Instituto de Biotecnologia UNAM

IBT-UNAM : Dr. Sabino Pacheco Guillen

Dr.

Dr. Sabino Pacheco Guillen


Investigador

Tutor de Maestría y Doctorado

Grupo de la Dra. Maria Alejandra Bravo

email: spacheco@ibt.unam.mx

Teléfonos

Oficina +52 (777) 311-4900 ext 227

Laboratorio +52 (777) 329-1624
desde la CDMX 562-27624

red UNAM 27624
+52 (777) 311-4900 ext 227



Estudiantes

M.C. Maria Luisa Zardo

Emanuel Christian Macario

I.B.Q. Aurora Massiel Diaz

Ing. Diego Peinado

Jean Piere Jesús Quiliche

Publicaciones recientes

Pacheco,S. Quiliche,J.P.J. Gomez,I. Sanchez,J. Soberon,M. Bravo,A. 2020. Rearrangement of N-Terminal alpha-Helices of Bacillus thuringiensis Cry1Ab Toxin Essential for Oligomer Assembly and Toxicity Toxins (Basel), 12, E647.

Onofre,J. Pacheco,S. Torres-Quintero,M.C. Gill,S.S. Soberon,M. Bravo,A. 2020. The Cyt1Aa toxin from Bacillus thuringiensis inserts into target membranes via different mechanisms in insects, red blood cells, and lipid liposomes Journal of Biological Chemistry, 295, 9606-9617.

Chimal-Cazares,F. Hernandez-Martinez,G. Pacheco,S. Ares,M.A. Soria-Bustos,J. Sanchez-Gutierrez,M. Izquierdo-Vega,J.A. Ibarra,J.A. Gonzalez,Y.M.J. Gorvel,J.P. Meresse,S. De la Cruz,M.A. 2020. Molecular Characterization of SehB, a Type II Antitoxin of Salmonella enterica Serotype Typhimurium: Amino Acid Residues Involved in DNA-Binding, Homodimerization, Toxin Interaction, and Virulence Frontiers in Microbiology, 11, 614.

do Nascimento,N.A. Torres-Quintero,M.C. Lopez-Molina,S. Pacheco,S. Romao,T.P. Pereira-Neves,A. Soberon,M. Bravo,A. Silva-Filha,M.H.N.L. 2020. Functional Bacillus thuringiensis Cyt1Aa is necessary to synergize Lysinibacillus sphaericus Binary toxin against Bin-resistant and refractory mosquito species Applied and Environmental Microbiology, 86, 02770-19.

Gomez,I. Rodriguez-Chamorro,D.E. Flores-Ramirez,G. Grande,R. Zuniga,F. Portugal,F.J. Sanchez,J. Pacheco,S. Bravo,A. Soberon,M. 2018. Spodoptera frugiperda (J. E. Smith) aminopeptidase N1 is functional receptor of Bacillus thuringiensis Cry1Ca toxin Applied and Environmental Microbiology, 84, UNSP e01089-18.

Pacheco,S. Gomez,I. Sanchez,J. Garcia-Gomez,B.I. Czajkowsky,D.M. Zhang,J. Soberon,M. Bravo,A. 2018. Helix alpha-3 inter-molecular salt bridges and conformational changes are essential for toxicity of Bacillus thuringiensis 3D-Cry toxin family Scientific Reports, 8, 10331.

Wang,Z. Fang,L. Zhou,Z. Pacheco,S. Gomez,I. Song,F. Soberon,M. Zhang,J. Bravo,A. 2018. Specific binding between Bacillus thuringiensis Cry9Aa and Vip3Aa toxins synergizes their toxicity against Asiatic rice borer (Chilo suppressalis) Journal of Biological Chemistry, 293, 11447.

Torres-Quintero,M.C. Gomez,I. Pacheco,S. Sanchez,J. Flores,H. Osuna,J. Mendoza,G. Soberon,M. Bravo,A. 2018. Engineering Bacillus thuringiensis Cyt1Aa toxin specificity from dipteran to lepidopteran toxicity Scientific Reports, 8, 4989.

Soberon,M. Portugal,L. Garcia-Gomez,B.I. Sanchez,J. Onofre,J. Gomez,I. Pacheco,S. Bravo,A. 2018. Cell lines as models for the study of Cry toxins from Bacillus thuringiensis Insect Biochemistry and Molecular Biology, 93, 66-78.

Pacheco,S. Gomez,I. Sanchez,J. Garcia-Gomez,B.I. Soberon,M. Bravo,A. 2017. Intra-molecular salt bridge in Bacillus thuringiensis Cry4Ba toxin is involved in the stability of helix alpha-3 that is needed for oligomerization and insecticidal activity Applied and Environmental Microbiology, 83, e01515-e01517.

Ares,M.A. Rios-Sarabia,N. De la Cruz,M.A. Rivera-Gutierrez,S. Garcia-Morales,L. Leon-Solis,L. Espitia,C. Pacheco,S. Cerna-Cortes,J.F. Helguera-Repetto,C.A. Garcia,M.J. Gonzalez Y Merchand J.A. 2017. The sigma factor SigD of Mycobacterium tuberculosis putatively enhances gene expression of the septum site determining protein under stressful environments New Microbiologica, 40, .

Ares,M.A. Fernandez-Vazquez,J.L. Pacheco,S. Martinez-Santos,V.I. Jarillo-Quijada,M.D. Torres,J. Alcantar-Curiel,M.D. Gonzalez Y Merchand J.A. De la Cruz,M.A. 2017. Additional regulatory activities of MrkH for the transcriptional expression of the Klebsiella pneumoniae mrk genes: Antagonist of H-NS and repressor PLoS ONE, 12, e0173285.

Onofre,J. Gaytan,M.O. Pena-Cardena,A. Garcia-Gomez,B.I. Pacheco,S. Gomez,I. Bravo,A. Soberon,M. 2017. Identification of Aminopeptidase-N2 as a Cry2Ab binding protein in Manduca sexta Peptides, 98, 93-98.

Xiao,Y. Dai,Q. Hu,R. Pacheco,S. Yang,Y. Liang,G. Soberon,M. Bravo,A. Liu,K. Wu,K. 2017. A Single Point Mutation Resulting in Cadherin Mis-localization Underpins Resistance against Bacillus thuringiensis Toxin in Cotton Bollworm Journal of Biological Chemistry, 292, 2933-2943.

De la Cruz,M.A. Ruiz-Tagle,A. Ares,M.A. Pacheco,S. Yanez,J.A. Cedillo,L. Torres,J. Giron,J.A. 2017. The Expression of Longus type 4 pilus of enterotoxigenic Escherichia coli is regulated by LngR and LngS, and by H-NS, CpxR, and CRP global regulators Environmental Microbiology, 19, 1761-1775.

Cardenas-Mondragon,M.G. Ares,M.A. Panunzi,L.G. Pacheco,S. Camorlinga-Ponce,M. Giron,J.A. Torres,J. De la Cruz,M.A. 2016. Transcriptional Profiling of Type II Toxin-Antitoxin Genes of Helicobacter pylori under Different Environmental Conditions: Identification of HP0967-HP0968 System Frontiers in Microbiology, 7, 1872.

Libros y capítulos recientes

Bravo,A. Pacheco,S. Gomez,I. Garcia-Gomez,B. Onofre,J. Soberon,M. 2017. Insecticidal Proteins from Bacillus thuringiensis and Their Mechanism of Action en: Crickmore,N. Bacillus thuringiensis and Lysinibacillus sphaericus: Characterization and use in the field of biocontrol. Cham. Springer International Publishing. pags. 53-66

* Indica publicación con otra institución de adscripción



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