Dr. Gerardo Jose Orta Salazar
Investigador Posdoctoral CONAHCyT
Biología Molecular y Celular de Animales
- Graduados
1 - Loyo Celis, Veronica (2015). Caracterización electrofisiológica y farmacológica del canal slo3 en células espermatogénicas de ratón.
Facultad de Estudios Superiores Zaragoza,
Licenciatura en Biología,
UNAM.
*
Asesor: Orta Salazar, Gerardo Jose
Total de publicaciones: 32
- Tipo
- Fecha
Artículo
2 - Sanchez-Cardenas,C., de la Vega-Beltran,J.L., Weber,W.D., Orta,G., Sanchez-Guevara,Y., Hernandez-Cruz,A., Darszon,A., Visconti,P.E. (2024). Intracellular Mg2+ concentrations are differentially regulated in the sperm head and mid-piece in acrosome reaction inducing conditions.
FASEB Journal,
38 (21),
e70129.
Artículo
3 - Lopez-Gonzalez,I., Sanchez-Cardenas,C., de la Vega-Beltran,J.L., Alvarado-Quevedo,B., Ocelotl-Oviedo,J.P., Gonzalez-Cota,A.L., Aldana,A., Orta,G., Darszon,A. (2023). ATP increases head volume in capacitated human sperm via a purinergic channel.
Biochemical and Biophysical Research Communications,
671,
318-326.
Artículo
4 - Mendoza-Sanchez,J.E., Rodriguez-Tobon,A., Arenas-Rios,E., Orta-Salazar,G., Leon-Galvan,M.A., Trevino Santa Cruz,C.L., Chavez,J.C. (2023). Sperm calcium flux and membrane potential hyperpolarization observed in the Mexican big-eared bat Corynorhinus mexicanus.
Journal of Experimental Biology,
226 (2),
jeb.244878.
Artículo
5 - Yang,F., Gervasi,M.G., Leu,N.A., Orta,G., Tourzani,D.A., de la Vega-Beltran,J.L., Ruthel,G., Darszon,A., Visconti,P.E., Wang,P.J. (2022). C2CD6 regulates targeting and organization of the CatSper calcium channel complex in sperm flagella.
Development,
149 (2),
dev.199988.
Revisión
6 - Gonzalez-Cota,A.L., Santana-Calvo,C., Servin-Vences,R., Orta,G., Balderas,E. (2021). Regulatory mechanisms of mitochondrial BK(Ca) channels.
Channels (Austin.),
15 (1),
424-437.
Artículo
7 - Loyo-Celis,V., Orta,G., Beltran,C., Darszon,A. (2021). CatSper channels in sea urchin sperm.
Cell Calcium,
99,
102466.
Artículo
8 - Luque,G.M., Xu,X., Romarowski,A., Gervasi,M.G., Orta,G., de la Vega-Beltran,J.L., Stival,C., Gilio,N., Dalotto-Moreno,T., Krapf,D., Visconti,P.E., Krapf,D., Darszon,A., Buffone,M.G. (2021). Cdc42 localized in the CatSper signaling complex regulates cAMP-dependent pathways in mouse sperm.
FASEB Journal,
35 (8),
e21723.
Artículo
9 - Sanchez-Cardenas,C., Romarowski,A., Orta,G., de la Vega-Beltran,J.L., Martin-Hidalgo,D., Hernandez-Cruz,A., Visconti,P.E., Darszon,A. (2021). Starvation induces an increase in intracellular calcium and potentiates the progesterone-induced mouse sperm acrosome reaction.
FASEB Journal,
35 (4),
e21528.
Artículo
10 - Zhao,R., Dai,H., Arias,R.J., de Blas,G.A., Orta,G., Pavarotti,M.A., Shen,R., Perozo,E., Mayorga,L.S., Darszon,A., Goldstein,S.A.N. (2021). Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils.
Nature Communications,
12 (1),
3855.
Artículo
11 - Orta, G., Vega-Beltran, J. L., Hidalgo, D., Santi, C. M., Visconti, P., Darszon, A. (2018). CatSper channels are regulated by protein kinase A.
Journal of Biological Chemistry,
293 (43),
16830.
Artículo
12 - Zhao,R., Kennedy,K., de Blas,G.A., Orta,G., Pavarotti,M.A., Arias,R.J., De la Vega-Beltran JL, Li,Q., Dai,H., Perozo,E., Mayorga,L.S., Darszon,A., Goldstein,S.A.N. (2018). Role of human Hv1 channels in sperm capacitation and white blood cell respiratory burst established by a designed peptide inhibitor.
Proceedings of the National Academy of Sciences of the United States of America,
115 (50),
E11847-E11856.
Artículo
13 - Ernesto,J.I., Weigel-Munoz M., Battistone,M.A., Vasen,G., Martinez-Lopez,P., Orta,G., Figueiras-Fierro,D., de la Vega-Beltran,J.L., Moreno,I.A., Guidobaldi,H.A., Giojalas,L., Darszon,A., Cohen,D.J., Cuasnicu,P.S. (2015). CRISP1 as a novel CatSper regulator that modulates sperm motility and orientation during fertilization.
Journal of Cell Biology,
210 (7),
1213-1224.
Revisión
14 - Perez-Gonzalez,D., Sedeno-Monge,V., Orta-Salazar,G. (2015). The Role of Transient Receptor Potential Channels in Cancer.
Journal of Cancerology,
2 (4),
151-16.
*
Artículo
15 - Figueiras-Fierro,D., Acevedo,J.J., Martinez-Lopez,P., Escoffier,J., Sepulveda,F.V., Balderas,E., Orta,G., Visconti,P., Darszon,A. (2013). Electrophysiological evidence for the presence of cystic fibrosis transmembrane conductance regulator (CFTR) in mouse sperm.
Journal of Cellular Physiology,
228 (3),
590-601.
Revisión
16 - Santi,C.M., Orta,G., Salkoff,L., Visconti,P.E., Darszon,A., Trevino,C.L. (2013). K(+) and cl(-) channels and transporters in sperm function.
Current Topics in Developmental Biology,
102,
385-421.
Revisión
17 - Darszon,A., Sanchez-Cardenas,C., Orta,G., Sanchez-Tusie,A.A., Beltran,C., Lopez-Gonzalez,I., Granados-Gonzalez,G., Trevino,C.L. (2012). Are TRP channels involved in sperm development and function?.
Cell and Tissue Research,
349 (3),
749-764.
Artículo
18 - Orta,G., Ferreira,G., Jose,O., Trevino,C.L., Beltran,C., Darszon,A. (2012). Human spermatozoa possess a calcium-dependent chloride channel that may participate in the acrosomal reaction.
Journal of Physiology,
590 (11),
2659-2675.
Artículo
19 - Gibbs,G.M., Orta,G., Reddy,T., Koppers,A.J., Martinez-Lopez,P., de la Vega-Beltran,J.L., Lo,J.C., Veldhuis,N., Jamsai,D., McIntyre,P., Darszon,A., O'Bryan,M.K. (2011). Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function.
Proceedings of the National Academy of Sciences of the United States of America,
108 (17),
7034-7039.
Artículo
20 - Martinez-Lopez,P., Trevino,C.L., de la Vega-Beltran,J.L., Blas,G.D., Monroy,E., Beltran,C., Orta,G., Gibbs,G.M., O'Bryan,M.K., Darszon,A. (2011). TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction.
Journal of Cellular Physiology,
226 (6),
1620-1631.
Artículo
21 - Brauchi,S., Orta,G., Mascayano,C., Salazar,M., Raddatz,N., Urbina,H., Rosenmann,E., Gonzalez-Nilo,F., Latorre,R. (2007). Dissection of the components for PIP2 activation and thermosensation in TRP channels.
Proceedings of the National Academy of Sciences of the United States of America,
104 (24),
10246-10251.
*
Artículo
22 - Latorre,R., Brauchi,S., Orta,G., Zaelzer,C., Vargas,G. (2007). Thermo TRP channels as modular proteins with allosteric gating.
Cell Calcium,
42 (4-5),
427-438.
*
Artículo
23 - Brauchi,S., Orta,G., Salazar,M., Rosenmann,E., Latorre,R. (2006). A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels.
Journal of Neuroscience,
26 (18),
4835-4840.
*
Artículo
24 - Alvarez,J.L., Salinas-Stefanon,E., Orta,G., Ferrer,T., Talavera,K., Galan,L., Vassort,G. (2004). Occurrence of a tetrodotoxin-sensitive calcium current in rat ventricular myocytes after long-term myocardial infarction.
Cardiovascular Research,
63 (4),
653-661.
*
Artículo
25 - Cruz,S.L., Orta-Salazar,G., Gauthereau,M.Y., Millan-Perez Pena,L., Salinas-Stefanon,E.M. (2003). Inhibition of cardiac sodium currents by toluene exposure.
British Journal of Pharmacology,
140 (4),
653-660.
*
Artículo
26 - Orta-Salazar,G., Bouchard,R.A., Morales-Salgado,F., Salinas-Stefanon,E.M. (2002). Inhibition of cardiac Na+ current by primaquine.
British Journal of Pharmacology,
135 (3),
751-763.
*
Artículo
27 - Galan,L., Ferrer,T., Artiles,A., Talavera,K., Salinas,E., Orta,G., Garcia-Barreto,D., Alvarez,J.L. (2001). Cardiac cellular actions of hydrochlorothiazide.
Fundamental and Clinical Pharmacology,
15 (1),
9-17.
*
Capítulo internacional
28 - Darszon, A., Ferreira, J.J., López-González, I., Orta, G., Treviño, C.L., Santi, C.M. (2022). Voltage-Dependent Calcium Channels (CaVs) and CatSper in Spermatogenic and Sperm Cells, in Voltage Gated Calcium Channels. Voltage-Gated Calcium Channels.
Cham: Springer.
Internacional
29 - Nishigaki,T., Gonzalez-Cota,A.L., Orta Salazar,G.J. (2014). CatSper in Male Infertility. Pathologies of Calcium Channels.
713-728,
Berlin, Heidelberg: Springer.
Memoria in extenso
30 - Trevino,C.L., Orta,G., Figueiras-Fierro,D., De la Vega-Beltran JL, Ferreira,G., Balderas,E., Jose,O., Darszon,A. (2014). Cl- channels and transporters in sperm physiology. Sexual Reproduction in Animals and Plants .
59-84,
Tokyo.
Internacional
31 - Brauchi,S., Vargas,G., Latorre,R., Orta,G. (2006). Voltage and Temperature Gating of ThermoTRP Channels. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades.
Frontiers in Neuroscience,
287-302.
*
Nacional divulgación
32 - de la Vega-Beltran,J.L., Sanchez-Cardenas,C., Orta,G. (2022). ¿Espermatozoides más fértiles después de una privación de nutrientes?.
Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM,
31 (Octubre-Diciembre).
Preprint
33 - Luque,G.M., Romarowski,A., Gervasi,M.G., Orta,G., de la Vega-Beltran,J., Stival,C., Gilio,N., Dalotto-Moreno,T., Krapf,D., Visconti,P.E., Krapf,D., Darszon,A., Buffone,M.G. (2020). Cdc42 activity is essential for the interplay between cAMP/PKA pathway and CatSper function.
bioRxiv,
Preprint posted August 25, 2020.
Artículo
34 - Sanchez-Cardenas,C., de la Vega-Beltran,J.L., Weber,W.D., Orta,G., Sanchez-Guevara,Y., Hernandez-Cruz,A., Darszon,A., Visconti,P.E.. Intracellular Mg2+ concentrations are differentially regulated in the sperm head and mid-piece in acrosome reaction inducing conditions.
FASEB Journal,
38 (21),
e70129.
Artículo
35 - Lopez-Gonzalez,I., Sanchez-Cardenas,C., de la Vega-Beltran,J.L., Alvarado-Quevedo,B., Ocelotl-Oviedo,J.P., Gonzalez-Cota,A.L., Aldana,A., Orta,G., Darszon,A.. ATP increases head volume in capacitated human sperm via a purinergic channel.
Biochemical and Biophysical Research Communications,
671,
318-326.
Artículo
36 - Mendoza-Sanchez,J.E., Rodriguez-Tobon,A., Arenas-Rios,E., Orta-Salazar,G., Leon-Galvan,M.A., Trevino Santa Cruz,C.L., Chavez,J.C.. Sperm calcium flux and membrane potential hyperpolarization observed in the Mexican big-eared bat Corynorhinus mexicanus.
Journal of Experimental Biology,
226 (2),
jeb.244878.
Artículo
37 - Yang,F., Gervasi,M.G., Leu,N.A., Orta,G., Tourzani,D.A., de la Vega-Beltran,J.L., Ruthel,G., Darszon,A., Visconti,P.E., Wang,P.J.. C2CD6 regulates targeting and organization of the CatSper calcium channel complex in sperm flagella.
Development,
149 (2),
dev.199988.
Capítulo internacional
38 - Darszon, A., Ferreira, J.J., López-González, I., Orta, G., Treviño, C.L., Santi, C.M.. Voltage-Dependent Calcium Channels (CaVs) and CatSper in Spermatogenic and Sperm Cells, in Voltage Gated Calcium Channels. Voltage-Gated Calcium Channels.
Cham: Springer.
Nacional divulgación
39 - de la Vega-Beltran,J.L., Sanchez-Cardenas,C., Orta,G.. ¿Espermatozoides más fértiles después de una privación de nutrientes?.
Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM,
31 (Octubre-Diciembre).
Revisión
40 - Gonzalez-Cota,A.L., Santana-Calvo,C., Servin-Vences,R., Orta,G., Balderas,E.. Regulatory mechanisms of mitochondrial BK(Ca) channels.
Channels (Austin.),
15 (1),
424-437.
Artículo
41 - Loyo-Celis,V., Orta,G., Beltran,C., Darszon,A.. CatSper channels in sea urchin sperm.
Cell Calcium,
99,
102466.
Artículo
42 - Luque,G.M., Xu,X., Romarowski,A., Gervasi,M.G., Orta,G., de la Vega-Beltran,J.L., Stival,C., Gilio,N., Dalotto-Moreno,T., Krapf,D., Visconti,P.E., Krapf,D., Darszon,A., Buffone,M.G.. Cdc42 localized in the CatSper signaling complex regulates cAMP-dependent pathways in mouse sperm.
FASEB Journal,
35 (8),
e21723.
Artículo
43 - Sanchez-Cardenas,C., Romarowski,A., Orta,G., de la Vega-Beltran,J.L., Martin-Hidalgo,D., Hernandez-Cruz,A., Visconti,P.E., Darszon,A.. Starvation induces an increase in intracellular calcium and potentiates the progesterone-induced mouse sperm acrosome reaction.
FASEB Journal,
35 (4),
e21528.
Artículo
44 - Zhao,R., Dai,H., Arias,R.J., de Blas,G.A., Orta,G., Pavarotti,M.A., Shen,R., Perozo,E., Mayorga,L.S., Darszon,A., Goldstein,S.A.N.. Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils.
Nature Communications,
12 (1),
3855.
Preprint
45 - Luque,G.M., Romarowski,A., Gervasi,M.G., Orta,G., de la Vega-Beltran,J., Stival,C., Gilio,N., Dalotto-Moreno,T., Krapf,D., Visconti,P.E., Krapf,D., Darszon,A., Buffone,M.G.. Cdc42 activity is essential for the interplay between cAMP/PKA pathway and CatSper function.
bioRxiv,
Preprint posted August 25, 2020.
Artículo
46 - Orta, G., Vega-Beltran, J. L., Hidalgo, D., Santi, C. M., Visconti, P., Darszon, A.. CatSper channels are regulated by protein kinase A.
Journal of Biological Chemistry,
293 (43),
16830.
Artículo
47 - Zhao,R., Kennedy,K., de Blas,G.A., Orta,G., Pavarotti,M.A., Arias,R.J., De la Vega-Beltran JL, Li,Q., Dai,H., Perozo,E., Mayorga,L.S., Darszon,A., Goldstein,S.A.N.. Role of human Hv1 channels in sperm capacitation and white blood cell respiratory burst established by a designed peptide inhibitor.
Proceedings of the National Academy of Sciences of the United States of America,
115 (50),
E11847-E11856.
Artículo
48 - Ernesto,J.I., Weigel-Munoz M., Battistone,M.A., Vasen,G., Martinez-Lopez,P., Orta,G., Figueiras-Fierro,D., de la Vega-Beltran,J.L., Moreno,I.A., Guidobaldi,H.A., Giojalas,L., Darszon,A., Cohen,D.J., Cuasnicu,P.S.. CRISP1 as a novel CatSper regulator that modulates sperm motility and orientation during fertilization.
Journal of Cell Biology,
210 (7),
1213-1224.
Revisión
49 - Perez-Gonzalez,D., Sedeno-Monge,V., Orta-Salazar,G.. The Role of Transient Receptor Potential Channels in Cancer.
Journal of Cancerology,
2 (4),
151-16.
*
Internacional
50 - Nishigaki,T., Gonzalez-Cota,A.L., Orta Salazar,G.J.. CatSper in Male Infertility. Pathologies of Calcium Channels.
713-728,
Berlin, Heidelberg: Springer.
Memoria in extenso
51 - Trevino,C.L., Orta,G., Figueiras-Fierro,D., De la Vega-Beltran JL, Ferreira,G., Balderas,E., Jose,O., Darszon,A.. Cl- channels and transporters in sperm physiology. Sexual Reproduction in Animals and Plants .
59-84,
Tokyo.
Artículo
52 - Figueiras-Fierro,D., Acevedo,J.J., Martinez-Lopez,P., Escoffier,J., Sepulveda,F.V., Balderas,E., Orta,G., Visconti,P., Darszon,A.. Electrophysiological evidence for the presence of cystic fibrosis transmembrane conductance regulator (CFTR) in mouse sperm.
Journal of Cellular Physiology,
228 (3),
590-601.
Revisión
53 - Santi,C.M., Orta,G., Salkoff,L., Visconti,P.E., Darszon,A., Trevino,C.L.. K(+) and cl(-) channels and transporters in sperm function.
Current Topics in Developmental Biology,
102,
385-421.
Revisión
54 - Darszon,A., Sanchez-Cardenas,C., Orta,G., Sanchez-Tusie,A.A., Beltran,C., Lopez-Gonzalez,I., Granados-Gonzalez,G., Trevino,C.L.. Are TRP channels involved in sperm development and function?.
Cell and Tissue Research,
349 (3),
749-764.
Artículo
55 - Orta,G., Ferreira,G., Jose,O., Trevino,C.L., Beltran,C., Darszon,A.. Human spermatozoa possess a calcium-dependent chloride channel that may participate in the acrosomal reaction.
Journal of Physiology,
590 (11),
2659-2675.
Artículo
56 - Gibbs,G.M., Orta,G., Reddy,T., Koppers,A.J., Martinez-Lopez,P., de la Vega-Beltran,J.L., Lo,J.C., Veldhuis,N., Jamsai,D., McIntyre,P., Darszon,A., O'Bryan,M.K.. Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function.
Proceedings of the National Academy of Sciences of the United States of America,
108 (17),
7034-7039.
Artículo
57 - Martinez-Lopez,P., Trevino,C.L., de la Vega-Beltran,J.L., Blas,G.D., Monroy,E., Beltran,C., Orta,G., Gibbs,G.M., O'Bryan,M.K., Darszon,A.. TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction.
Journal of Cellular Physiology,
226 (6),
1620-1631.
Artículo
58 - Brauchi,S., Orta,G., Mascayano,C., Salazar,M., Raddatz,N., Urbina,H., Rosenmann,E., Gonzalez-Nilo,F., Latorre,R.. Dissection of the components for PIP2 activation and thermosensation in TRP channels.
Proceedings of the National Academy of Sciences of the United States of America,
104 (24),
10246-10251.
*
Artículo
59 - Latorre,R., Brauchi,S., Orta,G., Zaelzer,C., Vargas,G.. Thermo TRP channels as modular proteins with allosteric gating.
Cell Calcium,
42 (4-5),
427-438.
*
Artículo
60 - Brauchi,S., Orta,G., Salazar,M., Rosenmann,E., Latorre,R.. A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels.
Journal of Neuroscience,
26 (18),
4835-4840.
*
Internacional
61 - Brauchi,S., Vargas,G., Latorre,R., Orta,G.. Voltage and Temperature Gating of ThermoTRP Channels. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades.
Frontiers in Neuroscience,
287-302.
*
Artículo
62 - Alvarez,J.L., Salinas-Stefanon,E., Orta,G., Ferrer,T., Talavera,K., Galan,L., Vassort,G.. Occurrence of a tetrodotoxin-sensitive calcium current in rat ventricular myocytes after long-term myocardial infarction.
Cardiovascular Research,
63 (4),
653-661.
*
Artículo
63 - Cruz,S.L., Orta-Salazar,G., Gauthereau,M.Y., Millan-Perez Pena,L., Salinas-Stefanon,E.M.. Inhibition of cardiac sodium currents by toluene exposure.
British Journal of Pharmacology,
140 (4),
653-660.
*
Artículo
64 - Orta-Salazar,G., Bouchard,R.A., Morales-Salgado,F., Salinas-Stefanon,E.M.. Inhibition of cardiac Na+ current by primaquine.
British Journal of Pharmacology,
135 (3),
751-763.
*
Artículo
65 - Galan,L., Ferrer,T., Artiles,A., Talavera,K., Salinas,E., Orta,G., Garcia-Barreto,D., Alvarez,J.L.. Cardiac cellular actions of hydrochlorothiazide.
Fundamental and Clinical Pharmacology,
15 (1),
9-17.
*