Dra. Gloria Saab Rincon
Investigador
Desarrollo de biosensores
Evolución de la relación estructura/función de proteínas
Ingeniería y Tecnología de Enzimas
Plegamiento de proteínas
Número de registros: 12
- Activos
- Vencidos
- Diseño de proteínas a través de evolución dirigida con retroalimentación estructural, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2023 - 2025
- Fortalecimiento a infraestructura para el análisis de interacción proteína-ligando del ibt-unam, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2021
- Estrategias para guiar con diseño semi-racional la evolución dirigida de proteínas, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2020 - 2022
- estabilización del dominio reductasa de cytp450 de b. megaterium a través de consenso, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2017 - 2020
- Determinantes estructurales de agregación fibrilar de triosa fosfato isomerasa, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2014 - 2017
- Evolución dirigida y plegamiento de proteínas, PRESUPUESTO UNAM, 2014 - 2020
- Evolución dirigida de la alfa-amilasa de thermotoga marítima para incrementar actividad transglicosídica, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2012 - 2015
- 3er usa-mexico workshop in biological chemestry: protein folding and dynamics: nature´s keys to function, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2012 - 2013
- Permutación circular en barriles tim, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2011 - 2013
- Evolución dirigida de alfa-amilasa para la producción de alquil-glucósidos, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2008 - 2010
- Estudio del efecto de la topología en el plegamiento de un barril tim mediante permutación circular., CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2007 - 2010
- Evolución dirigida de proteínas., DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2004 - 2006
Nivel C del PRIDE
Nivel II del SNII
Nivel II del SNII
Doctorado, Química, Universidad del Estado de Pensylvania, E.U.A. (1989-1994)
Maestría, en Química Farmaceutica, Fac. de Química-UNAM (1985-1986)
Licenciatura, Química Farmaceutica Biologa, Fac. de Química-UNAM (1979-1984)
Miembro de la Academia Mexicana de Ciencias, 2005
- Activos
- Graduados
-
Doctorado
-
M.C. Emma Liliana Arévalo Salina
Construcción de una proteína de unión a endoxifeno con alta afinidad y selectividad. -
Incremento de la actividad alcoholítica de la alfa-amilasa AmyA de Thermotoga marítima
-
Maestría
-
Lic. Ekaterina Jalomo Khayrova
Evaluación del efecto de la capacidad calorífica sobre la catálisis de una enzima dimérica
1 - Arreola Barroso, Rodrigo Alejandro (2024). Analisis de los contactos entre aminoacidos para identificar moduladores de la funcion fuera del sitio catalitico de enzimas : el caso de hidrolisis y transglicosidacion en la familia de las glicosido hidrolasas GH13 .
Instituto de Biotecnologia,
Doctorado en Bioquimicas,
UNAM.
Asesor: Saab Rincon, Gloria
2 - Lopez Meza, Jesus Manuel (2024). Construccion de una biblioteca de mutantes del citocromo P450BM3 para hidroxilar acido p-cumarico.
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Saab Rincon, Gloria
3 - Llopiz Arzuaga, Alexey (2023). Determinantes de las actividades hidroliticas y transglicosidicas en enzimas de la familia de las glicosil hidrolasas.
Instituto de Biotecnologia,
Doctorado en Bioquimicas,
UNAM.
Asesor: Saab Rincon, Gloria
4 - Maya Malerva, Tomas Francisco (2022). Construccion de quimeras de proteinas con plegamiento de barril TIM.
Instituto de Biotecnologia,
Maestro en Ciencias Bioquimicas,
UNAM.
Asesor: Saab Rincon, Gloria
5 - Jalomo Khayrova, Ekaterina (2020). Caracterizacion del desplegamiento y comportamiento cinetico de una proteina dimerica para su uso como herramienta en la evaluacion del efecto de la capacidad calorifica sobre la catalisis enzimatica.
Instituto de Biotecnologia,
Maestría en Ciencias Bioquímicas,
UNAM.
Asesor: Saab Rincon, Gloria
6 - Jimenez Niebla, Jorge Luis (2019). Síntesis de ácido cafeico usando variantes del citocromo bm3 .
Instituto de Biotecnologia,
Maestría en Ciencias Bioquímicas,
UNAM.
Asesor: Saab Rincon, Gloria
7 - Carcamo Noriega, Edson Norberto (2016). Identificacion de regiones amiloidogenicas en triosa fosfato isomerasa humana.
Instituto de Biotecnologia,
Doctorado en Bioquimicas,
UNAM.
Asesor: Saab Rincon, Gloria
8 - Arevalo Salina, Emma Liliana (2016). Construccion de una proteina sensora de calcio tipo efhand a partir de una proteina moduladora .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Saab Rincon, Gloria
9 - Arreola Barroso, Rodrigo Alejandro (2015). Incremento de la actividad alcoholitica de la alfaamilasa de amya de thermotoga maritima.
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Saab Rincon, Gloria
10 - Perusquia Hernandez, Carolina (2014). Estudio del plegamiento de la triosa fosfato isomerasa humana .
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Saab Rincon, Gloria
11 - Ochoa Leyva, Adrian (2008). Diseno de proteinas a traves de intercambio de asas cataliticas en barriles TIM.
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Saab Rincon, Gloria
12 - Carrillo Hernandez, Azucena (2008). Translocacion del asa-6 de la subunidad alfa de triptofano sintetasa en el asa-6 de PRAI (Fosforribosil Antranilato Isomerasa) .
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
*
Asesor: Saab Rincon, Gloria
13 - Damian Almazo, Juanita Yazmin (2006). Generacion de mutantes de alfa amilasa de Thermotoga maritima con una actividad alcoholitica incrementada.
Instituto de Biotecnologia,
Maestria en Ciencias Bioquimicas,
UNAM.
Asesor: Saab Rincon, Gloria
14 - Rivera, Heriberto Manuel (2004). Especificidad y funcion de la actividad de transglicosidacion de la alfa amilasa de Bacillus licheniformis .
Instituto de Biotecnologia,
Doctorado en Biotecnologia,
UNAM.
Asesor: Saab Rincon, Gloria
15 - Mancera Ramos, Eugenio (2002). Recombinacion in vivo de fragmentos de la enzima fosforribosil antranilato isomerasa (PRAI).
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
*
Asesor: Saab Rincon, Gloria
16 - Fuentes Gallego, Patricia (2001). Fragmentacion del gene de la enzima fosforribosil antranilato isomerasa (PRAI) de E. coli y regeneracion de su actividad mediante complementacion de fragmentos.
Instituto de Biotecnologia,
Maestria en Ciencias (Bioquimica),
UNAM.
Asesor: Saab Rincon, Gloria
17 - Diaz Mireles, Edith (2001). Fosforilacion de la proteina de 24 kDa (24RNP) y su efecto en la afinidad al extremo 3` de petD de RNA de cloroplasto .
Facultad de Quimica,
Maestro en Ciencias (Bioquimica),
UNAM.
*
Asesor: Saab Rincon, Gloria
18 - Juarez Gonzalez, Victor Rivelino (2000). Regeneracion enzimatica de una variante monomerica de la enzima Triosafosfato Isomerasa de Trypanosoma brucei mediante mutagenesis al azar .
Instituto de Biotecnologia,
Maestria en Ciencias (Bioquimica),
UNAM.
Asesor: Saab Rincon, Gloria
19 - Rivera, Manuel Heriberto (1999). Importancia del dominio B de una alfa -amilasa de Bacillus stearothermophilus para reacciones de transferencia.
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
*
Asesor: Saab Rincon, Gloria
Total de publicaciones: 59
- Tipo
- Fecha
Artículo
20 - Rendon-Luna,D.F., Arroyo-Mosso,I.A., De Luna-Valenciano,H., Campos,F., Segovia,L., Saab-Rincon,G., Cuevas-Velazquez,C.L., Reyes,J.L., Covarrubias,A.A. (2024). Alternative conformations of a group 4 Late Embryogenesis Abundant protein associated to its in vitro protective activity.
Scientific Reports,
14 (1),
2770.
Artículo
21 - Uribe-Vazquez,B., Diaz-Vilchis,A, Avila-Linares,A., Saab-Rincon,G, Marin-Tovar,Y., Flores,H, Pastor,N, Huerta-Miranda,G, Rudino-Pinera,E., Soberon,X (2024). Characterization of a catalase-peroxidase variant (L333V-KatG) identified in an INH-resistant Mycobacterium tuberculosis clinical isolate.
Biochemistry and Biophysics Reports,
37,
101649.
Artículo
22 - Llopiz,A., Ramirez-Martinez,M.A., Olvera,L., Xolalpa-Villanueva,W., Pastor,N., Saab-Rincon,G. (2023). The Role of a Loop in the Non-catalytic Domain B on the Hydrolysis/Transglycosylation Specificity of the 4-x¤-Glucanotransferase from Thermotoga maritima.
Protein Journal,
42 (5),
502-518.
Artículo
23 - Tovar-Ramirez,M.E., Schuth,N., Rodriguez-Meza,O., Kroll,T., Saab-Rincon,G., Costas,M., Lampi,K., Quintanar,L. (2023). ATCUN-like Copper Site in B B2-Crystallin Plays a Protective Role in Cataract-Associated Aggregation.
Inorganic Chemistry,
62 (27),
10592-10604.
Artículo
24 - Arevalo-Salina,E.L., Osuna,J., Flores,H., Saab-Rincon,G. (2021). Engineering a calcium-dependent conformational change in Calbindin D(9k) by secondary elements replacement.
Archives of Biochemistry and Biophysics,
714,
109065 [corrigendum 109108].
Artículo
25 - Arreola-Barroso,R.A., Llopiz,A., Olvera,L., Saab-Rincon,G. (2021). Modulating Glycoside Hydrolase Activity between Hydrolysis and Transfer Reactions Using an Evolutionary Approach.
Molecules,
26 (21),
6586.
Artículo
26 - Netzahual-Lopantzi,A., Sanchez-Ramirez,J.F., Saab-Rincon,G., Jimenez-Perez,J.L. (2020). Thermal diffusivity monitoring during the stages of formation of core-shell structures of SiO2@Au.
Applied Physics A-Materials Science & Processing,
126 (5),
392.
Artículo
27 - Cesa-Luna,C., Munoz-Rojas,J., Saab-Rincon,G., Baez,A., Morales-Garcia,Y.E., Juarez-Gonzalez,V.R., Quintero-Hernandez,V. (2019). Structural characterization of scorpion peptides and their bactericidal activity against clinical isolates of multidrug-resistant bacteria.
PLoS ONE,
14 (11),
e0222438.
Artículo
28 - Garcia-Orozco,K.D., Cinco-Moroyoqui,F., Angulo-Sanchez,L.T., Marquez-Rios,E., Burgos-Hernandez,A., Cardenas-Lopez,J.L., Gomez-Aguilar,C., Corona-Martinez,D.O., Saab-Rincon,G., Sotelo-Mundo,R.R. (2019). Biochemical Characterization of a Novel alpha/beta-Hydrolase/FSH from the White Shrimp Litopenaeus vannamei.
Biomolecules,
9 (11),
E674,
E674.
Artículo
29 - Miranda-Molina,A., Xolalpa,W., Strompen,S., Arreola-Barroso,R., Olvera,L., Lopez-Munguia,A., Castillo,E., Saab-Rincon,G. (2019). Deep Eutectic Solvents as New Reaction Media to Produce Alkyl-Glycosides Using Alpha-Amylase from Thermotoga maritima.
International Journal of Molecular Sciences,
20 (21),
E5439,
E5439.
Artículo
30 - Saab-Rincon, G., Alwaseem, H., Guzman-Luna, V., Olvera, L., Fasan, R. (2018). Stabilization of the Reductase Domain in the Catalytically Self-Sufficient Cytochrome P450BM3 via Consensus-Guided Mutagenesis.
Chembiochem,
19 (6),
622-632.
Artículo
31 - Carcamo, E., Roldan-Salgado, A., Osuna, J., Bello San-Martin, I., Yanez, J.A., Saab-Rincon, G., Viadiu, H., Gaytan, P. (2017). Spiked Genes: A Method to Introduce Random Point Nucleotide Mutations Evenly throughout an Entire Gene Using a Complete Set of Spiked Oligonucleotides for the Assembly.
ACS Omega,
2 (7),
3183-3191.
Artículo
32 - Guzman-Luna, V., Olvera-Rodriguez, L., Bustamante-Villalobos, P., Saab-Rincon, G. (2017). Characterization of a New Allelic Variant of Triosephosphate Isomerase from the LNCaP Human Prostate Cancer Cell Line: Enzyme Inhibition and Spectroscopic Studies.
Current Enzyme Inhibition,
13 (3),
184-190.
Artículo
33 - Carcamo-Noriega,E.N., Saab-Rincon,G. (2016). Identification of fibrillogenic regions in human triosephosphate isomerase.
PeerJ,
4,
e1676.
Artículo
34 - Cuevas-Velazquez,C.L., Saab-Rincon,G., Reyes,J.L., Covarrubias,A.A. (2016). The unstructured N-terminal region of Arabidopsis group 4 Late Embryogenesis Abundant Proteins (LEA) is required for folding and for chaperone-like activity under water deficit.
Journal of Biological Chemistry,
291 (20),
10893-10903.
Artículo
35 - Montero-Moran,G.M., Sampedro,J.G., Saab-Rincon,G., Cervantes-Gonzalez,M.A., Huerta-Ocampo,J.A., De Leon-Rodriguez,A., Barba de la Rosa,A.P. (2015). Biochemical and Molecular Characterization of a Novel Cu/Zn Superoxide Dismutase from Amaranthus hypochondriacus L.: an Intrinsically Disordered Protein.
Applied Biochemistry and Biotechnology,
176 (8),
2328-2345.
Artículo
36 - Strompen,S., Miranda-Molina,A., Lopez-Munguia,A., Castillo,E., Saab-Rincon,G. (2015). Acceptor-induced modification of regioselectivity in CGTase-catalyzed glycosylations of p-nitrophenyl-glucopyranosides.
Carbohydrate Research,
404,
46-54.
Artículo
37 - Bushey,D.F., Bannon,G.A., Delaney,B.F., Graser,G., Hefford,M., Jiang,X., Lee,T.C., Madduri,K.M., Pariza,M., Privalle,L.S., Ranjan,R., Saab-Rincon,G., Schafer,B.W., Thelen,J.J., Zhang,J.X., Harper,M.S. (2014). Characteristics and Safety Assessment of Intractable Proteins in Genetically Modified Crops.
Regulatory Toxicology and Pharmacology,
69 (2),
154-170.
Artículo
38 - Hernandez-Moreno,A.V., Villasenor,F., Medina-Rivero,E., Perez,N.O., Flores-Ortiz,L.F., Saab-Rincon,G., Luna-Barcenas,G. (2014). Kinetics and conformational stability studies of recombinant leucine aminopeptidase.
International Journal of Biological Macromolecules,
64,
306-312.
Artículo
39 - Rivera-Najera,L.Y., Saab-Rincon,G., Battaglia,M., Amero,C., Pulido,N.O., Garcia-Hernandez,E., Solorzano,R.M., Reyes,J.L., Covarrubias,A.A. (2014). A Group 6 Late Embryogenesis Abundant Protein from Common Bean is a Disordered Protein with Extended Helical Structure and Oligomer-Forming Properties.
Journal of Biological Chemistry,
289 (46),
31995-32009.
Artículo
40 - Ochoa-Leyva,A., Montero-Moran,G., Saab-Rincon,G., Brieba,L.G., Soberon,X. (2013). Alternative Splice Variants in TIM Barrel Proteins from Human Genome Correlate with the Structural and Evolutionary Modularity of this Versatile Protein Fold.
PLoS ONE,
8 (8),
e70582.
Artículo
41 - Figueroa-Angulo,E.E., Estrella-Hernandez,P., Salgado-Lugo,H., Ochoa-Leyva,A., Gomez-Puyou,A., Campos,S.S., Montero-Moran,G., Ortega-Lopez,J., Saab-Rincon,G., Arroyo,R., Benitez-Cardoza,C.G., Brieba,L.G. (2012). Cellular and biochemical characterization of two closely related triosephosphate isomerases from Trichomonas vaginalis.
Parasitology,
139 (13),
1729-1738.
Artículo
42 - Osuna,J., Flores,H., Saab-Rincon,G. (2012). The beta1 domain of protein G can replace the chorismate mutase domain of the T-protein.
FEBS Letters,
586 (4),
466-471.
Artículo
43 - Saab-Rincon,G., Olvera,L., Olvera,M., Rudino-Pinera,E., Benites,E., Soberon,X., Morett,E. (2012). Evolutionary Walk between (beta/alpha)(8) Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase.
Journal of Molecular Biology,
416 (2),
255-270.
Artículo
44 - Ochoa-Leyva,A., Barona-Gomez,F., Saab-Rincon,G., Verdel-Aranda,K., Sanchez,F., Soberon,X. (2011). Exploring the Structure-Function Loop Adaptability of a (beta/alpha)(8)-Barrel Enzyme through Loop Swapping and Hinge Variability.
Journal of Molecular Biology,
411 (1),
143-157.
Artículo
45 - Moreno,A., Damian-Almazo,J.Y., Miranda,A., Saab-Rincon,G., Gonzalez,F., Lopez-Munguia,A. (2010). Transglycosylation reactions of Thermotoga maritima [alpha]-amylase.
Enzyme and Microbial Technology,
46 (5),
331-337.
Artículo
46 - Munoz-Garay,C., Rodriguez-Almazan,C., Aguilar,J.N., Portugal,L., Gomez,I., Saab-Rincon,G., Soberon,M., Bravo,A. (2009). Oligomerization of Cry11Aa from Bacillus thuringiensis has an important role in toxicity against Aedes aegypti.
Applied and Environmental Microbiology,
75 (23),
7548-7550.
Artículo
47 - Ochoa-Leyva,A., Soberon,X., Sanchez,F., Arguello,M., Montero-Moran,G., Saab-Rincon,G. (2009). Protein design through systematic catalytic loop exchange (SCLE) in the (beta/alpha)(8)-fold.
Journal of Molecular Biology,
387 (4),
949-964.
Artículo
48 - Pacheco,S., Gomez,I., Arenas,I., Saab-Rincon,G., Rodriguez-Almazan,C., Gill,S.S., Bravo,A., Soberon,M. (2009). Domain II loop 3 of Bacillus thuringiensis Cry1Ab toxin is involved in a "ping-pong" binding mechanism with Manduca sexta aminopetidase-N and cadherin receptors.
Journal of Biological Chemistry,
284 (47),
32750-32757.
Revisión
49 - Saab-Rincon,G., Valderrama,B. (2009). Protein engineering of redox-active enzymes.
Antioxidants and Redox Signaling,
11 (2),
167-192.
Artículo
50 - Damian-Almazo,J.Y., Moreno,A., Lopez-Munguia,A., Soberon,X., Gonzalez-Munoz,F., Saab-Rincon,G. (2008). Enhancement of the alcoholytic activity of {alpha}-amylase AmyA from Thermotoga maritima MSB8 (DSM 3109) by site directed mutagenesis.
Applied and Environmental Microbiology,
74 (16),
5168-5177.
Artículo; Actas Paper
Artículo
52 - Morett,E., Saab-Rincon,G., Olvera,L., Olvera,M., Flores,H., Grande,R. (2008). Sensitive Genome-Wide Screen for Low Secondary Enzymatic Activities: The YjbQ Family Shows Thiamin Phosphate Synthase Activity.
Journal of Molecular Biology,
376 (3),
839-853.
Artículo
53 - Jimenez-Juarez,N., Munoz-Garay,C., Gomez,I., Saab-Rincon,G., Damian-Almazo,J.Y., Gill,S.S., Soberon,M., Bravo,A. (2007). Bacillus thuringiensis Cry1Ab mutants affecting oligomer formation are non toxic to Manduca sexta larvae.
Journal of Biological Chemistry,
282 (29),
21222-21229.
Artículo
54 - Saab-Rincon,G., Mancera,E., Montero-Moran,G., Sanchez,F., Soberon,X. (2005). Generation of variability by in vivo recombination of halves of a (beta/alpha)(8) barrel protein.
Biomolecular Engineering,
22 (4),
113-120.
Artículo
Artículo
56 - Soberon,X., Fuentes-Gallego,P., Saab-Rincon,G. (2004). In vivo fragment complementation of a (beta/alpha)(8) barrel protein: generation of variability by recombination.
FEBS Letters,
560 (1-3),
167-172.
Artículo
57 - Morett,E., Korbel,J.O., Rajan,E., Saab-Rincon,G., Olvera,L., Olvera,M., Schmidt,S., Snel,B., Bork,P. (2003). Systematic discovery of analogous enzymes in thiamin biosynthesis.
Nature Biotechnology,
21 (7),
790-795.
Artículo
58 - Rivera,M.H., Lopez-Munguia,A., Soberon,X., Saab-Rincon,G. (2003). alpha-Amylase from Bacillus licheniformis mutants near to the catalytic site: effects on hydrolytic and transglycosylation activity.
Protein Engineering,
16 (7),
505-514.
Artículo
59 - Chanez-Cardenas,M.E., Fernandez-Velasco,D.A., Vazquez-Contreras,E., Coria,R., Saab-Rincon,G., Perez-Montfort,R. (2002). Unfolding of Triosephosphate Isomerase from Trypanosoma brucei: Identification of Intermediates and Insight into the Denaturation Pathway Using Tryptophan Mutants.
Archives of Biochemistry and Biophysics,
399 (2),
117-129.
Artículo
60 - Garcia-Arellano,H., Valderrama,B., Saab-Rincon,G., Vazquez-Duhalt,R. (2002). High temperature biocatalysis by chemically modified cytochrome C.
Bioconjugate Chemistry,
13 (6),
1336-1344.
Artículo; Actas
61 - Morett,E., Korbel,J.O., Rajan,E., Saab-Rincon,G., Olvera,L., Olvera,M., Schmidt,S., Snel,B., Bork,P. (2002). Discovery of Analogous Enzymes in Thiamin Biosynthesis by Anticorrelation.
Genome Informatics,
13,
365-366.
Artículo
62 - Saab-Rincon,G., Juarez,V.R., Osuna,J., Sanchez,F., Soberon,X. (2001). Different strategies to recover the activity of monomeric triosephosphate isomerase by directed evolution.
Protein Engineering,
14 (3),
149-155.
Artículo
63 - Saab-Rincon,G., Del Rio,G., Santamaria,R.I., Lopez-Munguia,A., Soberon,X. (1999). Introducing transglycosylation activity in a liquefying alpha-amylase.
FEBS Letters,
453 (1-2),
100-106.
Artículo
64 - Santamaria,R.I., Del Rio,G., Saab,G., Rodriguez,M.E., Soberon,X., Lopez-Manguia,A. (1999). Alcoholysis reactions from starch with alpha-amylases.
FEBS Letters,
452 (3),
346-350.
Artículo
65 - Saab-Rincon,G., Gualfetti,P.J., Matthews,C.R. (1996). Mutagenic and thermodynamic analyses of residual structure in the alpha subunit of tryptophan synthase.
Biochemistry,
35 (6),
1988-1994.
*
Artículo
66 - Saab-Rincon,G., Froebe,C.L., Matthews,C.R. (1993). Urea-induced unfolding of the alpha subunit of tryptophan synthase: one-dimensional proton NMR evidence for residual structure near histidine-92 at high denaturant concentration.
Biochemistry,
32 (50),
13981-13990.
*
Capítulo
67 - Saab-Rincon,G., Llopiz,A., Arreola-Barroso,R. (2023). The use of biocatalysis for biosurfactant production. Biosurfactants: Research and Development.
265-301.
Reimpresion
68 - Miranda-Molina,A., Xolalpa,W., Strompen,S., Arreola-Barroso,R., Olvera,L., Lopez-Munguia,A., Castillo,E., Saab-Rincon,G. (2020). Deep Eutectic Solvents as New Reaction Media to Produce Alkyl-Glycosides Using Alpha-Amylase from Thermotoga maritima [Reimpresión International Journal of Molecular Sciences special issue 2019] ]. Carbohydrate- Active Enzymes Structure, Activity and Reaction Products. A special issue of International Journal of Molecular Sciences.
169-184.
Internacional
69 - Damian-Almazo,J.Y., Saab-Rincon,G. (2013). Site directed-combinatorial mutagenesis for biocatalysis. Genetic Manipulation of DNA and Protein - Examples from Current Research.
303-330.
Internacional
70 - Castillo,E., Saab-Rincon,G., Chavez-Mercado,C. (2012). Noncovalent interactions in proteins. Tools to Understand Protein-Protein Interactions.
1-20,
Kerala: Research Signpost.
Internacional
71 - Saab-Rincon,G., Li,Y.G., Meyer,M., Carbone,M., Landwehr,M., Arnold,F.H. (2009). Protein Engineering by Structure-Guided (SCHEMA) Recombination. Protein Engineering Handbook cap 20 .
481-493,
2,
Weinheim: Wiley-VCH.
Internacional
Memoria in extenso
73 - Saab-Rincon,G., Del Rio,G, Santamaria,R, Diaz,M.L, Soberon,X., Lopez-Munguia,A. (2002). Novel and potential applications of alpha-amylases in the food industry. Engineering and Food for the 21st Century. Proceedings of the Eighth International Congress on Engineering and Food.
913-924,
Boca Raton, Fla.
Divulgación
74 - Saab-Rincon,G. (2019). El Premio Nobel de Química 2018: Evolución dirigida de enzimas y anticuerpos.
Educación Química,
30 (1),
3-9.
Divulgación
75 - Carcamo-Noriega,E.N., Saab-Rincon,G. (2016). Tejiendo proteínas en fibras dañinas.
Biotecnología en Movimiento. Revista de divulgación del Instituto de Biotecnología de la UNAM,
7,
3-5.
Divulgación
76 - Damian-Almazo,J.Y., Saab-Rincon,G. (2014). Las bacterias generadoras de enzimas que se encuentran hasta en los detergentes.
Hypatia,
47.
77 - Saab Rincon, Gloria (1987). Desarrollo de metodologia analitica para la determinacion de hipoglucemiantes del tipo de los sulfonilureas en formulaciones orales y en plasma humano .
Facultad de Quimica,
Maestro en Ciencias,
UNAM.
*
Asesor: Capella Vizcaino, Santiago
78 - Saab Rincon, Gloria, Ortuno Pineda, Ma de Lourdes (1985). Determinacion del contenido de Ca,Fe,Mg,Mn,yZn, en hojas y granos de maiz y su relacion con la germinacion prematuro .
Facultad de Quimica,
Quimico Farmaceutico Biologo,
UAM.
*
Asesor: Saldivar y Osorio, Liliana Virginia Raquel
Artículo
79 - Rendon-Luna,D.F., Arroyo-Mosso,I.A., De Luna-Valenciano,H., Campos,F., Segovia,L., Saab-Rincon,G., Cuevas-Velazquez,C.L., Reyes,J.L., Covarrubias,A.A.. Alternative conformations of a group 4 Late Embryogenesis Abundant protein associated to its in vitro protective activity.
Scientific Reports,
14 (1),
2770.
Artículo
80 - Uribe-Vazquez,B., Diaz-Vilchis,A, Avila-Linares,A., Saab-Rincon,G, Marin-Tovar,Y., Flores,H, Pastor,N, Huerta-Miranda,G, Rudino-Pinera,E., Soberon,X. Characterization of a catalase-peroxidase variant (L333V-KatG) identified in an INH-resistant Mycobacterium tuberculosis clinical isolate.
Biochemistry and Biophysics Reports,
37,
101649.
Artículo
81 - Llopiz,A., Ramirez-Martinez,M.A., Olvera,L., Xolalpa-Villanueva,W., Pastor,N., Saab-Rincon,G.. The Role of a Loop in the Non-catalytic Domain B on the Hydrolysis/Transglycosylation Specificity of the 4-x¤-Glucanotransferase from Thermotoga maritima.
Protein Journal,
42 (5),
502-518.
Artículo
82 - Tovar-Ramirez,M.E., Schuth,N., Rodriguez-Meza,O., Kroll,T., Saab-Rincon,G., Costas,M., Lampi,K., Quintanar,L.. ATCUN-like Copper Site in B B2-Crystallin Plays a Protective Role in Cataract-Associated Aggregation.
Inorganic Chemistry,
62 (27),
10592-10604.
Capítulo
83 - Saab-Rincon,G., Llopiz,A., Arreola-Barroso,R.. The use of biocatalysis for biosurfactant production. Biosurfactants: Research and Development.
265-301.
Artículo
84 - Arevalo-Salina,E.L., Osuna,J., Flores,H., Saab-Rincon,G.. Engineering a calcium-dependent conformational change in Calbindin D(9k) by secondary elements replacement.
Archives of Biochemistry and Biophysics,
714,
109065 [corrigendum 109108].
Artículo
Artículo
86 - Netzahual-Lopantzi,A., Sanchez-Ramirez,J.F., Saab-Rincon,G., Jimenez-Perez,J.L.. Thermal diffusivity monitoring during the stages of formation of core-shell structures of SiO2@Au.
Applied Physics A-Materials Science & Processing,
126 (5),
392.
Reimpresion
87 - Miranda-Molina,A., Xolalpa,W., Strompen,S., Arreola-Barroso,R., Olvera,L., Lopez-Munguia,A., Castillo,E., Saab-Rincon,G.. Deep Eutectic Solvents as New Reaction Media to Produce Alkyl-Glycosides Using Alpha-Amylase from Thermotoga maritima [Reimpresión International Journal of Molecular Sciences special issue 2019] ]. Carbohydrate- Active Enzymes Structure, Activity and Reaction Products. A special issue of International Journal of Molecular Sciences.
169-184.
Artículo
88 - Cesa-Luna,C., Munoz-Rojas,J., Saab-Rincon,G., Baez,A., Morales-Garcia,Y.E., Juarez-Gonzalez,V.R., Quintero-Hernandez,V.. Structural characterization of scorpion peptides and their bactericidal activity against clinical isolates of multidrug-resistant bacteria.
PLoS ONE,
14 (11),
e0222438.
Artículo
89 - Garcia-Orozco,K.D., Cinco-Moroyoqui,F., Angulo-Sanchez,L.T., Marquez-Rios,E., Burgos-Hernandez,A., Cardenas-Lopez,J.L., Gomez-Aguilar,C., Corona-Martinez,D.O., Saab-Rincon,G., Sotelo-Mundo,R.R.. Biochemical Characterization of a Novel alpha/beta-Hydrolase/FSH from the White Shrimp Litopenaeus vannamei.
Biomolecules,
9 (11),
E674,
E674.
Artículo
90 - Miranda-Molina,A., Xolalpa,W., Strompen,S., Arreola-Barroso,R., Olvera,L., Lopez-Munguia,A., Castillo,E., Saab-Rincon,G.. Deep Eutectic Solvents as New Reaction Media to Produce Alkyl-Glycosides Using Alpha-Amylase from Thermotoga maritima.
International Journal of Molecular Sciences,
20 (21),
E5439,
E5439.
Divulgación
91 - Saab-Rincon,G.. El Premio Nobel de Química 2018: Evolución dirigida de enzimas y anticuerpos.
Educación Química,
30 (1),
3-9.
Artículo
92 - Saab-Rincon, G., Alwaseem, H., Guzman-Luna, V., Olvera, L., Fasan, R.. Stabilization of the Reductase Domain in the Catalytically Self-Sufficient Cytochrome P450BM3 via Consensus-Guided Mutagenesis.
Chembiochem,
19 (6),
622-632.
Artículo
93 - Carcamo, E., Roldan-Salgado, A., Osuna, J., Bello San-Martin, I., Yanez, J.A., Saab-Rincon, G., Viadiu, H., Gaytan, P.. Spiked Genes: A Method to Introduce Random Point Nucleotide Mutations Evenly throughout an Entire Gene Using a Complete Set of Spiked Oligonucleotides for the Assembly.
ACS Omega,
2 (7),
3183-3191.
Artículo
Artículo
95 - Carcamo-Noriega,E.N., Saab-Rincon,G.. Identification of fibrillogenic regions in human triosephosphate isomerase.
PeerJ,
4,
e1676.
Artículo
96 - Cuevas-Velazquez,C.L., Saab-Rincon,G., Reyes,J.L., Covarrubias,A.A.. The unstructured N-terminal region of Arabidopsis group 4 Late Embryogenesis Abundant Proteins (LEA) is required for folding and for chaperone-like activity under water deficit.
Journal of Biological Chemistry,
291 (20),
10893-10903.
Divulgación
97 - Carcamo-Noriega,E.N., Saab-Rincon,G.. Tejiendo proteínas en fibras dañinas.
Biotecnología en Movimiento. Revista de divulgación del Instituto de Biotecnología de la UNAM,
7,
3-5.
Artículo
98 - Montero-Moran,G.M., Sampedro,J.G., Saab-Rincon,G., Cervantes-Gonzalez,M.A., Huerta-Ocampo,J.A., De Leon-Rodriguez,A., Barba de la Rosa,A.P.. Biochemical and Molecular Characterization of a Novel Cu/Zn Superoxide Dismutase from Amaranthus hypochondriacus L.: an Intrinsically Disordered Protein.
Applied Biochemistry and Biotechnology,
176 (8),
2328-2345.
Artículo
99 - Strompen,S., Miranda-Molina,A., Lopez-Munguia,A., Castillo,E., Saab-Rincon,G.. Acceptor-induced modification of regioselectivity in CGTase-catalyzed glycosylations of p-nitrophenyl-glucopyranosides.
Carbohydrate Research,
404,
46-54.
Artículo
100 - Bushey,D.F., Bannon,G.A., Delaney,B.F., Graser,G., Hefford,M., Jiang,X., Lee,T.C., Madduri,K.M., Pariza,M., Privalle,L.S., Ranjan,R., Saab-Rincon,G., Schafer,B.W., Thelen,J.J., Zhang,J.X., Harper,M.S.. Characteristics and Safety Assessment of Intractable Proteins in Genetically Modified Crops.
Regulatory Toxicology and Pharmacology,
69 (2),
154-170.
Artículo
101 - Hernandez-Moreno,A.V., Villasenor,F., Medina-Rivero,E., Perez,N.O., Flores-Ortiz,L.F., Saab-Rincon,G., Luna-Barcenas,G.. Kinetics and conformational stability studies of recombinant leucine aminopeptidase.
International Journal of Biological Macromolecules,
64,
306-312.
Artículo
102 - Rivera-Najera,L.Y., Saab-Rincon,G., Battaglia,M., Amero,C., Pulido,N.O., Garcia-Hernandez,E., Solorzano,R.M., Reyes,J.L., Covarrubias,A.A.. A Group 6 Late Embryogenesis Abundant Protein from Common Bean is a Disordered Protein with Extended Helical Structure and Oligomer-Forming Properties.
Journal of Biological Chemistry,
289 (46),
31995-32009.
Divulgación
Artículo
104 - Ochoa-Leyva,A., Montero-Moran,G., Saab-Rincon,G., Brieba,L.G., Soberon,X.. Alternative Splice Variants in TIM Barrel Proteins from Human Genome Correlate with the Structural and Evolutionary Modularity of this Versatile Protein Fold.
PLoS ONE,
8 (8),
e70582.
Internacional
105 - Damian-Almazo,J.Y., Saab-Rincon,G.. Site directed-combinatorial mutagenesis for biocatalysis. Genetic Manipulation of DNA and Protein - Examples from Current Research.
303-330.
Artículo
106 - Figueroa-Angulo,E.E., Estrella-Hernandez,P., Salgado-Lugo,H., Ochoa-Leyva,A., Gomez-Puyou,A., Campos,S.S., Montero-Moran,G., Ortega-Lopez,J., Saab-Rincon,G., Arroyo,R., Benitez-Cardoza,C.G., Brieba,L.G.. Cellular and biochemical characterization of two closely related triosephosphate isomerases from Trichomonas vaginalis.
Parasitology,
139 (13),
1729-1738.
Artículo
107 - Osuna,J., Flores,H., Saab-Rincon,G.. The beta1 domain of protein G can replace the chorismate mutase domain of the T-protein.
FEBS Letters,
586 (4),
466-471.
Artículo
108 - Saab-Rincon,G., Olvera,L., Olvera,M., Rudino-Pinera,E., Benites,E., Soberon,X., Morett,E.. Evolutionary Walk between (beta/alpha)(8) Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase.
Journal of Molecular Biology,
416 (2),
255-270.
Internacional
109 - Castillo,E., Saab-Rincon,G., Chavez-Mercado,C.. Noncovalent interactions in proteins. Tools to Understand Protein-Protein Interactions.
1-20,
Kerala: Research Signpost.
Artículo
110 - Ochoa-Leyva,A., Barona-Gomez,F., Saab-Rincon,G., Verdel-Aranda,K., Sanchez,F., Soberon,X.. Exploring the Structure-Function Loop Adaptability of a (beta/alpha)(8)-Barrel Enzyme through Loop Swapping and Hinge Variability.
Journal of Molecular Biology,
411 (1),
143-157.
Artículo
111 - Moreno,A., Damian-Almazo,J.Y., Miranda,A., Saab-Rincon,G., Gonzalez,F., Lopez-Munguia,A.. Transglycosylation reactions of Thermotoga maritima [alpha]-amylase.
Enzyme and Microbial Technology,
46 (5),
331-337.
Artículo
112 - Munoz-Garay,C., Rodriguez-Almazan,C., Aguilar,J.N., Portugal,L., Gomez,I., Saab-Rincon,G., Soberon,M., Bravo,A.. Oligomerization of Cry11Aa from Bacillus thuringiensis has an important role in toxicity against Aedes aegypti.
Applied and Environmental Microbiology,
75 (23),
7548-7550.
Artículo
113 - Ochoa-Leyva,A., Soberon,X., Sanchez,F., Arguello,M., Montero-Moran,G., Saab-Rincon,G.. Protein design through systematic catalytic loop exchange (SCLE) in the (beta/alpha)(8)-fold.
Journal of Molecular Biology,
387 (4),
949-964.
Artículo
114 - Pacheco,S., Gomez,I., Arenas,I., Saab-Rincon,G., Rodriguez-Almazan,C., Gill,S.S., Bravo,A., Soberon,M.. Domain II loop 3 of Bacillus thuringiensis Cry1Ab toxin is involved in a "ping-pong" binding mechanism with Manduca sexta aminopetidase-N and cadherin receptors.
Journal of Biological Chemistry,
284 (47),
32750-32757.
Revisión
115 - Saab-Rincon,G., Valderrama,B.. Protein engineering of redox-active enzymes.
Antioxidants and Redox Signaling,
11 (2),
167-192.
Internacional
116 - Saab-Rincon,G., Li,Y.G., Meyer,M., Carbone,M., Landwehr,M., Arnold,F.H.. Protein Engineering by Structure-Guided (SCHEMA) Recombination. Protein Engineering Handbook cap 20 .
481-493,
2,
Weinheim: Wiley-VCH.
Artículo
117 - Damian-Almazo,J.Y., Moreno,A., Lopez-Munguia,A., Soberon,X., Gonzalez-Munoz,F., Saab-Rincon,G.. Enhancement of the alcoholytic activity of {alpha}-amylase AmyA from Thermotoga maritima MSB8 (DSM 3109) by site directed mutagenesis.
Applied and Environmental Microbiology,
74 (16),
5168-5177.
Artículo; Actas Paper
118 - Damian-Almazo,J.Y., Lopez-Munguia A., Soberon-Mainero,X., Saab-Rincon,G.. Role of the phenylalanine 260 residue in defining product profile and alcoholytic activity of the a-amylase AmyA from Thermotoga maritima.
Biologia,
63 (6),
1035-1043.
Artículo
119 - Morett,E., Saab-Rincon,G., Olvera,L., Olvera,M., Flores,H., Grande,R.. Sensitive Genome-Wide Screen for Low Secondary Enzymatic Activities: The YjbQ Family Shows Thiamin Phosphate Synthase Activity.
Journal of Molecular Biology,
376 (3),
839-853.
Artículo
120 - Jimenez-Juarez,N., Munoz-Garay,C., Gomez,I., Saab-Rincon,G., Damian-Almazo,J.Y., Gill,S.S., Soberon,M., Bravo,A.. Bacillus thuringiensis Cry1Ab mutants affecting oligomer formation are non toxic to Manduca sexta larvae.
Journal of Biological Chemistry,
282 (29),
21222-21229.
Artículo
121 - Saab-Rincon,G., Mancera,E., Montero-Moran,G., Sanchez,F., Soberon,X.. Generation of variability by in vivo recombination of halves of a (beta/alpha)(8) barrel protein.
Biomolecular Engineering,
22 (4),
113-120.
Artículo
122 - Moreno,A., Saab-Rincon,G., Santamaria,R.I., Soberon,X., Lopez-Munguia,A.. A more efficient starch degradation by the combination of hydrolase and transferase activities of alpha-amylase and cyclomaltodextrin glucanotransferase.
Starch-Starke,
56 (2),
63-68.
Artículo
123 - Soberon,X., Fuentes-Gallego,P., Saab-Rincon,G.. In vivo fragment complementation of a (beta/alpha)(8) barrel protein: generation of variability by recombination.
FEBS Letters,
560 (1-3),
167-172.
Artículo
124 - Morett,E., Korbel,J.O., Rajan,E., Saab-Rincon,G., Olvera,L., Olvera,M., Schmidt,S., Snel,B., Bork,P.. Systematic discovery of analogous enzymes in thiamin biosynthesis.
Nature Biotechnology,
21 (7),
790-795.
Artículo
125 - Rivera,M.H., Lopez-Munguia,A., Soberon,X., Saab-Rincon,G.. alpha-Amylase from Bacillus licheniformis mutants near to the catalytic site: effects on hydrolytic and transglycosylation activity.
Protein Engineering,
16 (7),
505-514.
Internacional
Artículo
127 - Chanez-Cardenas,M.E., Fernandez-Velasco,D.A., Vazquez-Contreras,E., Coria,R., Saab-Rincon,G., Perez-Montfort,R.. Unfolding of Triosephosphate Isomerase from Trypanosoma brucei: Identification of Intermediates and Insight into the Denaturation Pathway Using Tryptophan Mutants.
Archives of Biochemistry and Biophysics,
399 (2),
117-129.
Artículo
128 - Garcia-Arellano,H., Valderrama,B., Saab-Rincon,G., Vazquez-Duhalt,R.. High temperature biocatalysis by chemically modified cytochrome C.
Bioconjugate Chemistry,
13 (6),
1336-1344.
Artículo; Actas
129 - Morett,E., Korbel,J.O., Rajan,E., Saab-Rincon,G., Olvera,L., Olvera,M., Schmidt,S., Snel,B., Bork,P.. Discovery of Analogous Enzymes in Thiamin Biosynthesis by Anticorrelation.
Genome Informatics,
13,
365-366.
Memoria in extenso
130 - Saab-Rincon,G., Del Rio,G, Santamaria,R, Diaz,M.L, Soberon,X., Lopez-Munguia,A.. Novel and potential applications of alpha-amylases in the food industry. Engineering and Food for the 21st Century. Proceedings of the Eighth International Congress on Engineering and Food.
913-924,
Boca Raton, Fla.
Artículo
131 - Saab-Rincon,G., Juarez,V.R., Osuna,J., Sanchez,F., Soberon,X.. Different strategies to recover the activity of monomeric triosephosphate isomerase by directed evolution.
Protein Engineering,
14 (3),
149-155.
Artículo
132 - Saab-Rincon,G., Del Rio,G., Santamaria,R.I., Lopez-Munguia,A., Soberon,X.. Introducing transglycosylation activity in a liquefying alpha-amylase.
FEBS Letters,
453 (1-2),
100-106.
Artículo
133 - Santamaria,R.I., Del Rio,G., Saab,G., Rodriguez,M.E., Soberon,X., Lopez-Manguia,A.. Alcoholysis reactions from starch with alpha-amylases.
FEBS Letters,
452 (3),
346-350.
Artículo
134 - Saab-Rincon,G., Gualfetti,P.J., Matthews,C.R.. Mutagenic and thermodynamic analyses of residual structure in the alpha subunit of tryptophan synthase.
Biochemistry,
35 (6),
1988-1994.
*
Artículo
135 - Saab-Rincon,G., Froebe,C.L., Matthews,C.R.. Urea-induced unfolding of the alpha subunit of tryptophan synthase: one-dimensional proton NMR evidence for residual structure near histidine-92 at high denaturant concentration.
Biochemistry,
32 (50),
13981-13990.
*
136 - Saab Rincon, Gloria. Desarrollo de metodologia analitica para la determinacion de hipoglucemiantes del tipo de los sulfonilureas en formulaciones orales y en plasma humano .
Facultad de Quimica,
Maestro en Ciencias,
UNAM.
*
Asesor: Saldivar y Osorio, Liliana Virginia Raquel
137 - Saab Rincon, Gloria, Ortuno Pineda, Ma de Lourdes. Determinacion del contenido de Ca,Fe,Mg,Mn,yZn, en hojas y granos de maiz y su relacion con la germinacion prematuro .
Facultad de Quimica,
Quimico Farmaceutico Biologo,
UAM.
*
Asesor: Saldivar y Osorio, Liliana Virginia Raquel
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