14Oct - 2024
Opening Windows into the Cell: Bringing Structure to Cell Biology using Cryo-electron Tomography
12:00 PM - 02:00 PM|Dra. Elizabeth Villa|Investigator, Howard Hughes Medical Institute Professor of Molecular Biology. School of Biological Sciences, UC San Diego|Invitado por: Dr. Omar Pantoja
Seminario
To perform their function, biological systems need to operate across multiple scales.
Current techniques in structural and cellular biology lack either the resolution or the
context to observe the structure of individual biomolecules in their natural
environment, and are often hindered by artifacts. Our goal is to build tools that can
reveal molecular structures in their native cellular environment using the power of
cryo-electron tomography to image biomolecules at molecular resolution in situ. I will
show how we used these techniques to discover how jumbo phage build a sequence
of compartments, membrane- and protein-bound, that protect the replicating
genomes to avoid host defenses while functioning akin to a eukaryotic nucleus.
Actualizado 2024-10-07 19:01:41