
18Feb - 2025
FRONTIERS IN GENOMICS
10:00 AM - 11:00 AM|Alicia Martin.|Analytic & Translational Genetics Unit. Massachusetts General Hospital & Broad Institute. Harvard Medical School USA.
Seminario
Genomics for the world: ancestral diversity enhances genomic discovery, resolution, interpretation, and contextualization.
Resumen de la plática:
Genomic studies are transforming precision medicine, yet their benefits often overlook diverse, underserved populations. Our research shows that embracing ancestral diversity not only addresses this ethical concern but also enhances genomic discovery, resolution, interpretation, and contextualization. Analyzing lung diseases across multiple biobanks, we found consistent genetic effects and improved our understanding of pleiotropy in lung comorbidities. Leveraging the All of Us Research Program’s diversity, we improved polygenic risk scores across various traits, particularly for African ancestry populations and traits with large ancestry-enriched effects. To understand how genetic and environmental factors influence disease, we investigated their impact on the plasma proteome, revealing that many disease-associated proteins are affected by environmental exposures like smoking. This work emphasizes the importance of diverse representation in genomic and multi-omic studies for equitable healthcare and deeper understanding of complex traits and diseases. By integrating diverse ancestries and environmental contexts, we advance comprehensive genomic insights benefiting all populations.
Genomic studies are transforming precision medicine, yet their benefits often overlook diverse, underserved populations. Our research shows that embracing ancestral diversity not only addresses this ethical concern but also enhances genomic discovery, resolution, interpretation, and contextualization. Analyzing lung diseases across multiple biobanks, we found consistent genetic effects and improved our understanding of pleiotropy in lung comorbidities. Leveraging the All of Us Research Program’s diversity, we improved polygenic risk scores across various traits, particularly for African ancestry populations and traits with large ancestry-enriched effects. To understand how genetic and environmental factors influence disease, we investigated their impact on the plasma proteome, revealing that many disease-associated proteins are affected by environmental exposures like smoking. This work emphasizes the importance of diverse representation in genomic and multi-omic studies for equitable healthcare and deeper understanding of complex traits and diseases. By integrating diverse ancestries and environmental contexts, we advance comprehensive genomic insights benefiting all populations.
Auditorio Dr. Francisco G. Bolívar Zapata.
Actualizado 2025-02-18 09:56:48
09-Junio-2025 al 09-Junio-2025
12:00 PM
Dra. Anayántzin Paulina Heredia Antúnez
12:00 PM
Dra. Anayántzin Paulina Heredia Antúnez
Bienestar y evaluación del dolor en animales de experimentación
El bienestar animal es un concepto utilizado para caracterizar el estado físico y mental de un animal y cómo éste enfrenta las condiciones en las que vive. La American Veterinary Medical Association, indica para que haya bienestar animal se “requiere la prevención y el tratamiento de enfermedades y dolor, un cuidado responsable, un alojamiento adecuado, manejo, nutrición, trato humanitario y cuando sea necesario, la eutanasia humanitaria”.
La Dra. Anayántzin Paulina Heredia Antúnez es académica de la Facultad de Estudios Superiores Iztacala y es Presidenta de la Federación de Sociedades y Asociaciones Hispanas de América del Norte, Centroamérica y Caribe de la Ciencia de los Animales de Laboratorio; cuenta con la certificación en Animales de Laboratorio por la Universidad de Guelph, Canadá y en México, por CONCERVET, y está certificada como técnica de bioterio por la Asociación Americana de la Ciencia de Animales de Laboratorio.