Dra. Constance Genevieve Jeanne Henriette Auvynet
Investigadora Titular A Tiempo Completo
Pequeños péptidos de defensa e inflamación
Número de registros: 3
- Activos
- Vencidos
- Identificación y caracterización de péptidos antimicrobianos con actividad antiinflamatoria derivados de la piel de ambystoma mexicanum, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2024 - 2025
- Caracterización del mecanismo de inducción de muerte bacteriana y de células inmunes por un péptido de defensa aislado de la rana mexicana pachymedusa dacnicolor, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2022 - 2023
- Pequeños péptidos antiinflamatorios y antimicrobianos aislados de la rana mexicana pachymedusa dacnicolor en el tratamiento de enfermedades inflamatorias, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2020 - 2021
Nivel I del SNII
Doctorado, Doctorado
- Activos
- Graduados
1 - Ronald Alejandro Zárate Andrade (2024). Caracterización del mecanismo de acción inmunosupresor del péptido de defensa DA2N.
Licenciatura en Ingeniería en Biotecnología,
Universidad Catolica Boliviana.
*
2 - Hernandez Gonzalez, Juan Antonio (2024). Mutantes de dermaseptinas como herramientas ante respuesta anti-inflamatoria.
Licenciatura en Ciencias orientación en Bioquímica y Biología Molecular,
UAEM.
*
3 - Fajardo Brigido, Lorena Elizabeth (2024). Caracterizacion del mecanismo de muerte de celulas del sistema inmunologico inducida por pequenos peptidos de defensa de la rana P. dacnicolor.
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: AUVYNET, CONSTANCE
Total de publicaciones: 26
- Tipo
- Fecha
Artículo
4 - Lacombe,C., Aleman-Navarro,E., Drujon,T., Martinez-Osorio,V., Sachon,E., Melchy-Perez,E., Carlier,L., Fajardo-Brigido,E., Fleury,Y., Piesse,C., Gutierrez-Escobedo,G., de las Penas,A., Castano,I., Desriac,A., Beristain-Hernandez,J.L., Combadiere,C., Rosenstein,Y., Auvynet,C. (2024). Characterization of a New Immunosuppressive and Antimicrobial Peptide, DRS-DA2, Isolated from the Mexican Frog, Pachymedusa dacnicolor.
International Journal of Inflammation,
2024.
Artículo
5 - Sandoval-Hernandez,M.A., Fierro,N.A., Veytia-Bucheli,J.I., Alvarado-Velazquez,D.A., Aleman-Navarro,E., Melchy-Perez,E., Auvynet,C., Imaz-Rosshandler,I., Carneiro,J., Perez-Rueda,E., Rosenstein,Y. (2024). Differential Impact of CD43 and CD28 on T-Cell Differentiation Depending on the Order of Engagement with the TCR.
International Journal of Molecular Sciences,
25 (6),
3135.
Articulo
6 - Gallegos-Monterrosa,R., Nunez,Y., Auvynet,C., Kumar,K.M., Tang,B., Ruiz-Ortega,L.I., Bustamante,V.H. (2023). Antibacterial and antibiofilm activities of ZIF-67.
Journal of Antibiotics,
76,
603?612.
Artículo
7 - Vega-Mendoza,D., Canas-Linares,A., Flores-Alcantar,A., Espinosa-Neira,R., Melchy-Perez,E., Vera-Estrella,R., Auvynet,C., Rosenstein,Y. (2021). CD43 (sialophorin) is involved in the induction of extracellular matrix remodeling and angiogenesis by lung cancer cells.
Journal of Cellular Physiology,
236 (9),
6643-6656.
Artículo
8 - Cardon,S., Sachon,E., Carlier,L., Drujon,T., Walrant,A., Aleman-Navarro,E., Martinez-Osorio,V., Guianvarc'h,D., Sagan,S., Fleury,Y., Marquant,R., Piesse,C., Rosenstein,Y., Auvynet,C., Lacombe,C. (2018). Peptidoglycan potentiates the membrane disrupting effect of the carboxyamidated form of DMS-DA6, a Gram-positive selective antimicrobial peptide isolated from Pachymedusa dacnicolor skin.
PLoS ONE,
13 (10),
e0205727.
Artículo
9 - Krishnan,M.L., Van Steenwinckel,J., Schang,A.L., Yan,J., Arnadottir,J., Le Charpentier,T., Csaba,Z., Dournaud,P., Cipriani,S., Auvynet,C., Titomanlio,L., Pansiot,J., Ball,G., Boardman,J.P., Walley,A.J., Saxena,A., Mirza,G., Fleiss,B., Edwards,A.D., Petretto,E., Gressens,P. (2017). Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infant.
Nature Communications,
8 (1).
*
Artículo
10 - Auvynet,C., Baudesson De Chanville,C., Hermand,P., Dorgham,K., Piesse,C., Pouchy,C., Carlier,L., Poupel,L., Barthelemy,S., Felouzis,V., Lacombe,C., Sagan,S., Salomon,B., Deterre,P., Sennlaub,F., Combadiere,C. (2016). ECL1i, d(LGTFLKC), a novel, small peptide that specifically inhibits CCL2-dependent migration.
FASEB Journal,
30 (6),
2370-2381.
*
Artículo
11 - Lacombe,C., Piesse,C., Sagan,S., Combadiere,C., Rosenstein,Y., Auvynet,C. (2015). Pachymodulin, a new functional formyl peptide receptor 2 (FPR2) peptidic ligand isolated from frog skin, has Janus-like immunomodulatory capacities.
Journal of Medicinal Chemistry,
58 (3),
1089-1099.
Artículo
12 - Van Steenwinckel,J., Auvynet,C., Sapienza,A., Reaux-Le Goazigo,A., Combadiere,C., Melik Parsadaniantz,S. (2015). Stromal cell-derived CCL2 drives neuropathic pain states through myeloid cell infiltration in injured nerve.
Brain, Behavior, and Immunity,
45,
198-210.
*
Artículo
13 - Auvynet,C., Moreno,S., Melchy,E., Coronado-Martinez,I., Montiel,J.L., Aguilar-Delfin,I., Rosenstein,Y. (2013). Galectin-1 promotes human neutrophil migration.
Glycobiology,
23 (1),
32-42.
Artículo
14 - Poupel,L., Boissonnas,A., Hermand,P., Dorgham,K., Guyon,E., Auvynet,C., Charles,F.S., Lesnik,P., Deterre,P., Combadiere,C. (2013). Pharmacological inhibition of the chemokine receptor, CX3CR1, reduces atherosclerosis in mice.
Arteriosclerosis, Thrombosis, and Vascular Biology,
33 (10),
2297-2305.
*
Artículo
15 - Rodero,M.P., Auvynet,C., Poupel,L., Combadiere,B., Combadiere,C. (2013). Control of both myeloid cell infiltration and angiogenesis by ccr1 promotes liver cancer metastasis development in mice.
Neoplasia,
15 (6),
641-648.
*
Artículo
16 - Sennlaub,F., Auvynet,C., Calippe,B., Lavalette,S., Poupel,L., Hu,S.J., Dominguez,E., Camelo,S., Levy,O., Guyon,E., Saederup,N., Charo,I.F., Rooijen,N.V., Nandrot,E., Bourges,J., Behar-Cohen,F., Sahel,J.A., Guillonneau,X., Raoul,W., Combadiere,C. (2013). CCR2 + monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice.
EMBO Molecular Medicine,
5 (11),
1775-1793.
*
Artículo
17 - Cochain,C., Auvynet,C., Poupel,L., Vilar,J., Dumeau,E., Richart,A., Zouggari,Y., Yin,K.Y.H.W., Bruneval,P., Renault,G., Marchiol,C., Bonnin,P., Bonecchi,R., Locati,M., Silvestre,J.S. (2012). The chemokine decoy receptor D6 prevents excessive inflammation and adverse ventricular remodeling after myocardial infarction.
Arteriosclerosis, Thrombosis, and Vascular Biology,
32 (9),
2206-2213.
*
Artículo
18 - Ramos,M.V., Auvynet,C., Poupel,L., Rodero,M., Mejias,M.P., Panek,C.A., Vanzulli,S., Combadiere,C., Palermo,M. (2012). Chemokine receptor CCR1 disruption limits renal damage in a murine model of hemolytic uremic syndrome.
American Journal of Pathology,
180 (3),
1040-1048.
*
Revisión
19 - Raoul,W., Lelievre,E., Auvynet,C., Feumi,C., Combadiere,C., Sennlaub,F. (2010). Role of chemokines in the development of age-related macular degeneration.
Biologie Aujourd'hui,
204 (4),
311-319.
*
Revisión
20 - Raoul,W., Auvynet,C., Camelo,S., Guillonneau,X., Feumi,C., Combadiere,C., Sennlaub,F. (2010). CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration.
Journal of Neuroinflammation,
7.
*
Artículo
21 - Auvynet,C., Joanne,P., Bourdais,J., Nicolas,P., Lacombe,C., Rosenstein,Y. (2009). Dermaseptin DA4, although closely related to dermaseptin B2, presents chemotactic and Gram-negative selective bactericidal activities.
Febs Journal,
272 (22),
6773-6786.
Revisión
22 - Auvynet,C., Rosenstein,Y. (2009). Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity.
Febs Journal,
276 (22),
6497-6508.
Artículo
23 - Auvynet,C., Topalis,D., Caillat,C., Munier-Lehmann,H., Seclaman,E., Balzarini,J., Agrofoglio,L.A., Kaminski,P.A., Meyer,P., Deville-Bonne,D., El Amri,C. (2009). Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase.
Biochemical and Biophysical Research Communications,
388 (1),
6-11.
*
Artículo
24 - Joanne,P., Falord,M., Chesneau,O., Lacombe,C., Castano,S., Desbat,B., Auvynet,C., Nicolas,P., Msadek,T., El-Amri,C. (2009). Comparative study of two plasticins: specificity, interfacial behavior, and bactericidal activity.
Biochemistry,
48 (40),
9372-9383.
Artículo
25 - Auvynet,C., El-Amri,C., Lacombe,C., Bruston,F., Bourdais,J., Nicolas,P., Rosenstein,Y. (2008). Structural requirements for antimicrobial versus chemoattractant activities for dermaseptin S9.
Febs Journal,
275 (16),
4134-4151.
Artículo
26 - Auvynet,C., Seddiki,N., Dunia,I., Nicolas,P., Amiche,M., Lacombe,C. (2006). Post-translational amino acid racemization in the frog skin peptide deltorphin I in the secretion granules of cutaneous serous glands.
European Journal of Cell Biology,
85 (1),
25-34.
*
Preprint
27 - Auvynet,C., Duarte-Mata,D.I., Vazquez-Marmolejo,A.V., Aleman-Navarro,E., Piesse,C., Rosenstein,Y., Salinas-Carmona,M.C. (2025). Dermaseptin DMS-DA6, a promising alternative to conventional antibiotic in the treatment of N. brasiliensis induced actinomycetoma.
bioRxiv,
Posted 16 junio.
Editorial material
28 - Chemtob,S., Rosenstein,Y., Auvynet,C. (2022). Editorial: Use of small peptides in the treatment of inflammatory diseases.
Frontiers in Pharmacology,
13,
1090014.
Nacional divulgacion
29 - Rosenstein,Y., Auvynet,C. (2022). Las ranas: de la medicina tradicional a nuevos fármacos.
Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM,
31 (Octubre-Diciembre).
Preprint
30 - Auvynet,C., Duarte-Mata,D.I., Vazquez-Marmolejo,A.V., Aleman-Navarro,E., Piesse,C., Rosenstein,Y., Salinas-Carmona,M.C.. Dermaseptin DMS-DA6, a promising alternative to conventional antibiotic in the treatment of N. brasiliensis induced actinomycetoma.
bioRxiv,
Posted 16 junio.
Artículo
31 - Lacombe,C., Aleman-Navarro,E., Drujon,T., Martinez-Osorio,V., Sachon,E., Melchy-Perez,E., Carlier,L., Fajardo-Brigido,E., Fleury,Y., Piesse,C., Gutierrez-Escobedo,G., de las Penas,A., Castano,I., Desriac,A., Beristain-Hernandez,J.L., Combadiere,C., Rosenstein,Y., Auvynet,C.. Characterization of a New Immunosuppressive and Antimicrobial Peptide, DRS-DA2, Isolated from the Mexican Frog, Pachymedusa dacnicolor.
International Journal of Inflammation,
2024.
Artículo
32 - Sandoval-Hernandez,M.A., Fierro,N.A., Veytia-Bucheli,J.I., Alvarado-Velazquez,D.A., Aleman-Navarro,E., Melchy-Perez,E., Auvynet,C., Imaz-Rosshandler,I., Carneiro,J., Perez-Rueda,E., Rosenstein,Y.. Differential Impact of CD43 and CD28 on T-Cell Differentiation Depending on the Order of Engagement with the TCR.
International Journal of Molecular Sciences,
25 (6),
3135.
Articulo
33 - Gallegos-Monterrosa,R., Nunez,Y., Auvynet,C., Kumar,K.M., Tang,B., Ruiz-Ortega,L.I., Bustamante,V.H.. Antibacterial and antibiofilm activities of ZIF-67.
Journal of Antibiotics,
76,
603?612.
Editorial material
34 - Chemtob,S., Rosenstein,Y., Auvynet,C.. Editorial: Use of small peptides in the treatment of inflammatory diseases.
Frontiers in Pharmacology,
13,
1090014.
Nacional divulgacion
35 - Rosenstein,Y., Auvynet,C.. Las ranas: de la medicina tradicional a nuevos fármacos.
Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM,
31 (Octubre-Diciembre).
Artículo
36 - Vega-Mendoza,D., Canas-Linares,A., Flores-Alcantar,A., Espinosa-Neira,R., Melchy-Perez,E., Vera-Estrella,R., Auvynet,C., Rosenstein,Y.. CD43 (sialophorin) is involved in the induction of extracellular matrix remodeling and angiogenesis by lung cancer cells.
Journal of Cellular Physiology,
236 (9),
6643-6656.
Artículo
37 - Cardon,S., Sachon,E., Carlier,L., Drujon,T., Walrant,A., Aleman-Navarro,E., Martinez-Osorio,V., Guianvarc'h,D., Sagan,S., Fleury,Y., Marquant,R., Piesse,C., Rosenstein,Y., Auvynet,C., Lacombe,C.. Peptidoglycan potentiates the membrane disrupting effect of the carboxyamidated form of DMS-DA6, a Gram-positive selective antimicrobial peptide isolated from Pachymedusa dacnicolor skin.
PLoS ONE,
13 (10),
e0205727.
Artículo
38 - Krishnan,M.L., Van Steenwinckel,J., Schang,A.L., Yan,J., Arnadottir,J., Le Charpentier,T., Csaba,Z., Dournaud,P., Cipriani,S., Auvynet,C., Titomanlio,L., Pansiot,J., Ball,G., Boardman,J.P., Walley,A.J., Saxena,A., Mirza,G., Fleiss,B., Edwards,A.D., Petretto,E., Gressens,P.. Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infant.
Nature Communications,
8 (1).
*
Artículo
39 - Auvynet,C., Baudesson De Chanville,C., Hermand,P., Dorgham,K., Piesse,C., Pouchy,C., Carlier,L., Poupel,L., Barthelemy,S., Felouzis,V., Lacombe,C., Sagan,S., Salomon,B., Deterre,P., Sennlaub,F., Combadiere,C.. ECL1i, d(LGTFLKC), a novel, small peptide that specifically inhibits CCL2-dependent migration.
FASEB Journal,
30 (6),
2370-2381.
*
Artículo
40 - Lacombe,C., Piesse,C., Sagan,S., Combadiere,C., Rosenstein,Y., Auvynet,C.. Pachymodulin, a new functional formyl peptide receptor 2 (FPR2) peptidic ligand isolated from frog skin, has Janus-like immunomodulatory capacities.
Journal of Medicinal Chemistry,
58 (3),
1089-1099.
Artículo
41 - Van Steenwinckel,J., Auvynet,C., Sapienza,A., Reaux-Le Goazigo,A., Combadiere,C., Melik Parsadaniantz,S.. Stromal cell-derived CCL2 drives neuropathic pain states through myeloid cell infiltration in injured nerve.
Brain, Behavior, and Immunity,
45,
198-210.
*
Artículo
42 - Auvynet,C., Moreno,S., Melchy,E., Coronado-Martinez,I., Montiel,J.L., Aguilar-Delfin,I., Rosenstein,Y.. Galectin-1 promotes human neutrophil migration.
Glycobiology,
23 (1),
32-42.
Artículo
43 - Poupel,L., Boissonnas,A., Hermand,P., Dorgham,K., Guyon,E., Auvynet,C., Charles,F.S., Lesnik,P., Deterre,P., Combadiere,C.. Pharmacological inhibition of the chemokine receptor, CX3CR1, reduces atherosclerosis in mice.
Arteriosclerosis, Thrombosis, and Vascular Biology,
33 (10),
2297-2305.
*
Artículo
44 - Rodero,M.P., Auvynet,C., Poupel,L., Combadiere,B., Combadiere,C.. Control of both myeloid cell infiltration and angiogenesis by ccr1 promotes liver cancer metastasis development in mice.
Neoplasia,
15 (6),
641-648.
*
Artículo
45 - Sennlaub,F., Auvynet,C., Calippe,B., Lavalette,S., Poupel,L., Hu,S.J., Dominguez,E., Camelo,S., Levy,O., Guyon,E., Saederup,N., Charo,I.F., Rooijen,N.V., Nandrot,E., Bourges,J., Behar-Cohen,F., Sahel,J.A., Guillonneau,X., Raoul,W., Combadiere,C.. CCR2 + monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice.
EMBO Molecular Medicine,
5 (11),
1775-1793.
*
Artículo
46 - Cochain,C., Auvynet,C., Poupel,L., Vilar,J., Dumeau,E., Richart,A., Zouggari,Y., Yin,K.Y.H.W., Bruneval,P., Renault,G., Marchiol,C., Bonnin,P., Bonecchi,R., Locati,M., Silvestre,J.S.. The chemokine decoy receptor D6 prevents excessive inflammation and adverse ventricular remodeling after myocardial infarction.
Arteriosclerosis, Thrombosis, and Vascular Biology,
32 (9),
2206-2213.
*
Artículo
47 - Ramos,M.V., Auvynet,C., Poupel,L., Rodero,M., Mejias,M.P., Panek,C.A., Vanzulli,S., Combadiere,C., Palermo,M.. Chemokine receptor CCR1 disruption limits renal damage in a murine model of hemolytic uremic syndrome.
American Journal of Pathology,
180 (3),
1040-1048.
*
Revisión
48 - Raoul,W., Lelievre,E., Auvynet,C., Feumi,C., Combadiere,C., Sennlaub,F.. Role of chemokines in the development of age-related macular degeneration.
Biologie Aujourd'hui,
204 (4),
311-319.
*
Revisión
49 - Raoul,W., Auvynet,C., Camelo,S., Guillonneau,X., Feumi,C., Combadiere,C., Sennlaub,F.. CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration.
Journal of Neuroinflammation,
7.
*
Artículo
50 - Auvynet,C., Joanne,P., Bourdais,J., Nicolas,P., Lacombe,C., Rosenstein,Y.. Dermaseptin DA4, although closely related to dermaseptin B2, presents chemotactic and Gram-negative selective bactericidal activities.
Febs Journal,
272 (22),
6773-6786.
Revisión
51 - Auvynet,C., Rosenstein,Y.. Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity.
Febs Journal,
276 (22),
6497-6508.
Artículo
52 - Auvynet,C., Topalis,D., Caillat,C., Munier-Lehmann,H., Seclaman,E., Balzarini,J., Agrofoglio,L.A., Kaminski,P.A., Meyer,P., Deville-Bonne,D., El Amri,C.. Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase.
Biochemical and Biophysical Research Communications,
388 (1),
6-11.
*
Artículo
53 - Joanne,P., Falord,M., Chesneau,O., Lacombe,C., Castano,S., Desbat,B., Auvynet,C., Nicolas,P., Msadek,T., El-Amri,C.. Comparative study of two plasticins: specificity, interfacial behavior, and bactericidal activity.
Biochemistry,
48 (40),
9372-9383.
Artículo
54 - Auvynet,C., El-Amri,C., Lacombe,C., Bruston,F., Bourdais,J., Nicolas,P., Rosenstein,Y.. Structural requirements for antimicrobial versus chemoattractant activities for dermaseptin S9.
Febs Journal,
275 (16),
4134-4151.
Artículo
55 - Auvynet,C., Seddiki,N., Dunia,I., Nicolas,P., Amiche,M., Lacombe,C.. Post-translational amino acid racemization in the frog skin peptide deltorphin I in the secretion granules of cutaneous serous glands.
European Journal of Cell Biology,
85 (1),
25-34.
*