M.B. Timoteo Celso Olamendi Portugal
Técnico Académico Titular C Tiempo Completo
Biología Molecular y Bioquímica de venenos de animales ponzoñosos
Total de publicaciones: 56
- Tipo
- Fecha
Tipo
Artículo
1 - Restano-Cassulini,R., Olamendi-Portugal,T., Riano-Umbarila,L., Zamudio,F.Z., Delgado-Prudencio,G., Becerril,B., Possani,L.D. (2024). Characterization of Sodium Channel Peptides Obtained from the Venom of the Scorpion Centruroides bonito.
Toxins (Basel),
16 (3),
125.
Articulo
2 - Riano-Umbarila,L., Olamendi-Portugal,T., Romero-Moreno,J.A., Delgado-Prudencio,G., Zamudio,F.Z., Becerril,B., Possani,L.D. (2024). Toxic Peptides from the Mexican Scorpion Centruroides villegasi: Chemical Structure and Evaluation of Recognition by Human Single-Chain Antibodies.
Toxins (Basel),
16 (7),
301.
Artículo
3 - Romero-Moreno,J.A., Serrano-Posada,H., Olamendi-Portugal,T., Possani,L.D., Becerril,B., Riano-Umbarila,L. (2023). Development of a human antibody fragment cross-neutralizing scorpion toxins.
Molecular Immunology,
155,
165-174.
Artículo
4 - Shakeel,K., Olamendi-Portugal,T., Naseem,M.U., Becerril,B., Zamudio,F.Z., Delgado-Prudencio,G., Possani,L.D., Panyi,G. (2023). Of Seven New K(+) Channel Inhibitor Peptides of Centruroides bonito, a-KTx 2.24 Has a Picomolar Affinity for Kv1.2.
Toxins (Basel),
15 (8),
506.
Artículo
5 - Valencia-Martinez,H., Riano-Umbarila,L., Olamendi-Portugal,T., Romero-Moreno,J.A., Possani,L.D., Becerril,B. (2023). Neutralization of Centruroides tecomanus scorpion venom by the use of two human recombinant antibody fragments.
Molecular Immunology,
164,
79-87.
Memoria in extenso
55 - Possani,L.D., Gurrola,G.B., Portugal,T.O., Zamudio,F.Z., Vaca,L.D., Calderon,S.A., Kirsch,G.E. (1991). Scorpion toxins: a model for peptide synthesis of new drugs. Proceedings First Brazilian Congress on Proteins.
352-367,
Brasil.
56 - Olamendi Portugal, Timoteo Celso (1991). Sintesis quimica y caracterizacion inmunologica de peptidos correspondientes a la secuencia de la toxina II9.2.2 del alacran Centruroides noxius .
Instituto de Biotecnologia,
Especialista en Biotecnologia,
UNAM.
Asesor: Possani, Lourival Domingos
Fecha
Artículo
57 - Restano-Cassulini,R., Olamendi-Portugal,T., Riano-Umbarila,L., Zamudio,F.Z., Delgado-Prudencio,G., Becerril,B., Possani,L.D.. Characterization of Sodium Channel Peptides Obtained from the Venom of the Scorpion Centruroides bonito.
Toxins (Basel),
16 (3),
125.
Articulo
58 - Riano-Umbarila,L., Olamendi-Portugal,T., Romero-Moreno,J.A., Delgado-Prudencio,G., Zamudio,F.Z., Becerril,B., Possani,L.D.. Toxic Peptides from the Mexican Scorpion Centruroides villegasi: Chemical Structure and Evaluation of Recognition by Human Single-Chain Antibodies.
Toxins (Basel),
16 (7),
301.
Artículo
59 - Romero-Moreno,J.A., Serrano-Posada,H., Olamendi-Portugal,T., Possani,L.D., Becerril,B., Riano-Umbarila,L.. Development of a human antibody fragment cross-neutralizing scorpion toxins.
Molecular Immunology,
155,
165-174.
Artículo
60 - Shakeel,K., Olamendi-Portugal,T., Naseem,M.U., Becerril,B., Zamudio,F.Z., Delgado-Prudencio,G., Possani,L.D., Panyi,G.. Of Seven New K(+) Channel Inhibitor Peptides of Centruroides bonito, a-KTx 2.24 Has a Picomolar Affinity for Kv1.2.
Toxins (Basel),
15 (8),
506.
Artículo
61 - Valencia-Martinez,H., Riano-Umbarila,L., Olamendi-Portugal,T., Romero-Moreno,J.A., Possani,L.D., Becerril,B.. Neutralization of Centruroides tecomanus scorpion venom by the use of two human recombinant antibody fragments.
Molecular Immunology,
164,
79-87.
Artículo
62 - Mejia-Sanchez,M.A., Clement, H., Corrales-Garcia,L.L., Olamendi-Portugal,T., Carbajal,A., Corzo,G.. Crotoxin B: Heterologous Expression, Protein Folding, Immunogenic Properties, and Irregular Presence in Crotalid Venoms.
Toxins,
14 (6),
382.
Artículo
63 - Valencia-Martinez,H., Olamendi-Portugal,T., Restano-Cassulini,R., Serrano-Posada,H., Zamudio,F., Possani,L.D., Riano-Umbarila,L., Becerril,B.. Characterization of Four Medically Important Toxins from Centruroides huichol Scorpion Venom and Its Neutralization by a Single Recombinant Antibody Fragment.
Toxins,
14 (6),
369.
Artículo
64 - Alamilla,J., Jimenez-Vargas,J.M., Galvan-Hernandez,A.R., Reyes-Mendez,M.E., Bermudez-Guzman,M.J., Restano-Cassulini,R., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D., Valdez-Velazquez,L.L.. Toxin Ct1a, from venom of Centruroides tecomanus, modifies the spontaneous firing frequency of neurons in the suprachiasmatic nucleus.
Toxicon,
197,
114-125.
Artículo
65 - Alvarado,D., Cardoso-Arenas,S., Corrales-Garcia,L.L., Clement,H., Arenas,I., Montero-Dominguez,P.A., Olamendi-Portugal,T., Zamudio,F., Agota,C., Borrego,J., Panyi,G., Papp,F., Corzo,G.. A Novel Insecticidal Spider Peptide that Affects the Mammalian Voltage-Gated Ion Channel hKv1.5.
Frontiers in Pharmacology,
11,
563858.
Artículo
Artículo
67 - Gomez-Ramirez,I.V., Riano-Umbarila,L., Olamendi-Portugal,T., Restano-Cassulini,R., Possani,L.D., Becerril,B.. Biochemical, electrophysiological and immunological characterization of the venom from Centruroides baergi, a new scorpion species of medical importance in Mexico.
Toxicon,
184,
10-18.
Artículo
68 - Lopez-Giraldo,A.E., Olamendi-Portugal,T., Riano-Umbarila,L., Becerril,B., Possani,L.D., Delepierre,M., Rio-Portilla,F.D.. The three-dimensional structure of the toxic peptide Cl13 from the scorpion Centruroides limpidus.
Toxicon,
184,
158-166.
Artículo
69 - Riano-Umbarila,L., Rojas-Trejo,V.M., Romero-Moreno,J.A., Costas,M., Utrera-Espindola,I., Olamendi-Portugal,T., Possani,L.D., Becerril,B.. Comparative assessment of the VH-VL and VL-VH orientations of single-chain variable fragments of scorpion toxin-neutralizing antibodies.
Molecular Immunology,
122,
141-147.
Artículo
70 - Valdez-Velazquez,L.L., Cid-Uribe,J., Romero-Gutierrez,M.T., Olamendi-Portugal,T., Jimenez-Vargas,J.M., Possani,L.D.. Transcriptomic and proteomic analyses of the venom and venom glands of Centruroides hirsutipalpus, a dangerous scorpion from Mexico.
Toxicon,
179,
21-32.
Artículo
71 - Riano-Umbarila,L., Gomez-Ramirez,I.V., Ledezma-Candanoza,L.M., Olamendi-Portugal,T., Rodriguez-Rodriguez,E.R., Fernandez-Taboada,G., Possani,L.D., Becerril,B.. Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms.
Toxins (Basel),
11 (1),
32.
Artículo
72 - Rincon-Cortes,C.A., Olamendi-Portugal,T., Carcamo-Noriega,E.N., Gonzalez-Santillan,E., Zamudio-Zuniga,F., Reyes-Montano,E.A., Vega Castro,N.A., Possani,L.D.. Structural and functional characterization of toxic peptides purified from the venom of the Colombian scorpion Tityus macrochirus.
Toxicon,
169,
5-11.
Artículo
73 - Carcamo-Noriega, E.N., Olamendi-Portugal, T., Restano-Cassulini, R., Rowe, A., Uribe-Romero, S.J., Becerril, B., Possani, L.D.. Intraspecific variation of Centruroides sculpturatus scorpion venom from two regions of Arizona.
Archives of Biochemistry and Biophysics,
638,
52-57.
Artículo
74 - Olamendi-Portugal, T., Batista, C.V.F., Pedraza-Escalona, M., Restano-Cassulini, R., Zamudio, F.Z., Benard-Valle, M., de Roodt, A.R., Possani, L.D.. New insights into the proteomic characterization of the coral snake Micrurus pyrrhocryptus venom.
Toxicon,
153,
23-31.
Artículo
75 - Valdez-Velazquez, L.L., Olamendi-Portugal, T., Restano-Cassulini, R., Zamudio, F.Z., Possani, L.D.. Mass fingerprinting and electrophysiological analysis of the venom from the scorpion Centruroides hirsutipalpus (Scorpiones: Buthidae).
Journal of Venomous Animals and Toxins Including Tropical Diseases,
24,
17.
Artículo
76 - Garcia-Garcia, F., Corrales-Garcia, L.L., Olamendi-Portugal, T., Restano-Cassulini, R., Vega, R., Vega, M., Ortiz, E., Sandoval-Lopez, G., Soto, E., Corzo, G.. Identification, chemical synthesis and heterologous expression of an antinociceptive peptide from the veined tree frog Trachycephalus typhonius.
Process Biochemistry,
62,
205-214.
Artículo
77 - Olamendi-Portugal, T., Restano-Cassulini, R., Riano-Umbarila, L., Becerril, B., Possani, L.D.. Functional and immuno-reactive characterization of a previously undescribed peptide from the venom of the scorpion centruroides limpidus.
Peptides,
87,
34-40.
Artículo
78 - Olamendi-Portugal, T., Csoti, A., Jimenez-Vargas, J.M., Gomez-Lagunas, F., Panyi, G., Possani, L.D.. Pi5 and Pi6, two undescribed peptides from the venom of the scorpion Pandinus imperator and their effects on K+-channels.
Toxicon,
133,
136-144.
Artículo
79 - Olamendi-Portugal,T., Bartok,A., Zamudio-Zuniga,F., Balajthy,A., Becerril,B., Panyi,G., Possani,L.D.. Isolation, chemical and functional characterization of several new K-channel blocking peptides from the venom of the scorpion Centruroides tecomanus.
Toxicon,
115,
1-12.
Artículo
80 - Riano-Umbarila,L., Ledezma-Candanoza,L.M., Serrano-Posada,H., Fernandez-Taboada,G., Olamendi-Portugal,T., Rojas-Trejo,S., Gomez-Ramirez,I.V., Rudino-Pinera,E., Possani,L.D., Becerril,B.. Optimal neutralization of Centruroides noxius venom is understood through a structural complex between two antibody fragments and the Cn2 toxin.
Journal of Biological Chemistry,
291 (4),
1619-1630.
Artículo
81 - Rodriguez-Rodriguez,E.R., Olamendi-Portugal,T., Serrano-Posada,H., Arredondo-Lopez,J.N., Gomez-Ramirez,I., Fernandez-Taboada,G., Possani,L.D., Vega,G.A., Riano-Umbarila,L., Becerril,B.. Broadening the neutralizing capacity of a family of antibody fragments against different toxins from Mexican scorpions.
Toxicon,
119,
52-63.
Artículo
82 - Villalba,M.I., Canul-Tec,J.C., Luna-Martinez,O.D., Sanchez-Alcala,R., Olamendi-Portugal,T., Rudino-Pinera,E., Rojas,S., Sanchez-Lopez,R., Fernandez-Velasco,D.A., Becerril,B.. Site-directed Mutagenesis Reveals Regions Implicated in the Stability and Fiber Formation of Human lambda3r Light Chains.
Journal of Biological Chemistry,
290,
2577-2592 .
Artículo
Artículo
84 - Rodriguez-Rodriguez,E.R., Ledezma-Candanoza,L.M., Contreras-Ferrat,L.G., Olamendi-Portugal,T., Possani,L.D., Becerril,B., Riano-Umbarila,L.. A Single Mutation in Framework 2 of the Heavy Variable Domain Improves the Properties of a Diabody and a Related Single-Chain Antibody.
Journal of Molecular Biology,
423 (3),
337-350.
Artículo
85 - Schiavon,E., Pedraza-Escalona,M., Gurrola,G.B., Olamendi-Portugal,T., Corzo,G., Wanke,E., Possani,L.D.. Negative-shift activation, current reduction and resurgent currents induced by beta-toxins from Centruroides scorpions in sodium channels.
Toxicon,
59 (2),
283-293.
Artículo
86 - Espino-Solis,G.P., Estrada,G., Olamendi-Portugal,T., Villegas,E., Zamudio,F., Cestele,S., Possani,L.D., Corzo,G.. Isolation and molecular cloning of beta-neurotoxins from the venom of the scorpion Centruroides suffusus suffusus.
Toxicon,
57 (5),
739-746.
Artículo
87 - Olivares,J.E., Diaz-Camino,C., Estrada-Navarrete,G., Alvarado-Affantranger,X., Rodriguez-Kessler,M., Zamudio,F.Z., Olamendi-Portugal,T., Marquez,Y., Servin,L.E., Sanchez,F.. Nodulin 41, a novel late nodulin of common bean with peptidase activity.
BMC Plant Biology,
11 (1),
134.
Artículo
88 - Riano-Umbarila,L., Contreras-Ferrat,G., Olamendi-Portugal,T., Morelos-Juarez,C., Corzo,G., Possani,L.D., Becerril,B.. Exploiting cross-reactivity to neutralize two different scorpion venoms with one single-chain antibody fragment.
Journal of Biological Chemistry,
286 (8),
6143-6151.
Artículo
89 - Vandendriessche,T., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D., Tytgat,J.. Isolation and characterization of two novel scorpion toxins: the alpha-toxin-like CeII8, specific for Na(v)1.7 channels and the classical anti-mammalian CeII9, specific for Na(v)1.4 channels.
Toxicon,
56 (4),
613-623.
Artículo
90 - Garcia-Gomez,B.I., Olamendi-Portugal,T.C., Paniagua,J., van der Walt,J., Dyason,K., Possani,L.D.. Heterologous expression of a gene that codes for Pg8, a scorpion toxin of Parabuthus granulatus, capable of generating protecting antibodies in mice.
Toxicon,
53 (7-8),
770-778.
Artículo
91 - Olamendi-Portugal,T., Batista,C.V., Restano-Cassulini,R., Pando,V., Villa-Hernandez,O., Zavaleta-Martinez-Vargas,A., Salas-Arruz,M.C., de la Vega RC, Becerril,B., Possani,L.D.. Proteomic analysis of the venom from the fish eating coral snake Micrurus surinamensis: Novel toxins, their function and phylogeny.
Proteomics,
8 (9),
1919-1932.
Artículo
92 - Restano-Cassulini,R., Olamendi-Portugal,T., Zamudio,F., Becerril,B., Possani,L.D.. Two Novel Ergtoxins, Blockers of K(+)-channels, Purified from the Mexican Scorpion Centruroides elegans elegans.
Neurochemical Research,
33 (8),
1525-1533.
Artículo
93 - Juarez-Gonzalez,V.R., Riano-Umbarila,L., Quintero-Hernandez,V., Olamendi-Portugal,T., Ortiz-Leon,M., Ortiz,E., Possani,L.D., Becerril,B.. Directed Evolution, Phage Display and Combination of Evolved Mutants: A Strategy to Recover the Neutralization Properties of the scFv Version of BCF2 a Neutralizing Monoclonal Antibody Specific to Scorpion Toxin Cn2.
Journal of Molecular Biology,
346 (5),
1287-1297.
Artículo
94 - Olamendi-Portugal,T., Somodi,S., Fernandez,J.A., Zamudio,F.Z., Becerril,B., Varga,Z., Panyi,G., Gaspar,R., Possani,L.D.. Novel alpha-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockage Kv1.3 over IKCa1 K(+) channels of T cells.
Toxicon,
46 (4),
418-429.
Artículo
95 - Riano-Umbarila,L., Juarez-Gonzalez,V.R., Olamendi-Portugal,T., Ortiz-Leon,M., Possani,L.D., Becerril,B.. A strategy for the generation of specific human antibodies by directed evolution and phage display.
Febs Journal,
272 (10),
2591-2601.
Artículo
96 - Gomez-Lagunas,F., Batista,C.V., Olamendi-Portugal,T., Ramirez-Dominguez,M.E., Possani,L.D.. Inhibition of the collapse of the shaker k+ conductance by specific scorpion toxins.
Journal of General Physiology,
123 (3),
265-279.
Artículo
97 - Huys,I., Olamendi-Portugal,T., Garcia-Gomez,B.I., Vandenberghe,I., Van Beeumen,J., Dyason,K., Clynen,E., Zhu,S., van der Walt,J., Possani,L., Tytgat,J.. A subfamily of acidic alpha -K+ toxins.
Journal of Biological Chemistry,
279 (4),
2781-2789.
Artículo
98 - Coronas,F.V., de Roodt,A.R., Portugal,T.O., Zamudio,F.Z., Batista,C.V., Gomez-Lagunas,F., Possani,L.D.. Disulfide bridges and blockage of Shaker B K(+)-channels by another butantoxin peptide purified from the Argentinean scorpion Tityus trivittatus.
Toxicon,
41 (2),
173-179.
Artículo
99 - Lopez-Gonzalez,I., Olamendi-Portugal,T., de la Vega-Beltran,J.L., van der Walt,J., Dyason,K., Possani,L.D., Felix,R., Darszon,A.. Scorpion toxins that block T-type Ca(2+) channels in spermatogenic cells inhibit the sperm acrosome reaction.
Biochemical and Biophysical Research Communications,
300 (2),
408-414.
Artículo
100 - M'Barek,S., Mosbah,A., Sandoz,G., Fajloun,Z., Olamendi-Portugal,T., Rochat,H., Sampieri,F., Guijarro,J.I., Mansuelle,P., Delepierre,M., De Waard,M., Sabatier,J.M.. Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels.
European Journal of Biochemistry,
270 (17),
3583-3592.
Artículo
101 - Angulo,Y., Olamendi-Portugal,T., Alape-Giron,A., Possani,L.D., Lomonte,B.. Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A(2) homologue.
International Journal of Biochemistry and Cell Biology,
34 (10),
1268-1278.
Artículo
102 - Olamendi-Portugal,T., Garcia,B.I., Lopez-Gonzalez,I., van der Walt,J., Dyason,K., Ulens,C., Tytgat,J., Felix,R., Darszon,A., Possani,L.D.. Two new scorpion toxins that target voltage-gated Ca(2+) and Na(+) channels.
Biochemical and Biophysical Research Communications,
299 (4),
562-568.
Artículo
103 - Ramirez-Dominguez,M.E., Olamendi-Portugal,T., Garcia,U., Garcia,C., Arechiga,H., Possani,L.D.. Cn11, the first example of a scorpion toxin that is a true blocker of Na(+) currents in crayfish neurons.
Journal of Experimental Biology,
205 (Pt 6),
869-876.
Artículo
104 - Angulo,Y., Olamendi-Portugal,T., Possani,L.D., Lomonte,B.. Isolation and characterization of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a new Lys49 phospholipase A2 homologue.
International Journal of Biochemistry and Cell Biology,
32 (1),
63-71.
Artículo
105 - Batista,C.V., da Silva,L.R., Sebben,A., Scaloni,A., Ferrara,L., Paiva,G.R., Olamendi-Portugal,T., Possani,L.D., Bloch,C.. Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.
Peptides,
20 (6),
679-686.
Artículo
Artículo
107 - Gomez-Lagunas,F., Olamendi-Portugal,T., Possani,L.D.. Block of ShakerB K+ channels by Pi1, a novel class of scorpion toxin.
FEBS Letters,
400 (2),
197-200.
Artículo
108 - Gomez-Lagunas,F., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D.. Two novel toxins from the venom of the scorpion Pandinus imperator show that the N-terminal amino acid sequence is important for their affinities towards Shaker B K+ channels.
Journal of Membrane Biology,
152 (1),
49-56.
Artículo
109 - Olamendi-Portugal,T., Gomez-Lagunas,F., Gurrola,G.B., Possani,L.D.. A novel structural class of K+-channel blocking toxin from the scorpion Pandinus imperator.
Biochemical Journal,
315 (Pt 3),
977-981.
Artículo
110 - Calderon-Aranda,E.S., Olamendi-Portugal,T., Possani,L.D.. The use of synthetic peptides can be a misleading approach to generate vaccines against scorpion toxins.
Vaccine,
13 (13),
1198-1206.
Memoria in extenso
111 - Possani,L.D., Gurrola,G.B., Portugal,T.O., Zamudio,F.Z., Vaca,L.D., Calderon,S.A., Kirsch,G.E.. Scorpion toxins: a model for peptide synthesis of new drugs. Proceedings First Brazilian Congress on Proteins.
352-367,
Brasil.
112 - Olamendi Portugal, Timoteo Celso. Sintesis quimica y caracterizacion inmunologica de peptidos correspondientes a la secuencia de la toxina II9.2.2 del alacran Centruroides noxius .
Instituto de Biotecnologia,
Especialista en Biotecnologia,
UNAM.
Asesor: Possani, Lourival Domingos