Dra. Isabel Gomez Gomez
Investigador
Biología Molecular, Bioquímica y Fisiología de Bacterias
Microbiología Industrial utilizando proteinas bioinsecticidas
Número de registros: 6
- Activos
- Vencidos
- Determinantes moleculares de la interacción de la región c-terminal de las protoxinas cry de bacillus thuringiensis con los receptores aminopeptidasa y fosfatasa alcalina, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2021 - 2023
- Caracterización de las interacciones de las protoxinas cry1ab y cry1ac de bacillus thuringiensis con los receptores del lepidóptero manduca sexta, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2014 - 2017
- Estudio del papel del dominio iii de las toxinas cry1ab y cry1c en la interacción con los receptores de manduca sexta, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2011 - 2013
- Estudio del papel funcional de la amidopeptidasa-n y fosfatasa alcalina presentes en el intestino de m. sexta como receptores de las toxinas cry1 de bacillus thuringiensis, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2008 - 2011
- Estudio de la interacción del oligomero de las toxinas cry1a de bacillus thuringiensis con su receptor en el lepidóptero manduca sexta, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2008 - 2010
- Papel de múltiples receptores en el reconocimiento celular de toxinas bacterianas., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2005 - 2008
Nivel c del Pride
Nivel I del SNI
Nivel I del SNI
Distinción Universidad Nacional para Jóvenes Académicos (DUNJA), UNAM, 2012
Premio Weizmann, Academia Mexicana de Ciencias, 2003
-
Doctorado
-
M.C. Arlen Idalia Peña Cardena
Estudio de la interacción de las protoxinas Cry1Ab y Cry1Ac de Bacillus thuringiensis con los receptores de Manduca sexta
-
Maestría
-
La dominancia negative como evidencia de hetero-oligomerización entre diferentes toxinas Cry de bacillus thuringiensis
-
Estancia Temporal
1 - Flores Escobar, Biviana (2014). Papel diferencial de la aminopeptidasa N y la fosfatasa alcalina como receptores funcionales de las toxinas Cry1As de Bacillus thuringiensis .
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
Asesor: Gomez Gomez, Isabel
2 - Rodriguez Chamorro, Daniel Eduardo (2013). Identificacion de los receptores de la toxina cry1ca de bacillus thuringiensis en el intestino de spodoptera frugiperda y manduca sexta .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Gomez Gomez, Isabel
3 - Ocelotl Oviedo, Josue (2011). Analisis del papel de la region SS16 del dominio III de la toxina Cry1Ca de Bacillus thuringiensis en toxicidad contra Manduca sexta.
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Gomez Gomez, Isabel
4 - Arenas Sosa, Ivan (2010). El papel de la fosfatasa alcalina de Manduca sexta en el mecanismo de toxicidad de la toxina Cry1AB de Bacillus thuringiensis.
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
Asesor: Gomez Gomez, Isabel
5 - Martinez Estrada, Maria Teresa de Jesus (2008). Seleccion de peptidos que unen receptores de las toxinas Cry1A de Bacillus thuringiensis empleando la tecnologia de despliegue en fagos .
Instituto de Biotecnologia,
Maestro en Ciencias Bioquimicas,
UNAM.
Asesor: Gomez Gomez, Isabel
6 - Benitez Hernandez, Itzel (2003). Aislamiento de anticuerpos monoclonales que reconocen al asa 3 del dominio II de la toxina Cry1Ab de Bacillus thuringiensis.
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
Asesor: Gomez Gomez, Isabel
Total de publicaciones: 70
- Tipo
- Fecha
Artículo
7 - Sena da Silva,I.H., Gomez,I., Pacheco,S., Sanchez,J., Zhang,J., Luque Castellane,T.C., Aparecida Desiderio J., Soberon,M., Bravo,A., Polanczyk,R.A. (2021). Bacillus thuringiensis Cry1Ab domain III -16 is involved in binding to prohibitin which correlates with toxicity against Helicoverpa armigera (Lepidoptera: Noctuidae).
Applied and Environmental Microbiology,
87 (2).
Artículo
8 - Almanza-Martinez,N., Martinez-Diaz,S.F., Flores-Ramirez,G., Zuniga-Navarrete,F., Gomez,I., Cardona-Felix,C.S. (2020). An alpha amylase-like protein interacts with PirB toxin from Vibrio parahaemolyticus in digestive tract tissue of white shrimp Litopenaeus vannamei.
Aquaculture Research,
51 (9),
3910-3914.
Artículo
9 - Gomez,I., Ocelotl,J., Sanchez,J., Aguilar-Medel,S., Pena-Chora,G., Lina-Garcia,L., Bravo,A., Soberon,M. (2020). Bacillus thuringiensis Cry1Ab domain III beta-22 mutants with enhanced toxicity to Spodoptera frugiperda (J. E. Smith).
Applied and Environmental Microbiology,
86 (22).
Artículo
10 - Pacheco,S., Quiliche,J.P.J., Gomez,I., Sanchez,J., Soberon,M., Bravo,A. (2020). Rearrangement of N-Terminal alpha-Helices of Bacillus thuringiensis Cry1Ab Toxin Essential for Oligomer Assembly and Toxicity.
Toxins (Basel),
12 (10).
Artículo
11 - Zhang,J., Jin,M., Yang,Y., Liu,L., Yang,Y., Gomez,I., Bravo,A., Soberon,M., Xiao,Y., Liu,K. (2020). The Cadherin Protein Is Not Involved in Susceptibility to Bacillus thuringiensis Cry1Ab or Cry1Fa Toxins in Spodoptera frugiperda.
Toxins (Basel),
12 (6),
375.
Artículo
12 - Gomez, I., Ocelotl, J., Sanchez, J., Lima, C., Martins, E., Rosales-Juarez, A., Aguilar-Medel, S., Abad, A., Dong, H., Monnerat, R., Pena, G., Zhang, J., Nelson, M., Wu, G., Bravo, A., Soberon, M. (2018). Enhancement of Bacillus thuringiensis Cry1Ab and Cry1Fa toxicity to Spodoptera frugiperda by domain III mutations indicates two limiting steps in toxicity as defined by receptor binding and protein stability.
Applied and Environmental Microbiology,
84 (20).
Artículo
13 - Gomez, I., Rodriguez-Chamorro, D.E., Flores-Ramirez, G., Grande, R., Zuniga, F., Portugal, F.J., Sanchez, J., Pacheco, S., Bravo, A., Soberon, M. (2018). Spodoptera frugiperda (J. E. Smith) aminopeptidase N1 is functional receptor of Bacillus thuringiensis Cry1Ca toxin.
Applied and Environmental Microbiology,
84 (17).
Artículo
14 - Pacheco, S., Gomez, I., Sanchez, J., Garcia-Gomez, B.I., Czajkowsky, D.M., Zhang, J., Soberon, M., Bravo, A. (2018). Helix alpha-3 inter-molecular salt bridges and conformational changes are essential for toxicity of Bacillus thuringiensis 3D-Cry toxin family.
Scientific Reports,
8 (1),
10331.
Artículo
15 - Pena-Cardena,A., Grande,R., Sanchez,J., Tabashnik,B.E., Bravo,A., Soberon,M., Gomez,I. (2018). The C-terminal protoxin domain of Bacillus thuringiensis Cry1Ab toxin has a functional role in binding to GPI-anchored receptors in the insect midgut.
Journal of Biological Chemistry,
293 (52),
20263-20272.
Artículo
16 - Sena de Silva,I., Gomez,I., Sanchez,J., Martinez de Castro,D.L., Valicente,F.H., Soberon,M., Polanczyk,R.A., Bravo,A. (2018). Identification of midgut membrane proteins from different instars of Helicoverpa armigera (Lepidoptera: Noctuidae) that bind to Cry1Ac toxin.
PLoS ONE,
13 (12).
Revisión
17 - Soberon, M., Portugal, L., Garcia-Gomez, B.I., Sanchez, J., Onofre, J., Gomez, I., Pacheco, S., Bravo, A. (2018). Cell lines as models for the study of Cry toxins from Bacillus thuringiensis.
Insect Biochemistry and Molecular Biology,
93,
66-78.
Artículo
18 - Torres-Quintero, M.C., Gomez, I., Pacheco, S., Sanchez, J., Flores, H., Osuna, J., Mendoza, G., Soberon, M., Bravo, A. (2018). Engineering Bacillus thuringiensis Cyt1Aa toxin specificity from dipteran to lepidopteran toxicity.
Scientific Reports,
8 (1),
4989.
Artículo
19 - Wang, Z., Fang, L., Zhou, Z., Pacheco, S., Gomez, I., Song, F., Soberon, M., Zhang, J., Bravo, A. (2018). Specific binding between Bacillus thuringiensis Cry9Aa and Vip3Aa toxins synergizes their toxicity against Asiatic rice borer (Chilo suppressalis).
Journal of Biological Chemistry,
293 (29),
11447-11458.
Artículo
20 - Martinez de Castro, D.L, Garcia-Gomez, B.I., Gomez, I., Bravo, A., Soberon, M. (2017). Identification of Bacillus thuringiensis Cry1AbMod binding-proteins from Spodoptera frugiperda.
Peptides,
98,
99-105.
Artículo
21 - Ocelotl, J., Sanchez, J., Gomez, I., Tabashnik, B.E., Bravo, A., Soberon, M. (2017). ABCC2 is associated with Bacillus thuringiensis Cry1Ac toxin oligomerization and membrane insertion in diamondback moth.
Scientific Reports,
7 (1),
2386.
Artículo; Actas Paper
22 - Onofre, J., Gaytan, M.O., Pena-Cardena, A., Garcia-Gomez, B.I., Pacheco, S., Gomez, I., Bravo, A., Soberon, M. (2017). Identification of Aminopeptidase-N2 as a Cry2Ab binding protein in Manduca sexta.
Peptides,
98,
93-98.
Artículo
23 - Pacheco, S., Gomez, I., Sanchez, J., Garcia-Gomez, B.I., Soberon, M., Bravo, A. (2017). Intra-molecular salt bridge in Bacillus thuringiensis Cry4Ba toxin is involved in the stability of helix alpha-3 that is needed for oligomerization and insecticidal activity.
Applied and Environmental Microbiology,
83 (20).
Artículo
24 - Serratos,I.N., Castellanos,P., Pastor,N., Millan-Pacheco,C., Colin-Gonzalez,A.L., Rembao,D., Perez-Montfort,R., Cabrera,N., Sanchez-Garcia,A., Gomez,I., Rangel-Lopez,E., Santamaria,A. (2016). Early expression of the receptor for advanced glycation end products in a toxic model produced by 6-hydroxydopamine in the rat striatum.
Chemico-Biological Interactions,
249,
10-18.
Artículo
25 - Gomez,I., Flores,B., Bravo,A., Soberon,M. (2015). Bacillus thuringiensis Cry1AbMod toxin counters tolerance associated with low cadherin expression but not that associated with low alkaline phosphatase expression in Manduca sexta.
Peptides,
68 (1),
130-133.
Artículo
26 - Ocelotl,J., Sanchez,J., Arroyo,R., Garcia-Gomez,B.I., Gomez,I., Unnithan,G.C., Tabashnik,B.E., Bravo,A., Soberon,M. (2015). Binding and Oligomerization of Modified and Native Bt Toxins in Resistant and Susceptible Pink Bollworm.
PLoS ONE,
10 (12).
Artículo
27 - Zuniga-Navarrete,F., Gomez,I., Pena,G., Amaro,I., Ortiz,E., Becerril,B., Ibarra,J.E., Bravo,A., Soberon,M. (2015). Identification of Bacillus thuringiensis Cry3Aa toxin domain II loop 1 as the binding site of Tenebrio molitor cadherin repeat CR12.
Insect Biochemistry and Molecular Biology,
59,
50-57.
Artículo
28 - Gomez,I., Sanchez,J., Munoz-Garay,C., Matus,V., Gill,S.S., Soberon,M., Bravo,A. (2014). Bacillus thuringiensis Cry1A toxins are versatile-proteins with multiple modes of action: two distinct pre-pores are involved in toxicity.
Biochemical Journal,
459 (2),
383-396.
Revisión
29 - Bravo,A., Gomez,I., Porta,H., Garcia-Gomez,B.I., Rodriguez-Almazan,C., Pardo,L., Soberon,M. (2013). Evolution of Bacillus thuringiensis Cry toxins insecticidal activity.
Microbial Biotechnology,
6 (1),
17-26.
Artículo
30 - Flores-Escobar,B., Rodriguez-Magadan,H., Bravo,A., Soberon,M., Gomez,I. (2013). Differential role of Manduca sexta aminopeptidase-N and alkaline phosphatase in the mode of action of Cry1Aa, Cry1Ab, and Cry1Ac toxins from Bacillus thuringiensis.
Applied and Environmental Microbiology,
79 (15),
4543-4550.
Artículo; Actas Paper
31 - Zuniga-Navarrete,F., Gomez,I., Pena,G., Bravo,A., Soberon,M. (2013). A Tenebrio molitor GPI-anchored alkaline phosphatase is involved in binding of Bacillus thuringiensis Cry3Aa to brush border membrane vesicles.
Peptides,
41,
81-86.
Artículo
32 - Rodriguez-Almazan,C., Reyes,E.Z., Zuniga-Navarrete,F., Munoz-Garay,C., Gomez,I., Evans,A.M., Likitvivatanavong,S., Bravo,A., Gill,S.S., Soberon,M. (2012). Cadherin binding is not a limiting step for Bacillus thuringiensis subs. israelensis Cry4Ba toxicity to Aedes aegypti larvae.
Biochemical Journal,
443,
711-717.
Revisión
33 - Terenius,O., Papanicolaou,A., Garbutt,J.S., Eleftherianos,I., Huvenne,H., Sriramana,K., Albrechtsen,M., An,C., Aymeric,J.L., Barthel,A., Bebas,P., Bitra,K., Bravo,A., Chevalier,F., Collinge,D.P., Crava,C.M., de Maagd,R.A., Duvic,B., Erlandson,M., Faye,I., Felfoldi,G., Fujiwara,H., Futahashi,R., Gandhe,A.S., Gatehouse,H.S., Gatehouse,L.N., Giebultowicz,J., Gomez,I., Grimmelikhuijzen,C.J., Groot,A.T., Hauser,F., Heckel,D.G., Hegedus,D.D., Hrycaj,S., Huang,L., Hull,J.J., Iatrou,K., Iga,M., Kanost,M.R., Kotwica,J., Li,C., Li,J., Liu,J., Lundmark,M., Matsumoto,S., Meyering-Vos,M., Millichap,P.J., Monteiro,A., Mrinal,N., Niimi,T., Nowara,D., Ohnishi,A., Oostra,V., Ozaki,K., Papakonstantinou,M., Popadic,A., Rajam,M.V., Saenko,S., Simpson,R.M., Soberon,M., Strand,M.R., Tomita,S., Toprak,U., Wang,P., Wee,C.W., Whyard,S., Zhang,W., Nagaraju,J., Ffrench-Constant,R.H., Herrero,S., Gordon,K., Swevers,L., Smagghe,G., et al (2011). RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design.
Journal of Insect Physiology,
57 (2),
231-245.
Artículo
34 - Zavala,L.E., Pardo-Lopez,L., Canton,P.E., Gomez,I., Soberon,M., Bravo,A. (2011). Domains II and III of Bacillus thuringiensis Cry1Ab toxin remain exposed to the solvent after insertion of part of domain I into the membrane.
Journal of Biological Chemistry,
286 (21),
19109-19117.
Artículo
35 - Arenas,I., Bravo,A., Soberon,M., Gomez,I. (2010). Role of alkaline phosphatase from Manduca sexta in the mechanism of action of Bacillus thuringiensis Cry1Ab toxin.
Journal of Biological Chemistry,
285 (17),
12497-503.
Artículo
36 - Gomez,I., Arenas,I., Pacheco,S., Bravo,A., Soberon,M. (2010). New Insights into the Mode of Action of Cry1Ab Toxin Used in Transgenic Insect-resistant Crops.
Southwestern Entomologist,
35 (3),
387-390.
Artículo
37 - Munoz-Garay,C., Portugal,L., Pardo-Lopez,L., Jimenez-Juarez,N., Arenas,I., Gomez,I., Sanchez-Lopez,R., Arroyo,R., Holzenburg,A., Savva,C.G., Soberon,M., Bravo,A. (2009). Characterization of the mechanism of action of the genetically modified Cry1AbMod toxin that is active against Cry1Ab-resistant insects.
Biochimica et Biophysica Acta (BBA) - Biomembranes,
1788 (10),
2229-2237.
Artículo
38 - Munoz-Garay,C., Rodriguez-Almazan,C., Aguilar,J.N., Portugal,L., Gomez,I., Saab-Rincon,G., Soberon,M., Bravo,A. (2009). Oligomerization of Cry11Aa from Bacillus thuringiensis has an important role in toxicity against Aedes aegypti.
Applied and Environmental Microbiology,
75 (23),
7548-7550.
Artículo
39 - Pacheco,S., Gomez,I., Arenas,I., Saab-Rincon,G., Rodriguez-Almazan,C., Gill,S.S., Bravo,A., Soberon,M. (2009). Domain II loop 3 of Bacillus thuringiensis Cry1Ab toxin is involved in a "ping-pong" binding mechanism with Manduca sexta aminopetidase-N and cadherin receptors.
Journal of Biological Chemistry,
284 (47),
32750-32757.
Artículo
40 - Pacheco,S., Gomez,I., Gill,S.S., Bravo,A., Soberon,M. (2009). Enhancement of insecticidal activity of Bacillus thuringiensis Cry1A toxins by fragments of a toxin-binding cadherin correlates with oligomer formation.
Peptides,
30 (3),
583-588.
Artículo; Actas Paper
41 - Fernandez,L.E., Gomez,I., Pacheco,S., Arenas,I., Gill,S.S., Bravo,A., Soberon,M. (2008). Employing phage display to study the mode of action of Bacillus thuringiensis Cry toxins.
Peptides,
29 (2),
324-329.
Artículo; Actas Paper
42 - Jimenez-Juarez,N., Munoz-Garay,C., Gomez,I., Gill,S.S., Soberon,M., Bravo,A. (2008). The pre-pore from Bacillus thuringiensis Cry1Ab toxin is necessary to induce insect death in Manduca sexta.
Peptides,
29 (2),
318-323.
Artículo; Actas Paper
43 - Gomez,I., Pardo-Lopez,L., Munoz-Garay,C., Fernandez,L.E., Perez,C., Sanchez,J., Soberon,M., Bravo,A. (2007). Role of receptor interaction in the mode of action of insecticidal Cry and Cyt toxins produced by Bacillus thuringiensis.
Peptides,
28 (1),
169-173.
Artículo
44 - Jimenez-Juarez,N., Munoz-Garay,C., Gomez,I., Saab-Rincon,G., Damian-Almazo,J.Y., Gill,S.S., Soberon,M., Bravo,A. (2007). Bacillus thuringiensis Cry1Ab mutants affecting oligomer formation are non toxic to Manduca sexta larvae.
Journal of Biological Chemistry,
282 (29),
21222-21229.
Artículo
45 - Soberon,M., Pardo-Lopez,L., Lopez,I., Gomez,I., Tabashnik,B.E., Bravo,A. (2007). Engineering Modified Bt Toxins to Counter Insect Resistance.
Science,
318 (5856),
1640-1642 [erratum vol 345 (6198) art num 1256132].
Artículo
46 - Gomez,I., Arenas,I., Benitez,I., Miranda-Rios,J., Becerril,B., Grande,R., Almagro,J.C., Bravo,A., Soberon,M. (2006). Specific epitopes of domains II and IIII of bacillus thuringiensis Cry1Ab toxin involved in the sequential interaction with cadherin and aminopeptidase-N receptors in manduca sexta.
Journal of Biological Chemistry,
281 (45),
34032-34039.
Artículo
47 - Pacheco,S., Gomez,I., Sato,R., Bravo,A., Soberon,M. (2006). Functional display of Bacillus thuringiensis Cry1Ac toxin on T7 phage.
Journal of Invertebrate Pathology,
92 (1),
45-49.
Artículo
48 - Padilla,C., Pardo-Lopez,L., de la Riva,G., Gomez,I., Sanchez,J., Hernandez,G., Nunez,M.E., Carey,M.P., Dean,D.H., Alzate,O., Soberon,M., Bravo,A. (2006). Role of Tryptophan Residues in Toxicity of Cry1Ab Toxin from Bacillus thuringiensis.
Applied and Environmental Microbiology,
72 (1),
901-907.
Artículo
49 - Pardo-Lopez,L., Gomez,I., Rausell,C., Sanchez,J., Soberon,M., Bravo,A. (2006). Structural Changes of the Cry1Ac Oligomeric Pre-Pore from Bacillus thuringiensis Induced by N-Acetylgalactosamine Facilitates Toxin Membrane Insertion.
Biochemistry,
45 (34),
10329-10336.
Artículo; Actas Paper
50 - Pardo-Lopez,L., Gomez,I., Munoz-Garay,C., Jimenez-Juarez,N., Soberon,M., Bravo,A. (2006). Structural and functional analysis of the pre-pore and membrane-inserted pore of Cry1Ab toxin.
Journal of Invertebrate Pathology,
92 (3),
172-177.
Artículo
51 - Xie,R., Zhuang,M., Ross,L.S., Gomez,I., Oltean,D.I., Bravo,A., Soberon,M., Gill,S.S. (2005). Single amino acid mutations in the cadherin receptor from heliothis virescens affect its toxin binding ability to Cry1A toxins.
Journal of Biological Chemistry,
280 (9),
8416-8425.
Artículo
52 - Bravo,A., Gomez,I., Conde,J., Munoz-Garay,C., Sanchez,J., Miranda,R., Zhuang,M., Gill,S.S., Soberon,M. (2004). Oligomerization triggers binding of a Bacillus thuringiensis Cry1Ab pore-forming toxin to aminopeptidase N receptor leading to insertion into membrane microdomains.
1667 (1),
38-46.
Artículo
53 - Rausell,C., Munoz-Garay,C., Miranda-CassoLuengo,R., Gomez,I., Rudino-Pinera,E., Soberon,M., Bravo,A. (2004). Tryptophan Spectroscopy Studies and Black Lipid Bilayer Analysis Indicate that the Oligomeric Structure of Cry1Ab Toxin from Bacillus thuringiensis Is the Membrane-Insertion Intermediate.
Biochemistry,
43 (1),
166-174.
Artículo
54 - Gomez,I., Dean,D.H., Bravo,A., Soberon,M. (2003). Molecular Basis for Bacillus thuringiensis Cry1Ab Toxin Specificity: Two Structural Determinants in the Manduca sexta Bt-R(1) Receptor Interact with Loops alpha-8 and 2 in Domain II of Cy1Ab Toxin.
Biochemistry,
42 (35),
10482-10489.
Artículo
55 - Bravo,A., Miranda,R., Gomez,I., Soberon,M. (2002). Pore formation activity of Cry1Ab toxin from Bacillus thuringiensis in an improved membrane vesicle preparation from Manduca sexta midgut cell microvilli.
1562 (1-2),
63-69.
Artículo
56 - Gomez,I., Miranda-Rios,J., Rudino-Pinera,E., Oltean,D.I., Gill,S.S., Bravo,A., Soberon,M. (2002). Hydropathic complementarity determines interaction of epitope 869HITDTNNK876 in Manduca sexta Bt-R1 receptor with loop 2 of domain II of Bacillus thuringiensis Cry1A toxins.
Journal of Biological Chemistry,
277 (33),
30137-30143.
Artículo
57 - Gomez,I., Sanchez,J., Miranda,R., Bravo,A., Soberon,M. (2002). Cadherin-like receptor binding facilitates proteolytic cleavage of helix alpha-1 in domain I and oligomer pre-pore formation of Bacillus thuringiensis Cry1Ab toxin.
FEBS Letters,
513 (2-3),
242-246.
Artículo
58 - Miranda,R., Gomez,I., Soberon,M., Bravo,A. (2002). Mecanismo de accion de las toxinas Cry de Bacillus Thuringiensis.
TIP revista especializada en Ciencias Quimico-Biologicas,
5,
5-13.
Artículo
59 - Zhuang,M., Oltean,D.I., Gomez,I., Pullikuth,A.K., Soberon,M., Bravo,A., Gill,S.S. (2002). Heliothis virescens and Manduca sexta lipid rafts are involved in Cry1A toxin binding to the midgut epithelium and subsequent pore formation.
Journal of Biological Chemistry,
277 (16),
13863-13872.
Artículo
60 - Gomez,I., Oltean,D.I., Gill,S., Bravo,A., Soberon,M. (2001). Mapping the epitope in cadherin-like receptors involved in Bacillus thuringiensis Cry1A toxins interaction using phage display.
Journal of Biological Chemistry,
276 (31),
28906-28912.
Artículo
61 - Soberon,M., Perez,R.V., Nunez-Valdez,M.E., Lorence,A., Gomez,I., Sanchez,J., Bravo,A. (2000). Evidence for intermolecular interaction as a necessary step for pore-formation activity and toxicity of Bacillus thuringiensis Cry1Ab toxin.
Fems Microbiology Letters,
191 (2),
221-225.
62 - Bravo, A., Pacheco, S., Gomez, I., Garcia-Gomez, B., Onofre, J., Soberon, M. (2017). Insecticidal Proteins from Bacillus thuringiensis and Their Mechanism of Action. Bacillus thuringiensis and Lysinibacillus sphaericus: Characterization and use in the field of biocontrol.
53-66,
Cham: Springer.
*
Internacional
63 - Bravo, A., Martinez-de-Castro, D. L., Sanchez-Quintana, J., Canton, P. E., Mendoza, G., Gomez, I., Pacheco, S., Garcia-Gomez, B. I., Onofre, J., Ocelotl, J., Soberon, M. (2015). Mechanism of action of Bacillus thuringiensis insecticidal toxins and their use in the control of insect pests. Comprehensive Sourcebook of Bacterial Protein Toxins.
858-873,
4a ed.
Internacional
64 - Bravo,A., Gomez,I., Mendoza,G., Gaytan,M., Soberon,M. (2015). Different models of the mode of action of Bt 3d-Cry toxins. Bt resistance - characterization and strategies for GM crops expressing Bacillus thuringiensis toxins .
56-68,
Oxford.
Internacional
65 - Grande-Cano,R.A., Gomez I. (2015). Identification and characterization of receptors for insecticidal toxins from Bacillus thuringiensis. Biocontrol of Lepidopteran Pests: Use of Soil Microbes and their Metabolites .
Soil Biology,
71-88.
Memoria in extenso
66 - Soberon,M., Gomez,I., Garcia-Gomez,B.I., Carmona,D., Ocelotl,J., Villanueva,F., Flores,B., Bravo,A. (2014). Mode of action of mosquitocidal toxins from Bacillus thuringiensis and their use in control of insect vectors of human diseases. Biotechnology: beyond borders.
Proceedings of the Indo-Mexico workshop on Biotechnology held at CSIR NCL, Pune, India from October 7-9, 2013.,
279-288.
Internacional
67 - Flores-Escobar,B., Zuniga-Navarrete,F., Sanchez,J., Gomez,I. (2012). Protein-protein interaction detection on membrane supports. Tools to Understand Protein-Protein Interactions.
55-70,
Kerala: Research Signpost.
Internacional
68 - Grande-Cano,R., Gomez,I. (2012). Protein expression and purification. Tools to Understand Protein-Protein Interactions.
41-54,
Kerala: Research Signpost.
Internacional
69 - Zuniga-Navarrete,F., Bravo,A., Soberon,M., Gomez,I. (2012). Role of GPI-anchored membrane receptors in the mode of action of Bacillus thuringiensis Cry toxins. Integrated Pest Management and Pest Control- Current and Future Tactics .
551-566.
Internacional
70 - Soberon,M., Pardo,L., Munoz-Garay,C., Sanchez,J., Gomez,I., Porta,H., Bravo,A. (2010). Pore Formation by Cry Toxins. Proteins: Membrane Binding and Pore Formation.
Advances in Experimental Medicine and Biology,
127-142,
Austin, TX: Landes Bioscience.
Memoria in extenso
71 - Gomez,I., Miranda-Rios,J., Arenas,I., Grande,R., Becerril,B., Bravo,A., Soberon,M. (2007). Identification of scFv Molecules that Recognize Loop 3 of Domain II and Domain III of Cry1Ab Toxin from Bacillus thuringiensis. 6th Pacific Rim Conference on the biotechnology of Bacillus thuringiensis and its Environmental Impact .
12-14,
Montreal.
Memoria in extenso
72 - Pardo,L., Gomez,I., Munoz-Garay,C., Jimenez-Juarez,N., Sanchez,J., Perez,C., Soberon,M., Bravo,A. (2007). Oligomer Formation of Different Cry Toxins Indicates that a Pre-Pore is an Essential Intermediate in the Mode of Action of the Three-Domain Cry Family. Proceedings of the 6th Pacific Rim Conference on the Biotechnology of Bacillus thuringiensis and its Environmental Impact.
7-8.
Memoria in extenso
73 - Soberon,M., Gomez,I., Pardo,L., Munoz,C., Fernandez,L.E., Perez,C., Gill,S.S., Bravo,A. (2007). Important Interactions with membrane Receptors in the Mode of Action of Bacillus thuringiensis Cry toxins. 6th Pacific Rim Conference on the biotechnology of Bacillus thuringiensis and its Environmental Impact , cap 1.
1-6,
Montreal.
Internacional
74 - Soberon,M., Nuñez,M., Gomez I., Sanchez-Quintana,J., Bravo,A. (2004). Functional studies of helix a-5 region from Bacillus thuringiensis Cry1Ab d-endotoxin shows that conserved residues are important for pore formation and stability but not for oligomer formation. Pore-forming peptides and protein toxins.
Cellular and molecular mechanisms of toxin action ;v. 5,
90-101,
London ;New York.
Nacional
75 - Ibarra,J.E., Castro,M.C., Galindo,E., Patino,M., Serrano,L., Garcia,R., Carrillo,J.A., Pereyra-Alferez,B., Alcazar-Pizana,A., Luna-Olvera,H., Galan-Wong,L., Pardo,L., Munoz-Garay,C., Gomez,I., Soberon,M., Bravo,A. (2006). [Microorganisms in the biological control of insects and phytopathogens].
Revista Latinoamericana de Microbiologia,
48 (2),
113-120.
76 - Gomez Gomez, Isabel (2002). Caracterizacion de un anticuerpo scFv que mimetiza el receptor natural de la proteina Cry1Ab de Bacillus thuringienisis .
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
Asesor: Soberon Chavez, Mario
Artículo
77 - Sena da Silva,I.H., Gomez,I., Pacheco,S., Sanchez,J., Zhang,J., Luque Castellane,T.C., Aparecida Desiderio J., Soberon,M., Bravo,A., Polanczyk,R.A.. Bacillus thuringiensis Cry1Ab domain III -16 is involved in binding to prohibitin which correlates with toxicity against Helicoverpa armigera (Lepidoptera: Noctuidae).
Applied and Environmental Microbiology,
87 (2).
Artículo
78 - Almanza-Martinez,N., Martinez-Diaz,S.F., Flores-Ramirez,G., Zuniga-Navarrete,F., Gomez,I., Cardona-Felix,C.S.. An alpha amylase-like protein interacts with PirB toxin from Vibrio parahaemolyticus in digestive tract tissue of white shrimp Litopenaeus vannamei.
Aquaculture Research,
51 (9),
3910-3914.
Artículo
79 - Gomez,I., Ocelotl,J., Sanchez,J., Aguilar-Medel,S., Pena-Chora,G., Lina-Garcia,L., Bravo,A., Soberon,M.. Bacillus thuringiensis Cry1Ab domain III beta-22 mutants with enhanced toxicity to Spodoptera frugiperda (J. E. Smith).
Applied and Environmental Microbiology,
86 (22).
Artículo
80 - Pacheco,S., Quiliche,J.P.J., Gomez,I., Sanchez,J., Soberon,M., Bravo,A.. Rearrangement of N-Terminal alpha-Helices of Bacillus thuringiensis Cry1Ab Toxin Essential for Oligomer Assembly and Toxicity.
Toxins (Basel),
12 (10).
Artículo
81 - Zhang,J., Jin,M., Yang,Y., Liu,L., Yang,Y., Gomez,I., Bravo,A., Soberon,M., Xiao,Y., Liu,K.. The Cadherin Protein Is Not Involved in Susceptibility to Bacillus thuringiensis Cry1Ab or Cry1Fa Toxins in Spodoptera frugiperda.
Toxins (Basel),
12 (6),
375.
Artículo
82 - Gomez, I., Ocelotl, J., Sanchez, J., Lima, C., Martins, E., Rosales-Juarez, A., Aguilar-Medel, S., Abad, A., Dong, H., Monnerat, R., Pena, G., Zhang, J., Nelson, M., Wu, G., Bravo, A., Soberon, M.. Enhancement of Bacillus thuringiensis Cry1Ab and Cry1Fa toxicity to Spodoptera frugiperda by domain III mutations indicates two limiting steps in toxicity as defined by receptor binding and protein stability.
Applied and Environmental Microbiology,
84 (20).
Artículo
83 - Gomez, I., Rodriguez-Chamorro, D.E., Flores-Ramirez, G., Grande, R., Zuniga, F., Portugal, F.J., Sanchez, J., Pacheco, S., Bravo, A., Soberon, M.. Spodoptera frugiperda (J. E. Smith) aminopeptidase N1 is functional receptor of Bacillus thuringiensis Cry1Ca toxin.
Applied and Environmental Microbiology,
84 (17).
Artículo
84 - Pacheco, S., Gomez, I., Sanchez, J., Garcia-Gomez, B.I., Czajkowsky, D.M., Zhang, J., Soberon, M., Bravo, A.. Helix alpha-3 inter-molecular salt bridges and conformational changes are essential for toxicity of Bacillus thuringiensis 3D-Cry toxin family.
Scientific Reports,
8 (1),
10331.
Artículo
85 - Pena-Cardena,A., Grande,R., Sanchez,J., Tabashnik,B.E., Bravo,A., Soberon,M., Gomez,I.. The C-terminal protoxin domain of Bacillus thuringiensis Cry1Ab toxin has a functional role in binding to GPI-anchored receptors in the insect midgut.
Journal of Biological Chemistry,
293 (52),
20263-20272.
Artículo
86 - Sena de Silva,I., Gomez,I., Sanchez,J., Martinez de Castro,D.L., Valicente,F.H., Soberon,M., Polanczyk,R.A., Bravo,A.. Identification of midgut membrane proteins from different instars of Helicoverpa armigera (Lepidoptera: Noctuidae) that bind to Cry1Ac toxin.
PLoS ONE,
13 (12).
Revisión
87 - Soberon, M., Portugal, L., Garcia-Gomez, B.I., Sanchez, J., Onofre, J., Gomez, I., Pacheco, S., Bravo, A.. Cell lines as models for the study of Cry toxins from Bacillus thuringiensis.
Insect Biochemistry and Molecular Biology,
93,
66-78.
Artículo
88 - Torres-Quintero, M.C., Gomez, I., Pacheco, S., Sanchez, J., Flores, H., Osuna, J., Mendoza, G., Soberon, M., Bravo, A.. Engineering Bacillus thuringiensis Cyt1Aa toxin specificity from dipteran to lepidopteran toxicity.
Scientific Reports,
8 (1),
4989.
Artículo
89 - Wang, Z., Fang, L., Zhou, Z., Pacheco, S., Gomez, I., Song, F., Soberon, M., Zhang, J., Bravo, A.. Specific binding between Bacillus thuringiensis Cry9Aa and Vip3Aa toxins synergizes their toxicity against Asiatic rice borer (Chilo suppressalis).
Journal of Biological Chemistry,
293 (29),
11447-11458.
Artículo
90 - Martinez de Castro, D.L, Garcia-Gomez, B.I., Gomez, I., Bravo, A., Soberon, M.. Identification of Bacillus thuringiensis Cry1AbMod binding-proteins from Spodoptera frugiperda.
Peptides,
98,
99-105.
Artículo
91 - Ocelotl, J., Sanchez, J., Gomez, I., Tabashnik, B.E., Bravo, A., Soberon, M.. ABCC2 is associated with Bacillus thuringiensis Cry1Ac toxin oligomerization and membrane insertion in diamondback moth.
Scientific Reports,
7 (1),
2386.
Artículo; Actas Paper
92 - Onofre, J., Gaytan, M.O., Pena-Cardena, A., Garcia-Gomez, B.I., Pacheco, S., Gomez, I., Bravo, A., Soberon, M.. Identification of Aminopeptidase-N2 as a Cry2Ab binding protein in Manduca sexta.
Peptides,
98,
93-98.
Artículo
93 - Pacheco, S., Gomez, I., Sanchez, J., Garcia-Gomez, B.I., Soberon, M., Bravo, A.. Intra-molecular salt bridge in Bacillus thuringiensis Cry4Ba toxin is involved in the stability of helix alpha-3 that is needed for oligomerization and insecticidal activity.
Applied and Environmental Microbiology,
83 (20).
94 - Bravo, A., Pacheco, S., Gomez, I., Garcia-Gomez, B., Onofre, J., Soberon, M.. Insecticidal Proteins from Bacillus thuringiensis and Their Mechanism of Action. Bacillus thuringiensis and Lysinibacillus sphaericus: Characterization and use in the field of biocontrol.
53-66,
Cham: Springer.
*
Artículo
95 - Serratos,I.N., Castellanos,P., Pastor,N., Millan-Pacheco,C., Colin-Gonzalez,A.L., Rembao,D., Perez-Montfort,R., Cabrera,N., Sanchez-Garcia,A., Gomez,I., Rangel-Lopez,E., Santamaria,A.. Early expression of the receptor for advanced glycation end products in a toxic model produced by 6-hydroxydopamine in the rat striatum.
Chemico-Biological Interactions,
249,
10-18.
Artículo
96 - Gomez,I., Flores,B., Bravo,A., Soberon,M.. Bacillus thuringiensis Cry1AbMod toxin counters tolerance associated with low cadherin expression but not that associated with low alkaline phosphatase expression in Manduca sexta.
Peptides,
68 (1),
130-133.
Artículo
97 - Ocelotl,J., Sanchez,J., Arroyo,R., Garcia-Gomez,B.I., Gomez,I., Unnithan,G.C., Tabashnik,B.E., Bravo,A., Soberon,M.. Binding and Oligomerization of Modified and Native Bt Toxins in Resistant and Susceptible Pink Bollworm.
PLoS ONE,
10 (12).
Artículo
98 - Zuniga-Navarrete,F., Gomez,I., Pena,G., Amaro,I., Ortiz,E., Becerril,B., Ibarra,J.E., Bravo,A., Soberon,M.. Identification of Bacillus thuringiensis Cry3Aa toxin domain II loop 1 as the binding site of Tenebrio molitor cadherin repeat CR12.
Insect Biochemistry and Molecular Biology,
59,
50-57.
Internacional
99 - Bravo, A., Martinez-de-Castro, D. L., Sanchez-Quintana, J., Canton, P. E., Mendoza, G., Gomez, I., Pacheco, S., Garcia-Gomez, B. I., Onofre, J., Ocelotl, J., Soberon, M.. Mechanism of action of Bacillus thuringiensis insecticidal toxins and their use in the control of insect pests. Comprehensive Sourcebook of Bacterial Protein Toxins.
858-873,
4a ed.
Internacional
100 - Bravo,A., Gomez,I., Mendoza,G., Gaytan,M., Soberon,M.. Different models of the mode of action of Bt 3d-Cry toxins. Bt resistance - characterization and strategies for GM crops expressing Bacillus thuringiensis toxins .
56-68,
Oxford.
Internacional
101 - Grande-Cano,R.A., Gomez I.. Identification and characterization of receptors for insecticidal toxins from Bacillus thuringiensis. Biocontrol of Lepidopteran Pests: Use of Soil Microbes and their Metabolites .
Soil Biology,
71-88.
Artículo
102 - Gomez,I., Sanchez,J., Munoz-Garay,C., Matus,V., Gill,S.S., Soberon,M., Bravo,A.. Bacillus thuringiensis Cry1A toxins are versatile-proteins with multiple modes of action: two distinct pre-pores are involved in toxicity.
Biochemical Journal,
459 (2),
383-396.
Memoria in extenso
103 - Soberon,M., Gomez,I., Garcia-Gomez,B.I., Carmona,D., Ocelotl,J., Villanueva,F., Flores,B., Bravo,A.. Mode of action of mosquitocidal toxins from Bacillus thuringiensis and their use in control of insect vectors of human diseases. Biotechnology: beyond borders.
Proceedings of the Indo-Mexico workshop on Biotechnology held at CSIR NCL, Pune, India from October 7-9, 2013.,
279-288.
Revisión
104 - Bravo,A., Gomez,I., Porta,H., Garcia-Gomez,B.I., Rodriguez-Almazan,C., Pardo,L., Soberon,M.. Evolution of Bacillus thuringiensis Cry toxins insecticidal activity.
Microbial Biotechnology,
6 (1),
17-26.
Artículo
105 - Flores-Escobar,B., Rodriguez-Magadan,H., Bravo,A., Soberon,M., Gomez,I.. Differential role of Manduca sexta aminopeptidase-N and alkaline phosphatase in the mode of action of Cry1Aa, Cry1Ab, and Cry1Ac toxins from Bacillus thuringiensis.
Applied and Environmental Microbiology,
79 (15),
4543-4550.
Artículo; Actas Paper
Artículo
107 - Rodriguez-Almazan,C., Reyes,E.Z., Zuniga-Navarrete,F., Munoz-Garay,C., Gomez,I., Evans,A.M., Likitvivatanavong,S., Bravo,A., Gill,S.S., Soberon,M.. Cadherin binding is not a limiting step for Bacillus thuringiensis subs. israelensis Cry4Ba toxicity to Aedes aegypti larvae.
Biochemical Journal,
443,
711-717.
Internacional
108 - Flores-Escobar,B., Zuniga-Navarrete,F., Sanchez,J., Gomez,I.. Protein-protein interaction detection on membrane supports. Tools to Understand Protein-Protein Interactions.
55-70,
Kerala: Research Signpost.
Internacional
109 - Grande-Cano,R., Gomez,I.. Protein expression and purification. Tools to Understand Protein-Protein Interactions.
41-54,
Kerala: Research Signpost.
Internacional
110 - Zuniga-Navarrete,F., Bravo,A., Soberon,M., Gomez,I.. Role of GPI-anchored membrane receptors in the mode of action of Bacillus thuringiensis Cry toxins. Integrated Pest Management and Pest Control- Current and Future Tactics .
551-566.
Revisión
111 - Terenius,O., Papanicolaou,A., Garbutt,J.S., Eleftherianos,I., Huvenne,H., Sriramana,K., Albrechtsen,M., An,C., Aymeric,J.L., Barthel,A., Bebas,P., Bitra,K., Bravo,A., Chevalier,F., Collinge,D.P., Crava,C.M., de Maagd,R.A., Duvic,B., Erlandson,M., Faye,I., Felfoldi,G., Fujiwara,H., Futahashi,R., Gandhe,A.S., Gatehouse,H.S., Gatehouse,L.N., Giebultowicz,J., Gomez,I., Grimmelikhuijzen,C.J., Groot,A.T., Hauser,F., Heckel,D.G., Hegedus,D.D., Hrycaj,S., Huang,L., Hull,J.J., Iatrou,K., Iga,M., Kanost,M.R., Kotwica,J., Li,C., Li,J., Liu,J., Lundmark,M., Matsumoto,S., Meyering-Vos,M., Millichap,P.J., Monteiro,A., Mrinal,N., Niimi,T., Nowara,D., Ohnishi,A., Oostra,V., Ozaki,K., Papakonstantinou,M., Popadic,A., Rajam,M.V., Saenko,S., Simpson,R.M., Soberon,M., Strand,M.R., Tomita,S., Toprak,U., Wang,P., Wee,C.W., Whyard,S., Zhang,W., Nagaraju,J., Ffrench-Constant,R.H., Herrero,S., Gordon,K., Swevers,L., Smagghe,G., et al. RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design.
Journal of Insect Physiology,
57 (2),
231-245.
Artículo
112 - Zavala,L.E., Pardo-Lopez,L., Canton,P.E., Gomez,I., Soberon,M., Bravo,A.. Domains II and III of Bacillus thuringiensis Cry1Ab toxin remain exposed to the solvent after insertion of part of domain I into the membrane.
Journal of Biological Chemistry,
286 (21),
19109-19117.
Artículo
113 - Arenas,I., Bravo,A., Soberon,M., Gomez,I.. Role of alkaline phosphatase from Manduca sexta in the mechanism of action of Bacillus thuringiensis Cry1Ab toxin.
Journal of Biological Chemistry,
285 (17),
12497-503.
Artículo
114 - Gomez,I., Arenas,I., Pacheco,S., Bravo,A., Soberon,M.. New Insights into the Mode of Action of Cry1Ab Toxin Used in Transgenic Insect-resistant Crops.
Southwestern Entomologist,
35 (3),
387-390.
Internacional
115 - Soberon,M., Pardo,L., Munoz-Garay,C., Sanchez,J., Gomez,I., Porta,H., Bravo,A.. Pore Formation by Cry Toxins. Proteins: Membrane Binding and Pore Formation.
Advances in Experimental Medicine and Biology,
127-142,
Austin, TX: Landes Bioscience.
Artículo
116 - Munoz-Garay,C., Portugal,L., Pardo-Lopez,L., Jimenez-Juarez,N., Arenas,I., Gomez,I., Sanchez-Lopez,R., Arroyo,R., Holzenburg,A., Savva,C.G., Soberon,M., Bravo,A.. Characterization of the mechanism of action of the genetically modified Cry1AbMod toxin that is active against Cry1Ab-resistant insects.
Biochimica et Biophysica Acta (BBA) - Biomembranes,
1788 (10),
2229-2237.
Artículo
117 - Munoz-Garay,C., Rodriguez-Almazan,C., Aguilar,J.N., Portugal,L., Gomez,I., Saab-Rincon,G., Soberon,M., Bravo,A.. Oligomerization of Cry11Aa from Bacillus thuringiensis has an important role in toxicity against Aedes aegypti.
Applied and Environmental Microbiology,
75 (23),
7548-7550.
Artículo
118 - Pacheco,S., Gomez,I., Arenas,I., Saab-Rincon,G., Rodriguez-Almazan,C., Gill,S.S., Bravo,A., Soberon,M.. Domain II loop 3 of Bacillus thuringiensis Cry1Ab toxin is involved in a "ping-pong" binding mechanism with Manduca sexta aminopetidase-N and cadherin receptors.
Journal of Biological Chemistry,
284 (47),
32750-32757.
Artículo
119 - Pacheco,S., Gomez,I., Gill,S.S., Bravo,A., Soberon,M.. Enhancement of insecticidal activity of Bacillus thuringiensis Cry1A toxins by fragments of a toxin-binding cadherin correlates with oligomer formation.
Peptides,
30 (3),
583-588.
Artículo; Actas Paper
120 - Fernandez,L.E., Gomez,I., Pacheco,S., Arenas,I., Gill,S.S., Bravo,A., Soberon,M.. Employing phage display to study the mode of action of Bacillus thuringiensis Cry toxins.
Peptides,
29 (2),
324-329.
Artículo; Actas Paper
121 - Jimenez-Juarez,N., Munoz-Garay,C., Gomez,I., Gill,S.S., Soberon,M., Bravo,A.. The pre-pore from Bacillus thuringiensis Cry1Ab toxin is necessary to induce insect death in Manduca sexta.
Peptides,
29 (2),
318-323.
Artículo; Actas Paper
122 - Gomez,I., Pardo-Lopez,L., Munoz-Garay,C., Fernandez,L.E., Perez,C., Sanchez,J., Soberon,M., Bravo,A.. Role of receptor interaction in the mode of action of insecticidal Cry and Cyt toxins produced by Bacillus thuringiensis.
Peptides,
28 (1),
169-173.
Artículo
123 - Jimenez-Juarez,N., Munoz-Garay,C., Gomez,I., Saab-Rincon,G., Damian-Almazo,J.Y., Gill,S.S., Soberon,M., Bravo,A.. Bacillus thuringiensis Cry1Ab mutants affecting oligomer formation are non toxic to Manduca sexta larvae.
Journal of Biological Chemistry,
282 (29),
21222-21229.
Artículo
124 - Soberon,M., Pardo-Lopez,L., Lopez,I., Gomez,I., Tabashnik,B.E., Bravo,A.. Engineering Modified Bt Toxins to Counter Insect Resistance.
Science,
318 (5856),
1640-1642 [erratum vol 345 (6198) art num 1256132].
Memoria in extenso
125 - Gomez,I., Miranda-Rios,J., Arenas,I., Grande,R., Becerril,B., Bravo,A., Soberon,M.. Identification of scFv Molecules that Recognize Loop 3 of Domain II and Domain III of Cry1Ab Toxin from Bacillus thuringiensis. 6th Pacific Rim Conference on the biotechnology of Bacillus thuringiensis and its Environmental Impact .
12-14,
Montreal.
Memoria in extenso
126 - Pardo,L., Gomez,I., Munoz-Garay,C., Jimenez-Juarez,N., Sanchez,J., Perez,C., Soberon,M., Bravo,A.. Oligomer Formation of Different Cry Toxins Indicates that a Pre-Pore is an Essential Intermediate in the Mode of Action of the Three-Domain Cry Family. Proceedings of the 6th Pacific Rim Conference on the Biotechnology of Bacillus thuringiensis and its Environmental Impact.
7-8.
Memoria in extenso
127 - Soberon,M., Gomez,I., Pardo,L., Munoz,C., Fernandez,L.E., Perez,C., Gill,S.S., Bravo,A.. Important Interactions with membrane Receptors in the Mode of Action of Bacillus thuringiensis Cry toxins. 6th Pacific Rim Conference on the biotechnology of Bacillus thuringiensis and its Environmental Impact , cap 1.
1-6,
Montreal.
Artículo
128 - Gomez,I., Arenas,I., Benitez,I., Miranda-Rios,J., Becerril,B., Grande,R., Almagro,J.C., Bravo,A., Soberon,M.. Specific epitopes of domains II and IIII of bacillus thuringiensis Cry1Ab toxin involved in the sequential interaction with cadherin and aminopeptidase-N receptors in manduca sexta.
Journal of Biological Chemistry,
281 (45),
34032-34039.
Artículo
129 - Pacheco,S., Gomez,I., Sato,R., Bravo,A., Soberon,M.. Functional display of Bacillus thuringiensis Cry1Ac toxin on T7 phage.
Journal of Invertebrate Pathology,
92 (1),
45-49.
Artículo
130 - Padilla,C., Pardo-Lopez,L., de la Riva,G., Gomez,I., Sanchez,J., Hernandez,G., Nunez,M.E., Carey,M.P., Dean,D.H., Alzate,O., Soberon,M., Bravo,A.. Role of Tryptophan Residues in Toxicity of Cry1Ab Toxin from Bacillus thuringiensis.
Applied and Environmental Microbiology,
72 (1),
901-907.
Artículo
131 - Pardo-Lopez,L., Gomez,I., Rausell,C., Sanchez,J., Soberon,M., Bravo,A.. Structural Changes of the Cry1Ac Oligomeric Pre-Pore from Bacillus thuringiensis Induced by N-Acetylgalactosamine Facilitates Toxin Membrane Insertion.
Biochemistry,
45 (34),
10329-10336.
Artículo; Actas Paper
132 - Pardo-Lopez,L., Gomez,I., Munoz-Garay,C., Jimenez-Juarez,N., Soberon,M., Bravo,A.. Structural and functional analysis of the pre-pore and membrane-inserted pore of Cry1Ab toxin.
Journal of Invertebrate Pathology,
92 (3),
172-177.
Nacional
133 - Ibarra,J.E., Castro,M.C., Galindo,E., Patino,M., Serrano,L., Garcia,R., Carrillo,J.A., Pereyra-Alferez,B., Alcazar-Pizana,A., Luna-Olvera,H., Galan-Wong,L., Pardo,L., Munoz-Garay,C., Gomez,I., Soberon,M., Bravo,A.. [Microorganisms in the biological control of insects and phytopathogens].
Revista Latinoamericana de Microbiologia,
48 (2),
113-120.
Artículo
134 - Xie,R., Zhuang,M., Ross,L.S., Gomez,I., Oltean,D.I., Bravo,A., Soberon,M., Gill,S.S.. Single amino acid mutations in the cadherin receptor from heliothis virescens affect its toxin binding ability to Cry1A toxins.
Journal of Biological Chemistry,
280 (9),
8416-8425.
Artículo
135 - Bravo,A., Gomez,I., Conde,J., Munoz-Garay,C., Sanchez,J., Miranda,R., Zhuang,M., Gill,S.S., Soberon,M.. Oligomerization triggers binding of a Bacillus thuringiensis Cry1Ab pore-forming toxin to aminopeptidase N receptor leading to insertion into membrane microdomains.
1667 (1),
38-46.
Artículo
136 - Rausell,C., Munoz-Garay,C., Miranda-CassoLuengo,R., Gomez,I., Rudino-Pinera,E., Soberon,M., Bravo,A.. Tryptophan Spectroscopy Studies and Black Lipid Bilayer Analysis Indicate that the Oligomeric Structure of Cry1Ab Toxin from Bacillus thuringiensis Is the Membrane-Insertion Intermediate.
Biochemistry,
43 (1),
166-174.
Internacional
137 - Soberon,M., Nuñez,M., Gomez I., Sanchez-Quintana,J., Bravo,A.. Functional studies of helix a-5 region from Bacillus thuringiensis Cry1Ab d-endotoxin shows that conserved residues are important for pore formation and stability but not for oligomer formation. Pore-forming peptides and protein toxins.
Cellular and molecular mechanisms of toxin action ;v. 5,
90-101,
London ;New York.
Artículo
138 - Gomez,I., Dean,D.H., Bravo,A., Soberon,M.. Molecular Basis for Bacillus thuringiensis Cry1Ab Toxin Specificity: Two Structural Determinants in the Manduca sexta Bt-R(1) Receptor Interact with Loops alpha-8 and 2 in Domain II of Cy1Ab Toxin.
Biochemistry,
42 (35),
10482-10489.
Artículo
139 - Bravo,A., Miranda,R., Gomez,I., Soberon,M.. Pore formation activity of Cry1Ab toxin from Bacillus thuringiensis in an improved membrane vesicle preparation from Manduca sexta midgut cell microvilli.
1562 (1-2),
63-69.
Artículo
140 - Gomez,I., Miranda-Rios,J., Rudino-Pinera,E., Oltean,D.I., Gill,S.S., Bravo,A., Soberon,M.. Hydropathic complementarity determines interaction of epitope 869HITDTNNK876 in Manduca sexta Bt-R1 receptor with loop 2 of domain II of Bacillus thuringiensis Cry1A toxins.
Journal of Biological Chemistry,
277 (33),
30137-30143.
Artículo
141 - Gomez,I., Sanchez,J., Miranda,R., Bravo,A., Soberon,M.. Cadherin-like receptor binding facilitates proteolytic cleavage of helix alpha-1 in domain I and oligomer pre-pore formation of Bacillus thuringiensis Cry1Ab toxin.
FEBS Letters,
513 (2-3),
242-246.
Artículo
142 - Miranda,R., Gomez,I., Soberon,M., Bravo,A.. Mecanismo de accion de las toxinas Cry de Bacillus Thuringiensis.
TIP revista especializada en Ciencias Quimico-Biologicas,
5,
5-13.
Artículo
143 - Zhuang,M., Oltean,D.I., Gomez,I., Pullikuth,A.K., Soberon,M., Bravo,A., Gill,S.S.. Heliothis virescens and Manduca sexta lipid rafts are involved in Cry1A toxin binding to the midgut epithelium and subsequent pore formation.
Journal of Biological Chemistry,
277 (16),
13863-13872.
144 - Gomez Gomez, Isabel. Caracterizacion de un anticuerpo scFv que mimetiza el receptor natural de la proteina Cry1Ab de Bacillus thuringienisis .
Instituto de Biotecnologia,
Doctorado en Ciencias Bioquimicas,
UNAM.
Asesor: Soberon Chavez, Mario
Artículo
145 - Gomez,I., Oltean,D.I., Gill,S., Bravo,A., Soberon,M.. Mapping the epitope in cadherin-like receptors involved in Bacillus thuringiensis Cry1A toxins interaction using phage display.
Journal of Biological Chemistry,
276 (31),
28906-28912.
Artículo
146 - Soberon,M., Perez,R.V., Nunez-Valdez,M.E., Lorence,A., Gomez,I., Sanchez,J., Bravo,A.. Evidence for intermolecular interaction as a necessary step for pore-formation activity and toxicity of Bacillus thuringiensis Cry1Ab toxin.
Fems Microbiology Letters,
191 (2),
221-225.