Q.F.B. Rafaela Maria del Pilar Espinosa Organista
Técnica Académica Titular C Tiempo Completo
Biología y epidemiología molecular de virus y bacterias
Genómica funcional de la interacción virus-célula hospedera
Nivel C del PRIDE
Premio Bienal FUNSALUD en Infecciones Gastrointestinales, Fundación Mexicana para la Salud, 2000
Total de publicaciones: 27
- Tipo
- Fecha
Artículo
1 - Lanning,S., Aguilar-Hernandez,N., Serrao,V.H.B., Lopez,T., Rourke,Sara M., Lentz,A., Ricemeyer,L., Espinosa,R., Lopez,S., Arias,C.F., DuBois,R.M. (2025). Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization.
Journal of Virology,
99 (2),
e01619-24.
Artículo
2 - Ramirez-Bello,I., Lopez,T., Espinosa,R., Ghosh,A., Green,K., Gaspar-Castillo,C., Aguilera-Flores,C., Alpuche-Aranda,C.M., Lopez,S., DuBois,R.M., Arias,C.F. (2024). Mouse and human immune responses share neutralization epitopes of HAstV-VA1.
Journal of Virology,
98 (7),
e0097124.
Artículo
3 - Guzman-Martinez,O., Guardado,K., Varela-Cardoso,M., Trujillo-Rivera,A., Marin-Hernandez,A., Ortiz-Leon,M.C., Gomez-Nanez,I., Gutierrez,M., Espinosa,R., Sampieri,C.L., Ramos,C., Lopez-Guerrero,D.V., Zenteno-Cuevas,R., Perez-Carreon,J.I., Canales-Vazquez,G., Montero,H. (2022). Generation and persistence of S1 IgG and neutralizing antibodies in post-COVID-19 patients.
Infection,
50,
447-456.
Artículo
4 - Ricemeyer,L., Aguilar-Hernandez,N., Lopez,T., Espinosa,R., Lanning,S., Mukherjee,S., Cuellar,C., Lopez,S., Arias,C.F., DuBois,R.M. (2022). Structures of Two Human Astrovirus Capsid/Neutralizing Antibody Complexes Reveal Distinct Epitopes and Inhibition of Virus Attachment to Cells.
Journal of Virology,
96 (1),
JVI01415-21.
Artículo
5 - Guzman-Martinez,O., Guardado,K., Varela-Cardoso,M., Trujillo-Rivera,A., Gomez-Nanez,I., Ortiz-Leon,M.C., Espinosa,R., Ramos,C., Perez-Carreon,J.I., Lopez-Guerrero,D.V., Sampieri,C.L., Alanis-Garcia,A.B., Rojas-Duran,F., Zenteno-Cuevas,R., Gutierrez,M., Montero,H. (2021). Potential protection of pre-existent antibodies to human coronavirus 229e on covid-19 severity.
International Journal of Environmental Research and Public Health,
18 (17),
9058.
Artículo
6 - Janowski,A.B., Owen,M.C., Dudley,H., Lopez,T., Espinosa,R., Elvin-Lewis,M., Colichon,A., Arias,C.F., Burbelo,P.D., Wang,D. (2021). High Seropositivity Rate of Neutralizing Antibodies to Astrovirus VA1 in Human Populations.
mSphere,
6 (5),
e0048421.
Artículo
7 - Espinosa,R., Lopez,T., Bogdanoff,W.A., Espinoza,M.A., Lopez,S., DuBois,R.M., Arias,C.F. (2019). Isolation of neutralizing monoclonal antibodies to human astrovirus and characterization of virus variants that escape neutralization.
Journal of Virology,
93 (2),
e01465-18.
Artículo
8 - Meyer, L., Lopez, T., Espinosa, R., Arias, C. F., Vollmers, C., DuBois, R. M. (2019). A simplified workflow for monoclonal antibody sequencing.
PLoS ONE,
14 (6),
e0218717.
Artículo
9 - Mendez,E., Munoz-Yanez,C., Sanchez-SanMartin,C., Aguirre-Crespo,G., Banos-Lara,M.D., Gutierrez,M., Espinosa,R., Acevedo,Y., Arias,C.F., Lopez,S. (2014). Characterization of human astrovirus cell entry.
Journal of Virology,
88 (5),
2452-2460.
Artículo
10 - Diaz-Salinas,M.A., Romero,P., Espinosa,R., Hoshino,Y., Lopez,S., Arias,C.F. (2013). The spike protein VP4 defines the endocytic pathway used by rotavirus to enter MA104 cells.
Journal of Virology,
87 (3),
1658-1663.
Artículo
11 - Gutierrez,M., Isa,P., Sanchez-SanMartin,C., Perez-Vargas,J., Espinosa,R., Arias,C.F., Lopez,S. (2010). Different rotavirus strains enter MA104 cells through different endocytic pathways: The role of clathrin-mediated endocytosis.
Journal of Virology,
84 (18),
9161-9169.
Artículo
12 - Realpe,M., Espinosa,R., Lopez,S., Arias,C.F. (2010). Rotaviruses require basolateral molecules for efficient infection of polarized MDCKII cells.
Virus Research,
147 (2),
231-241.
Artículo
13 - Ayala-Breton,C., Arias,M., Espinosa,R., Romero,P., Arias,C.F., Lopez,S. (2009). Analysis of the kinetics of transcription and replication of the rotavirus genome by RNAi.
Journal of Virology,
83 (17),
8829-8831.
Artículo
14 - Espinosa,A.C., Mazari-Hiriart,M., Espinosa,R., Maruri-Avidal,L., Mendez,E., Arias,C.F. (2008). Infectivity and genome persistence of rotavirus and astrovirus in groundwater and surface water.
Water Research,
42 (10-11),
2618-2628.
Artículo
15 - Arias,C.F., Dector,M.A., Segovia,L., Lopez,T., Camacho,M., Isa,P., Espinosa,R., Lopez,S. (2004). RNA silencing of rotavirus gene expression.
Virus Research,
102 (1),
43-51.
Artículo
16 - Zarate,S., Romero,P., Espinosa,R., Arias,C.F., Lopez,S. (2004). VP7 Mediates the Interaction of Rotaviruses with Integrin {alpha}v{beta}3 through a Novel Integrin-Binding Site.
Journal of Virology,
78 (20),
10839-10847.
Artículo
17 - Zarate,S., Cuadras,M.A., Espinosa,R., Romero,P., Juarez,K.O., Camacho-Nuez,M., Arias,C.F., Lopez,S. (2003). Interaction of Rotaviruses with Hsc70 during Cell Entry Is Mediated by VP5.
Journal of Virology,
77 (13),
7254-7260.
Artículo
18 - Arias,C.F., Isa,P., Guerrero,C., Mendez,E., Zarate,S., Lopez,T., Espinosa,R., Romero,P., Lopez,S. (2002). Molecular biology of rotavirus cell entry.
Archives of Medical Research,
33 (4),
356-361.
Artículo
19 - Guerrero,C.A., Bouyssounade,D., Zarate,S., Isa,P., Lopez,T., Espinosa,R., Romero,P., Mendez,E., Lopez,S., Arias,C.F. (2002). Heat shock cognate protein 70 is involved in rotavirus cell entry.
Journal of Virology,
76 (8),
4096-4102.
Artículo
20 - Gonzalez,R.A., Espinosa,R., Romero,P., Lopez,S., Arias,C.F. (2000). Relative localization of viroplasmic and endoplasmic reticulum- resident rotavirus proteins in infected cells - Brief report.
Archives of Virology,
145 (9),
1963-1973.
Artículo
21 - Lopez,S., Espinosa,R., Isa,P., Merchant,M.T., Zarate,S., Mendez,E., Arias,C.F. (2000). Characterization of a monoclonal antibody directed to the surface of MA104 cells that blocks the infectivity of rotaviruses.
Virology,
273 (1),
160-168.
Artículo
22 - Zarate,S., Espinosa,R., Romero,P., Guerrero,C.A., Arias,C.F., Lopez,S. (2000). Integrin alpha2beta1 mediates the cell attachment of the rotavirus neuraminidase-resistant variant nar3.
Virology,
278 (1),
50-54.
Artículo
23 - Zarate,S., Espinosa,R., Romero,P., Mendez,E., Arias,C.F., Lopez,S. (2000). The VP5 domain of VP4 can mediate attachment of rotaviruses to cells.
Journal of Virology,
74 (2),
593-599.
Artículo
24 - Lopez,S., Espinosa,R., Greenberg,H.B., Arias,C.F. (1994). Mapping the Subgroup Epitopes of Rotavirus Protein VP6.
Virology,
204 (1),
153-162.
Memoria in extenso
25 - Arias,C.F., Guerrero,C.A., Mendez,E., Zarate,S., Isa,P., Espinosa,R., Romero,P., Lopez,S. (2001). Early events of rotavirus infection: the search for the receptor(s). Gastroenteritis Viruses.
Novartis Foundation Symposia.vol 238.,
47-60 discussion 60-3..
Preprint
26 - Lanning,S., Aguilar-Hernandez,N., Serrao,V.H.B., Lopez,T., Rourke,Sara M., Lentz,A., Ricemeyer,L., Espinosa,R., Lopez,S., Arias,C.F., DuBois,R.M. (2024). Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization.
bioRxiv,
Preprint posted September 16.
Preprint
27 - Ramirez-Bello,I., Lopez,T., Espinosa,R., Ghosh,A., Green,K., Riano-Umbarila,L., Gaspar-Castillo,C., Alpuche-Aranda,C., Lopez,S., DuBois,R., Arias,C.F. (2024). Antigenic determinants of HAstV-VA1 neutralization and their relevance in the human immune response.
bioRxiv,
Preprint posted March 08.
Artículo
28 - Lanning,S., Aguilar-Hernandez,N., Serrao,V.H.B., Lopez,T., Rourke,Sara M., Lentz,A., Ricemeyer,L., Espinosa,R., Lopez,S., Arias,C.F., DuBois,R.M.. Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization.
Journal of Virology,
99 (2),
e01619-24.
Artículo
29 - Ramirez-Bello,I., Lopez,T., Espinosa,R., Ghosh,A., Green,K., Gaspar-Castillo,C., Aguilera-Flores,C., Alpuche-Aranda,C.M., Lopez,S., DuBois,R.M., Arias,C.F.. Mouse and human immune responses share neutralization epitopes of HAstV-VA1.
Journal of Virology,
98 (7),
e0097124.
Preprint
30 - Lanning,S., Aguilar-Hernandez,N., Serrao,V.H.B., Lopez,T., Rourke,Sara M., Lentz,A., Ricemeyer,L., Espinosa,R., Lopez,S., Arias,C.F., DuBois,R.M.. Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization.
bioRxiv,
Preprint posted September 16.
Preprint
31 - Ramirez-Bello,I., Lopez,T., Espinosa,R., Ghosh,A., Green,K., Riano-Umbarila,L., Gaspar-Castillo,C., Alpuche-Aranda,C., Lopez,S., DuBois,R., Arias,C.F.. Antigenic determinants of HAstV-VA1 neutralization and their relevance in the human immune response.
bioRxiv,
Preprint posted March 08.
Artículo
32 - Guzman-Martinez,O., Guardado,K., Varela-Cardoso,M., Trujillo-Rivera,A., Marin-Hernandez,A., Ortiz-Leon,M.C., Gomez-Nanez,I., Gutierrez,M., Espinosa,R., Sampieri,C.L., Ramos,C., Lopez-Guerrero,D.V., Zenteno-Cuevas,R., Perez-Carreon,J.I., Canales-Vazquez,G., Montero,H.. Generation and persistence of S1 IgG and neutralizing antibodies in post-COVID-19 patients.
Infection,
50,
447-456.
Artículo
33 - Ricemeyer,L., Aguilar-Hernandez,N., Lopez,T., Espinosa,R., Lanning,S., Mukherjee,S., Cuellar,C., Lopez,S., Arias,C.F., DuBois,R.M.. Structures of Two Human Astrovirus Capsid/Neutralizing Antibody Complexes Reveal Distinct Epitopes and Inhibition of Virus Attachment to Cells.
Journal of Virology,
96 (1),
JVI01415-21.
Artículo
34 - Guzman-Martinez,O., Guardado,K., Varela-Cardoso,M., Trujillo-Rivera,A., Gomez-Nanez,I., Ortiz-Leon,M.C., Espinosa,R., Ramos,C., Perez-Carreon,J.I., Lopez-Guerrero,D.V., Sampieri,C.L., Alanis-Garcia,A.B., Rojas-Duran,F., Zenteno-Cuevas,R., Gutierrez,M., Montero,H.. Potential protection of pre-existent antibodies to human coronavirus 229e on covid-19 severity.
International Journal of Environmental Research and Public Health,
18 (17),
9058.
Artículo
35 - Janowski,A.B., Owen,M.C., Dudley,H., Lopez,T., Espinosa,R., Elvin-Lewis,M., Colichon,A., Arias,C.F., Burbelo,P.D., Wang,D.. High Seropositivity Rate of Neutralizing Antibodies to Astrovirus VA1 in Human Populations.
mSphere,
6 (5),
e0048421.
Artículo
36 - Espinosa,R., Lopez,T., Bogdanoff,W.A., Espinoza,M.A., Lopez,S., DuBois,R.M., Arias,C.F.. Isolation of neutralizing monoclonal antibodies to human astrovirus and characterization of virus variants that escape neutralization.
Journal of Virology,
93 (2),
e01465-18.
Artículo
37 - Meyer, L., Lopez, T., Espinosa, R., Arias, C. F., Vollmers, C., DuBois, R. M.. A simplified workflow for monoclonal antibody sequencing.
PLoS ONE,
14 (6),
e0218717.
Artículo
38 - Mendez,E., Munoz-Yanez,C., Sanchez-SanMartin,C., Aguirre-Crespo,G., Banos-Lara,M.D., Gutierrez,M., Espinosa,R., Acevedo,Y., Arias,C.F., Lopez,S.. Characterization of human astrovirus cell entry.
Journal of Virology,
88 (5),
2452-2460.
Artículo
39 - Diaz-Salinas,M.A., Romero,P., Espinosa,R., Hoshino,Y., Lopez,S., Arias,C.F.. The spike protein VP4 defines the endocytic pathway used by rotavirus to enter MA104 cells.
Journal of Virology,
87 (3),
1658-1663.
Artículo
40 - Gutierrez,M., Isa,P., Sanchez-SanMartin,C., Perez-Vargas,J., Espinosa,R., Arias,C.F., Lopez,S.. Different rotavirus strains enter MA104 cells through different endocytic pathways: The role of clathrin-mediated endocytosis.
Journal of Virology,
84 (18),
9161-9169.
Artículo
41 - Realpe,M., Espinosa,R., Lopez,S., Arias,C.F.. Rotaviruses require basolateral molecules for efficient infection of polarized MDCKII cells.
Virus Research,
147 (2),
231-241.
Artículo
42 - Ayala-Breton,C., Arias,M., Espinosa,R., Romero,P., Arias,C.F., Lopez,S.. Analysis of the kinetics of transcription and replication of the rotavirus genome by RNAi.
Journal of Virology,
83 (17),
8829-8831.
Artículo
43 - Espinosa,A.C., Mazari-Hiriart,M., Espinosa,R., Maruri-Avidal,L., Mendez,E., Arias,C.F.. Infectivity and genome persistence of rotavirus and astrovirus in groundwater and surface water.
Water Research,
42 (10-11),
2618-2628.
Artículo
44 - Arias,C.F., Dector,M.A., Segovia,L., Lopez,T., Camacho,M., Isa,P., Espinosa,R., Lopez,S.. RNA silencing of rotavirus gene expression.
Virus Research,
102 (1),
43-51.
Artículo
45 - Zarate,S., Romero,P., Espinosa,R., Arias,C.F., Lopez,S.. VP7 Mediates the Interaction of Rotaviruses with Integrin {alpha}v{beta}3 through a Novel Integrin-Binding Site.
Journal of Virology,
78 (20),
10839-10847.
Artículo
46 - Zarate,S., Cuadras,M.A., Espinosa,R., Romero,P., Juarez,K.O., Camacho-Nuez,M., Arias,C.F., Lopez,S.. Interaction of Rotaviruses with Hsc70 during Cell Entry Is Mediated by VP5.
Journal of Virology,
77 (13),
7254-7260.
Artículo
47 - Arias,C.F., Isa,P., Guerrero,C., Mendez,E., Zarate,S., Lopez,T., Espinosa,R., Romero,P., Lopez,S.. Molecular biology of rotavirus cell entry.
Archives of Medical Research,
33 (4),
356-361.
Artículo
48 - Guerrero,C.A., Bouyssounade,D., Zarate,S., Isa,P., Lopez,T., Espinosa,R., Romero,P., Mendez,E., Lopez,S., Arias,C.F.. Heat shock cognate protein 70 is involved in rotavirus cell entry.
Journal of Virology,
76 (8),
4096-4102.
Memoria in extenso
49 - Arias,C.F., Guerrero,C.A., Mendez,E., Zarate,S., Isa,P., Espinosa,R., Romero,P., Lopez,S.. Early events of rotavirus infection: the search for the receptor(s). Gastroenteritis Viruses.
Novartis Foundation Symposia.vol 238.,
47-60 discussion 60-3..
Artículo
50 - Gonzalez,R.A., Espinosa,R., Romero,P., Lopez,S., Arias,C.F.. Relative localization of viroplasmic and endoplasmic reticulum- resident rotavirus proteins in infected cells - Brief report.
Archives of Virology,
145 (9),
1963-1973.
Artículo
51 - Lopez,S., Espinosa,R., Isa,P., Merchant,M.T., Zarate,S., Mendez,E., Arias,C.F.. Characterization of a monoclonal antibody directed to the surface of MA104 cells that blocks the infectivity of rotaviruses.
Virology,
273 (1),
160-168.
Artículo
52 - Zarate,S., Espinosa,R., Romero,P., Guerrero,C.A., Arias,C.F., Lopez,S.. Integrin alpha2beta1 mediates the cell attachment of the rotavirus neuraminidase-resistant variant nar3.
Virology,
278 (1),
50-54.
Artículo
53 - Zarate,S., Espinosa,R., Romero,P., Mendez,E., Arias,C.F., Lopez,S.. The VP5 domain of VP4 can mediate attachment of rotaviruses to cells.
Journal of Virology,
74 (2),
593-599.
Artículo
54 - Lopez,S., Espinosa,R., Greenberg,H.B., Arias,C.F.. Mapping the Subgroup Epitopes of Rotavirus Protein VP6.
Virology,
204 (1),
153-162.