel hKv1.5.
Frontiers in Pharmacology,
11,
563858.
Artículo
Artículo
77 - Gomez-Ramirez,I.V., Riano-Umbarila,L., Olamendi-Portugal,T., Restano-Cassulini,R., Possani,L.D., Becerril,B.. Biochemical, electrophysiological and immunological characterization of the venom from Centruroides baergi, a new scorpion species of medical importance in Mexico.
Toxicon,
184,
10-18.
Artículo
78 - Lopez-Giraldo,A.E., Olamendi-Portugal,T., Riano-Umbarila,L., Becerril,B., Possani,L.D., Delepierre,M., Rio-Portilla,F.D.. The three-dimensional structure of the toxic peptide Cl13 from the scorpion Centruroides limpidus.
Toxicon,
184,
158-166.
Artículo
79 - Riano-Umbarila,L., Rojas-Trejo,V.M., Romero-Moreno,J.A., Costas,M., Utrera-Espindola,I., Olamendi-Portugal,T., Possani,L.D., Becerril,B.. Comparative assessment of the VH-VL and VL-VH orientations of single-chain variable fragments of scorpion toxin-neutralizing antibodies.
Molecular Immunology,
122,
141-147.
Artículo
80 - Valdez-Velazquez,L.L., Cid-Uribe,J., Romero-Gutierrez,M.T., Olamendi-Portugal,T., Jimenez-Vargas,J.M., Possani,L.D.. Transcriptomic and proteomic analyses of the venom and venom glands of Centruroides hirsutipalpus, a dangerous scorpion from Mexico.
Toxicon,
179,
21-32.
Artículo
81 - Riano-Umbarila,L., Gomez-Ramirez,I.V., Ledezma-Candanoza,L.M., Olamendi-Portugal,T., Rodriguez-Rodriguez,E.R., Fernandez-Taboada,G., Possani,L.D., Becerril,B.. Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms.
Toxins (Basel),
11 (1),
32.
Artículo
82 - Rincon-Cortes,C.A., Olamendi-Portugal,T., Carcamo-Noriega,E.N., Gonzalez-Santillan,E., Zamudio-Zuniga,F., Reyes-Montano,E.A., Vega Castro,N.A., Possani,L.D.. Structural and functional characterization of toxic peptides purified from the venom of the Colombian scorpion Tityus macrochirus.
Toxicon,
169,
5-11.
Artículo
83 - Carcamo-Noriega, E.N., Olamendi-Portugal, T., Restano-Cassulini, R., Rowe, A., Uribe-Romero, S.J., Becerril, B., Possani, L.D.. Intraspecific variation of Centruroides sculpturatus scorpion venom from two regions of Arizona.
Archives of Biochemistry and Biophysics,
638,
52-57.
Artículo
84 - Olamendi-Portugal, T., Batista, C.V.F., Pedraza-Escalona, M., Restano-Cassulini, R., Zamudio, F.Z., Benard-Valle, M., de Roodt, A.R., Possani, L.D.. New insights into the proteomic characterization of the coral snake Micrurus pyrrhocryptus venom.
Toxicon,
153,
23-31.
Artículo
85 - Valdez-Velazquez, L.L., Olamendi-Portugal, T., Restano-Cassulini, R., Zamudio, F.Z., Possani, L.D.. Mass fingerprinting and electrophysiological analysis of the venom from the scorpion Centruroides hirsutipalpus (Scorpiones: Buthidae).
Journal of Venomous Animals and Toxins Including Tropical Diseases,
24,
17.
Artículo
86 - Garcia-Garcia, F., Corrales-Garcia, L.L., Olamendi-Portugal, T., Restano-Cassulini, R., Vega, R., Vega, M., Ortiz, E., Sandoval-Lopez, G., Soto, E., Corzo, G.. Identification, chemical synthesis and heterologous expression of an antinociceptive peptide from the veined tree frog Trachycephalus typhonius.
Process Biochemistry,
62,
205-214.
Artículo
87 - Olamendi-Portugal, T., Restano-Cassulini, R., Riano-Umbarila, L., Becerril, B., Possani, L.D.. Functional and immuno-reactive characterization of a previously undescribed peptide from the venom of the scorpion centruroides limpidus.
Peptides,
87,
34-40.
Artículo
88 - Olamendi-Portugal, T., Csoti, A., Jimenez-Vargas, J.M., Gomez-Lagunas, F., Panyi, G., Possani, L.D.. Pi5 and Pi6, two undescribed peptides from the venom of the scorpion Pandinus imperator and their effects on K+-channels.
Toxicon,
133,
136-144.
Artículo
89 - Olamendi-Portugal,T., Bartok,A., Zamudio-Zuniga,F., Balajthy,A., Becerril,B., Panyi,G., Possani,L.D.. Isolation, chemical and functional characterization of several new K-channel blocking peptides from the venom of the scorpion Centruroides tecomanus.
Toxicon,
115,
1-12.
Artículo
90 - Riano-Umbarila,L., Ledezma-Candanoza,L.M., Serrano-Posada,H., Fernandez-Taboada,G., Olamendi-Portugal,T., Rojas-Trejo,S., Gomez-Ramirez,I.V., Rudino-Pinera,E., Possani,L.D., Becerril,B.. Optimal neutralization of Centruroides noxius venom is understood through a structural complex between two antibody fragments and the Cn2 toxin.
Journal of Biological Chemistry,
291 (4),
1619-1630.
Artículo
91 - Rodriguez-Rodriguez,E.R., Olamendi-Portugal,T., Serrano-Posada,H., Arredondo-Lopez,J.N., Gomez-Ramirez,I., Fernandez-Taboada,G., Possani,L.D., Vega,G.A., Riano-Umbarila,L., Becerril,B.. Broadening the neutralizing capacity of a family of antibody fragments against different toxins from Mexican scorpions.
Toxicon,
119,
52-63.
Artículo
92 - Villalba,M.I., Canul-Tec,J.C., Luna-Martinez,O.D., Sanchez-Alcala,R., Olamendi-Portugal,T., Rudino-Pinera,E., Rojas,S., Sanchez-Lopez,R., Fernandez-Velasco,D.A., Becerril,B.. Site-directed Mutagenesis Reveals Regions Implicated in the Stability and Fiber Formation of Human lambda3r Light Chains.
Journal of Biological Chemistry,
290,
2577-2592 .
Artículo
Artículo
94 - Rodriguez-Rodriguez,E.R., Ledezma-Candanoza,L.M., Contreras-Ferrat,L.G., Olamendi-Portugal,T., Possani,L.D., Becerril,B., Riano-Umbarila,L.. A Single Mutation in Framework 2 of the Heavy Variable Domain Improves the Properties of a Diabody and a Related Single-Chain Antibody.
Journal of Molecular Biology,
423 (3),
337-350.
Artículo
95 - Schiavon,E., Pedraza-Escalona,M., Gurrola,G.B., Olamendi-Portugal,T., Corzo,G., Wanke,E., Possani,L.D.. Negative-shift activation, current reduction and resurgent currents induced by beta-toxins from Centruroides scorpions in sodium channels.
Toxicon,
59 (2),
283-293.
Artículo
96 - Espino-Solis,G.P., Estrada,G., Olamendi-Portugal,T., Villegas,E., Zamudio,F., Cestele,S., Possani,L.D., Corzo,G.. Isolation and molecular cloning of beta-neurotoxins from the venom of the scorpion Centruroides suffusus suffusus.
Toxicon,
57 (5),
739-746.
Artículo
97 - Olivares,J.E., Diaz-Camino,C., Estrada-Navarrete,G., Alvarado-Affantranger,X., Rodriguez-Kessler,M., Zamudio,F.Z., Olamendi-Portugal,T., Marquez,Y., Servin,L.E., Sanchez,F.. Nodulin 41, a novel late nodulin of common bean with peptidase activity.
BMC Plant Biology,
11 (1),
134.
Artículo
98 - Riano-Umbarila,L., Contreras-Ferrat,G., Olamendi-Portugal,T., Morelos-Juarez,C., Corzo,G., Possani,L.D., Becerril,B.. Exploiting cross-reactivity to neutralize two different scorpion venoms with one single-chain antibody fragment.
Journal of Biological Chemistry,
286 (8),
6143-6151.
Artículo
99 - Vandendriessche,T., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D., Tytgat,J.. Isolation and characterization of two novel scorpion toxins: the alpha-toxin-like CeII8, specific for Na(v)1.7 channels and the classical anti-mammalian CeII9, specific for Na(v)1.4 channels.
Toxicon,
56 (4),
613-623.
Artículo
100 - Garcia-Gomez,B.I., Olamendi-Portugal,T.C., Paniagua,J., van der Walt,J., Dyason,K., Possani,L.D.. Heterologous expression of a gene that codes for Pg8, a scorpion toxin of Parabuthus granulatus, capable of generating protecting antibodies in mice.
Toxicon,
53 (7-8),
770-778.
Artículo
101 - Olamendi-Portugal,T., Batista,C.V., Restano-Cassulini,R., Pando,V., Villa-Hernandez,O., Zavaleta-Martinez-Vargas,A., Salas-Arruz,M.C., de la Vega RC, Becerril,B., Possani,L.D.. Proteomic analysis of the venom from the fish eating coral snake Micrurus surinamensis: Novel toxins, their function and phylogeny.
Proteomics,
8 (9),
1919-1932.
Artículo
102 - Restano-Cassulini,R., Olamendi-Portugal,T., Zamudio,F., Becerril,B., Possani,L.D.. Two Novel Ergtoxins, Blockers of K(+)-channels, Purified from the Mexican Scorpion Centruroides elegans elegans.
Neurochemical Research,
33 (8),
1525-1533.
Artículo
103 - Juarez-Gonzalez,V.R., Riano-Umbarila,L., Quintero-Hernandez,V., Olamendi-Portugal,T., Ortiz-Leon,M., Ortiz,E., Possani,L.D., Becerril,B.. Directed Evolution, Phage Display and Combination of Evolved Mutants: A Strategy to Recover the Neutralization Properties of the scFv Version of BCF2 a Neutralizing Monoclonal Antibody Specific to Scorpion Toxin Cn2.
Journal of Molecular Biology,
346 (5),
1287-1297.
Artículo
104 - Olamendi-Portugal,T., Somodi,S., Fernandez,J.A., Zamudio,F.Z., Becerril,B., Varga,Z., Panyi,G., Gaspar,R., Possani,L.D.. Novel alpha-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockage Kv1.3 over IKCa1 K(+) channels of T cells.
Toxicon,
46 (4),
418-429.
Artículo
105 - Riano-Umbarila,L., Juarez-Gonzalez,V.R., Olamendi-Portugal,T., Ortiz-Leon,M., Possani,L.D., Becerril,B.. A strategy for the generation of specific human antibodies by directed evolution and phage display.
Febs Journal,
272 (10),
2591-2601.
Artículo
106 - Gomez-Lagunas,F., Batista,C.V., Olamendi-Portugal,T., Ramirez-Dominguez,M.E., Possani,L.D.. Inhibition of the collapse of the shaker k+ conductance by specific scorpion toxins.
Journal of General Physiology,
123 (3),
265-279.
Artículo
107 - Huys,I., Olamendi-Portugal,T., Garcia-Gomez,B.I., Vandenberghe,I., Van Beeumen,J., Dyason,K., Clynen,E., Zhu,S., van der Walt,J., Possani,L., Tytgat,J.. A subfamily of acidic alpha -K+ toxins.
Journal of Biological Chemistry,
279 (4),
2781-2789.
Artículo
108 - Coronas,F.V., de Roodt,A.R., Portugal,T.O., Zamudio,F.Z., Batista,C.V., Gomez-Lagunas,F., Possani,L.D.. Disulfide bridges and blockage of Shaker B K(+)-channels by another butantoxin peptide purified from the Argentinean scorpion Tityus trivittatus.
Toxicon,
41 (2),
173-179.
Artículo
109 - Lopez-Gonzalez,I., Olamendi-Portugal,T., de la Vega-Beltran,J.L., van der Walt,J., Dyason,K., Possani,L.D., Felix,R., Darszon,A.. Scorpion toxins that block T-type Ca(2+) channels in spermatogenic cells inhibit the sperm acrosome reaction.
Biochemical and Biophysical Research Communications,
300 (2),
408-414.
Artículo
110 - M'Barek,S., Mosbah,A., Sandoz,G., Fajloun,Z., Olamendi-Portugal,T., Rochat,H., Sampieri,F., Guijarro,J.I., Mansuelle,P., Delepierre,M., De Waard,M., Sabatier,J.M.. Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels.
European Journal of Biochemistry,
270 (17),
3583-3592.
Artículo
111 - Angulo,Y., Olamendi-Portugal,T., Alape-Giron,A., Possani,L.D., Lomonte,B.. Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A(2) homologue.
International Journal of Biochemistry and Cell Biology,
34 (10),
1268-1278.
Artículo
112 - Olamendi-Portugal,T., Garcia,B.I., Lopez-Gonzalez,I., van der Walt,J., Dyason,K., Ulens,C., Tytgat,J., Felix,R., Darszon,A., Possani,L.D.. Two new scorpion toxins that target voltage-gated Ca(2+) and Na(+) channels.
Biochemical and Biophysical Research Communications,
299 (4),
562-568.
Artículo
113 - Ramirez-Dominguez,M.E., Olamendi-Portugal,T., Garcia,U., Garcia,C., Arechiga,H., Possani,L.D.. Cn11, the first example of a scorpion toxin that is a true blocker of Na(+) currents in crayfish neurons.
Journal of Experimental Biology,
205 (Pt 6),
869-876.
Artículo
114 - Angulo,Y., Olamendi-Portugal,T., Possani,L.D., Lomonte,B.. Isolation and characterization of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a new Lys49 phospholipase A2 homologue.
International Journal of Biochemistry and Cell Biology,
32 (1),
63-71.
Artículo
115 - Batista,C.V., da Silva,L.R., Sebben,A., Scaloni,A., Ferrara,L., Paiva,G.R., Olamendi-Portugal,T., Possani,L.D., Bloch,C.. Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.
Peptides,
20 (6),
679-686.
Artículo
Artículo
117 - Gomez-Lagunas,F., Olamendi-Portugal,T., Possani,L.D.. Block of ShakerB K+ channels by Pi1, a novel class of scorpion toxin.
FEBS Letters,
400 (2),
197-200.
Artículo
118 - Gomez-Lagunas,F., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D.. Two novel toxins from the venom of the scorpion Pandinus imperator show that the N-terminal amino acid sequence is important for their affinities towards Shaker B K+ channels.
Journal of Membrane Biology,
152 (1),
49-56.
Artículo
119 - Olamendi-Portugal,T., Gomez-Lagunas,F., Gurrola,G.B., Possani,L.D.. A novel structural class of K+-channel blocking toxin from the scorpion Pandinus imperator.
Biochemical Journal,
315 (Pt 3),
977-981.
Artículo
120 - Calderon-Aranda,E.S., Olamendi-Portugal,T., Possani,L.D.. The use of synthetic peptides can be a misleading approach to generate vaccines against scorpion toxins.
Vaccine,
13 (13),
1198-1206.
Memoria in extenso
121 - Possani,L.D., Gurrola,G.B., Portugal,T.O., Zamudio,F.Z., Vaca,L.D., Calderon,S.A., Kirsch,G.E.. Scorpion toxins: a model for peptide synthesis of new drugs. Proceedings First Brazilian Congress on Proteins.
352-367,
Brasil.
122 - Olamendi Portugal, Timoteo Celso. Sintesis quimica y caracterizacion inmunologica de peptidos correspondientes a la secuencia de la toxina II9.2.2 del alacran Centruroides noxius .
Instituto de Biotecnologia,
Especialista en Biotecnologia,
UNAM.
Asesor: Possani, Lourival Domingos