Dra. Aimée Bastidas Ponce
Investigadora Titular A Tiempo Completo

Biología del desarrollo de células pancreáticas
Diabetes
Homeostasis metabólica

  • Doctorado, Doctorado en Biología del Desarrollo

Total de publicaciones: 27
  • Tipo
  • Fecha
Open Access Artículo
1 - Akindehin,S., Liskiewicz,A., Liskiewicz,D., Bernecker,M., Garcia-Caceres,C., Drucker,D.J., Finan,B., Grandl,G., Gutgesell,R., Hofmann,S.M., Khalil,A., Liu,X., Cota,P., Bakhti,M., Czarnecki,O., Bastidas-Ponce,A., Lickert,H., Kang,L., Maity,G., Novikoff,A., Parlee,S., Pathak,E., Schriever,S.C., Sterr,M., Ussar,S., Zhang,Q., DiMarchi,R., Tschop,M.H., Pfluger,P.T., Douros,J.D., Muller,T.D. (2024). Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice. Molecular Metabolism, 83, 101915. *
Open Access Artículo
2 - Cota,P., Caliskan,O.S., Bastidas-Ponce,A., Jing,C., Jaki,J., Saber,L., Czarnecki,O., Taskin,D., Blochinger,A.K., Kurth,T., Sterr,M., Burtscher,I., Krahmer,N., Lickert,H., Bakhti,M. (2024). Insulin regulates human pancreatic endocrine cell differentiation invitro. Molecular Metabolism, 79, 101853. *
Open Access Carta
3 - Grandl,G., Collden,G., Feng,J., Bhattacharya,S., Klingelhuber,F., Schomann,L., Bilekova,S., Ansarullah, Xu,W., Far,F.F., Tost,M., Gruber,T., Bastidas-Ponce,A., Zhang,Q., Novikoff,A., Liskiewicz,A., Liskiewicz,D., Garcia-Caceres,C., Feuchtinger,A., Tschop,M.H., Krahmer,N., Lickert,H., Muller,T.D. (2024). Global, neuronal or B cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity. Nature Metabolism, 6 (3), 448-457. *
Open Access Artículo
4 - Cota,P., Saber,L., Taskin,D., Jing,C., Bastidas-Ponce,A., Vanheusden,M., Shahryari,A., Sterr,M., Burtscher,I., Bakhti,M., Lickert,H. (2023). NEUROD2 function is dispensable for human pancreatic B cell specification. Frontiers in Endocrinology, 14, 1286590. *
Artículo
5 - Hrovatin,K., Bastidas-Ponce,A., Bakhti,M., Zappia,L., Buttner,M., Salinno,C., Sterr,M., Bottcher,A., Migliorini,A., Lickert,H., Theis,F.J. (2023). Delineating mouse Iý-cell identity during lifetime and in diabetes with a single cell atlas. Nature Metabolism, 5 (9), 1615-1637. *
Open Access Artículo
6 - Liskiewicz,A., Khalil,A., Liskiewicz,D., Novikoff,A., Grandl,G., Maity-Kumar,G., Gutgesell,R.M., Bakhti,M., Bastidas-Ponce,A., Czarnecki,O., Makris,K., Lickert,H., Feuchtinger,A., Tost,M., Coupland,C., Stander,L., Akindehin,S., Prakash,S., Abrar,F., Castelino,R.L., He,Y., Knerr,P.J., Yang,B., Hogendorf,W.F.J., Zhang,S., Hofmann,S.M., Finan,B., DiMarchi,R.D., Tschop,M.H., Douros,J.D., Muller,T.D. (2023). Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice. Nature Metabolism, 5 (12), 2075-2085. *
Open Access Artículo
7 - Bakhti,M., Bastidas-Ponce,A., Tritschler,S., Czarnecki,O., Tarquis-Medina,M., Nedvedova,E., Jaki,J., Willmann,S.J., Scheibner,K., Cota,P., Salinno,C., Boldt,K., Horn,N., Ueffing,M., Burtscher,I., Theis,F.J., Coskun,U., Lickert,H. (2022). Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis. Nature Communications, 13 (1), 4540. *
Open Access Artículo
8 - Quarta,C., Stemmer,K., Novikoff,A., Yang,B., Klingelhuber,F., Harger,A., Bakhti,M., Bastidas-Ponce,A., Bauge,E., Campbell,J.E., Capozzi,M., Clemmensen,C., Collden,G., Cota,P., Douros,J., Drucker,D.J., DuBois,B., Feuchtinger,A., Garcia-Caceres,C., Grandl,G., Hennuyer,N., Herzig,S., Hofmann,S.M., Knerr,P.J., Kulaj,K., Lalloyer,F., Lickert,H., Liskiewicz,A., Liskiewicz,D., Maity,G., Perez-Tilve,D., Prakash,S., Sanchez-Garrido,M.A., Zhang,Q., Staels,B., Krahmer,N., DiMarchi,R.D., Tschop,M.H., Finan,B., Muller,T.D. (2022). GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice. Nature Metabolism, 4 (8), 1071-1083. *
Artículo
9 - Ansarullah, Jain,C., Far,F.F., Homberg,S., Wissmiller,K., von Hahn,F.G., Raducanu,A., Schirge,S., Sterr,M., Bilekova,S., Siehler,J., Wiener,J., Oppenlander,L., Morshedi,A., Bastidas-Ponce,A., Irmler,M., Beckers,J., Feuchtinger,A., Grzybek,M., Ahlbrecht,C., Feederle,R., Plettenburg,O., Muller,T.D., Meier,M., Tschop,M.H., Coskun,U., Lickert,H. (2021). Inceptor counteracts insulin signalling in B -cells to control glycaemia. Nature, 590 (7845), 326-331 [correction vol 502 (9852)]. *
Open Access Artículo
10 - Chhabra,N.F., Amend,A.L., Bastidas-Ponce,A., Sabrautzki,S., Tarquis-Medina,M., Sachs,S., Rubey,M., Lorenz-Depiereux,B., Feuchtinger,A., Bakhti,M., Lickert,H., Przemeck,G.K.H., de Angelis,M.H. (2021). A point mutation in the Pdia6 gene results in loss of pancreatic B -cell identity causing overt diabetes. Molecular Metabolism, 54, 101334. *
Open Access Artículo
11 - Nasteska,D., Fine,N.H.F., Ashford,F.B., Cuozzo,F., Viloria,K., Smith,G., Dahir,A., Dawson,P.W.J., Lai,Y.C., Bastidas-Ponce,A., Bakhti,M., Rutter,G.A., Fiancette,R., Nano,R., Piemonti,L., Lickert,H., Zhou,Q., Akerman,I., Hodson,D.J. (2021). PDX1(LOW) MAFA(LOW) B -cells contribute to islet function and insulin release. Nature Communications, 12 (1), 674 [Correction vol 12 p 4521 ]. *
Open Access Artículo
12 - Oppenlander,L., Palit,S., Stemmer,K., Greisle,T., Sterr,M., Salinno,C., Bastidas-Ponce,A., Feuchtinger,A., Bottcher,A., Ansarullah, Theis,F.J., Lickert,H. (2021). Vertical sleeve gastrectomy triggers fast B -cell recovery upon overt diabetes. Molecular Metabolism, 54. *
Open Access Artículo
13 - Salinno,C., Buttner,M., Cota,P., Tritschler,S., Tarquis-Medina,M., Bastidas-Ponce,A., Scheibner,K., Burtscher,I., Bottcher,A., Theis,F.J., Bakhti,M., Lickert,H. (2021). CD81 marks immature and dedifferentiated pancreatic B -cells. Molecular Metabolism, 49, 101188. *
Open Access Artículo
14 - Tarquis-Medina,M., Scheibner,K., Gonzalez-Garcia,I., Bastidas-Ponce,A., Sterr,M., Jaki,J., Schirge,S., Garcia-Caceres,C., Lickert,H., Bakhti,M. (2021). Synaptotagmin-13 Is a Neuroendocrine Marker in Brain, Intestine and Pancreas. International Journal of Molecular Sciences, 22 (22). *
Artículo
15 - Sachs,S., Bastidas-Ponce,A., Tritschler,S., Bakhti,M., Bottcher,A., Sanchez-Garrido,M.A., Tarquis-Medina,M., Kleinert,M., Fischer,K., Jall,S., Harger,A., Bader,E., Roscioni,S., Ussar,S., Feuchtinger,A., Yesildag,B., Neelakandhan,A., Jensen,C.B., Cornu,M., Yang,B., Finan,B., DiMarchi,R.D., Tschop,M.H., Theis,F.J., Hofmann,S.M., Muller,T.D., Lickert,H. (2020). Targeted pharmacological therapy restores B -cell function for diabetes remission. Nature Metabolism, 2 (2), 192-209 [Correction vol 2 (4) p 380]. *
Open Access Artículo
16 - Bakhti,M., Scheibner,K., Tritschler,S., Bastidas-Ponce,A., Tarquis-Medina,M., Theis,F.J., Lickert,H. (2019). Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology invitro. Molecular Metabolism, 30, 16-29. *
Open Access Artículo
17 - Bastidas-Ponce,A., Tritschler,S., Dony,L., Scheibner,K., Tarquis-Medina,M., Salinno,C., Schirge,S., Burtscher,I., Bottcher,A., Theis,F.J., Lickert,H., Bakhti,M. (2019). Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis. Development, 146 (12). *
Artículo
18 - Fischer,D.S., Fiedler,A.K., Kernfeld,E.M., Genga,R.M.J., Bastidas-Ponce,A., Bakhti,M., Lickert,H., Hasenauer,J., Maehr,R., Theis,F.J. (2019). Inferring population dynamics from single-cell RNA-sequencing time series data. Nature Biotechnology, 37 (4), 461-468. *
Open Access Revisión
19 - Salinno,C., Cota,P., Bastidas-Ponce,A., Tarquis-Medina,M., Lickert,H., Bakhti,M. (2019). B -Cell Maturation and Identity in Health and Disease. International Journal of Molecular Sciences, 20 (21). *
Revisión
20 - Scheibner,K., Bakhti,M., Bastidas-Ponce,A., Lickert,H. (2019). Wnt signaling: implications in endoderm development and pancreas organogenesis. Current Opinion in Cell Biology, 61, 48-55. *
Open Access Revisión
21 - Bastidas-Ponce,A., Scheibner,K., Lickert,H., Bakhti,M. (2017). Cellular and molecular mechanisms coordinating pancreas development. Development, 144 (16), 2873-2888. *
Open Access Artículo
22 - Bastidas-Ponce,A., Roscioni,S.S., Burtscher,I., Bader,E., Sterr,M., Bakhti,M., Lickert,H. (2017). Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic Iý-cells. Molecular Metabolism, 6 (6), 524-534. *
Open Access Artículo
24 - Quarta,C., Clemmensen,C., Zhu,Z., Yang,B., Joseph,S.S., Lutter,D., Yi,C.X., Graf,E., Garcia-Caceres,C., Legutko,B., Fischer,K., Brommage,R., Zizzari,P., Franklin,B.S., Krueger,M., Koch,M., Vettorazzi,S., Li,P., Hofmann,S.M., Bakhti,M., Bastidas-Ponce,A., Lickert,H., Strom,T.M., Gailus-Durner,V., Bechmann,I., Perez-Tilve,D., Tuckermann,J., de Angelis,M.H., Sandoval,D., Cota,D., Latz,E., Seeley,R.J., Muller,T.D., DiMarchi,R.D., Finan,B., Tschop,M.H. (2017). Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. Cell Metabolism, 26 (4), 620-632. *
Open Access Editorial material
25 - Bakhti,M., Bastidas-Ponce,A., Lickert,H. (2019). Sorting Out Fate Determination. Developmental Cell, 49 (1), 1-3. *
26 - Bastidas Ponce, Aimee (2020). Identification and characterization of novel genes involved in pancreas development. Fakultät für Medizin, Doktors der Naturwissenschaften, Technische Universitat Mnchen. *
Asesor: Lickert, Heiko

Open Access Artículo
28 - Akindehin,S., Liskiewicz,A., Liskiewicz,D., Bernecker,M., Garcia-Caceres,C., Drucker,D.J., Finan,B., Grandl,G., Gutgesell,R., Hofmann,S.M., Khalil,A., Liu,X., Cota,P., Bakhti,M., Czarnecki,O., Bastidas-Ponce,A., Lickert,H., Kang,L., Maity,G., Novikoff,A., Parlee,S., Pathak,E., Schriever,S.C., Sterr,M., Ussar,S., Zhang,Q., DiMarchi,R., Tschop,M.H., Pfluger,P.T., Douros,J.D., Muller,T.D.. Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice. Molecular Metabolism, 83, 101915. *
Open Access Artículo
29 - Cota,P., Caliskan,O.S., Bastidas-Ponce,A., Jing,C., Jaki,J., Saber,L., Czarnecki,O., Taskin,D., Blochinger,A.K., Kurth,T., Sterr,M., Burtscher,I., Krahmer,N., Lickert,H., Bakhti,M.. Insulin regulates human pancreatic endocrine cell differentiation invitro. Molecular Metabolism, 79, 101853. *
Open Access Carta
30 - Grandl,G., Collden,G., Feng,J., Bhattacharya,S., Klingelhuber,F., Schomann,L., Bilekova,S., Ansarullah, Xu,W., Far,F.F., Tost,M., Gruber,T., Bastidas-Ponce,A., Zhang,Q., Novikoff,A., Liskiewicz,A., Liskiewicz,D., Garcia-Caceres,C., Feuchtinger,A., Tschop,M.H., Krahmer,N., Lickert,H., Muller,T.D.. Global, neuronal or B cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity. Nature Metabolism, 6 (3), 448-457. *
Open Access Artículo
31 - Cota,P., Saber,L., Taskin,D., Jing,C., Bastidas-Ponce,A., Vanheusden,M., Shahryari,A., Sterr,M., Burtscher,I., Bakhti,M., Lickert,H.. NEUROD2 function is dispensable for human pancreatic B cell specification. Frontiers in Endocrinology, 14, 1286590. *
Artículo
32 - Hrovatin,K., Bastidas-Ponce,A., Bakhti,M., Zappia,L., Buttner,M., Salinno,C., Sterr,M., Bottcher,A., Migliorini,A., Lickert,H., Theis,F.J.. Delineating mouse Iý-cell identity during lifetime and in diabetes with a single cell atlas. Nature Metabolism, 5 (9), 1615-1637. *
Open Access Artículo
33 - Liskiewicz,A., Khalil,A., Liskiewicz,D., Novikoff,A., Grandl,G., Maity-Kumar,G., Gutgesell,R.M., Bakhti,M., Bastidas-Ponce,A., Czarnecki,O., Makris,K., Lickert,H., Feuchtinger,A., Tost,M., Coupland,C., Stander,L., Akindehin,S., Prakash,S., Abrar,F., Castelino,R.L., He,Y., Knerr,P.J., Yang,B., Hogendorf,W.F.J., Zhang,S., Hofmann,S.M., Finan,B., DiMarchi,R.D., Tschop,M.H., Douros,J.D., Muller,T.D.. Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice. Nature Metabolism, 5 (12), 2075-2085. *
Open Access Artículo
34 - Bakhti,M., Bastidas-Ponce,A., Tritschler,S., Czarnecki,O., Tarquis-Medina,M., Nedvedova,E., Jaki,J., Willmann,S.J., Scheibner,K., Cota,P., Salinno,C., Boldt,K., Horn,N., Ueffing,M., Burtscher,I., Theis,F.J., Coskun,U., Lickert,H.. Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis. Nature Communications, 13 (1), 4540. *
Open Access Artículo
35 - Quarta,C., Stemmer,K., Novikoff,A., Yang,B., Klingelhuber,F., Harger,A., Bakhti,M., Bastidas-Ponce,A., Bauge,E., Campbell,J.E., Capozzi,M., Clemmensen,C., Collden,G., Cota,P., Douros,J., Drucker,D.J., DuBois,B., Feuchtinger,A., Garcia-Caceres,C., Grandl,G., Hennuyer,N., Herzig,S., Hofmann,S.M., Knerr,P.J., Kulaj,K., Lalloyer,F., Lickert,H., Liskiewicz,A., Liskiewicz,D., Maity,G., Perez-Tilve,D., Prakash,S., Sanchez-Garrido,M.A., Zhang,Q., Staels,B., Krahmer,N., DiMarchi,R.D., Tschop,M.H., Finan,B., Muller,T.D.. GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice. Nature Metabolism, 4 (8), 1071-1083. *
Artículo
36 - Ansarullah, Jain,C., Far,F.F., Homberg,S., Wissmiller,K., von Hahn,F.G., Raducanu,A., Schirge,S., Sterr,M., Bilekova,S., Siehler,J., Wiener,J., Oppenlander,L., Morshedi,A., Bastidas-Ponce,A., Irmler,M., Beckers,J., Feuchtinger,A., Grzybek,M., Ahlbrecht,C., Feederle,R., Plettenburg,O., Muller,T.D., Meier,M., Tschop,M.H., Coskun,U., Lickert,H.. Inceptor counteracts insulin signalling in B -cells to control glycaemia. Nature, 590 (7845), 326-331 [correction vol 502 (9852)]. *
Open Access Artículo
37 - Chhabra,N.F., Amend,A.L., Bastidas-Ponce,A., Sabrautzki,S., Tarquis-Medina,M., Sachs,S., Rubey,M., Lorenz-Depiereux,B., Feuchtinger,A., Bakhti,M., Lickert,H., Przemeck,G.K.H., de Angelis,M.H.. A point mutation in the Pdia6 gene results in loss of pancreatic B -cell identity causing overt diabetes. Molecular Metabolism, 54, 101334. *
Open Access Artículo
38 - Nasteska,D., Fine,N.H.F., Ashford,F.B., Cuozzo,F., Viloria,K., Smith,G., Dahir,A., Dawson,P.W.J., Lai,Y.C., Bastidas-Ponce,A., Bakhti,M., Rutter,G.A., Fiancette,R., Nano,R., Piemonti,L., Lickert,H., Zhou,Q., Akerman,I., Hodson,D.J.. PDX1(LOW) MAFA(LOW) B -cells contribute to islet function and insulin release. Nature Communications, 12 (1), 674 [Correction vol 12 p 4521 ]. *
Open Access Artículo
39 - Oppenlander,L., Palit,S., Stemmer,K., Greisle,T., Sterr,M., Salinno,C., Bastidas-Ponce,A., Feuchtinger,A., Bottcher,A., Ansarullah, Theis,F.J., Lickert,H.. Vertical sleeve gastrectomy triggers fast B -cell recovery upon overt diabetes. Molecular Metabolism, 54. *
Open Access Artículo
40 - Salinno,C., Buttner,M., Cota,P., Tritschler,S., Tarquis-Medina,M., Bastidas-Ponce,A., Scheibner,K., Burtscher,I., Bottcher,A., Theis,F.J., Bakhti,M., Lickert,H.. CD81 marks immature and dedifferentiated pancreatic B -cells. Molecular Metabolism, 49, 101188. *
Open Access Artículo
41 - Tarquis-Medina,M., Scheibner,K., Gonzalez-Garcia,I., Bastidas-Ponce,A., Sterr,M., Jaki,J., Schirge,S., Garcia-Caceres,C., Lickert,H., Bakhti,M.. Synaptotagmin-13 Is a Neuroendocrine Marker in Brain, Intestine and Pancreas. International Journal of Molecular Sciences, 22 (22). *
Artículo
42 - Sachs,S., Bastidas-Ponce,A., Tritschler,S., Bakhti,M., Bottcher,A., Sanchez-Garrido,M.A., Tarquis-Medina,M., Kleinert,M., Fischer,K., Jall,S., Harger,A., Bader,E., Roscioni,S., Ussar,S., Feuchtinger,A., Yesildag,B., Neelakandhan,A., Jensen,C.B., Cornu,M., Yang,B., Finan,B., DiMarchi,R.D., Tschop,M.H., Theis,F.J., Hofmann,S.M., Muller,T.D., Lickert,H.. Targeted pharmacological therapy restores B -cell function for diabetes remission. Nature Metabolism, 2 (2), 192-209 [Correction vol 2 (4) p 380]. *
43 - Bastidas Ponce, Aimee. Identification and characterization of novel genes involved in pancreas development. Fakultät für Medizin, Doktors der Naturwissenschaften, Technische Universitat Mnchen. *
Open Access Artículo
44 - Bakhti,M., Scheibner,K., Tritschler,S., Bastidas-Ponce,A., Tarquis-Medina,M., Theis,F.J., Lickert,H.. Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology invitro. Molecular Metabolism, 30, 16-29. *
Open Access Artículo
45 - Bastidas-Ponce,A., Tritschler,S., Dony,L., Scheibner,K., Tarquis-Medina,M., Salinno,C., Schirge,S., Burtscher,I., Bottcher,A., Theis,F.J., Lickert,H., Bakhti,M.. Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis. Development, 146 (12). *
Artículo
46 - Fischer,D.S., Fiedler,A.K., Kernfeld,E.M., Genga,R.M.J., Bastidas-Ponce,A., Bakhti,M., Lickert,H., Hasenauer,J., Maehr,R., Theis,F.J.. Inferring population dynamics from single-cell RNA-sequencing time series data. Nature Biotechnology, 37 (4), 461-468. *
Open Access Revisión
47 - Salinno,C., Cota,P., Bastidas-Ponce,A., Tarquis-Medina,M., Lickert,H., Bakhti,M.. B -Cell Maturation and Identity in Health and Disease. International Journal of Molecular Sciences, 20 (21). *
Revisión
48 - Scheibner,K., Bakhti,M., Bastidas-Ponce,A., Lickert,H.. Wnt signaling: implications in endoderm development and pancreas organogenesis. Current Opinion in Cell Biology, 61, 48-55. *
Open Access Editorial material
49 - Bakhti,M., Bastidas-Ponce,A., Lickert,H.. Sorting Out Fate Determination. Developmental Cell, 49 (1), 1-3. *
Open Access Revisión
50 - Bastidas-Ponce,A., Scheibner,K., Lickert,H., Bakhti,M.. Cellular and molecular mechanisms coordinating pancreas development. Development, 144 (16), 2873-2888. *
Open Access Artículo
51 - Bastidas-Ponce,A., Roscioni,S.S., Burtscher,I., Bader,E., Sterr,M., Bakhti,M., Lickert,H.. Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic Iý-cells. Molecular Metabolism, 6 (6), 524-534. *
Artículo
Open Access Artículo
53 - Quarta,C., Clemmensen,C., Zhu,Z., Yang,B., Joseph,S.S., Lutter,D., Yi,C.X., Graf,E., Garcia-Caceres,C., Legutko,B., Fischer,K., Brommage,R., Zizzari,P., Franklin,B.S., Krueger,M., Koch,M., Vettorazzi,S., Li,P., Hofmann,S.M., Bakhti,M., Bastidas-Ponce,A., Lickert,H., Strom,T.M., Gailus-Durner,V., Bechmann,I., Perez-Tilve,D., Tuckermann,J., de Angelis,M.H., Sandoval,D., Cota,D., Latz,E., Seeley,R.J., Muller,T.D., DiMarchi,R.D., Finan,B., Tschop,M.H.. Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. Cell Metabolism, 26 (4), 620-632. *