Dr. Baltazar Becerril Lujan
Investigador
Biología Molecular y Bioquímica de venenos de animales ponzoñosos
Estructura, Función y Manipulación de Péptidos y Proteínas
Medicina molecular
Número de registros: 13
- Activos
- Vencidos
- Desarrollo de un anti-veneno recombinante de origen humano contra picaduras de alacranes ponzoñosos, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2015 - 2025
- Neutralización del veneno de una nueva especie de alacrán de importancia médica usando bibliotecas de scfvs desplegados en fagos y madurados in vitro por diversas estrategias, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2018 - 2021
- Apoyo de cátedra conacyt/195 desarrollo de un anti-veneno recombinante de origen humano contra picaduras de alacranes ponzoñosos, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2015 - 2016
- Desarrollo de un anti-veneno recombinante de origen humano contra las picaduras de alacranes mexicanos, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2015 - 2017
- Construcción y selección de bibliotecas de anticuerpos humanos y murinos desplegados en fagos filamentosos para el aislamiento y caracterización de anticuerpos neutralizantes de venenos de alacranes del género centruroides, PRESUPUESTO UNAM, 2014 - 2020
- Generación de anticuerpos humanos neutralizantes de un segundo epítope de las toxinas cn2 y css2 así como de los venenos de los alacranes centruroides noxius y centruroides suffusus suffusus, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2013 - 2016
- Modificación in vitro de la especificidad de dos anticuerpos (c1 y 3f): de reconocer a la toxina cn2 a reconocer a las toxinas cii1 y cii2, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2012 - 2015
- Evaluación de la estabilidad termodinámica y de la fibrilogénesis in vitro de mutantes sitio específicas de las cadenas ligeras 6ajl2 y ar para explicar la alta tendencia a la agregación amiloide de la familia lambda vi, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2010 - 2012
- Estudio de los cambios conformacionales asociados a la agregación amiloide in vitro del dominio variable de las cadenas ligeras lambda vi, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2007 - 2009
- Estudio de las bases fisicoquímicas y estructurales de la agregación amiloide de las cadenas ligeras lambda vi, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 2004 - 2007
- Estudio sobre las bases moleculares de la amiloidodogenicidad de las cadenas ligeras lambda vi y diseño de ligandos inhibidores de la agregación amiloide., DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 2003 - 2005
- Obtención de anticuerpos recombinantes, con capacidad neutralizante del veneno de alacrán, a partir de una biblioteca inmune de despliegue de fagos, CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍA, 1999 - 2001
- Bcf2 un anticuerpo monoclonal neutralizante en contra del veneno de alacranes mexicanos, DIRECCIÓN GENERAL DE ASUNTOS DEL PERSONAL ACADÉMICO/UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO, 1996 - 2000
Nivel D del PRIDE
Nivel II del SNI
Nivel III del SNI
Nivel II del SNI
Nivel III del SNI
Doctorado, en Ciencias Químicas (Bioquímica), Fac. de Química-UNAM (1986)
Maestría, en Ciencias Químicas, Fac. de Química-UNAM (1982)
Licenciatura, en Biología, Fac. de Ciencias-UNAM (1979)
-
Doctorado
-
Estrategia racional para la neutralización del veneno de una nueva especie de alacrán de importancia médica usando scFvs humanos.
-
M.C. Guillermo Fernandez Taboada
Obtención de un scFv murino neutralizante de la toxina Cl13, presente en el veneno del alacrán Centruroides limpidus, a través de inmunización y evolución dirigida.
-
Estancia Temporal
Total de publicaciones: 99
- Tipo
- Fecha
Artículo
1 - Gomez-Ramirez,I.V., Riano-Umbarila,L., Olamendi-Portugal,T., Restano-Cassulini,R., Possani,L.D., Becerril,B. (2020). Biochemical, electrophysiological and immunological characterization of the venom from Centruroides baergi, a new scorpion species of medical importance in Mexico.
Toxicon,
184,
10-18.
Artículo
2 - Lopez-Giraldo,A.E., Olamendi-Portugal,T., Riano-Umbarila,L., Becerril,B., Possani,L.D., Delepierre,M., Rio-Portilla,F.D. (2020). The three-dimensional structure of the toxic peptide Cl13 from the scorpion Centruroides limpidus.
Toxicon,
184,
158-166.
Artículo
3 - Riano-Umbarila,L., Rojas-Trejo,V.M., Romero-Moreno,J.A., Costas,M., Utrera-Espindola,I., Olamendi-Portugal,T., Possani,L.D., Becerril,B. (2020). Comparative assessment of the VH-VL and VL-VH orientations of single-chain variable fragments of scorpion toxin-neutralizing antibodies.
Molecular Immunology,
122,
141-147.
Artículo
4 - Delgado-Prudencio, G., Possani, L. D., Becerril, B., Ortiz, E. (2019). The Dual alpha-Amidation System in Scorpion Venom Glands.
Toxins (Basel),
11 (7).
Artículo
5 - Riano-Umbarila,L., Gomez-Ramirez,I.V., Ledezma-Candanoza,L.M., Olamendi-Portugal,T., Rodriguez-Rodriguez,E.R., Fernandez-Taboada,G., Possani,L.D., Becerril,B. (2019). Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms.
Toxins (Basel),
11 (1),
32.
Artículo
6 - Ruiz-Zamora,R.A., Guillaume,S., Al-Hilaly,Y.K., Al-Garawi,Z., Rodriguez-Alvarez,F.J., Zavala-Padilla,G., Perez-Carreon,J.I., Rodriguez-Ambriz,S.L., Herrera,G.A., Becerril-Lujan,B., Ochoa-Leyva,A., Melendez-Zajgla,J., Serpell,L., Del Pozo-Yauner,L. (2019). The CDR1 and Other Regions of Immunoglobulin Light Chains are Hot Spots for Amyloid Aggregation.
Scientific Reports,
9 (1),
3123.
Artículo
7 - Carcamo-Noriega, E.N., Olamendi-Portugal, T., Restano-Cassulini, R., Rowe, A., Uribe-Romero, S.J., Becerril, B., Possani, L.D. (2018). Intraspecific variation of Centruroides sculpturatus scorpion venom from two regions of Arizona.
Archives of Biochemistry and Biophysics,
638,
52-57.
Artículo
8 - Luna-Martinez, O.D., Hernandez-Santoyo, A., Villalba-Velazquez, M.I., Sanchez-Alcala, R., Fernandez-Velasco, D.A., Becerril, B. (2017). Stabilizing an amyloidogenic lambda6 light chain variable domain.
Febs Journal,
294 (21),
3702-3717.
Artículo
9 - Olamendi-Portugal, T., Restano-Cassulini, R., Riano-Umbarila, L., Becerril, B., Possani, L.D. (2017). Functional and immuno-reactive characterization of a previously undescribed peptide from the venom of the scorpion centruroides limpidus.
Peptides,
87,
34-40.
Artículo
10 - Riano-Umbarila, L., Rodriguez-Rodriguez, E.R., Santibanez-Lopez, C.E., Guereca, L., Uribe-Romero, S.J., Gomez-Ramirez, I.V., Carcamo-Noriega, E.N., Possani, L.D., Becerril, B. (2017). Updating knowledge on new medically important scorpion species in Mexico.
Toxicon,
138,
130-137.
Artículo
11 - Luna-Martinez,O.D., Vidal-Limon,A., Villalba-Velazquez,M.I., Sanchez-Alcala,R., Garduno-Juarez,R., Uversky,V.N., Becerril,B. (2016). Simple approach for ranking structure determining residues.
PeerJ,
4.
Artículo
12 - Olamendi-Portugal,T., Bartok,A., Zamudio-Zuniga,F., Balajthy,A., Becerril,B., Panyi,G., Possani,L.D. (2016). Isolation, chemical and functional characterization of several new K-channel blocking peptides from the venom of the scorpion Centruroides tecomanus.
Toxicon,
115,
1-12.
Artículo
13 - Riano-Umbarila,L., Ledezma-Candanoza,L.M., Serrano-Posada,H., Fernandez-Taboada,G., Olamendi-Portugal,T., Rojas-Trejo,S., Gomez-Ramirez,I.V., Rudino-Pinera,E., Possani,L.D., Becerril,B. (2016). Optimal neutralization of Centruroides noxius venom is understood through a structural complex between two antibody fragments and the Cn2 toxin.
Journal of Biological Chemistry,
291 (4),
1619-1630.
Artículo
14 - Rodriguez-Rodriguez,E.R., Olamendi-Portugal,T., Serrano-Posada,H., Arredondo-Lopez,J.N., Gomez-Ramirez,I., Fernandez-Taboada,G., Possani,L.D., Vega,G.A., Riano-Umbarila,L., Becerril,B. (2016). Broadening the neutralizing capacity of a family of antibody fragments against different toxins from Mexican scorpions.
Toxicon,
119,
52-63.
Artículo
15 - Quintero-Hernandez,V., Ramirez-Carreto,S., Romero-Gutierrez,M.T., Valdez-Velazquez,L.L., Becerril,B., Possani,L.D., Ortiz,E. (2015). Transcriptome Analysis of Scorpion Species Belonging to the Vaejovis Genus.
PLoS ONE,
10 (2).
Artículo
16 - Ramirez-Carreto,S., Jimenez-Vargas,J.M., Rivas-Santiago,B., Corzo,G., Possani,L.D., Becerril,B., Ortiz,E. (2015). Peptides from the scorpion Vaejovis punctatus with broad antimicrobial activity.
Peptides,
73,
51-59.
Artículo
17 - Villalba,M.I., Canul-Tec,J.C., Luna-Martinez,O.D., Sanchez-Alcala,R., Olamendi-Portugal,T., Rudino-Pinera,E., Rojas,S., Sanchez-Lopez,R., Fernandez-Velasco,D.A., Becerril,B. (2015). Site-directed Mutagenesis Reveals Regions Implicated in the Stability and Fiber Formation of Human lambda3r Light Chains.
Journal of Biological Chemistry,
290,
2577-2592 .
Artículo
18 - Zuniga-Navarrete,F., Gomez,I., Pena,G., Amaro,I., Ortiz,E., Becerril,B., Ibarra,J.E., Bravo,A., Soberon,M. (2015). Identification of Bacillus thuringiensis Cry3Aa toxin domain II loop 1 as the binding site of Tenebrio molitor cadherin repeat CR12.
Insect Biochemistry and Molecular Biology,
59,
50-57.
Artículo; Actas Paper
19 - Aguilar,M.B., Ortiz,E., Kaas,Q., Lopez-Vera,E., Becerril,B., Possani,L.D., de la Cotera,E.P. (2013). Precursor De13.1 from Conus delessertii defines the novel G gene superfamily.
Peptides,
41,
17-20.
Artículo
20 - Gonzalez-Andrade,M., Becerril-Lujan,B., Sanchez-Lopez,R., Cecena-Alvarez,H., Perez-Carreon,J.I., Ortiz-Suri,E., Fernandez-Velasco,D.A., Del Pozo-Yauner,L. (2013). Mutational and genetic determinants of lambda6 light chain amyloidogenesis.
Febs Journal,
280 (23),
6173-6183.
Artículo
21 - Riano-Umbarila,L., Olamendi-Portugal,T., Morelos-Juarez,C., Gurrola,G.B., Possani,L.D., Becerril,B. (2013). A novel human recombinant antibody fragment capable of neutralizing Mexican scorpion toxins.
Toxicon,
76,
370-376.
Artículo
22 - Quintero-Hernandez,V., Del Pozo-Yauner,L., Pedraza-Escalona,M., Juarez-Gonzalez,V.R., Alcantara-Recillas,I., Possani,L.D., Becerril,B. (2012). Evaluation of three different formats of a neutralizing single chain human antibody against toxin Cn2: Neutralization capacity versus thermodynamic stability.
Immunology Letters,
143 (2),
152-160.
Artículo
23 - Ramirez-Carreto,S., Quintero-Hernandez,V., Jimenez-Vargas,J.M., Corzo,G., Possani,L.D., Becerril,B., Ortiz,E. (2012). Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae.
Peptides,
34 (2),
290-295.
Artículo
24 - Rodriguez-Rodriguez,E.R., Ledezma-Candanoza,L.M., Contreras-Ferrat,L.G., Olamendi-Portugal,T., Possani,L.D., Becerril,B., Riano-Umbarila,L. (2012). A Single Mutation in Framework 2 of the Heavy Variable Domain Improves the Properties of a Diabody and a Related Single-Chain Antibody.
Journal of Molecular Biology,
423 (3),
337-350.
Artículo
25 - Amaro,I., Riano-Umbarila,L., Becerril,B., Possani,L.D. (2011). Isolation and characterization of a human antibody fragment specific for Ts1 toxin from Tityus serrulatus scorpion.
Immunology Letters,
139 (1-2),
73-79.
Artículo
26 - Canul-Tec,J.C., Riano-Umbarila,L., Rudino-Pinera,E., Becerril,B., Possani,L.D., Torres-Larios,A. (2011). Structural basis of neutralization of the major toxic component from the scorpion centruroides noxius hoffmann by a human-derived single chain antibody fragment.
Journal of Biological Chemistry,
286 (23),
20892-20900.
Revisión
27 - Quintero-Hernandez,V., Ortiz,E., Rendon,M.R., Schwartz,E.F., Becerril,B., Corzo,G., Possani,L.D. (2011). Scorpion and spider venom peptides: Gene cloning and peptide expression.
Toxicon,
58 (8),
644-663.
Artículo
28 - Riano-Umbarila,L., Contreras-Ferrat,G., Olamendi-Portugal,T., Morelos-Juarez,C., Corzo,G., Possani,L.D., Becerril,B. (2011). Exploiting cross-reactivity to neutralize two different scorpion venoms with one single-chain antibody fragment.
Journal of Biological Chemistry,
286 (8),
6143-6151.
Artículo
29 - Hernandez-Santoyo,A., Del Pozo-Yauner,L., Fuentes-Silva,D., Ortiz,E., Rudino-Pinera,E., Sanchez-Lopez,R., Horjales,E., Becerril,B., Rodriguez-Romero,A. (2010). A single mutation at the sheet switch region results in conformational changes favoring lambda6-light-chain fibrillogenesis.
Journal of Molecular Biology,
396 (2),
280-292.
Artículo
30 - Medecigo,M., Manoutcharian,K., Vasilevko,V., Govezensky,T., Munguia,M.E., Becerril,B., Luz-Madrigal,A., Vaca,L., Cribbs,D.H., Gevorkian,G. (2010). Novel amyloid-beta specific scFv and VH antibody fragments from human and mouse phage display antibody libraries.
Journal of Neuroimmunology,
223 (1-2),
104-114.
Artículo
31 - Blancas-Mejia,L.M., Tellez,L.A., Del Pozo-Yauner,L., Becerril,B., Sanchez-Ruiz,J.M., Fernandez-Velasco,D.A. (2009). Thermodynamic and Kinetic Characterization of a Germ Line Human lambda6 Light-Chain Protein: The Relation between Unfolding and Fibrillogenesis.
Journal of Molecular Biology,
386 (4),
1153-1166.
Revisión
32 - Espino-Solis,G.P., Riano-Umbarila,L., Becerril,B., Possani,L.D. (2009). Antidotes against venomous animals: State of the art and prospectives.
Journal of Proteomics,
72 (2),
183-199.
Artículo
33 - Pedraza-Escalona,M., Becerril-Lujan,B., Agundis,C., Dominguez-Ramirez,L., Pereyra,A., Riano-Umbarila,L., Rodriguez-Romero,A. (2009). Analysis of B-cell epitopes from the allergen Hev b 6.02 revealed by using blocking antibodies.
Molecular Immunology,
46 (4),
668-676.
Artículo
34 - Del Pozo-Yauner,L., Ortiz,E., Sanchez,R., Sanchez-Lopez,R., Guereca,L., Murphy,C.L., Allen,A., Wall,J.S., Fernandez-Velasco,D.A., Solomon,A., Becerril,B. (2008). Influence of the germline sequence on the thermodynamic stability and fibrillogenicity of human lambda 6 light chains.
Proteins,
72 (2),
684-692.
Artículo
35 - Olamendi-Portugal,T., Batista,C.V., Restano-Cassulini,R., Pando,V., Villa-Hernandez,O., Zavaleta-Martinez-Vargas,A., Salas-Arruz,M.C., de la Vega RC, Becerril,B., Possani,L.D. (2008). Proteomic analysis of the venom from the fish eating coral snake Micrurus surinamensis: Novel toxins, their function and phylogeny.
Proteomics,
8 (9),
1919-1932.
Artículo
36 - Restano-Cassulini,R., Olamendi-Portugal,T., Zamudio,F., Becerril,B., Possani,L.D. (2008). Two Novel Ergtoxins, Blockers of K(+)-channels, Purified from the Mexican Scorpion Centruroides elegans elegans.
Neurochemical Research,
33 (8),
1525-1533.
Artículo
37 - Gutierrez-Gonzalez,L., Muresanu,Lucia, Del Pozo-Yauner,L., Sanchez,R., Guereca,L., Becerril,B., Lucke,C. (2007). 1H, 13C and 15N resonance assignment of 6aJL2(R25G), a highly fibrillogenic ׯVI light chain variable domain.
Biomolecular NMR Assignments,
1 (2),
159-161.
Artículo
38 - Lopez-Vera,E., Aguilar,M.B., Schiavon,E., Marinzi,C., Ortiz,E., Restano-Cassulini,R., Batista,C.V.F., Possani,L.D., Heimer de la Cotera,E.P., Peri,F., Becerril,B., Wanke,E. (2007). Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors.
Febs Journal,
274 (15),
3972-3985.
Artículo
39 - Quintero-Hernandez,V., Juarez-Gonzalez,V.R., Ortiz-Leon,M., Sanchez,R., Possani,L.D., Becerril,B. (2007). The change of the scFv into the Fab format improves the stability and in vivo toxin neutralization capacity of recombinant antibodies.
Molecular Immunology,
44 (6),
1307-1315.
Artículo
40 - Romero-Martinez,R., Curiel-Quesada,E., Becerril-Lujan,B., Flores-Carreon,A., Perez-Torres,A., Taylor,M.L. (2007). Detection of constitutive molecules on Histoplasma capsulatum yeasts through single chain variable antibody fragments displayed in M13 phages.
Fems Immunology and Medical Microbiology,
50 (1),
77-85.
Artículo
41 - Almagro,J.C., Quintero-Hernandez,V., Ortiz-Leon,M., Velandia,A., Smith,S.L., Becerril,B. (2006). Design and validation of a synthetic V(H) repertoire with tailored diversity for protein recognition.
Journal of Molecular Recognition,
19 (5),
413-422.
Artículo
42 - Del Pozo-Yauner,L., Ortiz,E., Becerril,B. (2006). The CDR1 of the human lambdaVI light chains adopts a new canonical structure.
Proteins,
62 (1),
122-129.
Artículo
43 - Gomez,I., Arenas,I., Benitez,I., Miranda-Rios,J., Becerril,B., Grande,R., Almagro,J.C., Bravo,A., Soberon,M. (2006). Specific epitopes of domains II and IIII of bacillus thuringiensis Cry1Ab toxin involved in the sequential interaction with cadherin and aminopeptidase-N receptors in manduca sexta.
Journal of Biological Chemistry,
281 (45),
34032-34039.
Artículo
44 - Languren,M., Becerril,B., Cabral,A.R., Fernandez-Altuna,L.E., Pascual,V., Hernandez-Ramirez,D.F., Cabiedes,J. (2006). Characterization of monoclonal anti-beta(2)-glycoprotein-I and anti-prothrombin antibody fragments generated by phage display from a patient with primary antiphospholipid syndrome.
Journal of Autoimmunity,
26 (1),
57-65.
Artículo
45 - Aguilar,M.B., Lopez-Vera,E., Ortiz,E., Becerril,B., Possani,L.D., Olivera,B.M., Heimer de la Cotera,E.P. (2005). A Novel Conotoxin from Conus delessertii with Posttranslationally Modified Lysine Residues.
Biochemistry,
44 (33),
11130-11136.
Artículo
46 - Juarez-Gonzalez,V.R., Riano-Umbarila,L., Quintero-Hernandez,V., Olamendi-Portugal,T., Ortiz-Leon,M., Ortiz,E., Possani,L.D., Becerril,B. (2005). Directed Evolution, Phage Display and Combination of Evolved Mutants: A Strategy to Recover the Neutralization Properties of the scFv Version of BCF2 a Neutralizing Monoclonal Antibody Specific to Scorpion Toxin Cn2.
Journal of Molecular Biology,
346 (5),
1287-1297.
Artículo
47 - Olamendi-Portugal,T., Somodi,S., Fernandez,J.A., Zamudio,F.Z., Becerril,B., Varga,Z., Panyi,G., Gaspar,R., Possani,L.D. (2005). Novel alpha-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockage Kv1.3 over IKCa1 K(+) channels of T cells.
Toxicon,
46 (4),
418-429.
Artículo
48 - Riano-Umbarila,L., Juarez-Gonzalez,V.R., Olamendi-Portugal,T., Ortiz-Leon,M., Possani,L.D., Becerril,B. (2005). A strategy for the generation of specific human antibodies by directed evolution and phage display.
Febs Journal,
272 (10),
2591-2601.
Artículo
49 - Batista,C.V., Del Pozo,L., Zamudio,F.Z., Contreras,S., Becerril,B., Wanke,E., Possani,L.D. (2004). Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins.
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences,
803 (1),
55-66.
Artículo
50 - Manoutcharian,K., Acero,G., Munguia,M.E., Becerril,B., Massieu,L., Govezensky,T., Ortiz,E., Marks,J.D., Cao,C., Ugen,K., Gevorkian,G. (2004). Human single chain Fv antibodies and a complementarity determining region-derived peptide binding to amyloid-beta 1-42.
Neurobiology of Disease,
17 (1),
114-121.
Artículo
51 - Selisko,B., Cosio,G., Garcia,C., Becerril,B., Possani,L.D., Horjales,E. (2004). Bacterial expression, purification and functional characterization of a recombinant chimeric Fab derived from murine mAb BCF2 that neutralizes the venom of the scorpion Centruroides noxius hoffmann.
Toxicon,
43 (1),
43-51.
Artículo
52 - Corona,M., Coronas,F.V., Merino,E., Becerril,B., Gutierrez,R., Rebolledo-Antunez,S., Garcia,D.E., Possani,L.D. (2003). A novel class of peptide found in scorpion venom with neurodepressant effects in peripheral and central nervous system of the rat.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1649 (1),
58-67.
Artículo
53 - Garcia,C., Calderon-Aranda,E.S., Anguiano,G.A., Becerril,B., Possani,L.D. (2003). Analysis of the immune response induced by a scorpion venom sub-fraction, a pure peptide and a recombinant peptide, against toxin Cn2 of Centruroides noxius Hoffmann.
Toxicon,
41 (4),
417-427.
Artículo
54 - O'Connell,D., Becerril,B., Roy-Burman,A., Daws,M., Marks,J.D. (2002). Phage versus phagemid libraries for generation of human monoclonal antibodies.
Journal of Molecular Biology,
321 (1),
49-56.
*
Artículo
55 - Huie,M.A., Cheung,M.C., Muench,M.O., Becerril,B., Kan,Y.W., Marks,J.D. (2001). Antibodies to human fetal erythroid cells from a nonimmune phage antibody library.
Proceedings of the National Academy of Sciences of the United States of America,
98 (5),
2682-2687.
*
Artículo
56 - Possani,L.D., Merino,E., Corona,M., Bolivar,F., Becerril,B. (2000). Peptides and genes coding for scorpion toxins that affect ion-channels.
Biochimie,
82 (9-10),
861-868.
Artículo
57 - Poul,M.A., Becerril,B., Nielsen,U.B., Morisson,P., Marks,J.D. (2000). Selection of tumor-specific internalizing human antibodies from phage libraries.
Journal of Molecular Biology,
301 (5),
1149-1161.
*
Artículo
58 - Becerril,B., Poul,M.A., Marks,J.D. (1999). Toward selection of internalizing antibodies from phage libraries.
Biochemical and Biophysical Research Communications,
255 (2),
386-393.
Artículo
59 - Conde,R., Zamudio,F.Z., Becerril,B., Possani,L.D. (1999). Phospholipin, a novel heterodimeric phospholipase A2 from Pandinus imperator scp6pion venom.
FEBS Letters,
460 (3),
447-450.
Revisión
60 - Possani,L.D., Becerril,B., Delepierre,M., Tytgat,J. (1999). Scorpion toxins specific for Na+-channels.
European Journal of Biochemistry,
264 (2),
287-300.
Artículo
61 - Selisko,B., Licea,A.F., Becerril,B., Zamudio,F., Possani,L.D., Horjales,E. (1999). Antibody BCF2 against scorpion toxin Cn2 from Centuroides noxius Hoffmann: primary structure and three-dimensional model as free Fv fragment and complexed with its antigen.
Proteins,
37 (1),
130-143.
Artículo
62 - Martinez,F., Munoz-Garay,C., Gurrola,G., Darszon,A., Possani,L.D., Becerril,B. (1998). Site directed mutants of Noxiustoxin reveal specific interactions with potassium channels.
FEBS Letters,
429 (3),
381-384.
Revisión
63 - Selisko,B., Garcia,C., Becerril,B., Gomez-Lagunas,F., Garay,C., Possani,L.D. (1998). Cobatoxins 1 and 2 from Centruroides noxius Hoffmann constitute a subfamily of potassium-channel-blocking scorpion toxins.
European Journal of Biochemistry,
254 (3),
468-479.
Revisión
64 - Becerril,B., Marangoni,S., Possani,L.D. (1997). Toxins and genes isolated from scorpions of the genus Tityus.
Toxicon,
35 (6),
821-835.
Artículo
65 - Garcia,C., Becerril,B., Selisko,B., Delepierre,M., Possani,L.D. (1997). Isolation, characterization and comparison of a novel crustacean toxin with a mammalian toxin from the venom of the scorpion Centruroides noxius Hoffmann.
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology,
116 (3),
315-322.
Artículo
66 - Zamudio,F.Z., Conde,R., Arevalo,C., Becerril,B., Martin,B.M., Valdivia,H.H., Possani,L.D. (1997). The mechanism of inhibition of ryanodine receptor channels by imperatoxin I, a heterodimeric protein from the scorpion Pandinus imperator.
Journal of Biological Chemistry,
272 (18),
11886-11894.
Artículo
67 - Becerril,B., Corona,M., Coronas,F.I., Zamudio,F., Calderon-Aranda,E.S., Fletcher,P.L., Martin,B.M., Possani,L.D. (1996). Toxic peptides and genes encoding toxin gamma of the Brazilian scorpions Tityus bahiensis and Tityus stigmurus.
Biochemical Journal,
313 (Pt 3),
753-760.
Artículo
68 - Corona,M., Zurita,M., Possani,L.D., Becerril,B. (1996). Cloning and characterization of the genomic region encoding toxin IV-5 from the scorpion Tityus serrulatus Lutz and Mello.
Toxicon,
34 (2),
251-256.
Artículo
69 - Licea,A.F., Becerril,B., Possani,L.D. (1996). Fab fragments of the monoclonal antibody BCF2 are capable of neutralizing the whole soluble venom from the scorpion Centruroides noxius Hoffmann.
Toxicon,
34 (8),
843-847.
Artículo
70 - Martinez,F., Becerril,B., Gurrola,G.B., Martin,B.M., Possani,L.D. (1996). Synthesis and expression of the gene coding for noxiustoxin, a K+ channel-blocking peptide from the venom of the scorpion Centruroides noxius.
Toxicon,
34 (11-12),
1413-1419.
Artículo
71 - Selisko,B., Garcia,C., Becerril,B., Delepierre,M., Possani,L.D. (1996). An insect-specific toxin from Centruroides noxius Hoffmann. cDNA, primary structure, three-dimensional model and electrostatic surface potentials in comparison with other toxin variants.
European Journal of Biochemistry,
242 (2),
235-242.
Artículo
72 - Becerril,B., Corona,M., Garcia,C., Bolivar,F., Possani,L.D. (1995). Cloning of genes encoding scorpion toxins: An interpretative review.
Journal Of Toxicology-Toxin Reviews,
14 (3),
339-357.
Artículo
73 - Vazquez,A., Tapia,J.V., Eliason,W.K., Martin,B.M., Lebreton,F., Delepierre,M., Possani,L.D., Becerril,B. (1995). Cloning and characterization of the cDNAs encoding Na+ channel-specific toxins 1 and 2 of the scorpion Centruroides noxius Hoffmann.
Toxicon,
33 (9),
1161-1170.
Artículo
74 - Becerril,B., Corona,M., Mejia,M.C., Martin,B.M., Lucas,S., Bolivar,F., Possani,L.D. (1993). The genomic region encoding toxin gamma from the scorpion Tityus serrulatus contains an intron.
FEBS Letters,
335 (1),
6-8.
Artículo
75 - Becerril,B., Vazquez,A., Garcia,C., Corona,M., Bolivar,F., Possam,L.D. (1993). Cloning and characterization of cDNAs that code for Na(+)-channel-blocking toxins of the scorpion Centruroides noxius Hoffmann.
Gene,
128 (2),
165-171.
Artículo
76 - Vazquez,A., Becerril,B., Martin,B.M., Zamudio,F., Bolivar,F., Possani,L.D. (1993). Primary structure determination and cloning of the cDNA encoding toxin 4 of the scorpion Centruroides noxius Hoffmann.
FEBS Letters,
320 (1),
43-46.
Artículo
77 - Merino,E., Balbas,P., Aarons,S.R., Recillas,F., Becerril,B., Valle,F., Bolivar,F. (1992). Carbon regulation and the role in nature of the Escherichia coli penicillin acylase (pac) gene.
Molecular Microbiology,
6 (15),
2175-2182.
Artículo
78 - Martinez-Medellin,J., Valdes-Lopez,V., Alba Lois,L., Becerril,B., Mayani,H., Mainero,A. (1991). A study of erythropoiesis and iron metabolism in the rabbit in vivo. I. Characterization and limits of the physiological response.
Archivos de Investigacion Medica,
22 (3-4),
309-315.
Artículo
79 - Gosset,G., Merino,E., Recillas,F., Oliver,G., Becerril,B., Bolivar,F. (1989). Amino acid sequence analysis of the glutamate synthase enzyme from Escherichia coli K-12.
Protein sequences & data analysis,
2 (1),
9-16.
Artículo
80 - Riba,L., Becerril,B., Servin-Gonzalez,L., Valle,F., Bolivar,F. (1988). Identification of a functional promoter for the Escherichia coli gdhA gene and its regulation.
Gene,
71 (2),
233-246.
Artículo
81 - Oliver,G., Gosset,G., Sanchez-Pescador,R., Lozoya,E., Ku,L.M., FLORES,N., Becerril,B., Valle,F., Bolivar,F. (1987). Determination of the nucleotide sequence for the glutamate synthase structural genes of Escherichia coli K-12.
Gene,
60 (1),
1-11.
Artículo
82 - Becerril,B., Valle,F., Merino,E., Riba,L., Bolivar,F. (1985). Repetitive extragenic palindromic (REP) sequences in the Escherichia coli gdhA gene.
Gene,
37 (1-3),
53-62.
Artículo
83 - Valle,F., Becerril,B., Chen,E., Seeburg,P., Heyneker,H., Bolivar,F. (1984). Complete nucleotide sequence of the glutamate dehydrogenase gene from Escherichia coli K-12.
Gene,
27 (2),
193-199.
Internacional
84 - Pozo-Yauner,L., Becerril,B., Ochoa-Leyva,A., Rodriguez-Ambriz,S.L., Perez-Carrion,J.I., Zavala-Padilla,G., Sanchez-Lopez,R., Fernandez-Velasco,D.A. (2015). The Structural Determinants of the Immunoglobulin Light Chain Amyloid Aggregation. Physical Biology of Proteins and Peptides: Theory, Experiment, and Simulation.
1-28,
Cham.
Internacional
85 - Rodriguez-Rodriguez,E.R., Riano-Umbarila,L., Possani,L.D., Becerril,B. (2014). Recombinant neutralizing antibodies, a new generation of scorpion anti-venoms. Scorpion Venoms.
Toxinology,
139-159,
4,
Dordrecht: Springer.
Internacional
86 - del Pozo-Yauner,L, Ortiz,E., Becerril,B. (2009). Diseases related to protein misfolding. Advances in Protein Physical Chemistry.
469-501,
Kerala: Research Signpost.
Memoria in extenso
87 - Gomez,I., Miranda-Rios,J., Arenas,I., Grande,R., Becerril,B., Bravo,A., Soberon,M. (2007). Identification of scFv Molecules that Recognize Loop 3 of Domain II and Domain III of Cry1Ab Toxin from Bacillus thuringiensis. 6th Pacific Rim Conference on the biotechnology of Bacillus thuringiensis and its Environmental Impact .
12-14,
Montreal.
Internacional
88 - Possani,L.D., Merino,E., Corona,M., Becerril,B. (2002). Scorpion genes and peptides specific for potassium channels: Structure, function and evolution. Perspectives in Molecular Toxinology.
201-214.
Internacional
89 - Possani,L.D., Becerril,B., Tytgat,J., Delepierre,M. (2001). High Affinity Scorpion Toxins for Studying Potassium and Sodium Channels. Ion Channel Localization Methods and Protocols: Methods and Protocols.
145-165.
Divulgación
90 - Becerril,B., Villalba,M.I. (2015). Cuando las proteínas se agregan, te causan una enfermedad.
Biotecnología en Movimiento. Revista de divulgación del Instituto de Biotecnología de la UNAM,
3,
3-4.
Divulgación
91 - Becerril-Lujan,B., Riano,L., Possani,L (2014). Bancos de anticuerpos recombinantes de origen humano: una fuente ideal de antivenenos modernos contra la picadura de alacrán.
Revista Digital Universitaria,
15 (11),
art 84.
Divulgación
92 - Becerril-Lujan,B., Riano-Umbarila,L. (2008). Quinta Generación de anti-venenos contra la picadura de alacrán.
Hypatia,
25.
Editorial Material
93 - Rodriguez de la Vega,R.C., Merino,E., Becerril,B., Possani,L.D. (2003). Novel interactions between K(+) channels and scorpion toxins.
Trends in Pharmacological Sciences,
24 (5),
222-227.
Nacional
94 - Chanez-Cardenas,M.E., Cisneros-Armas,D.A., Del Pozo-Yauner,L., Becerril,B., Fernandez-Velasco,D.A. (2002). Enfermedades relacionadas al plegamiento anómalo de las proteinas.
Mensaje Bioquimico,
26,
73-97.
Note
95 - Bravo,A., Becerril,B., Mora,J. (1988). Introduction of the Escherichia coli gdhA gene into Rhizobium phaseoli: effect on nitrogen fixation.
Journal of Bacteriology,
170 (2),
985-988.
*
Note
97 - Becerril Lujan, Baltazar (1986). Caracterizacion de las regiones de regularizacion del gene estructural de la enzima glutamato deshidrogenasa de Escherichia Coli K12.
Instituto de Biotecnologia,
Doctor en Ciencias Quimicas (Bioquimica),
UNAM.
98 - Becerril Lujan, Baltazar (1982). Estudio sobre los niveles de acido 2,3-difosfoglicerico (2,3-DPG) en distintas especies de mamiferos, bajo condiciones normales : Relacion de este y otros metabolitos afines con la anemia cronica inducida.
Facultad de Quimica,
Maestia en Ciencias Quimicas (Bioquimica),
UNAM.
99 - Becerril Lujan, Baltazar (1979). Estudios sobre los niveles de acidos 2,3-difosfoglicirico (2,3-DPG) en consejos sujetos a un proceso de anemia experimental cronica.
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.
Artículo
100 - Gomez-Ramirez,I.V., Riano-Umbarila,L., Olamendi-Portugal,T., Restano-Cassulini,R., Possani,L.D., Becerril,B.. Biochemical, electrophysiological and immunological characterization of the venom from Centruroides baergi, a new scorpion species of medical importance in Mexico.
Toxicon,
184,
10-18.
Artículo
101 - Lopez-Giraldo,A.E., Olamendi-Portugal,T., Riano-Umbarila,L., Becerril,B., Possani,L.D., Delepierre,M., Rio-Portilla,F.D.. The three-dimensional structure of the toxic peptide Cl13 from the scorpion Centruroides limpidus.
Toxicon,
184,
158-166.
Artículo
102 - Riano-Umbarila,L., Rojas-Trejo,V.M., Romero-Moreno,J.A., Costas,M., Utrera-Espindola,I., Olamendi-Portugal,T., Possani,L.D., Becerril,B.. Comparative assessment of the VH-VL and VL-VH orientations of single-chain variable fragments of scorpion toxin-neutralizing antibodies.
Molecular Immunology,
122,
141-147.
Artículo
103 - Delgado-Prudencio, G., Possani, L. D., Becerril, B., Ortiz, E.. The Dual alpha-Amidation System in Scorpion Venom Glands.
Toxins (Basel),
11 (7).
Artículo
104 - Riano-Umbarila,L., Gomez-Ramirez,I.V., Ledezma-Candanoza,L.M., Olamendi-Portugal,T., Rodriguez-Rodriguez,E.R., Fernandez-Taboada,G., Possani,L.D., Becerril,B.. Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms.
Toxins (Basel),
11 (1),
32.
Artículo
105 - Ruiz-Zamora,R.A., Guillaume,S., Al-Hilaly,Y.K., Al-Garawi,Z., Rodriguez-Alvarez,F.J., Zavala-Padilla,G., Perez-Carreon,J.I., Rodriguez-Ambriz,S.L., Herrera,G.A., Becerril-Lujan,B., Ochoa-Leyva,A., Melendez-Zajgla,J., Serpell,L., Del Pozo-Yauner,L.. The CDR1 and Other Regions of Immunoglobulin Light Chains are Hot Spots for Amyloid Aggregation.
Scientific Reports,
9 (1),
3123.
Artículo
106 - Carcamo-Noriega, E.N., Olamendi-Portugal, T., Restano-Cassulini, R., Rowe, A., Uribe-Romero, S.J., Becerril, B., Possani, L.D.. Intraspecific variation of Centruroides sculpturatus scorpion venom from two regions of Arizona.
Archives of Biochemistry and Biophysics,
638,
52-57.
Artículo
107 - Luna-Martinez, O.D., Hernandez-Santoyo, A., Villalba-Velazquez, M.I., Sanchez-Alcala, R., Fernandez-Velasco, D.A., Becerril, B.. Stabilizing an amyloidogenic lambda6 light chain variable domain.
Febs Journal,
294 (21),
3702-3717.
Artículo
108 - Olamendi-Portugal, T., Restano-Cassulini, R., Riano-Umbarila, L., Becerril, B., Possani, L.D.. Functional and immuno-reactive characterization of a previously undescribed peptide from the venom of the scorpion centruroides limpidus.
Peptides,
87,
34-40.
Artículo
Artículo
110 - Luna-Martinez,O.D., Vidal-Limon,A., Villalba-Velazquez,M.I., Sanchez-Alcala,R., Garduno-Juarez,R., Uversky,V.N., Becerril,B.. Simple approach for ranking structure determining residues.
PeerJ,
4.
Artículo
111 - Olamendi-Portugal,T., Bartok,A., Zamudio-Zuniga,F., Balajthy,A., Becerril,B., Panyi,G., Possani,L.D.. Isolation, chemical and functional characterization of several new K-channel blocking peptides from the venom of the scorpion Centruroides tecomanus.
Toxicon,
115,
1-12.
Artículo
112 - Riano-Umbarila,L., Ledezma-Candanoza,L.M., Serrano-Posada,H., Fernandez-Taboada,G., Olamendi-Portugal,T., Rojas-Trejo,S., Gomez-Ramirez,I.V., Rudino-Pinera,E., Possani,L.D., Becerril,B.. Optimal neutralization of Centruroides noxius venom is understood through a structural complex between two antibody fragments and the Cn2 toxin.
Journal of Biological Chemistry,
291 (4),
1619-1630.
Artículo
113 - Rodriguez-Rodriguez,E.R., Olamendi-Portugal,T., Serrano-Posada,H., Arredondo-Lopez,J.N., Gomez-Ramirez,I., Fernandez-Taboada,G., Possani,L.D., Vega,G.A., Riano-Umbarila,L., Becerril,B.. Broadening the neutralizing capacity of a family of antibody fragments against different toxins from Mexican scorpions.
Toxicon,
119,
52-63.
Artículo
114 - Quintero-Hernandez,V., Ramirez-Carreto,S., Romero-Gutierrez,M.T., Valdez-Velazquez,L.L., Becerril,B., Possani,L.D., Ortiz,E.. Transcriptome Analysis of Scorpion Species Belonging to the Vaejovis Genus.
PLoS ONE,
10 (2).
Artículo
115 - Ramirez-Carreto,S., Jimenez-Vargas,J.M., Rivas-Santiago,B., Corzo,G., Possani,L.D., Becerril,B., Ortiz,E.. Peptides from the scorpion Vaejovis punctatus with broad antimicrobial activity.
Peptides,
73,
51-59.
Artículo
116 - Villalba,M.I., Canul-Tec,J.C., Luna-Martinez,O.D., Sanchez-Alcala,R., Olamendi-Portugal,T., Rudino-Pinera,E., Rojas,S., Sanchez-Lopez,R., Fernandez-Velasco,D.A., Becerril,B.. Site-directed Mutagenesis Reveals Regions Implicated in the Stability and Fiber Formation of Human lambda3r Light Chains.
Journal of Biological Chemistry,
290,
2577-2592 .
Artículo
117 - Zuniga-Navarrete,F., Gomez,I., Pena,G., Amaro,I., Ortiz,E., Becerril,B., Ibarra,J.E., Bravo,A., Soberon,M.. Identification of Bacillus thuringiensis Cry3Aa toxin domain II loop 1 as the binding site of Tenebrio molitor cadherin repeat CR12.
Insect Biochemistry and Molecular Biology,
59,
50-57.
Internacional
118 - Pozo-Yauner,L., Becerril,B., Ochoa-Leyva,A., Rodriguez-Ambriz,S.L., Perez-Carrion,J.I., Zavala-Padilla,G., Sanchez-Lopez,R., Fernandez-Velasco,D.A.. The Structural Determinants of the Immunoglobulin Light Chain Amyloid Aggregation. Physical Biology of Proteins and Peptides: Theory, Experiment, and Simulation.
1-28,
Cham.
Divulgación
119 - Becerril,B., Villalba,M.I.. Cuando las proteínas se agregan, te causan una enfermedad.
Biotecnología en Movimiento. Revista de divulgación del Instituto de Biotecnología de la UNAM,
3,
3-4.
Internacional
120 - Rodriguez-Rodriguez,E.R., Riano-Umbarila,L., Possani,L.D., Becerril,B.. Recombinant neutralizing antibodies, a new generation of scorpion anti-venoms. Scorpion Venoms.
Toxinology,
139-159,
4,
Dordrecht: Springer.
Divulgación
121 - Becerril-Lujan,B., Riano,L., Possani,L. Bancos de anticuerpos recombinantes de origen humano: una fuente ideal de antivenenos modernos contra la picadura de alacrán.
Revista Digital Universitaria,
15 (11),
art 84.
Artículo; Actas Paper
122 - Aguilar,M.B., Ortiz,E., Kaas,Q., Lopez-Vera,E., Becerril,B., Possani,L.D., de la Cotera,E.P.. Precursor De13.1 from Conus delessertii defines the novel G gene superfamily.
Peptides,
41,
17-20.
Artículo
123 - Gonzalez-Andrade,M., Becerril-Lujan,B., Sanchez-Lopez,R., Cecena-Alvarez,H., Perez-Carreon,J.I., Ortiz-Suri,E., Fernandez-Velasco,D.A., Del Pozo-Yauner,L.. Mutational and genetic determinants of lambda6 light chain amyloidogenesis.
Febs Journal,
280 (23),
6173-6183.
Artículo
Artículo
125 - Quintero-Hernandez,V., Del Pozo-Yauner,L., Pedraza-Escalona,M., Juarez-Gonzalez,V.R., Alcantara-Recillas,I., Possani,L.D., Becerril,B.. Evaluation of three different formats of a neutralizing single chain human antibody against toxin Cn2: Neutralization capacity versus thermodynamic stability.
Immunology Letters,
143 (2),
152-160.
Artículo
126 - Ramirez-Carreto,S., Quintero-Hernandez,V., Jimenez-Vargas,J.M., Corzo,G., Possani,L.D., Becerril,B., Ortiz,E.. Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae.
Peptides,
34 (2),
290-295.
Artículo
127 - Rodriguez-Rodriguez,E.R., Ledezma-Candanoza,L.M., Contreras-Ferrat,L.G., Olamendi-Portugal,T., Possani,L.D., Becerril,B., Riano-Umbarila,L.. A Single Mutation in Framework 2 of the Heavy Variable Domain Improves the Properties of a Diabody and a Related Single-Chain Antibody.
Journal of Molecular Biology,
423 (3),
337-350.
Artículo
128 - Amaro,I., Riano-Umbarila,L., Becerril,B., Possani,L.D.. Isolation and characterization of a human antibody fragment specific for Ts1 toxin from Tityus serrulatus scorpion.
Immunology Letters,
139 (1-2),
73-79.
Artículo
129 - Canul-Tec,J.C., Riano-Umbarila,L., Rudino-Pinera,E., Becerril,B., Possani,L.D., Torres-Larios,A.. Structural basis of neutralization of the major toxic component from the scorpion centruroides noxius hoffmann by a human-derived single chain antibody fragment.
Journal of Biological Chemistry,
286 (23),
20892-20900.
Revisión
130 - Quintero-Hernandez,V., Ortiz,E., Rendon,M.R., Schwartz,E.F., Becerril,B., Corzo,G., Possani,L.D.. Scorpion and spider venom peptides: Gene cloning and peptide expression.
Toxicon,
58 (8),
644-663.
Artículo
131 - Riano-Umbarila,L., Contreras-Ferrat,G., Olamendi-Portugal,T., Morelos-Juarez,C., Corzo,G., Possani,L.D., Becerril,B.. Exploiting cross-reactivity to neutralize two different scorpion venoms with one single-chain antibody fragment.
Journal of Biological Chemistry,
286 (8),
6143-6151.
Artículo
132 - Hernandez-Santoyo,A., Del Pozo-Yauner,L., Fuentes-Silva,D., Ortiz,E., Rudino-Pinera,E., Sanchez-Lopez,R., Horjales,E., Becerril,B., Rodriguez-Romero,A.. A single mutation at the sheet switch region results in conformational changes favoring lambda6-light-chain fibrillogenesis.
Journal of Molecular Biology,
396 (2),
280-292.
Artículo
133 - Medecigo,M., Manoutcharian,K., Vasilevko,V., Govezensky,T., Munguia,M.E., Becerril,B., Luz-Madrigal,A., Vaca,L., Cribbs,D.H., Gevorkian,G.. Novel amyloid-beta specific scFv and VH antibody fragments from human and mouse phage display antibody libraries.
Journal of Neuroimmunology,
223 (1-2),
104-114.
Artículo
134 - Blancas-Mejia,L.M., Tellez,L.A., Del Pozo-Yauner,L., Becerril,B., Sanchez-Ruiz,J.M., Fernandez-Velasco,D.A.. Thermodynamic and Kinetic Characterization of a Germ Line Human lambda6 Light-Chain Protein: The Relation between Unfolding and Fibrillogenesis.
Journal of Molecular Biology,
386 (4),
1153-1166.
Revisión
135 - Espino-Solis,G.P., Riano-Umbarila,L., Becerril,B., Possani,L.D.. Antidotes against venomous animals: State of the art and prospectives.
Journal of Proteomics,
72 (2),
183-199.
Artículo
136 - Pedraza-Escalona,M., Becerril-Lujan,B., Agundis,C., Dominguez-Ramirez,L., Pereyra,A., Riano-Umbarila,L., Rodriguez-Romero,A.. Analysis of B-cell epitopes from the allergen Hev b 6.02 revealed by using blocking antibodies.
Molecular Immunology,
46 (4),
668-676.
Internacional
137 - del Pozo-Yauner,L, Ortiz,E., Becerril,B.. Diseases related to protein misfolding. Advances in Protein Physical Chemistry.
469-501,
Kerala: Research Signpost.
Artículo
138 - Del Pozo-Yauner,L., Ortiz,E., Sanchez,R., Sanchez-Lopez,R., Guereca,L., Murphy,C.L., Allen,A., Wall,J.S., Fernandez-Velasco,D.A., Solomon,A., Becerril,B.. Influence of the germline sequence on the thermodynamic stability and fibrillogenicity of human lambda 6 light chains.
Proteins,
72 (2),
684-692.
Artículo
139 - Olamendi-Portugal,T., Batista,C.V., Restano-Cassulini,R., Pando,V., Villa-Hernandez,O., Zavaleta-Martinez-Vargas,A., Salas-Arruz,M.C., de la Vega RC, Becerril,B., Possani,L.D.. Proteomic analysis of the venom from the fish eating coral snake Micrurus surinamensis: Novel toxins, their function and phylogeny.
Proteomics,
8 (9),
1919-1932.
Artículo
140 - Restano-Cassulini,R., Olamendi-Portugal,T., Zamudio,F., Becerril,B., Possani,L.D.. Two Novel Ergtoxins, Blockers of K(+)-channels, Purified from the Mexican Scorpion Centruroides elegans elegans.
Neurochemical Research,
33 (8),
1525-1533.
Divulgación
Artículo
142 - Gutierrez-Gonzalez,L., Muresanu,Lucia, Del Pozo-Yauner,L., Sanchez,R., Guereca,L., Becerril,B., Lucke,C.. 1H, 13C and 15N resonance assignment of 6aJL2(R25G), a highly fibrillogenic ׯVI light chain variable domain.
Biomolecular NMR Assignments,
1 (2),
159-161.
Artículo
143 - Lopez-Vera,E., Aguilar,M.B., Schiavon,E., Marinzi,C., Ortiz,E., Restano-Cassulini,R., Batista,C.V.F., Possani,L.D., Heimer de la Cotera,E.P., Peri,F., Becerril,B., Wanke,E.. Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors.
Febs Journal,
274 (15),
3972-3985.
Artículo
144 - Quintero-Hernandez,V., Juarez-Gonzalez,V.R., Ortiz-Leon,M., Sanchez,R., Possani,L.D., Becerril,B.. The change of the scFv into the Fab format improves the stability and in vivo toxin neutralization capacity of recombinant antibodies.
Molecular Immunology,
44 (6),
1307-1315.
Artículo
145 - Romero-Martinez,R., Curiel-Quesada,E., Becerril-Lujan,B., Flores-Carreon,A., Perez-Torres,A., Taylor,M.L.. Detection of constitutive molecules on Histoplasma capsulatum yeasts through single chain variable antibody fragments displayed in M13 phages.
Fems Immunology and Medical Microbiology,
50 (1),
77-85.
Memoria in extenso
146 - Gomez,I., Miranda-Rios,J., Arenas,I., Grande,R., Becerril,B., Bravo,A., Soberon,M.. Identification of scFv Molecules that Recognize Loop 3 of Domain II and Domain III of Cry1Ab Toxin from Bacillus thuringiensis. 6th Pacific Rim Conference on the biotechnology of Bacillus thuringiensis and its Environmental Impact .
12-14,
Montreal.
Artículo
147 - Almagro,J.C., Quintero-Hernandez,V., Ortiz-Leon,M., Velandia,A., Smith,S.L., Becerril,B.. Design and validation of a synthetic V(H) repertoire with tailored diversity for protein recognition.
Journal of Molecular Recognition,
19 (5),
413-422.
Artículo
148 - Del Pozo-Yauner,L., Ortiz,E., Becerril,B.. The CDR1 of the human lambdaVI light chains adopts a new canonical structure.
Proteins,
62 (1),
122-129.
Artículo
149 - Gomez,I., Arenas,I., Benitez,I., Miranda-Rios,J., Becerril,B., Grande,R., Almagro,J.C., Bravo,A., Soberon,M.. Specific epitopes of domains II and IIII of bacillus thuringiensis Cry1Ab toxin involved in the sequential interaction with cadherin and aminopeptidase-N receptors in manduca sexta.
Journal of Biological Chemistry,
281 (45),
34032-34039.
Artículo
150 - Languren,M., Becerril,B., Cabral,A.R., Fernandez-Altuna,L.E., Pascual,V., Hernandez-Ramirez,D.F., Cabiedes,J.. Characterization of monoclonal anti-beta(2)-glycoprotein-I and anti-prothrombin antibody fragments generated by phage display from a patient with primary antiphospholipid syndrome.
Journal of Autoimmunity,
26 (1),
57-65.
Artículo
151 - Aguilar,M.B., Lopez-Vera,E., Ortiz,E., Becerril,B., Possani,L.D., Olivera,B.M., Heimer de la Cotera,E.P.. A Novel Conotoxin from Conus delessertii with Posttranslationally Modified Lysine Residues.
Biochemistry,
44 (33),
11130-11136.
Artículo
152 - Juarez-Gonzalez,V.R., Riano-Umbarila,L., Quintero-Hernandez,V., Olamendi-Portugal,T., Ortiz-Leon,M., Ortiz,E., Possani,L.D., Becerril,B.. Directed Evolution, Phage Display and Combination of Evolved Mutants: A Strategy to Recover the Neutralization Properties of the scFv Version of BCF2 a Neutralizing Monoclonal Antibody Specific to Scorpion Toxin Cn2.
Journal of Molecular Biology,
346 (5),
1287-1297.
Artículo
153 - Olamendi-Portugal,T., Somodi,S., Fernandez,J.A., Zamudio,F.Z., Becerril,B., Varga,Z., Panyi,G., Gaspar,R., Possani,L.D.. Novel alpha-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockage Kv1.3 over IKCa1 K(+) channels of T cells.
Toxicon,
46 (4),
418-429.
Artículo
154 - Riano-Umbarila,L., Juarez-Gonzalez,V.R., Olamendi-Portugal,T., Ortiz-Leon,M., Possani,L.D., Becerril,B.. A strategy for the generation of specific human antibodies by directed evolution and phage display.
Febs Journal,
272 (10),
2591-2601.
Artículo
155 - Batista,C.V., Del Pozo,L., Zamudio,F.Z., Contreras,S., Becerril,B., Wanke,E., Possani,L.D.. Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins.
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences,
803 (1),
55-66.
Artículo
156 - Manoutcharian,K., Acero,G., Munguia,M.E., Becerril,B., Massieu,L., Govezensky,T., Ortiz,E., Marks,J.D., Cao,C., Ugen,K., Gevorkian,G.. Human single chain Fv antibodies and a complementarity determining region-derived peptide binding to amyloid-beta 1-42.
Neurobiology of Disease,
17 (1),
114-121.
Artículo
157 - Selisko,B., Cosio,G., Garcia,C., Becerril,B., Possani,L.D., Horjales,E.. Bacterial expression, purification and functional characterization of a recombinant chimeric Fab derived from murine mAb BCF2 that neutralizes the venom of the scorpion Centruroides noxius hoffmann.
Toxicon,
43 (1),
43-51.
Artículo
158 - Corona,M., Coronas,F.V., Merino,E., Becerril,B., Gutierrez,R., Rebolledo-Antunez,S., Garcia,D.E., Possani,L.D.. A novel class of peptide found in scorpion venom with neurodepressant effects in peripheral and central nervous system of the rat.
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics,
1649 (1),
58-67.
Artículo
159 - Garcia,C., Calderon-Aranda,E.S., Anguiano,G.A., Becerril,B., Possani,L.D.. Analysis of the immune response induced by a scorpion venom sub-fraction, a pure peptide and a recombinant peptide, against toxin Cn2 of Centruroides noxius Hoffmann.
Toxicon,
41 (4),
417-427.
Editorial Material
160 - Rodriguez de la Vega,R.C., Merino,E., Becerril,B., Possani,L.D.. Novel interactions between K(+) channels and scorpion toxins.
Trends in Pharmacological Sciences,
24 (5),
222-227.
Artículo
161 - O'Connell,D., Becerril,B., Roy-Burman,A., Daws,M., Marks,J.D.. Phage versus phagemid libraries for generation of human monoclonal antibodies.
Journal of Molecular Biology,
321 (1),
49-56.
*
Internacional
162 - Possani,L.D., Merino,E., Corona,M., Becerril,B.. Scorpion genes and peptides specific for potassium channels: Structure, function and evolution. Perspectives in Molecular Toxinology.
201-214.
Nacional
163 - Chanez-Cardenas,M.E., Cisneros-Armas,D.A., Del Pozo-Yauner,L., Becerril,B., Fernandez-Velasco,D.A.. Enfermedades relacionadas al plegamiento anómalo de las proteinas.
Mensaje Bioquimico,
26,
73-97.
Artículo
164 - Huie,M.A., Cheung,M.C., Muench,M.O., Becerril,B., Kan,Y.W., Marks,J.D.. Antibodies to human fetal erythroid cells from a nonimmune phage antibody library.
Proceedings of the National Academy of Sciences of the United States of America,
98 (5),
2682-2687.
*
Internacional
165 - Possani,L.D., Becerril,B., Tytgat,J., Delepierre,M.. High Affinity Scorpion Toxins for Studying Potassium and Sodium Channels. Ion Channel Localization Methods and Protocols: Methods and Protocols.
145-165.
Artículo
166 - Possani,L.D., Merino,E., Corona,M., Bolivar,F., Becerril,B.. Peptides and genes coding for scorpion toxins that affect ion-channels.
Biochimie,
82 (9-10),
861-868.
Artículo
167 - Poul,M.A., Becerril,B., Nielsen,U.B., Morisson,P., Marks,J.D.. Selection of tumor-specific internalizing human antibodies from phage libraries.
Journal of Molecular Biology,
301 (5),
1149-1161.
*
Artículo
168 - Becerril,B., Poul,M.A., Marks,J.D.. Toward selection of internalizing antibodies from phage libraries.
Biochemical and Biophysical Research Communications,
255 (2),
386-393.
Artículo
169 - Conde,R., Zamudio,F.Z., Becerril,B., Possani,L.D.. Phospholipin, a novel heterodimeric phospholipase A2 from Pandinus imperator scp6pion venom.
FEBS Letters,
460 (3),
447-450.
Revisión
170 - Possani,L.D., Becerril,B., Delepierre,M., Tytgat,J.. Scorpion toxins specific for Na+-channels.
European Journal of Biochemistry,
264 (2),
287-300.
Artículo
Artículo
172 - Martinez,F., Munoz-Garay,C., Gurrola,G., Darszon,A., Possani,L.D., Becerril,B.. Site directed mutants of Noxiustoxin reveal specific interactions with potassium channels.
FEBS Letters,
429 (3),
381-384.
Revisión
173 - Selisko,B., Garcia,C., Becerril,B., Gomez-Lagunas,F., Garay,C., Possani,L.D.. Cobatoxins 1 and 2 from Centruroides noxius Hoffmann constitute a subfamily of potassium-channel-blocking scorpion toxins.
European Journal of Biochemistry,
254 (3),
468-479.
Revisión
174 - Becerril,B., Marangoni,S., Possani,L.D.. Toxins and genes isolated from scorpions of the genus Tityus.
Toxicon,
35 (6),
821-835.
Artículo
175 - Garcia,C., Becerril,B., Selisko,B., Delepierre,M., Possani,L.D.. Isolation, characterization and comparison of a novel crustacean toxin with a mammalian toxin from the venom of the scorpion Centruroides noxius Hoffmann.
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology,
116 (3),
315-322.
Artículo
176 - Zamudio,F.Z., Conde,R., Arevalo,C., Becerril,B., Martin,B.M., Valdivia,H.H., Possani,L.D.. The mechanism of inhibition of ryanodine receptor channels by imperatoxin I, a heterodimeric protein from the scorpion Pandinus imperator.
Journal of Biological Chemistry,
272 (18),
11886-11894.
Artículo
177 - Becerril,B., Corona,M., Coronas,F.I., Zamudio,F., Calderon-Aranda,E.S., Fletcher,P.L., Martin,B.M., Possani,L.D.. Toxic peptides and genes encoding toxin gamma of the Brazilian scorpions Tityus bahiensis and Tityus stigmurus.
Biochemical Journal,
313 (Pt 3),
753-760.
Artículo
178 - Corona,M., Zurita,M., Possani,L.D., Becerril,B.. Cloning and characterization of the genomic region encoding toxin IV-5 from the scorpion Tityus serrulatus Lutz and Mello.
Toxicon,
34 (2),
251-256.
Artículo
179 - Licea,A.F., Becerril,B., Possani,L.D.. Fab fragments of the monoclonal antibody BCF2 are capable of neutralizing the whole soluble venom from the scorpion Centruroides noxius Hoffmann.
Toxicon,
34 (8),
843-847.
Artículo
180 - Martinez,F., Becerril,B., Gurrola,G.B., Martin,B.M., Possani,L.D.. Synthesis and expression of the gene coding for noxiustoxin, a K+ channel-blocking peptide from the venom of the scorpion Centruroides noxius.
Toxicon,
34 (11-12),
1413-1419.
Artículo
181 - Selisko,B., Garcia,C., Becerril,B., Delepierre,M., Possani,L.D.. An insect-specific toxin from Centruroides noxius Hoffmann. cDNA, primary structure, three-dimensional model and electrostatic surface potentials in comparison with other toxin variants.
European Journal of Biochemistry,
242 (2),
235-242.
Artículo
182 - Becerril,B., Corona,M., Garcia,C., Bolivar,F., Possani,L.D.. Cloning of genes encoding scorpion toxins: An interpretative review.
Journal Of Toxicology-Toxin Reviews,
14 (3),
339-357.
Artículo
183 - Vazquez,A., Tapia,J.V., Eliason,W.K., Martin,B.M., Lebreton,F., Delepierre,M., Possani,L.D., Becerril,B.. Cloning and characterization of the cDNAs encoding Na+ channel-specific toxins 1 and 2 of the scorpion Centruroides noxius Hoffmann.
Toxicon,
33 (9),
1161-1170.
Artículo
184 - Becerril,B., Corona,M., Mejia,M.C., Martin,B.M., Lucas,S., Bolivar,F., Possani,L.D.. The genomic region encoding toxin gamma from the scorpion Tityus serrulatus contains an intron.
FEBS Letters,
335 (1),
6-8.
Artículo
185 - Becerril,B., Vazquez,A., Garcia,C., Corona,M., Bolivar,F., Possam,L.D.. Cloning and characterization of cDNAs that code for Na(+)-channel-blocking toxins of the scorpion Centruroides noxius Hoffmann.
Gene,
128 (2),
165-171.
Artículo
186 - Vazquez,A., Becerril,B., Martin,B.M., Zamudio,F., Bolivar,F., Possani,L.D.. Primary structure determination and cloning of the cDNA encoding toxin 4 of the scorpion Centruroides noxius Hoffmann.
FEBS Letters,
320 (1),
43-46.
Artículo
187 - Merino,E., Balbas,P., Aarons,S.R., Recillas,F., Becerril,B., Valle,F., Bolivar,F.. Carbon regulation and the role in nature of the Escherichia coli penicillin acylase (pac) gene.
Molecular Microbiology,
6 (15),
2175-2182.
Artículo
188 - Martinez-Medellin,J., Valdes-Lopez,V., Alba Lois,L., Becerril,B., Mayani,H., Mainero,A.. A study of erythropoiesis and iron metabolism in the rabbit in vivo. I. Characterization and limits of the physiological response.
Archivos de Investigacion Medica,
22 (3-4),
309-315.
Artículo
189 - Gosset,G., Merino,E., Recillas,F., Oliver,G., Becerril,B., Bolivar,F.. Amino acid sequence analysis of the glutamate synthase enzyme from Escherichia coli K-12.
Protein sequences & data analysis,
2 (1),
9-16.
Artículo
190 - Riba,L., Becerril,B., Servin-Gonzalez,L., Valle,F., Bolivar,F.. Identification of a functional promoter for the Escherichia coli gdhA gene and its regulation.
Gene,
71 (2),
233-246.
Note
191 - Bravo,A., Becerril,B., Mora,J.. Introduction of the Escherichia coli gdhA gene into Rhizobium phaseoli: effect on nitrogen fixation.
Journal of Bacteriology,
170 (2),
985-988.
*
Artículo
192 - Oliver,G., Gosset,G., Sanchez-Pescador,R., Lozoya,E., Ku,L.M., FLORES,N., Becerril,B., Valle,F., Bolivar,F.. Determination of the nucleotide sequence for the glutamate synthase structural genes of Escherichia coli K-12.
Gene,
60 (1),
1-11.
Note
194 - Becerril Lujan, Baltazar. Caracterizacion de las regiones de regularizacion del gene estructural de la enzima glutamato deshidrogenasa de Escherichia Coli K12.
Instituto de Biotecnologia,
Doctor en Ciencias Quimicas (Bioquimica),
UNAM.
Artículo
195 - Becerril,B., Valle,F., Merino,E., Riba,L., Bolivar,F.. Repetitive extragenic palindromic (REP) sequences in the Escherichia coli gdhA gene.
Gene,
37 (1-3),
53-62.
Artículo
196 - Valle,F., Becerril,B., Chen,E., Seeburg,P., Heyneker,H., Bolivar,F.. Complete nucleotide sequence of the glutamate dehydrogenase gene from Escherichia coli K-12.
Gene,
27 (2),
193-199.
197 - Becerril Lujan, Baltazar. Estudio sobre los niveles de acido 2,3-difosfoglicerico (2,3-DPG) en distintas especies de mamiferos, bajo condiciones normales : Relacion de este y otros metabolitos afines con la anemia cronica inducida.
Facultad de Quimica,
Maestia en Ciencias Quimicas (Bioquimica),
UNAM.
198 - Becerril Lujan, Baltazar. Estudios sobre los niveles de acidos 2,3-difosfoglicirico (2,3-DPG) en consejos sujetos a un proceso de anemia experimental cronica.
Facultad de Ciencias,
Licenciatura en Biología,
UNAM.