Instituto de Biotecnologia UNAM

IBT-UNAM : Dr. Fidel Alejandro Sanchez Flores

Dr.

Dr. Fidel Alejandro Sanchez Flores


Encargado de la Unidad de Secuenciación Masiva y Bioinformática

Investigador

Grupo del Dr. Lorenzo Patrick Segovia

email: alexsf@ibt.unam.mx

Teléfonos

Oficina +52 (777) 329-1864
desde la CDMX 562-27864

red UNAM 27864

Laboratorio +52 (777) 329-1777 ext 38151.
desde la CDMX 562-27777 ext 38151

red UNAM 38151


- Licenciatura: Investigación Biomédica Básica, IIB-UNAM (2001)
- Doctorado: Ciencias Bioquímicas, IBT-UNAM (2007) con especialidad en Bioinformática
- Estancia de Investigación: Postdoctoral Proyecto del genoma de Taenia solium, UNAM (2007-2008)
- Estancia de Investigación: Postdoctoral Wellcome Trust Sanger Insitute, Cambridge, UK (2009-2011)


Estudiantes

Biol. Jose Santiago Sanchez

Q.B.P. Micheel Vichi

Marisol Navarro

Q.F.B. Irwing David Vásquez

Publicaciones recientes

Breton-Deval,L. Juarez,K. Sanchez-Flores,A. Vera-Estrella,R. 2019. Water quality assessments and metagenomic analysis of the polluted river Apatlaco, Mexico bioRxiv, Preprint 21 January 2019, 536128.

Garcia-Lopez,G. Avila-Gonzalez,D. Garcia-Castro,I.L. Flores-Herrera,H. Molina-Hernandez,A. Portillo,W. Diaz-Martinez,N.E. Sanchez-Flores,A. Verleyen,J. Merchant-Larios,H. Diaz,N.F. 2019. Pluripotency markers in tissue and cultivated cells in vitro of different regions of human amniotic epithelium Experimental Cell Research, 375, 31-41.

Munoz-Medina,J.E. Garcia-Knight,M.A. Sanchez-Flores,A. Monroy-Munoz,I.E. Grande,R. Esbjornsson,J. Santacruz-Tinoco,C.E. Gonzalez-Bonilla,C.R. 2018. Evolutionary analysis of the Chikungunya virus epidemic in Mexico reveals intra-host mutational hotspots in the E1 protein PLoS ONE, 13, e0209292.

Godoy-Lozano,E.E. Escobar-Zepeda,A. Raggi,L. Merino,E. Gutierrez-Rios,R.M. Juarez,K. Segovia,L. Licea-Navarro,A.F. Gracia,A. Sanchez-Flores,A. Pardo-Lopez,L. 2018. Bacterial diversity and the geochemical landscape in the southwestern Gulf of Mexico Frontiers in Microbiology, 9, 2528.

Barreto-Curiel,F. Ramirez-Puebla,S.T. Ringo,E. Escobar-Zepeda,A. Godoy-Lozano,E. Vazquez-Duhalt,R. Sanchez-Flores,A. Viana,M.T. 2018. Effects of extruded aquafeed on growth performance and gut microbiome of juvenile Totoaba macdonaldi Animal Feed Science and Technology, 245, 91-103.

Garcia-Maldonado,J.Q. Escobar-Zepeda,A. Raggi,L. Bebout,B.M. Sanchez-Flores,A. Lopez-Cortes,A. 2018. Bacterial and archaeal profiling of hypersaline microbial mats and endoevaporites, under natural conditions and methanogenic microcosm experiments Extremophiles, 22, 903-916.

Escobar-Zepeda,A. Godoy-Lozano,E.E. Raggi,L. Segovia,L. Merino,E. Gutierrez-Rios,R.M. Juarez,K. Licea-Navarro,A.F. Pardo-Lopez,L. Sanchez-Flores,A. 2018. Analysis of sequencing strategies and tools for taxonomic annotation: Defining standards for progressive metagenomics Scientific Reports, 8, 12034.

Sanchez-Pozos,K. Ortiz-Lopez,M.G. Pena-Espinoza,B.I. Granados-Silvestre,M.A. Jimenez-Jacinto,V. Verleyen,J. Tekola-Ayele,F. Sanchez-Flores,A. Menjivar,M. 2018. Whole-exome sequencing in maya indigenous families: variant in PPP1R3A is associated with type 2 diabetes Molecular Genetics and Genomics, 293, 1205-1216.

Contreras-Castro,L. Maldonado,L.A. Quintana,E.T. Raggi,L. Sanchez-Flores,A. 2018. Draft Genome Sequence of Two Marine Plantactinospora spp. from the Gulf of California Microbiology Resource Announcements, 6, UNSP e00436-18.

Olvera-Garcia,M. Sanchez-Flores,A. Quirasco,B.M. 2018. Genomic and functional characterisation of two Enterococcus strains isolated from Cotija cheese and their potential role in ripening Applied Microbiology and Biotechnology, 102, 2251-2267.

Carrillo-Tapia,E. Garcia-Garcia,E. Herrera-Gonzalez,N.E. Yamazaki-Nakashimada,M.A. Staines-Boone,A.T. Segura-Mendez,N.H. Scheffler-Mendoza,S.C. Farrill-Romanillos,O. Gonzalez-Serrano,M.E. Rodriguez-Alba,J.C. Santos-Argumedo,L. Berron-Ruiz,L. Sanchez-Flores,A. Lopez-Herrera,G. 2018. Delayed diagnosis in X-linked agammaglobulinemia and its relationship to the occurrence of mutations in BTK non-kinase domains Expert Review of Clinical Immunology, 14, 83-93.

Garcia,C.F. Pedrini,N. Sanchez-Paz,A. Reyna-Blanco,C.S. Lavarias,S. Muhlia-Almazan,A. Fernandez-Gimenez,A. Laino,A. de-la-Re-Vega,E. Lukaszewicz,G. Lopez-Zavala,A.A. Brieba,L.G. Criscitello,M.F. Carrasco-Miranda,J.S. Garcia-Orozco,K.D. Ochoa-Leyva,A. Rudino-Pinera,E. Sanchez-Flores,A. Sotelo-Mundo,R.R. 2018. De novo assembly and transcriptome characterization of the freshwater prawn Palaemonetes argentinus: Implications for a detoxification response Marine Genomics, 37, 74-81.

Titulaer,M. Melgoza-Castillo,A. Panjabi,A.O. Sanchez-Flores,A. Martinez-Guerrero,J.H. Macias-Duarte,A. Fernandez,J.A. 2017. Molecular analysis of stomach contents reveals important grass seeds in the winter diet of Baird's and Grasshopper sparrows, two declining grassland bird species PLoS ONE, 12, e0189695.

Olvera,A. Martyniuk,C.J. Buisine,N. Jimenez-Jacinto,V. Sanchez-Flores,A. Sachs,L.M. Orozco,A. 2017. Differential transcriptome regulation by 3,5-T2 and 3',3,5-T3 in brain and liver uncovers novel roles for thyroid hormones in tilapia Scientific Reports, 7, 15043.

Ortiz-Berrocal,M. Lozano,L. Sanchez-Flores,A. Nava,N. Hernandez,G. Reddy,P.M. 2017. Expression in rice of an autoactive variant of Medicago truncatula DMI3, the Ca+2/calmodulin-dependent protein kinase from the common symbiotic pathway modifies root transcriptome and improves mycorrhizal colonization Plant Biotechnology Reports, 11, 271-287.

Sandoval-Azuara,S.E. Perea-Jacobo,R. Muniz-Salazar,R. Robbe-Austerman,S. Perera-Ortiz,A. Lopez-Valencia,G. Bravo,D.M. Sanchez-Flores,A. Miranda-Guzman,D. Flores-Lopez,C.A. Zenteno-Cuevas,R. Laniado-Laborin,R. Lafarga de la,C.F. Stuber,T.P. 2017. Whole genome sequencing of Mycobacterium bovis to obtain molecular fingerprints in human and cattle isolates from Baja California, Mexico International Journal of Infectious Diseases, 63, 48-56.

Rodriguez-Anaya,L.Z. Ibarra-Gamez,J.C. Lares-Villa,F. Casillas-Hernandez,R. Sanchez-Flores,A. Gonzalez-Galaviz,J.R. 2016. Analysis of repeated compound units in ORF94 of white spot syndrome virus isolated from Litopenaeus vannamei from outbreak and non-outbreak shrimp farms in Sonora, Mexico Latin American Journal of Aquatic Research, 44, 850-854.

Ramirez-Puebla,S.T. Ormeno-Orrillo,E. Vera-Ponce de Leon A. Lozano,L. Sanchez-Flores,A. Rosenblueth,M. Martinez-Romero,E. 2016. Genomes of Candidatus Wolbachia bourtzisii wDacA and Candidatus Wolbachia pipientis wDacB from the Cochineal Insect Dactylopius coccus (Hemiptera: Dactylopiidae) G3: Genes, Genomes, Genetics, 6, 3343-3349.

Sanchez-Flores,A. Penazola,F. Carpinteyro-Ponce,J. Nazario-Yepiz,N. Abreu-Goodger,C. Machado,C.A. Markow,T.A. 2016. Genome Evolution in Three Species of Cactophilic Drosophila G3: Genes, Genomes, Genetics, 6, 3097-3105.

Vera-Ponce De Leon,A. Sanchez-Flores,A. Rosenblueth,M. Martinez-Romero,E. 2016. Fungal Community Associated with Dactylopius (Hemiptera: Coccoidea: Dactylopiidae) and Its Role in Uric Acid Metabolism Frontiers in Microbiology, 7, 954.

Bedoya-Lopez,A. Estrada,K. Sanchez-Flores,A. Ramirez,O.T. Altamirano,C. Segovia,L. Miranda-Rios,J. Trujillo-Roldan,M.A. Valdez-Cruz,N.A. 2016. Effect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human Tissue Plasminogen Activator Production Culture PLoS ONE, 11, e0151529.

Escobar-Zepeda,A. Sanchez-Flores,A. Quirasco Baruch,M. 2016. Metagenomic analysis of a Mexican ripened cheese reveals a unique complex microbiota Food Microbiology, 57, 116-127.

Rodriguez-Anaya,L.Z. Gonzalez-Galaviz,J.R. Casillas-Hernandez,R. Lares-Villa,F. Estrada,K. Ibarra-Gamez,J.C. Sanchez-Flores,A. 2016. Draft Genome Sequence of White Spot Syndrome Virus Isolated from Cultured Litopenaeus vannamei in Mexico Genome Announcements, 4, .

Hunt,V.L. Tsai,I.J. Coghlan,A. Reid,A.J. Holroyd,N. Foth,B.J. Tracey,A. Cotton,J.A. Stanley,E.J. Beasley,H. Bennett,H.M. Brooks,K. Harsha,B. Kajitani,R. Kulkarni,A. Harbecke,D. Nagayasu,E. Nichol,S. Ogura,Y. Quail,M.A. Randle,N. Xia,D. Brattig,N.W. Soblik,H. Ribeiro,D.M. Sanchez-Flores,A. Hayashi,T. Itoh,T. Denver,D.R. Grant,W. Stoltzfus,J.D. Lok,J.B. Murayama,H. Wastling,J. Streit,A. Kikuchi,T. Viney,M. Berriman,M. 2016. The genomic basis of parasitism in the Strongyloides clade of nematodes Nature Genetics, 48, 299-307.

Escobar-Zepeda,A. Vera-Ponce De Leon,A. Sanchez-Flores,A. 2015. The road to metagenomics: from microbiology to DNA sequencing technologies and bioinformatics Frontiers in Genetics, 6, .

Olvera-Garcia,M. Fontes-Perez,H. Chavez-Martinez,A. Ruiz-Barrera O. Rodriguez-Almeida,F.A. Sanchez-Flores,A. Corral-Luna,A. 2015. Draft Genome Sequences for Five Strains of Trabulsiella odontotermitis, Isolated from Heterotermes sp. Termite Gut Genome Announcements, 3, art. no. e0128915.

Fontes-Perez,H. Olvera-Garcia,M. Chavez-Martinez,A. Rodriguez-Almeida,F.A. Arzola-Alvarez,C.A. Sanchez-Flores,A. Corral-Luna,A. 2015. Genome Sequence of Citrobacter sp. CtB7.12, Isolated from the Gut of the Desert Subterranean Termite Heterotermes aureus Genome Announcements, 3, art. no. e0129015.

Velez,P. Alejandri-Ramirez,N.D. Gonzalez,M.C. Estrada,K.J. Sanchez-Flores,A. Dinkova,T.D. 2015. Comparative Transcriptome Analysis of the Cosmopolitan Marine Fungus Corollospora maritima Under Two Physiological Conditions G3: Genes, Genomes, Genetics, 5, 1805-1814.

Gomez-Angulo,J. Vega-Alvarado,L. Escalante-Garcia,Z. Grande,R. Gschaedler-Mathis,A. Amaya-Delgado,L. Arrizon,J. Sanchez-Flores,A. 2015. Genome Sequence of Torulaspora delbrueckii NRRL Y-50541, Isolated from Mezcal Fermentation Genome Announcements, 3, .

Calva,E. Silva,C. Zaidi,M.B. Sanchez-Flores,A. Estrada,K. Silva,G.G. Soto-Jimenez,L.M. Wiesner,M. Fernandez-Mora,M. Edwards,R.A. Vinuesa,P. 2015. Complete Genome Sequencing of a Multidrug-Resistant and Human-Invasive Salmonella enterica Serovar Typhimurium Strain of the Emerging Sequence Type 213 Genotype Genome Announcements, 3, e00663-15.

Vega-Alvarado,L. Gomez-Angulo,J. Escalante-Garcia,Z. Grande,R. Gschaedler-Mathis,A. Amaya-Delgado,L. Sanchez-Flores,A. Arrizon,J. 2015. High-Quality Draft Genome Sequence of Candida apicola NRRL Y-50540 Genome Announcements, 3, [correction en vol 3 (4) 2015].

Valencia-Morales,M.P. Zaina,S. Heyn,H. Carmona,F.J. Varol,N. Sayols,S. Condom,E. Ramirez-Ruz,J. Gomez,A. Moran,S. Lund,G. Rodriguez-Rios,D. Lopez-Gonzalez,G. Ramirez-Nava,M. de la Rocha C. Sanchez-Flores,A. Esteller,M. 2015. The DNA methylation drift of the atherosclerotic aorta increases with lesion progression BMC Medical Genomics, 8, 85.

Dautt-Castro,M. Ochoa-Leyva,A. Contreras-Vergara,C.A. Pacheco-Sanchez,M.A. Casas-Flores,S. Sanchez-Flores,A. Kuhn,D.N. Islas-Osuna,M.A. 2015. Mango (Mangifera indica L.) cv. Kent fruit mesocarp de novo transcriptome assembly identifies gene families important for ripening Frontiers in Plant Science, 6, .

Glover,L. Alsford,S. Baker,N. Turner,D.J. Sanchez-Flores,A. Hutchinson,S. Hertz-Fowler,C. Berriman,M. Horn,D. 2015. Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes Nature Protocols, 10, 106-133.

Libros y capítulos recientes

Nabor-Romero,O. Rojas-Martinez,R.I. Zavaleta-Mejia,E. Ochoa-Martinez,D.L. Sanchez-Flores,F.A. Vega-Arreguin,J. 2018. Análisis del transcriptoma de chile cm-334 en el rompimiento de resistencia a Phytophthora capsici por Nacobbus aberrans en: Memoria del Simposio Avances de Investigación Posgrado en Fitosanidad Colegio de Postgraduados 22 agosto 2018. pags. 89-94

Sanchez-Flores,F. 2016. Secuenciacion masiva en la era genomica en: Ramirez-Bello,J. Genómica estructural y funcional en las enfermedades multifactoriales. UNAM.


Divulgación

Jimenez-Jacinto,V. Escobar-Zepeda,A. Godoy,E. Vega-Alvarado,L. Verleyen,J. Estrada,K. Sanchez-Flores,A. 2017. El metagenoma del taco Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 8, 29-32.

Sanchez-Flores,A. 2015. Unidad de Secuenciación Masiva y Bioinformática, a la vanguardia de la ciencia Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 2, 23-24.

Sanchez-Flores,A. 2015. Las nuevas tecnologías y el cómputo nos ayudan a estudiar detalladamente a los patógenos Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 2, 3-4.

* Indica publicación con otra institución de adscripción



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